Serveur d'exploration sur la maladie de Parkinson

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Pallidonigroluysian degeneration with iron deposition: a study of three autopsy cases

Identifieur interne : 002861 ( Main/Corpus ); précédent : 002860; suivant : 002862

Pallidonigroluysian degeneration with iron deposition: a study of three autopsy cases

Auteurs : J. Kawai ; M. Sasahara ; F. Hazama ; S. Kuno ; O. Komure ; S. Nomura ; M. Yamaguchi

Source :

RBID : ISTEX:3F48FF63283244CB23E9D177CAD10D540B589E3A

Abstract

Abstract: In the basal ganglia of three autopsy cases of pallidonigroluysian degeneration, we found marked iron deposition, a finding which has not been mentioned previously in the literature. Besides severe astrogliosis and neuronal loss in the pallidum, Luysian body and nigra, granular deposits of brown pigments were found in the neuropil, microglias, oligodendrocytes and astrocytes in three such the nuclei and the striatum. These brown pigments proved histochemically to be iron. Our histochemical semiquantitative study showed a significantly stronger reation for iron in the degenerated nuclei in these three cases than in control cases comprising non-degenerative and the other degenerative diseases. Quantitative study with inductively coupled emission spectrometry also demonstrated a markedly higher iron content in the globus pallidus and the striatum in comparison with the control cases. The possibility is discussed that iron deposition plays a role in generating the lesions of pallidonigroluysian degeneration.

