Essential tremor and Parkinson's disease: Lack of a link
Identifieur interne : 002875 ( Main/Corpus ); précédent : 002874; suivant : 002876Essential tremor and Parkinson's disease: Lack of a link
Auteurs : Charles. H. Adler ; Holly A. Shill ; Thomas G. BeachSource :
- Movement Disorders [ 0885-3185 ] ; 2011-02-15.
English descriptors
Abstract
Background:: Essential tremor (ET) is a very common disorder and proving that there is a relationship to another common movement disorder, Parkinson's disease (PD), has been debated for years. Methods:: Review of the literature for links between ET and PD primarily focused on neuropathology as well as neurochemistry, epidemiology, genetics, olfactory function, and neuroimaging. Results:: While there may be some evidence to suggest an increase in occurrence of PD in people who were previously diagnosed with ET, neuropathologic studies of ET with similarly assessed control subjects do not find an increase in Lewy bodies in the ET group. Studies of incidental Lewy body disease do not find an increase in ET or action tremor compared to controls. ET subjects as a group do not have neurochemical changes that are found in PD, do not respond to medications used to treat PD, are not hyposmic as is found in PD, and neuroimaging studies do not find changes of PD when groups are compared. Conclusion:: The overwhelming amount of evidence suggests that any link between ET and PD is coincidental and not biological. Prospective, longitudinal cohort studies with standardized clinical and biomarker assessments followed by neuropathologic confirmation are needed. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23509
Links to Exploration step
ISTEX:34497E4770D88A81C380C53A22B35349AD910B84Le document en format XML
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Adler</name><affiliation><mods:affiliation>Parkinson's Disease and Movement Disorders Center, Mayo Clinic, Scottsdale, Arizona, USA</mods:affiliation></affiliation></author><author><name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A." last="Shill">Holly A. Shill</name><affiliation><mods:affiliation>Sun Health Research Institute, Sun City, Arizona, USA</mods:affiliation></affiliation></author><author><name sortKey="Beach, Thomas G" sort="Beach, Thomas G" uniqKey="Beach T" first="Thomas G." last="Beach">Thomas G. Beach</name><affiliation><mods:affiliation>Sun Health Research Institute, Sun City, Arizona, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-15">2011-02-15</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="372">372</biblScope><biblScope unit="page" to="377">377</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">34497E4770D88A81C380C53A22B35349AD910B84</idno><idno type="DOI">10.1002/mds.23509</idno><idno type="ArticleID">MDS23509</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Lewy body</term><term>Parkinson's disease</term><term>essential tremor</term><term>neuropathology</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: Essential tremor (ET) is a very common disorder and proving that there is a relationship to another common movement disorder, Parkinson's disease (PD), has been debated for years. Methods:: Review of the literature for links between ET and PD primarily focused on neuropathology as well as neurochemistry, epidemiology, genetics, olfactory function, and neuroimaging. Results:: While there may be some evidence to suggest an increase in occurrence of PD in people who were previously diagnosed with ET, neuropathologic studies of ET with similarly assessed control subjects do not find an increase in Lewy bodies in the ET group. Studies of incidental Lewy body disease do not find an increase in ET or action tremor compared to controls. ET subjects as a group do not have neurochemical changes that are found in PD, do not respond to medications used to treat PD, are not hyposmic as is found in PD, and neuroimaging studies do not find changes of PD when groups are compared. Conclusion:: The overwhelming amount of evidence suggests that any link between ET and PD is coincidental and not biological. Prospective, longitudinal cohort studies with standardized clinical and biomarker assessments followed by neuropathologic confirmation are needed. © 2011 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Charles. H. Adler MD, PhD</name><affiliations><json:string>Parkinson's Disease and Movement Disorders Center, Mayo Clinic, Scottsdale, Arizona, USA</json:string></affiliations></json:item><json:item><name>Holly A. Shill MD</name><affiliations><json:string>Sun Health Research Institute, Sun City, Arizona, USA</json:string></affiliations></json:item><json:item><name>Thomas G. Beach MD, PhD</name><affiliations><json:string>Sun Health Research Institute, Sun City, Arizona, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>essential tremor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Lewy body</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>neuropathology</value></json:item></subject><articleId><json:string>MDS23509</json:string></articleId><language><json:string>eng</json:string></language><abstract>Background:: Essential tremor (ET) is a very common disorder and proving that there is a relationship to another common movement disorder, Parkinson's disease (PD), has been debated for years. Methods:: Review of the literature for links between ET and PD primarily focused on neuropathology as well as neurochemistry, epidemiology, genetics, olfactory function, and neuroimaging. Results:: While there may be some evidence to suggest an increase in occurrence of PD in people who were previously diagnosed with ET, neuropathologic studies of ET with similarly assessed control subjects do not find an increase in Lewy bodies in the ET group. Studies of incidental Lewy body disease do not find an increase in ET or action tremor compared to controls. ET subjects as a group do not have neurochemical changes that are found in PD, do not respond to medications used to treat PD, are not hyposmic as is found in PD, and neuroimaging studies do not find changes of PD when groups are compared. Conclusion:: The overwhelming amount of evidence suggests that any link between ET and PD is coincidental and not biological. 