Olfactory heterogeneity in LRRK2 related Parkinsonism
Identifieur interne : 002737 ( Main/Corpus ); précédent : 002736; suivant : 002738Olfactory heterogeneity in LRRK2 related Parkinsonism
Auteurs : Laura Silveira-Moriyama ; Renato Pupi Munhoz ; Margarete De J. Carvalho ; Salmo Raskin ; Ekaterina Rogaeva ; Patricia De C. Aguiar ; Rodrigo A. Bressan ; Andre C. Felicio ; Orlando G. P. Barsottini ; Luiz Augusto F. Andrade ; Hsin F. Chien ; Vincenzo Bonifati ; Egberto R. Barbosa ; Helio A. Teive ; Andrew J. LeesSource :
- Movement Disorders [ 0885-3185 ] ; 2010-12-15.
English descriptors
- KwdEn :
- LRRK2, PARK8, olfaction, parkinsonism, smell.
Abstract
LRRK2 mutations can cause familial and sporadic Parkinson's disease (PD) with Lewy‐body pathology at post‐mortem. Studies of olfaction in LRRK2 are sparse and incongruent. We applied a previously validated translation of the 16 item smell identification test from Sniffin' Sticks (SS‐16) to 14 parkinsonian carriers of heterozygous G2019S LRRK2 mutation and compared with 106 PD patients and 118 healthy controls. The mean SS‐16 score in LRRK2 was higher than in PD (p < 0.001, 95% CI for β = −4.7 to −1.7) and lower than in controls (p = 0.007, 95% CI for β = +0.6 to +3.6). In the LRRK2 group, subjects with low scores had significantly more dyskinesia. They also had younger age of onset, longer disease duration, and reported less frequently a family history of PD, but none of these other differences reached significance. Odor identification is diminished in LRRK2 parkinsonism but not to the same extent as in idiopathic PD. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23325
Links to Exploration step
ISTEX:812BDDD70A7C5A82FA206880E00F606B2AC14CD9Le document en format XML
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Carvalho">Margarete De J. Carvalho</name><affiliation><mods:affiliation>Department of Neurology, University of Sao Paulo School of Medicine, Sao Paulo‐SP, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Raskin, Salmo" sort="Raskin, Salmo" uniqKey="Raskin S" first="Salmo" last="Raskin">Salmo Raskin</name><affiliation><mods:affiliation>Movement Disorders Unit, Neurology Service, Internal Medicine Department Hospital de Clínicas, Federal University of Paraná, Curitiba‐PR, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Rogaeva, Ekaterina" sort="Rogaeva, Ekaterina" uniqKey="Rogaeva E" first="Ekaterina" last="Rogaeva">Ekaterina Rogaeva</name><affiliation><mods:affiliation>Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="De C Aguiar, Patricia" sort="De C Aguiar, Patricia" uniqKey="De C Aguiar P" first="Patricia" last="De C. Aguiar">Patricia De C. Aguiar</name><affiliation><mods:affiliation>Instituto do Cérebro ‐ Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Bressan, Rodrigo A" sort="Bressan, Rodrigo A" uniqKey="Bressan R" first="Rodrigo A." last="Bressan">Rodrigo A. Bressan</name><affiliation><mods:affiliation>Instituto do Cérebro ‐ Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratório Interdisciplinar de Neurosciencias Clínicas ‐ LiNC, Universidade Federal de Sao Paulo, UNIFESP, São Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Felicio, Andre C" sort="Felicio, Andre C" uniqKey="Felicio A" first="Andre C." last="Felicio">Andre C. Felicio</name><affiliation><mods:affiliation>Instituto do Cérebro ‐ Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratório Interdisciplinar de Neurosciencias Clínicas ‐ LiNC, Universidade Federal de Sao Paulo, UNIFESP, São Paulo, Brazil</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, SP, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Barsottini, Orlando G P" sort="Barsottini, Orlando G P" uniqKey="Barsottini O" first="Orlando G. P." last="Barsottini">Orlando G. P. Barsottini</name><affiliation><mods:affiliation>Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, SP, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Andrade, Luiz Augusto F" sort="Andrade, Luiz Augusto F" uniqKey="Andrade L" first="Luiz Augusto F." last="Andrade">Luiz Augusto F. Andrade</name><affiliation><mods:affiliation>Instituto do Cérebro ‐ Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Chien, Hsin F" sort="Chien, Hsin F" uniqKey="Chien H" first="Hsin F." last="Chien">Hsin F. Chien</name><affiliation><mods:affiliation>Department of Neurology, University of Sao Paulo School of Medicine, Sao Paulo‐SP, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Bonifati, Vincenzo" sort="Bonifati, Vincenzo" uniqKey="Bonifati V" first="Vincenzo" last="Bonifati">Vincenzo Bonifati</name><affiliation><mods:affiliation>Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Barbosa, Egberto R" sort="Barbosa, Egberto R" uniqKey="Barbosa E" first="Egberto R." last="Barbosa">Egberto R. Barbosa</name><affiliation><mods:affiliation>Department of Neurology, University of Sao Paulo School of Medicine, Sao Paulo‐SP, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Teive, Helio A" sort="Teive, Helio A" uniqKey="Teive H" first="Helio A." last="Teive">Helio A. Teive</name><affiliation><mods:affiliation>Movement Disorders Unit, Neurology Service, Internal Medicine Department Hospital de Clínicas, Federal University of Paraná, Curitiba‐PR, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew J. Lees</name><affiliation><mods:affiliation>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-12-15">2010-12-15</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="page" from="2879">2879</biblScope><biblScope