Url:
DOI: 10.1007/BF00294300

Links to Exploration step

ISTEX:3F48FF63283244CB23E9D177CAD10D540B589E3A

Le document en format XML

<record>
<TEI wicri:istexFullTextTei="biblStruct">
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Pallidonigroluysian degeneration with iron deposition: a study of three autopsy cases</title>
<author>
<name sortKey="Kawai, J" sort="Kawai, J" uniqKey="Kawai J" first="J." last="Kawai">J. Kawai</name>
<affiliation>
<mods:affiliation>Department of Pathology, Shiga University of Medical Science, Otsu, Japan</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Sasahara, M" sort="Sasahara, M" uniqKey="Sasahara M" first="M." last="Sasahara">M. Sasahara</name>
<affiliation>
<mods:affiliation>Department of Pathology, Shiga University of Medical Science, Otsu, Japan</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Hazama, F" sort="Hazama, F" uniqKey="Hazama F" first="F." last="Hazama">F. Hazama</name>
<affiliation>
<mods:affiliation>Department of Pathology, Shiga University of Medical Science, Otsu, Japan</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Kuno, S" sort="Kuno, S" uniqKey="Kuno S" first="S." last="Kuno">S. Kuno</name>
<affiliation>
<mods:affiliation>Department of Neurology, Utano National Hospital, Kyoto, Japan</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Komure, O" sort="Komure, O" uniqKey="Komure O" first="O." last="Komure">O. Komure</name>
<affiliation>
<mods:affiliation>Department of Neurology, Utano National Hospital, Kyoto, Japan</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Nomura, S" sort="Nomura, S" uniqKey="Nomura S" first="S." last="Nomura">S. Nomura</name>
<affiliation>
<mods:affiliation>Nihon Schering, Department of Research, Osaka, Japan</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Yamaguchi, M" sort="Yamaguchi, M" uniqKey="Yamaguchi M" first="M." last="Yamaguchi">M. Yamaguchi</name>
<affiliation>
<mods:affiliation>Nihon Schering, Department of Research, Osaka, Japan</mods:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:3F48FF63283244CB23E9D177CAD10D540B589E3A</idno>
<date when="1993" year="1993">1993</date>
<idno type="doi">10.1007/BF00294300</idno>
<idno type="url">https://api.istex.fr/document/3F48FF63283244CB23E9D177CAD10D540B589E3A/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">002861</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title level="a" type="main" xml:lang="en">Pallidonigroluysian degeneration with iron deposition: a study of three autopsy cases</title>
<author>
<name sortKey="Kawai, J" sort="Kawai, J" uniqKey="Kawai J" first="J." last="Kawai">J. Kawai</name>
<affiliation>
<mods:affiliation>Department of Pathology, Shiga University of Medical Science, Otsu, Japan</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Sasahara, M" sort="Sasahara, M" uniqKey="Sasahara M" first="M." last="Sasahara">M. Sasahara</name>
<affiliation>
<mods:affiliation>Department of Pathology, Shiga University of Medical Science, Otsu, Japan</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Hazama, F" sort="Hazama, F" uniqKey="Hazama F" first="F." last="Hazama">F. Hazama</name>
<affiliation>
<mods:affiliation>Department of Pathology, Shiga University of Medical Science, Otsu, Japan</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Kuno, S" sort="Kuno, S" uniqKey="Kuno S" first="S." last="Kuno">S. Kuno</name>
<affiliation>
<mods:affiliation>Department of Neurology, Utano National Hospital, Kyoto, Japan</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Komure, O" sort="Komure, O" uniqKey="Komure O" first="O." last="Komure">O. Komure</name>
<affiliation>
<mods:affiliation>Department of Neurology, Utano National Hospital, Kyoto, Japan</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Nomura, S" sort="Nomura, S" uniqKey="Nomura S" first="S." last="Nomura">S. Nomura</name>
<affiliation>
<mods:affiliation>Nihon Schering, Department of Research, Osaka, Japan</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Yamaguchi, M" sort="Yamaguchi, M" uniqKey="Yamaguchi M" first="M." last="Yamaguchi">M. Yamaguchi</name>
<affiliation>
<mods:affiliation>Nihon Schering, Department of Research, Osaka, Japan</mods:affiliation>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series>
<title level="j">Acta Neuropathologica</title>
<title level="j" type="abbrev">Acta Neuropathol</title>
<idno type="ISSN">0001-6322</idno>
<idno type="eISSN">1432-0533</idno>
<imprint>
<publisher>Springer-Verlag</publisher>
<pubPlace>Berlin/Heidelberg</pubPlace>
<date type="published" when="1993-11-01">1993-11-01</date>
<biblScope unit="volume">86</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="609">609</biblScope>
<biblScope unit="page" to="616">616</biblScope>
</imprint>
<idno type="ISSN">0001-6322</idno>
</series>
<idno type="istex">3F48FF63283244CB23E9D177CAD10D540B589E3A</idno>
<idno type="DOI">10.1007/BF00294300</idno>
<idno type="ArticleID">Art10</idno>
<idno type="ArticleID">BF00294300</idno>
</biblStruct>
</sourceDesc>
<seriesStmt>
<idno type="ISSN">0001-6322</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass></textClass>
<langUsage>
<language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Abstract: In the basal ganglia of three autopsy cases of pallidonigroluysian degeneration, we found marked iron deposition, a finding which has not been mentioned previously in the literature. Besides severe astrogliosis and neuronal loss in the pallidum, Luysian body and nigra, granular deposits of brown pigments were found in the neuropil, microglias, oligodendrocytes and astrocytes in three such the nuclei and the striatum. These brown pigments proved histochemically to be iron. Our histochemical semiquantitative study showed a significantly stronger reation for iron in the degenerated nuclei in these three cases than in control cases comprising non-degenerative and the other degenerative diseases. Quantitative study with inductively coupled emission spectrometry also demonstrated a markedly higher iron content in the globus pallidus and the striatum in comparison with the control cases. The possibility is discussed that iron deposition plays a role in generating the lesions of pallidonigroluysian degeneration.</div>
</front>
</TEI>
<istex>
<corpusName>springer</corpusName>
<author>
<json:item>
<name>J. Kawai</name>
<affiliations>
<json:string>Department of Pathology, Shiga University of Medical Science, Otsu, Japan</json:string>