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This work was funded by the Arizona Biomedical Research Commission (contracts 4001, 05‐901, 0011, and 1001), the Michael J. Fox Foundation for Parkinson's Research, the Arizona Department of Health Services (contract 211002), and the National Institute on Aging (P30 AG19610). Full financial disclosures and author roles may be found in the online version of this article.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Essential tremor and Parkinson's disease: Lack of a link</title><author><persName><forename type="first">Charles. H.</forename><surname>Adler</surname></persName><roleName type="degree">MD, PhD</roleName><note type="correspondence"><p>Correspondence: Parkinson's Disease and Movement Disorders Center, Mayo Clinic Arizona, 13400 E. Shea Blvd., Scottsdale, Arizona 85259</p></note><affiliation>Parkinson's Disease and Movement Disorders Center, Mayo Clinic, Scottsdale, Arizona, USA</affiliation></author><author><persName><forename type="first">Holly A.</forename><surname>Shill</surname></persName><roleName type="degree">MD</roleName><affiliation>Sun Health Research Institute, Sun City, Arizona, USA</affiliation></author><author><persName><forename type="first">Thomas G.</forename><surname>Beach</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Sun Health Research Institute, Sun City, Arizona, USA</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-15"></date><biblScope unit="volume">26</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="372">372</biblScope><biblScope unit="page" to="377">377</biblScope></imprint></monogr><idno type="istex">34497E4770D88A81C380C53A22B35349AD910B84</idno><idno type="DOI">10.1002/mds.23509</idno><idno type="ArticleID">MDS23509</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background:: Essential tremor (ET) is a very common disorder and proving that there is a relationship to another common movement disorder, Parkinson's disease (PD), has been debated for years. Methods:: Review of the literature for links between ET and PD primarily focused on neuropathology as well as neurochemistry, epidemiology, genetics, olfactory function, and neuroimaging. Results:: While there may be some evidence to suggest an increase in occurrence of PD in people who were previously diagnosed with ET, neuropathologic studies of ET with similarly assessed control subjects do not find an increase in Lewy bodies in the ET group. Studies of incidental Lewy body disease do not find an increase in ET or action tremor compared to controls. ET subjects as a group do not have neurochemical changes that are found in PD, do not respond to medications used to treat PD, are not hyposmic as is found in PD, and neuroimaging studies do not find changes of PD when groups are compared. Conclusion:: The overwhelming amount of evidence suggests that any link between ET and PD is coincidental and not biological. Prospective, longitudinal cohort studies with standardized clinical and biomarker assessments followed by neuropathologic confirmation are needed. © 2011 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>essential tremor</term></item><item><term>Lewy body</term></item><item><term>neuropathology</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Viewpoint</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-10-06">Received</change><change when="2010-10-11">Registration</change><change when="2011-02-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/34497E4770D88A81C380C53A22B35349AD910B84/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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Shea Blvd., Scottsdale, Arizona 85259</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS23509.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="0"></count><count type="referenceTotal" number="46"></count><count type="wordTotal" number="4957"></count></countGroup><titleGroup><title type="main" xml:lang="en">Essential tremor and Parkinson's disease: Lack of a link<link href="#fn1"></link></title><title type="short" xml:lang="en">ET and PD: Lack of a Link</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Charles. H.</givenNames><familyName>Adler</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email>cadler@mayo.edu</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Holly A.</givenNames><familyName>Shill</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Thomas G.</givenNames><familyName>Beach</familyName><degrees>MD, PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Parkinson's Disease and Movement Disorders Center, Mayo Clinic, Scottsdale, Arizona, USA</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Sun Health Research Institute, Sun City, Arizona, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">essential tremor</keyword><keyword xml:id="kwd3">Lewy body</keyword><keyword xml:id="kwd4">neuropathology</keyword></keywordGroup><supportingInformation><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds23509:MDS_23509_sm_authorroles"></mediaResource><caption>Author Roles and Disclosures</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main">Background:</title><p>Essential tremor (ET) is a very common disorder and proving that there is a relationship to another common movement disorder, Parkinson's disease (PD), has been debated for years.