Parkinson's Disease and Cancer
Identifieur interne : 002846 ( Main/Corpus ); précédent : 002845; suivant : 002847Parkinson's Disease and Cancer
Auteurs : Marco D'Amelio ; Paolo Ragonese ; Gabriella Sconzo ; Paolo Aridon ; Giovanni SavettieriSource :
- Annals of the New York Academy of SciencesSteroid Enzymes and Cancer [ 0077-8923 ] ; 2009-02.
English descriptors
- KwdEn :
Abstract
Epidemiological evidence suggests a reduced incidence of many common types of cancers in individuals with Parkinson's disease (PD). Parkinson's disease and cancer are two diseases that result from an excessive signaling by one of two forces driving cells to opposite directions. PD results from the excessive death of dopaminergic neurons in the substantia nigra pars compacta (SNc) in the brain, while uncontrolled growth is the key property of cancer. Parkinson's disease is a complex disorder, probably due in most of the cases to the interaction of environment and genes. Many genes responsible for familial forms of PD are supposed to have a supportive role in regulating or maintaining the cell cycle, a fact that allows us to assume their interaction in tumorigenesis. Understanding the nature of these processes may help researchers find new and more efficacious therapeutic approaches for both diseases.
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DOI: 10.1111/j.1749-6632.2008.03681.x
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ISTEX:32D051D15C7E7D5E8993A7022742B2886317CF38Le document en format XML
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type="abstract" xml:lang="en">Epidemiological evidence suggests a reduced incidence of many common types of cancers in individuals with Parkinson's disease (PD). Parkinson's disease and cancer are two diseases that result from an excessive signaling by one of two forces driving cells to opposite directions. PD results from the excessive death of dopaminergic neurons in the substantia nigra pars compacta (SNc) in the brain, while uncontrolled growth is the key property of cancer. Parkinson's disease is a complex disorder, probably due in most of the cases to the interaction of environment and genes. Many genes responsible for familial forms of PD are supposed to have a supportive role in regulating or maintaining the cell cycle, a fact that allows us to assume their interaction in tumorigenesis. Understanding the nature of these processes may help researchers find new and more efficacious therapeutic approaches for both diseases.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Marco D'Amelio</name><affiliations><json:string>Dipartimento Universitario di Neuroscienze Cliniche, Universitá degli Studi di Palermo, Palermo, Italy</json:string></affiliations></json:item><json:item><name>Paolo Ragonese</name><affiliations><json:string>Dipartimento Universitario di Neuroscienze Cliniche, Universitá degli Studi di Palermo, Palermo, Italy</json:string></affiliations></json:item><json:item><name>Gabriella Sconzo</name><affiliations><json:string>Dipartiomento di Biologia Cellulare e dello Sviluppo, Universitá degli Studi di Palermo, Palermo, Italy</json:string></affiliations></json:item><json:item><name>Paolo Aridon</name><affiliations><json:string>Dipartimento Universitario di Neuroscienze Cliniche, Universitá degli Studi di Palermo, Palermo, Italy</json:string></affiliations></json:item><json:item><name>Giovanni Savettieri</name><affiliations><json:string>Dipartimento Universitario di Neuroscienze Cliniche, Universitá degli Studi di Palermo, Palermo, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cancer</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>epidemiology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>genetics</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>risk factors</value></json:item></subject><articleId><json:string>NYAS03681</json:string></articleId><language><json:string>eng</json:string></language><abstract>Epidemiological evidence suggests a reduced incidence of many common types of cancers in individuals with Parkinson's disease (PD). 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Poster Papers</title></titleGroup><copyright>© 2009 New York Academy of Sciences</copyright><eventGroup><event type="firstOnline" date="2009-02-26"></event><event type="publishedOnlineFinalForm" date="2009-02-26"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.23 mode:FullText" date="2010-10-12"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-19"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="324">324</numbering><numbering type="pageLast" number="334">334</numbering></numberingGroup><correspondenceTo>Address for correspondence: Giovanni Savettieri, M.D., Dipartimento Universitario di Neuroscienze Cliniche, Università degli Studi di Palermo, Via Gaetano La Loggia 1‐90129 Palermo, Italy. Voice: +39‐091‐6555146; fax: +39‐091‐6555147. <email>gsavetti@tin.it</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:NYAS.NYAS03681.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="3"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="55"></count><count type="linksCrossRef" number="56"></count></countGroup><titleGroup><title type="main">Parkinson's Disease and Cancer</title><title type="subtitle">Insights for Pathogenesis from Epidemiology</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Marco</givenNames><familyName>D'Amelio</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Paolo</givenNames><familyName>Ragonese</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a2"><personName><givenNames>Gabriella</givenNames><familyName>Sconzo</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>Paolo</givenNames><familyName>Aridon</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>Giovanni</givenNames><familyName>Savettieri</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="IT"><unparsedAffiliation>Dipartimento Universitario di Neuroscienze Cliniche, Universitá degli Studi di Palermo, Palermo, Italy</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="IT"><unparsedAffiliation>Dipartiomento di Biologia Cellulare e dello Sviluppo, Universitá degli Studi di Palermo, Palermo, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Parkinson's disease</keyword><keyword xml:id="k2">cancer</keyword><keyword xml:id="k3">epidemiology</keyword><keyword xml:id="k4">genetics</keyword><keyword xml:id="k5">risk factors</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>Epidemiological evidence suggests a reduced incidence of many common types of cancers in individuals with Parkinson's disease (PD). 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Understanding the nature of these processes may help researchers find new and more efficacious therapeutic approaches for both diseases.</abstract><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>cancer</topic><topic>epidemiology</topic><topic>genetics</topic><topic>risk factors</topic></subject><relatedItem type="host"><titleInfo><title>Annals of the New York Academy of SciencesSteroid Enzymes and Cancer</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0077-8923</identifier><identifier type="eISSN">1749-6632</identifier><identifier type="DOI">10.1111/(ISSN)1749-6632</identifier><identifier type="PublisherID">NYAS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>1155</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>324</start><end>334</end><total>11</total></extent></part></relatedItem><identifier type="istex">32D051D15C7E7D5E8993A7022742B2886317CF38</identifier><identifier type="DOI">10.1111/j.1749-6632.2008.03681.x</identifier><identifier type="ArticleID">NYAS03681</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2009 New York Academy of Sciences</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Inc</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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