</affiliations>
</json:item>
<json:item>
<name>M. Sasahara</name>
<affiliations>
<json:string>Department of Pathology, Shiga University of Medical Science, Otsu, Japan</json:string>
</affiliations>
</json:item>
<json:item>
<name>F. Hazama</name>
<affiliations>
<json:string>Department of Pathology, Shiga University of Medical Science, Otsu, Japan</json:string>
</affiliations>
</json:item>
<json:item>
<name>S. Kuno</name>
<affiliations>
<json:string>Department of Neurology, Utano National Hospital, Kyoto, Japan</json:string>
</affiliations>
</json:item>
<json:item>
<name>O. Komure</name>
<affiliations>
<json:string>Department of Neurology, Utano National Hospital, Kyoto, Japan</json:string>
</affiliations>
</json:item>
<json:item>
<name>S. Nomura</name>
<affiliations>
<json:string>Nihon Schering, Department of Research, Osaka, Japan</json:string>
</affiliations>
</json:item>
<json:item>
<name>M. Yamaguchi</name>
<affiliations>
<json:string>Nihon Schering, Department of Research, Osaka, Japan</json:string>
</affiliations>
</json:item>
</author>
<articleId>
<json:string>Art10</json:string>
<json:string>BF00294300</json:string>
</articleId>
<language>
<json:string>eng</json:string>
</language>
<abstract>Abstract: In the basal ganglia of three autopsy cases of pallidonigroluysian degeneration, we found marked iron deposition, a finding which has not been mentioned previously in the literature. Besides severe astrogliosis and neuronal loss in the pallidum, Luysian body and nigra, granular deposits of brown pigments were found in the neuropil, microglias, oligodendrocytes and astrocytes in three such the nuclei and the striatum. These brown pigments proved histochemically to be iron. Our histochemical semiquantitative study showed a significantly stronger reation for iron in the degenerated nuclei in these three cases than in control cases comprising non-degenerative and the other degenerative diseases. Quantitative study with inductively coupled emission spectrometry also demonstrated a markedly higher iron content in the globus pallidus and the striatum in comparison with the control cases. The possibility is discussed that iron deposition plays a role in generating the lesions of pallidonigroluysian degeneration.</abstract>
<qualityIndicators>
<score>5.524</score>
<pdfVersion>1.3</pdfVersion>
<pdfPageSize>597.28 x 785 pts</pdfPageSize>
<refBibsNative>false</refBibsNative>
<keywordCount>0</keywordCount>
<abstractCharCount>1029</abstractCharCount>
<pdfWordCount>3784</pdfWordCount>
<pdfCharCount>18863</pdfCharCount>
<pdfPageCount>8</pdfPageCount>
<abstractWordCount>145</abstractWordCount>
</qualityIndicators>
<title>Pallidonigroluysian degeneration with iron deposition: a study of three autopsy cases</title>
<genre>
<json:string>research-article</json:string>
</genre>
<host>
<volume>86</volume>
<pages>
<last>616</last>
<first>609</first>
</pages>
<issn>
<json:string>0001-6322</json:string>
</issn>
<issue>6</issue>
<subject>
<json:item>
<value>Pathology</value>
</json:item>
</subject>
<journalId>
<json:string>401</json:string>
</journalId>
<genre>
<json:string>Journal</json:string>
</genre>
<language>
<json:string>unknown</json:string>
</language>
<eissn>
<json:string>1432-0533</json:string>
</eissn>
<title>Acta Neuropathologica</title>
<publicationDate>1993</publicationDate>
<copyrightDate>1993</copyrightDate>
</host>
<publicationDate>1993</publicationDate>
<copyrightDate>1993</copyrightDate>
<doi>
<json:string>10.1007/BF00294300</json:string>
</doi>
<id>3F48FF63283244CB23E9D177CAD10D540B589E3A</id>
<fulltext>
<json:item>
<original>true</original>
<mimetype>application/pdf</mimetype>
<extension>pdf</extension>
<uri>https://api.istex.fr/document/3F48FF63283244CB23E9D177CAD10D540B589E3A/fulltext/pdf</uri>
</json:item>
<json:item>
<original>false</original>
<mimetype>application/zip</mimetype>
<extension>zip</extension>
<uri>https://api.istex.fr/document/3F48FF63283244CB23E9D177CAD10D540B589E3A/fulltext/zip</uri>
</json:item>
<istex:fulltextTEI uri="https://api.istex.fr/document/3F48FF63283244CB23E9D177CAD10D540B589E3A/fulltext/tei">
<teiHeader>
<fileDesc>
<titleStmt>
<title level="a" type="main" xml:lang="en">Pallidonigroluysian degeneration with iron deposition: a study of three autopsy cases</title>
<respStmt xml:id="ISTEX-API" resp="Références bibliographiques récupérées via GROBID" name="ISTEX-API (INIST-CNRS)"></respStmt>
</titleStmt>
<publicationStmt>
<authority>ISTEX</authority>
<publisher>Springer-Verlag</publisher>
<pubPlace>Berlin/Heidelberg</pubPlace>
<availability>
<p>SPRINGER</p>
</availability>
<date>1991-06-24</date>
</publicationStmt>
<notesStmt>
<note>Regular Papers</note>
</notesStmt>
<sourceDesc>
<biblStruct type="inbook">
<analytic>
<title level="a" type="main" xml:lang="en">Pallidonigroluysian degeneration with iron deposition: a study of three autopsy cases</title>
<author corresp="yes">
<persName>
<forename type="first">J.</forename>
<surname>Kawai</surname>
</persName>
<affiliation>Department of Pathology, Shiga University of Medical Science, Otsu, Japan</affiliation>
</author>
<author>
<persName>
<forename type="first">M.</forename>
<surname>Sasahara</surname>
</persName>
<affiliation>Department of Pathology, Shiga University of Medical Science, Otsu, Japan</affiliation>
</author>
<author>
<persName>
<forename type="first">F.</forename>
<surname>Hazama</surname>
</persName>
<affiliation>Department of Pathology, Shiga University of Medical Science, Otsu, Japan</affiliation>
</author>
<author>
<persName>
<forename type="first">S.</forename>
<surname>Kuno</surname>
</persName>
<affiliation>Department of Neurology, Utano National Hospital, Kyoto, Japan</affiliation>
</author>
<author>
<persName>
<forename type="first">O.</forename>
<surname>Komure</surname>
</persName>
<affiliation>Department of Neurology, Utano National Hospital, Kyoto, Japan</affiliation>
</author>
<author>
<persName>
<forename type="first">S.</forename>
<surname>Nomura</surname>
</persName>
<affiliation>Nihon Schering, Department of Research, Osaka, Japan</affiliation>
</author>
<author>
<persName>
<forename type="first">M.</forename>
<surname>Yamaguchi</surname>
</persName>
<affiliation>Nihon Schering, Department of Research, Osaka, Japan</affiliation>
</author>
</analytic>
<monogr>
<title level="j">Acta Neuropathologica</title>
<title level="j" type="abbrev">Acta Neuropathol</title>