</p></section><section xml:id="abs1-2"><title type="main">Methods:</title><p>Review of the literature for links between ET and PD primarily focused on neuropathology as well as neurochemistry, epidemiology, genetics, olfactory function, and neuroimaging.</p></section><section xml:id="abs1-3"><title type="main">Results:</title><p>While there may be some evidence to suggest an increase in occurrence of PD in people who were previously diagnosed with ET, neuropathologic studies of ET with similarly assessed control subjects do not find an increase in Lewy bodies in the ET group. Studies of incidental Lewy body disease do not find an increase in ET or action tremor compared to controls. ET subjects as a group do not have neurochemical changes that are found in PD, do not respond to medications used to treat PD, are not hyposmic as is found in PD, and neuroimaging studies do not find changes of PD when groups are compared.</p></section><section xml:id="abs1-4"><title type="main">Conclusion:</title><p>The overwhelming amount of evidence suggests that any link between ET and PD is coincidental and not biological. Prospective, longitudinal cohort studies with standardized clinical and biomarker assessments followed by neuropathologic confirmation are needed. © 2011 Movement Disorder Society</p></section></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p><b>Relevant conflicts of interest/financial disclosures:</b> Nothing to report. This work was funded by the Arizona Biomedical Research Commission (contracts 4001, 05‐901, 0011, and 1001), the Michael J. Fox Foundation for Parkinson's Research, the Arizona Department of Health Services (contract 211002), and the National Institute on Aging (P30 AG19610). Full financial disclosures and author roles may be found in the online version of this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Essential tremor and Parkinson's disease: Lack of a link</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>ET and PD: Lack of a Link</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Essential tremor and Parkinson's disease: Lack of a link</title></titleInfo><name type="personal"><namePart type="given">Charles. H.</namePart><namePart type="family">Adler</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Parkinson's Disease and Movement Disorders Center, Mayo Clinic, Scottsdale, Arizona, USA</affiliation><description>Correspondence: Parkinson's Disease and Movement Disorders Center, Mayo Clinic Arizona, 13400 E. Shea Blvd., Scottsdale, Arizona 85259</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Holly A.</namePart><namePart type="family">Shill</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Sun Health Research Institute, Sun City, Arizona, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thomas G.</namePart><namePart type="family">Beach</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Sun Health Research Institute, Sun City, Arizona, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-02-15</dateIssued><dateCaptured encoding="w3cdtf">2010-10-06</dateCaptured><dateValid encoding="w3cdtf">2010-10-11</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">46</extent><extent unit="words">4957</extent></physicalDescription><abstract lang="en">Background:: Essential tremor (ET) is a very common disorder and proving that there is a relationship to another common movement disorder, Parkinson's disease (PD), has been debated for years. Methods:: Review of the literature for links between ET and PD primarily focused on neuropathology as well as neurochemistry, epidemiology, genetics, olfactory function, and neuroimaging. Results:: While there may be some evidence to suggest an increase in occurrence of PD in people who were previously diagnosed with ET, neuropathologic studies of ET with similarly assessed control subjects do not find an increase in Lewy bodies in the ET group. Studies of incidental Lewy body disease do not find an increase in ET or action tremor compared to controls. ET subjects as a group do not have neurochemical changes that are found in PD, do not respond to medications used to treat PD, are not hyposmic as is found in PD, and neuroimaging studies do not find changes of PD when groups are compared. Conclusion:: The overwhelming amount of evidence suggests that any link between ET and PD is coincidental and not biological. Prospective, longitudinal cohort studies with standardized clinical and biomarker assessments followed by neuropathologic confirmation are needed. © 2011 Movement Disorder Society</abstract><note type="additional physical form">Author Roles and Disclosures</note><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report. This work was funded by the Arizona Biomedical Research Commission (contracts 4001, 05‐901, 0011, and 1001), the Michael J. Fox Foundation for Parkinson's Research, the Arizona Department of Health Services (contract 211002), and the National Institute on Aging (P30 AG19610). Full financial disclosures and author roles may be found in the online version of this article.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>essential tremor</topic><topic>Lewy body</topic><topic>neuropathology</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. 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