<idno type="JournalID">401</idno>
<idno type="pISSN">0001-6322</idno>
<idno type="eISSN">1432-0533</idno>
<idno type="IssueArticleCount">18</idno>
<idno type="VolumeIssueCount">6</idno>
<imprint>
<publisher>Springer-Verlag</publisher>
<pubPlace>Berlin/Heidelberg</pubPlace>
<date type="published" when="1993-11-01"></date>
<biblScope unit="volume">86</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="609">609</biblScope>
<biblScope unit="page" to="616">616</biblScope>
</imprint>
</monogr>
<idno type="istex">3F48FF63283244CB23E9D177CAD10D540B589E3A</idno>
<idno type="DOI">10.1007/BF00294300</idno>
<idno type="ArticleID">Art10</idno>
<idno type="ArticleID">BF00294300</idno>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<creation>
<date>1991-06-24</date>
</creation>
<langUsage>
<language ident="en">en</language>
</langUsage>
<abstract xml:lang="en">
<p>Abstract: In the basal ganglia of three autopsy cases of pallidonigroluysian degeneration, we found marked iron deposition, a finding which has not been mentioned previously in the literature. Besides severe astrogliosis and neuronal loss in the pallidum, Luysian body and nigra, granular deposits of brown pigments were found in the neuropil, microglias, oligodendrocytes and astrocytes in three such the nuclei and the striatum. These brown pigments proved histochemically to be iron. Our histochemical semiquantitative study showed a significantly stronger reation for iron in the degenerated nuclei in these three cases than in control cases comprising non-degenerative and the other degenerative diseases. Quantitative study with inductively coupled emission spectrometry also demonstrated a markedly higher iron content in the globus pallidus and the striatum in comparison with the control cases. The possibility is discussed that iron deposition plays a role in generating the lesions of pallidonigroluysian degeneration.</p>
</abstract>
<textClass>
<keywords scheme="Journal Subject">
<list>
<head>Medicine & Public Health</head>
<item>
<term>Pathology</term>
</item>
</list>
</keywords>
</textClass>
</profileDesc>
<revisionDesc>
<change when="1991-06-24">Created</change>
<change when="1993-11-01">Published</change>
<change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-3-2">References added</change>
</revisionDesc>
</teiHeader>
</istex:fulltextTEI>
<json:item>
<original>false</original>
<mimetype>text/plain</mimetype>
<extension>txt</extension>
<uri>https://api.istex.fr/document/3F48FF63283244CB23E9D177CAD10D540B589E3A/fulltext/txt</uri>
</json:item>
</fulltext>
<metadata>
<istex:metadataXml wicri:clean="Springer, Publisher found" wicri:toSee="no header">
<istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration>
<istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType>
<istex:document>
<Publisher>
<PublisherInfo>
<PublisherName>Springer-Verlag</PublisherName>
<PublisherLocation>Berlin/Heidelberg</PublisherLocation>
</PublisherInfo>
<Journal>
<JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered">
<JournalID>401</JournalID>
<JournalPrintISSN>0001-6322</JournalPrintISSN>
<JournalElectronicISSN>1432-0533</JournalElectronicISSN>
<JournalTitle>Acta Neuropathologica</JournalTitle>
<JournalAbbreviatedTitle>Acta Neuropathol</JournalAbbreviatedTitle>
<JournalSubjectGroup>
<JournalSubject Type="Primary">Medicine & Public Health</JournalSubject>
<JournalSubject Type="Secondary">Pathology</JournalSubject>
</JournalSubjectGroup>
</JournalInfo>
<Volume>
<VolumeInfo VolumeType="Regular" TocLevels="0">
<VolumeIDStart>86</VolumeIDStart>
<VolumeIDEnd>86</VolumeIDEnd>
<VolumeIssueCount>6</VolumeIssueCount>
</VolumeInfo>
<Issue IssueType="Regular">
<IssueInfo TocLevels="0">
<IssueIDStart>6</IssueIDStart>
<IssueIDEnd>6</IssueIDEnd>
<IssueArticleCount>18</IssueArticleCount>
<IssueHistory>
<CoverDate>
<Year>1993</Year>
<Month>11</Month>
</CoverDate>
</IssueHistory>
<IssueCopyright>
<CopyrightHolderName>Springer-Verlag</CopyrightHolderName>
<CopyrightYear>1993</CopyrightYear>
</IssueCopyright>
</IssueInfo>
<Article ID="Art10">
<ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No">
<ArticleID>BF00294300</ArticleID>
<ArticleDOI>10.1007/BF00294300</ArticleDOI>
<ArticleSequenceNumber>10</ArticleSequenceNumber>
<ArticleTitle Language="En">Pallidonigroluysian degeneration with iron deposition: a study of three autopsy cases</ArticleTitle>
<ArticleCategory>Regular Papers</ArticleCategory>
<ArticleFirstPage>609</ArticleFirstPage>
<ArticleLastPage>616</ArticleLastPage>
<ArticleHistory>
<RegistrationDate>
<Year>2004</Year>
<Month>8</Month>
<Day>18</Day>
</RegistrationDate>
<Received>
<Year>1991</Year>
<Month>6</Month>
<Day>24</Day>
</Received>
<Revised>
<Year>1993</Year>
<Month>8</Month>
<Day>3</Day>
</Revised>
<Accepted>
<Year>1993</Year>
<Month>8</Month>
<Day>16</Day>
</Accepted>
</ArticleHistory>
<ArticleCopyright>
<CopyrightHolderName>Springer-Verlag</CopyrightHolderName>
<CopyrightYear>1993</CopyrightYear>
</ArticleCopyright>
<ArticleGrants Type="Regular">
<MetadataGrant Grant="OpenAccess"></MetadataGrant>
<AbstractGrant Grant="OpenAccess"></AbstractGrant>
<BodyPDFGrant Grant="Restricted"></BodyPDFGrant>
<BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant>
<BibliographyGrant Grant="Restricted"></BibliographyGrant>
<ESMGrant Grant="Restricted"></ESMGrant>
</ArticleGrants>
<ArticleContext>
<JournalID>401</JournalID>
<VolumeIDStart>86</VolumeIDStart>
<VolumeIDEnd>86</VolumeIDEnd>
<IssueIDStart>6</IssueIDStart>
<IssueIDEnd>6</IssueIDEnd>
</ArticleContext>
</ArticleInfo>
<ArticleHeader>
<AuthorGroup>
<Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1" PresentAffiliationID="Aff2">
<AuthorName DisplayOrder="Western">
<GivenName>J.</GivenName>
<FamilyName>Kawai</FamilyName>
</AuthorName>
</Author>
<Author AffiliationIDS="Aff1">
<AuthorName DisplayOrder="Western">
<GivenName>M.</GivenName>
<FamilyName>Sasahara</FamilyName>
</AuthorName>
</Author>
<Author AffiliationIDS="Aff1">
<AuthorName DisplayOrder="Western">
<GivenName>F.</GivenName>
<FamilyName>Hazama</FamilyName>
</AuthorName>
</Author>
<Author AffiliationIDS="Aff3">
<AuthorName DisplayOrder="Western">
<GivenName>S.</GivenName>
<FamilyName>Kuno</FamilyName>
</AuthorName>
</Author>
<Author AffiliationIDS="Aff3">
<AuthorName DisplayOrder="Western">
<GivenName>O.</GivenName>
<FamilyName>Komure</FamilyName>
</AuthorName>
</Author>
<Author AffiliationIDS="Aff4">
<AuthorName DisplayOrder="Western">
<GivenName>S.</GivenName>
<FamilyName>Nomura</FamilyName>
</AuthorName>
</Author>
<Author AffiliationIDS="Aff4">
<AuthorName DisplayOrder="Western">
<GivenName>M.</GivenName>
<FamilyName>Yamaguchi</FamilyName>
</AuthorName>
</Author>
<Affiliation ID="Aff1">
<OrgDivision>Department of Pathology</OrgDivision>
<OrgName>Shiga University of Medical Science</OrgName>
<OrgAddress>
<City>Otsu</City>
<Country>Japan</Country>
</OrgAddress>
</Affiliation>
<Affiliation ID="Aff3">
<OrgDivision>Department of Neurology</OrgDivision>
<OrgName>Utano National Hospital</OrgName>
<OrgAddress>
<City>Kyoto</City>
<Country>Japan</Country>
</OrgAddress>
</Affiliation>
<Affiliation ID="Aff4">
<OrgDivision>Nihon Schering</OrgDivision>
<OrgName>Department of Research</OrgName>
<OrgAddress>
<City>Osaka</City>
<Country>Japan</Country>
</OrgAddress>
</Affiliation>
<Affiliation ID="Aff2">
<OrgDivision>Department of Pathology</OrgDivision>
<OrgName>Kinki University School of Medicine</OrgName>
<OrgAddress>
<Street>Ono-Higashi 377-2</Street>
<Postcode>589</Postcode>
<City>Osaka-Sayama</City>
<Country>Japan</Country>
</OrgAddress>
</Affiliation>
</AuthorGroup>
<Abstract ID="Abs1" Language="En">
<Heading>Abstract</Heading>
<Para>In the basal ganglia of three autopsy cases of pallidonigroluysian degeneration, we found marked iron deposition, a finding which has not been mentioned previously in the literature. Besides severe astrogliosis and neuronal loss in the pallidum, Luysian body and nigra, granular deposits of brown pigments were found in the neuropil, microglias, oligodendrocytes and astrocytes in three such the nuclei and the striatum. These brown pigments proved histochemically to be iron. Our histochemical semiquantitative study showed a significantly stronger reation for iron in the degenerated nuclei in these three cases than in control cases comprising non-degenerative and the other degenerative diseases. Quantitative study with inductively coupled emission spectrometry also demonstrated a markedly higher iron content in the globus pallidus and the striatum in comparison with the control cases. The possibility is discussed that iron deposition plays a role in generating the lesions of pallidonigroluysian degeneration.</Para>
</Abstract>
<KeywordGroup Language="En">
<Heading>Key words</Heading>
<Keyword>Symptomatic Parkinson's disease</Keyword>
<Keyword>Pallidonigroluysian degeneration</Keyword>
<Keyword>Basal ganglia</Keyword>
<Keyword>Iron</Keyword>
</KeywordGroup>
</ArticleHeader>
<NoBody></NoBody>
</Article>
</Issue>
</Volume>
</Journal>
</Publisher>
</istex:document>
</istex:metadataXml>
<mods version="3.6">
<titleInfo lang="en">
<title>Pallidonigroluysian degeneration with iron deposition: a study of three autopsy cases</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA" lang="en">
<title>Pallidonigroluysian degeneration with iron deposition: a study of three autopsy cases</title>
</titleInfo>
<name type="personal" displayLabel="corresp">
<namePart type="given">J.</namePart>
<namePart type="family">Kawai</namePart>
<affiliation>Department of Pathology, Shiga University of Medical Science, Otsu, Japan</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">M.</namePart>
<namePart type="family">Sasahara</namePart>
<affiliation>Department of Pathology, Shiga University of Medical Science, Otsu, Japan</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">F.</namePart>
<namePart type="family">Hazama</namePart>
<affiliation>Department of Pathology, Shiga University of Medical Science, Otsu, Japan</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">S.</namePart>
<namePart type="family">Kuno</namePart>
<affiliation>Department of Neurology, Utano National Hospital, Kyoto, Japan</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">O.</namePart>
<namePart type="family">Komure</namePart>
<affiliation>Department of Neurology, Utano National Hospital, Kyoto, Japan</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">S.</namePart>
<namePart type="family">Nomura</namePart>
<affiliation>Nihon Schering, Department of Research, Osaka, Japan</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">M.</namePart>
<namePart type="family">Yamaguchi</namePart>
<affiliation>Nihon Schering, Department of Research, Osaka, Japan</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<typeOfResource>text</typeOfResource>
<genre type="research-article" displayLabel="OriginalPaper"></genre>
<originInfo>
<publisher>Springer-Verlag</publisher>
<place>
<placeTerm type="text">Berlin/Heidelberg</placeTerm>
</place>
<dateCreated encoding="w3cdtf">1991-06-24</dateCreated>
<dateIssued encoding="w3cdtf">1993-11-01</dateIssued>
<copyrightDate encoding="w3cdtf">1993</copyrightDate>
</originInfo>
<language>
<languageTerm type="code" authority="rfc3066">en</languageTerm>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
</language>
<physicalDescription>
<internetMediaType>text/html</internetMediaType>
</physicalDescription>
<abstract lang="en">Abstract: In the basal ganglia of three autopsy cases of pallidonigroluysian degeneration, we found marked iron deposition, a finding which has not been mentioned previously in the literature. Besides severe astrogliosis and neuronal loss in the pallidum, Luysian body and nigra, granular deposits of brown pigments were found in the neuropil, microglias, oligodendrocytes and astrocytes in three such the nuclei and the striatum. These brown pigments proved histochemically to be iron. Our histochemical semiquantitative study showed a significantly stronger reation for iron in the degenerated nuclei in these three cases than in control cases comprising non-degenerative and the other degenerative diseases. Quantitative study with inductively coupled emission spectrometry also demonstrated a markedly higher iron content in the globus pallidus and the striatum in comparison with the control cases. The possibility is discussed that iron deposition plays a role in generating the lesions of pallidonigroluysian degeneration.</abstract>
<note>Regular Papers</note>
<relatedItem type="host">
<titleInfo>
<title>Acta Neuropathologica</title>
</titleInfo>
<titleInfo type="abbreviated">
<title>Acta Neuropathol</title>
</titleInfo>
<genre type="Journal" displayLabel="Archive Journal"></genre>
<originInfo>
<dateIssued encoding="w3cdtf">1993-11-01</dateIssued>
<copyrightDate encoding="w3cdtf">1993</copyrightDate>
</originInfo>
<subject>
<genre>Medicine & Public Health</genre>
<topic>Pathology</topic>
</subject>
<identifier type="ISSN">0001-6322</identifier>
<identifier type="eISSN">1432-0533</identifier>
<identifier type="JournalID">401</identifier>
<identifier type="IssueArticleCount">18</identifier>
<identifier type="VolumeIssueCount">6</identifier>
<part>
<date>1993</date>
<detail type="volume">
<number>86</number>
<caption>vol.</caption>
</detail>
<detail type="issue">
<number>6</number>
<caption>no.</caption>
</detail>
<extent unit="pages">
<start>609</start>
<end>616</end>
</extent>
</part>
<recordInfo>
<recordOrigin>Springer-Verlag, 1993</recordOrigin>
</recordInfo>
</relatedItem>
<identifier type="istex">3F48FF63283244CB23E9D177CAD10D540B589E3A</identifier>
<identifier type="DOI">10.1007/BF00294300</identifier>
<identifier type="ArticleID">Art10</identifier>
<identifier type="ArticleID">BF00294300</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag</accessCondition>
<recordInfo>
<recordContentSource>SPRINGER</recordContentSource>
<recordOrigin>Springer-Verlag, 1993</recordOrigin>
</recordInfo>
</mods>
</metadata>
<enrichments>
<istex:refBibTEI uri="https://api.istex.fr/document/3F48FF63283244CB23E9D177CAD10D540B589E3A/enrichments/refBib">
<teiHeader></teiHeader>
<text>
<front></front>
<body></body>
<back>
<listBibl>
<biblStruct xml:id="b0">
<analytic>
<title level="a" type="main">Brain injury, edema and vascular permeability changes induced by oxygen-derived free radicals</title>
<author>
<persName>
<forename type="first">Ph</forename>
<surname>Chan</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Jw</forename>
<surname>Schmidley</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Ra</forename>
<surname>Fishman</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Sm</forename>
<surname>Longer</surname>
</persName>
</author>
</analytic>
<monogr>
<title level="j">Neurology</title>
<imprint>
<biblScope unit="volume">34</biblScope>
<biblScope unit="page" from="315" to="320"></biblScope>
<date type="published" when="1984"></date>
</imprint>
</monogr>
</biblStruct>
<biblStruct xml:id="b1">
<analytic>
<title level="a" type="main">Atrophie pallido-nigro-luysienne syndrome akinetique palielie, rigiditie oppositionelle et catatonie</title>
<author>
<persName>
<forename type="first">F</forename>
<surname>Contamin</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">R</forename>
<surname>Escourolle</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">J</forename>
<surname>Nick</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">R</forename>
<surname>Mignot</surname>
</persName>
</author>
</analytic>
<monogr>
<title level="j">Rev Neurol (Paris)</title>
<imprint>
<biblScope unit="volume">124</biblScope>
<biblScope unit="page" from="107" to="120"></biblScope>
<date type="published" when="1971"></date>
</imprint>
</monogr>
</biblStruct>
<biblStruct xml:id="b2">
<analytic>
<title level="a" type="main">Increased nigral iron content in postmortem parkinsonian brain</title>
<author>
<persName>
<forename type="first">Dt</forename>
<surname>Dexter</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Fr</forename>
<surname>Wells</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">E</forename>
<surname>Agid</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Y</forename>
<surname>Agid</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">A</forename>
<forename type="middle">J</forename>
<surname>Lees</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">E</forename>
<surname>Jenner</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Cd</forename>
<surname>Marsden</surname>
</persName>
</author>
</analytic>
<monogr>
<title level="j">Lancet</title>
<imprint>
<biblScope unit="volume">II</biblScope>
<biblScope unit="page" from="1219" to="1220"></biblScope>
<date type="published" when="1987"></date>
</imprint>
</monogr>
</biblStruct>
<biblStruct xml:id="b3">
<analytic>
<title level="a" type="main">Increased nigral iron content and alteration on other metal ions occurring in brain in Parkinson's disease</title>
<author>
<persName>
<forename type="first">Dt</forename>
<surname>Dexter</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Fr</forename>
<surname>Wells</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Aj</forename>
<surname>Lees</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">E</forename>
<surname>Agid</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Y</forename>
<surname>Agid</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">E</forename>
<surname>Jenner</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Cd</forename>
<surname>Marsden</surname>
</persName>
</author>
</analytic>
<monogr>
<title level="j">J Neurochem</title>
<imprint>
<biblScope unit="volume">52</biblScope>
<biblScope unit="page" from="1830" to="1836"></biblScope>
<date type="published" when="1989"></date>
</imprint>
</monogr>
</biblStruct>
<biblStruct xml:id="b4">
<analytic>
<title level="a" type="main">Microtechnical demonstration of iron, a criticism of its methods</title>
<author>
<persName>
<forename type="first">G</forename>
<surname>Gomori</surname>
</persName>
</author>
</analytic>
<monogr>
<title level="j">Am J Pathol</title>
<imprint>
<biblScope unit="volume">12</biblScope>
<biblScope unit="page" from="655" to="663"></biblScope>
<date type="published" when="1936"></date>
</imprint>
</monogr>
</biblStruct>
<biblStruct xml:id="b5">
<analytic>
<title level="a" type="main">Pallidoluysionigral atrophy and amyotrophic lateral sclerosis</title>
<author>
<persName>
<forename type="first">F</forename>
<surname>Gray</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">De</forename>
<surname>Baecque</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">C</forename>
<surname>Serdaru</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">M</forename>
<surname>Escourolle</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">R</forename>
</persName>
</author>
</analytic>
<monogr>
<title level="j">Acta Neuropathol</title>
<imprint>
<biblScope unit="page" from="348" to="351"></biblScope>
<date type="published" when="1981"></date>
</imprint>
</monogr>
<note>Suppl. ] VIII</note>
</biblStruct>
<biblStruct xml:id="b6">
<analytic>
<title level="a" type="main">Luysio-pallido-nigral atrophy and amyotrophic lateral sclerosis</title>
<author>
<persName>
<forename type="first">F</forename>
<surname>Gray</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Jf</forename>
<surname>Eizenbaum</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">R</forename>
<surname>Gherardi</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Jd</forename>
<surname>Degos</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">J</forename>
<surname>Poirier</surname>
</persName>
</author>
</analytic>
<monogr>
<title level="j">Acta Neuropathol (Berl)</title>
<imprint>
<biblScope unit="volume">66</biblScope>
<biblScope unit="page" from="78" to="82"></biblScope>
<date type="published" when="1985"></date>
</imprint>
</monogr>
</biblStruct>
<biblStruct xml:id="b7">
<analytic>
<title level="a" type="main">Iron and oxygen radicals in tissue damage: implications for the neuronal ceroid lipofuscinosis</title>
<author>
<persName>
<forename type="first">Jm</forename>
<surname>Gutteridge</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">T</forename>
<surname>Westermarck</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">P</forename>
<surname>Santavuori</surname>
</persName>
</author>
</analytic>
<monogr>
<title level="j">Acta Neurol Scand</title>
<imprint>
<biblScope unit="volume">68</biblScope>
<biblScope unit="page" from="365" to="370"></biblScope>
<date type="published" when="1983"></date>
</imprint>
</monogr>
</biblStruct>
<biblStruct xml:id="b8">
<analytic>
<title level="a" type="main">Superoxide-dependent formation of hydroxyl radicals in the presence of iron chelates</title>
<author>
<persName>
<forename type="first">B</forename>
<surname>Halliwell</surname>
</persName>
</author>
</analytic>
<monogr>
<title level="j">FEBS Lett</title>
<imprint>
<biblScope unit="volume">92</biblScope>
<biblScope unit="page" from="231" to="326"></biblScope>
<date type="published" when="1978"></date>
</imprint>
</monogr>
</biblStruct>
<biblStruct xml:id="b9">
<analytic>
<title level="a" type="main">Pallidal, pallidonigral and pallidoluysionigral degeneration including association with thalamic and dentate degeneration</title>
<author>
<persName>
<forename type="first">K</forename>
<surname>Jellinger</surname>
</persName>
</author>
</analytic>
<monogr>
<title level="j">Handb Clin</title>
<imprint>
<biblScope unit="volume">49</biblScope>
<biblScope unit="page" from="445" to="464"></biblScope>
<date type="published" when="1986"></date>
</imprint>
</monogr>
</biblStruct>
<biblStruct xml:id="b10">
<analytic>
<title level="a" type="main">Increase of iron in the substantia nigra of Parkinson's disease</title>
<author>
<persName>
<forename type="first">K</forename>
<surname>Jellinger</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">E</forename>
<surname>Kienzl</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">W</forename>
<surname>Paulus</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">W</forename>
<surname>Riederer</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">G</forename>
<surname>Rumpelmaier</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">M</forename>
<surname>Youdim</surname>
</persName>
</author>
</analytic>
<monogr>
<title level="j">Clin Neuropathol</title>
<imprint>
<biblScope unit="volume">11</biblScope>
<biblScope unit="page">227</biblScope>
<date type="published" when="1992"></date>
</imprint>
</monogr>
</biblStruct>
<biblStruct xml:id="b11">
<analytic>
<title level="a" type="main">Pallido-nigro-luysial atrophy with massive appearance of corpora amylacea in the CNS</title>
<author>
<persName>
<forename type="first">K</forename>
<surname>Kosaka</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">M</forename>
<surname>Matsushita</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">S</forename>
<surname>Oyanagi</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">S</forename>
<surname>Uchiyama</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">S</forename>
<surname>Iwase</surname>
</persName>
</author>
</analytic>
<monogr>
<title level="j">Acta Neuropathol (Berl)</title>
<imprint>
<biblScope unit="volume">53</biblScope>
<biblScope unit="page" from="169" to="172"></biblScope>
<date type="published" when="1981"></date>
</imprint>
</monogr>
</biblStruct>
<biblStruct xml:id="b12">
<analytic>
<title level="a" type="main">Superoxide-dependent production of hydroxyl radical catalyzed by iron-EDTA complex</title>
<author>
<persName>
<forename type="first">Jm</forename>
<surname>Mccord</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Ed</forename>
<surname>Day</surname>
</persName>
</author>
<author>
<persName>
<surname>Jr</surname>
</persName>
</author>
</analytic>
<monogr>
<title level="j">FEBS Lett</title>
<imprint>
<biblScope unit="volume">86</biblScope>
<biblScope unit="page" from="139" to="142"></biblScope>
<date type="published" when="1978"></date>
</imprint>
</monogr>
</biblStruct>
<biblStruct xml:id="b13">
<analytic>
<title level="a" type="main">The requirement for iron (III) in the initiation of lipid peroxidation by iron (II) and hydrogen peroxide</title>
<author>
<persName>
<forename type="first">G</forename>
<surname>Minotti</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Sd</forename>
<surname>Aust</surname>
</persName>
</author>
</analytic>
<monogr>
<title level="j">J Biol Chem</title>
<imprint>
<biblScope unit="volume">262</biblScope>
<biblScope unit="page" from="1098" to="1104"></biblScope>
<date type="published" when="1987"></date>
</imprint>
</monogr>
</biblStruct>
<biblStruct xml:id="b14">
<analytic>
<title level="a" type="main">Hallervorden-Spatz disease: cysteine accumulation and cysteine dioxygenese deficiency in the globus pallidus</title>
<author>
<persName>
<forename type="first">Tl</forename>
<surname>Perry</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Mg</forename>
<surname>Norman</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Vw</forename>
<surname>Yong</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">S</forename>
<surname>Whiting</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Ju</forename>
<surname>Crichton</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">S</forename>
<surname>Hansen</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">S</forename>
<surname>Kish</surname>
</persName>
</author>
</analytic>
<monogr>
<title level="j">Ann Neurol</title>
<imprint>
<biblScope unit="volume">18</biblScope>
<biblScope unit="page" from="482" to="489"></biblScope>
<date type="published" when="1985"></date>
</imprint>
</monogr>
</biblStruct>
<biblStruct xml:id="b15">
<analytic>
<title level="a" type="main">Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains</title>
<author>
<persName>
<forename type="first">R</forename>
<surname>Riederer</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">E</forename>
<surname>Sofic</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Wd</forename>
<surname>Rausch</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">B</forename>
<surname>Schmidt</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Gr</forename>
<surname>Reynolds</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">K</forename>
<surname>Jellinger</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Bh</forename>
<surname>Youdim</surname>
</persName>
</author>
</analytic>
<monogr>
<title level="j">J Neurochem</title>
<imprint>
<biblScope unit="volume">52</biblScope>
<biblScope unit="page" from="515" to="520"></biblScope>
<date type="published" when="1989"></date>
</imprint>
</monogr>
</biblStruct>
<biblStruct xml:id="b16">
<analytic>
<title level="a" type="main">Der mikrochemische Nachweis von Eisen in Gewebselementen Rhodanwasserstoffsaure und die Konservierung der Reactionin Paraffinol</title>
<author>
<persName>
<forename type="first">W</forename>
<surname>Schmelzer</surname>
</persName>
</author>
</analytic>
<monogr>
<title level="j">Z Wiss Mikrosk Mikrosk Tech</title>
<imprint>
<biblScope unit="volume">50</biblScope>
<biblScope unit="page" from="99" to="102"></biblScope>
<date type="published" when="1933"></date>
</imprint>
</monogr>
</biblStruct>
<biblStruct xml:id="b17">
<analytic>
<title level="a" type="main">Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain</title>
<author>
<persName>
<forename type="first">E</forename>
<surname>Sofic</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">H</forename>
<surname>Riederer R Heinsen</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">H</forename>
<surname>Beckmann</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Gr</forename>
<surname>Reynolds</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">G</forename>
<surname>Hebenstreit</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Mbh</forename>
<surname>Youdim</surname>
</persName>
</author>
</analytic>
<monogr>
<title level="j">J Neural Trnsm</title>
<imprint>
<biblScope unit="volume">74</biblScope>
<biblScope unit="page" from="199" to="205"></biblScope>
<date type="published" when="1988"></date>
</imprint>
</monogr>
</biblStruct>
<biblStruct xml:id="b18">
<analytic>
<title level="a" type="main">Pallido-nigro-luysial atrophy associated with degeneration o the centrum medianum</title>
<author>
<persName>
<forename type="first">K</forename>
<surname>Takahashi</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">R</forename>
<surname>Nakashima</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">T</forename>
<surname>Takao</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">H</forename>
<surname>Nakamura</surname>
</persName>
</author>
</analytic>
<monogr>
<title level="j">Acta Neuropathol (Berl)</title>
<imprint>
<biblScope unit="volume">37</biblScope>
<biblScope unit="page" from="81" to="85"></biblScope>
<date type="published" when="1977"></date>
</imprint>
</monogr>
</biblStruct>
<biblStruct xml:id="b19">
<analytic>
<title level="a" type="main">Simultaneous multi-element analysis by inductively-coupled plasma emission spectrometry utilizing micro-sampling techniques with internal standard</title>
<author>
<persName>
<forename type="first">H</forename>
<surname>Uchida</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">Y</forename>
<surname>Nojiri</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">H</forename>
<surname>Haraguch</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">K</forename>
<surname>Fuwa</surname>
</persName>
</author>
</analytic>
<monogr>
<title level="j">Anal Chim Acta</title>
<imprint>
<biblScope unit="volume">123</biblScope>
<biblScope unit="page" from="57" to="63"></biblScope>
<date type="published" when="1981"></date>
</imprint>
</monogr>
</biblStruct>
<biblStruct xml:id="b20">
<analytic>
<title level="a" type="main">Simultaneous multielement analysis of trace metals in hair and serum by inductively coupled emission spectrometry</title>
<author>
<persName>
<surname>Uchidah</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">S</forename>
<surname>Hisada</surname>
</persName>
</author>
<author>
<persName>
<surname>Toyodah</surname>
</persName>
</author>
<author>
<persName>
<surname>Takahashij</surname>
</persName>
</author>
<author>
<persName>
<surname>Tomitah</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">H</forename>
<surname>Ohmori</surname>
</persName>
</author>
</analytic>
<monogr>
<title level="j">Biryou Kinzoku Taisya</title>
<imprint>
<biblScope unit="volume">13</biblScope>
<biblScope unit="page" from="173" to="180"></biblScope>
<date type="published" when="1985"></date>
</imprint>
</monogr>
<note>in. Japanese</note>
</biblStruct>
<biblStruct xml:id="b21">
<analytic>
<title level="a" type="main">Is Parkinson's disease a progressive siderosis of substantia nigra resulting in iron-and melanin-induced neurodegeneration?</title>
<author>
<persName>
<forename type="first">Mbh</forename>
<surname>Youdim</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">D</forename>
<surname>Ben-Shachar</surname>
</persName>
</author>
<author>
<persName>
<forename type="first">P</forename>
<surname>Riederer</surname>
</persName>
</author>
</analytic>
<monogr>
<title level="j">Acta Neurol Scand</title>
<imprint>
<biblScope unit="volume">127</biblScope>
<biblScope unit="page" from="36" to="541"></biblScope>
<date type="published" when="1989"></date>
</imprint>
</monogr>
</biblStruct>
</listBibl>
</back>
</text>
</istex:refBibTEI>
</enrichments>
<serie></serie>
</istex>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002861 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 002861 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonV1
   |flux=    Main
   |étape=   Corpus
   |type=    RBID
   |clé=     ISTEX:3F48FF63283244CB23E9D177CAD10D540B589E3A
   |texte=   Pallidonigroluysian degeneration with iron deposition: a study of three autopsy cases
}}

Wicri

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 18:06:51 2016. Site generation: Wed Mar 6 18:46:03 2024