unit="page" to="2883">2883</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">812BDDD70A7C5A82FA206880E00F606B2AC14CD9</idno><idno type="DOI">10.1002/mds.23325</idno><idno type="ArticleID">MDS23325</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>LRRK2</term><term>PARK8</term><term>olfaction</term><term>parkinsonism</term><term>smell</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">LRRK2 mutations can cause familial and sporadic Parkinson's disease (PD) with Lewy‐body pathology at post‐mortem. Studies of olfaction in LRRK2 are sparse and incongruent. We applied a previously validated translation of the 16 item smell identification test from Sniffin' Sticks (SS‐16) to 14 parkinsonian carriers of heterozygous G2019S LRRK2 mutation and compared with 106 PD patients and 118 healthy controls. The mean SS‐16 score in LRRK2 was higher than in PD (p < 0.001, 95% CI for β = −4.7 to −1.7) and lower than in controls (p = 0.007, 95% CI for β = +0.6 to +3.6). In the LRRK2 group, subjects with low scores had significantly more dyskinesia. They also had younger age of onset, longer disease duration, and reported less frequently a family history of PD, but none of these other differences reached significance. Odor identification is diminished in LRRK2 parkinsonism but not to the same extent as in idiopathic PD. © 2010 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Laura Silveira‐Moriyama MD, PhD</name><affiliations><json:string>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom</json:string></affiliations></json:item><json:item><name>Renato Pupi Munhoz MD</name><affiliations><json:string>Movement Disorders Unit, Neurology Service, Internal Medicine Department Hospital de Clínicas, Federal University of Paraná, Curitiba‐PR, Brazil</json:string></affiliations></json:item><json:item><name>Margarete de J. Carvalho MD</name><affiliations><json:string>Department of Neurology, University of Sao Paulo School of Medicine, Sao Paulo‐SP, Brazil</json:string></affiliations></json:item><json:item><name>Salmo Raskin MD</name><affiliations><json:string>Movement Disorders Unit, Neurology Service, Internal Medicine Department Hospital de Clínicas, Federal University of Paraná, Curitiba‐PR, Brazil</json:string></affiliations></json:item><json:item><name>Ekaterina Rogaeva PhD</name><affiliations><json:string>Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Patricia de C. Aguiar MD, PhD</name><affiliations><json:string>Instituto do Cérebro ‐ Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</json:string></affiliations></json:item><json:item><name>Rodrigo A. Bressan MD, PhD</name><affiliations><json:string>Instituto do Cérebro ‐ Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</json:string><json:string>Laboratório Interdisciplinar de Neurosciencias Clínicas ‐ LiNC, Universidade Federal de Sao Paulo, UNIFESP, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>Andre C. Felicio MD</name><affiliations><json:string>Instituto do Cérebro ‐ Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</json:string><json:string>Laboratório Interdisciplinar de Neurosciencias Clínicas ‐ LiNC, Universidade Federal de Sao Paulo, UNIFESP, São Paulo, Brazil</json:string><json:string>Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, SP, Brazil</json:string></affiliations></json:item><json:item><name>Orlando G.P. Barsottini MD</name><affiliations><json:string>Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, SP, Brazil</json:string></affiliations></json:item><json:item><name>Luiz Augusto F. Andrade MD</name><affiliations><json:string>Instituto do Cérebro ‐ Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</json:string></affiliations></json:item><json:item><name>Hsin F. Chien MD</name><affiliations><json:string>Department of Neurology, University of Sao Paulo School of Medicine, Sao Paulo‐SP, Brazil</json:string></affiliations></json:item><json:item><name>Vincenzo Bonifati MD, PhD</name><affiliations><json:string>Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands</json:string></affiliations></json:item><json:item><name>Egberto R. Barbosa MD, PhD</name><affiliations><json:string>Department of Neurology, University of Sao Paulo School of Medicine, Sao Paulo‐SP, Brazil</json:string></affiliations></json:item><json:item><name>Helio A. Teive MD</name><affiliations><json:string>Movement Disorders Unit, Neurology Service, Internal Medicine Department Hospital de Clínicas, Federal University of Paraná, Curitiba‐PR, Brazil</json:string></affiliations></json:item><json:item><name>Andrew J. Lees MD</name><affiliations><json:string>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>olfaction</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>smell</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>LRRK2</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PARK8</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>parkinsonism</value></json:item></subject><articleId><json:string>MDS23325</json:string></articleId><language><json:string>eng</json:string></language><abstract>LRRK2 mutations can cause familial and sporadic Parkinson's disease (PD) with Lewy‐body pathology at post‐mortem. Studies of olfaction in LRRK2 are sparse and incongruent. We applied a previously validated translation of the 16 item smell identification test from Sniffin' Sticks (SS‐16) to 14 parkinsonian carriers of heterozygous G2019S LRRK2 mutation and compared with 106 PD patients and 118 healthy controls. The mean SS‐16 score in LRRK2 was higher than in PD (p > 0.001, 95% CI for β = −4.7 to −1.7) and lower than in controls (p = 0.007, 95% CI for β = +0.6 to +3.6). In the LRRK2 group, subjects with low scores had significantly more dyskinesia. They also had younger age of onset, longer disease duration, and reported less frequently a family history of PD, but none of these other differences reached significance. Odor identification is diminished in LRRK2 parkinsonism but not to the same extent as in idiopathic PD. © 2010 Movement Disorder Society</abstract><qualityIndicators><score>6.908</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>964</abstractCharCount><pdfWordCount>19371</pdfWordCount><pdfCharCount>127329</pdfCharCount><pdfPageCount>34</pdfPageCount><abstractWordCount>159</abstractWordCount></qualityIndicators><title>Olfactory heterogeneity in LRRK2 related Parkinsonism</title><genre><json:string>article</json:string></genre><host><volume>25</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>5</total><last>2883</last><first>2879</first></pages><issn><json:string>0885-3185</json:string></issn><issue>16</issue><subject><json:item><value>Brief Report</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1002/mds.23325</json:string></doi><id>812BDDD70A7C5A82FA206880E00F606B2AC14CD9</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/812BDDD70A7C5A82FA206880E00F606B2AC14CD9/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/812BDDD70A7C5A82FA206880E00F606B2AC14CD9/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/812BDDD70A7C5A82FA206880E00F606B2AC14CD9/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Olfactory heterogeneity in LRRK2 related Parkinsonism</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2010</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: The authors do not have any conflict of interest.</note><note>Reta Lila Weston Trust for Medical Research and Foundation Philantropique Edmond Safra</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Olfactory heterogeneity in LRRK2 related Parkinsonism</title><author><persName><forename type="first">Laura</forename><surname>Silveira‐Moriyama</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom</affiliation></author><author><persName><forename type="first">Renato Pupi</forename><surname>Munhoz</surname></persName><roleName type="degree">MD</roleName><affiliation>Movement Disorders Unit, Neurology Service, Internal Medicine Department Hospital de Clínicas, Federal University of Paraná, Curitiba‐PR, Brazil</affiliation></author><author><persName><forename type="first">Margarete</forename><surname>de J. Carvalho</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, University of Sao Paulo School of Medicine, Sao Paulo‐SP, Brazil</affiliation></author><author><persName><forename type="first">Salmo</forename><surname>Raskin</surname></persName><roleName type="degree">MD</roleName><affiliation>Movement Disorders Unit, Neurology Service, Internal Medicine Department Hospital de Clínicas, Federal University of Paraná, Curitiba‐PR, Brazil</affiliation></author><author><persName><forename type="first">Ekaterina</forename><surname>Rogaeva</surname></persName><roleName type="degree">PhD</roleName><affiliation>Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada</affiliation></author><author><persName><forename type="first">Patricia</forename><surname>de C. Aguiar</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Instituto do Cérebro ‐ Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</affiliation></author><author><persName><forename type="first">Rodrigo A.</forename><surname>Bressan</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Instituto do Cérebro ‐ Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</affiliation><affiliation>Laboratório Interdisciplinar de Neurosciencias Clínicas ‐ LiNC, Universidade Federal de Sao Paulo, UNIFESP, São Paulo, Brazil</affiliation></author><author><persName><forename type="first">Andre C.</forename><surname>Felicio</surname></persName><roleName type="degree">MD</roleName><affiliation>Instituto do Cérebro ‐ Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</affiliation><affiliation>Laboratório Interdisciplinar de Neurosciencias Clínicas ‐ LiNC, Universidade Federal de Sao Paulo, UNIFESP, São Paulo, Brazil</affiliation><affiliation>Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, SP, Brazil</affiliation></author><author><persName><forename type="first">Orlando G.P.</forename><surname>Barsottini</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, SP, Brazil</affiliation></author><author><persName><forename type="first">Luiz Augusto F.</forename><surname>Andrade</surname></persName><roleName type="degree">MD</roleName><affiliation>Instituto do Cérebro ‐ Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</affiliation></author><author><persName><forename type="first">Hsin F.</forename><surname>Chien</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, University of Sao Paulo School of Medicine, Sao Paulo‐SP, Brazil</affiliation></author><author><persName><forename type="first">Vincenzo</forename><surname>Bonifati</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands</affiliation></author><author><persName><forename type="first">Egberto R.</forename><surname>Barbosa</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, University of Sao Paulo School of Medicine, Sao Paulo‐SP, Brazil</affiliation></author><author><persName><forename type="first">Helio A.</forename><surname>Teive</surname></persName><roleName type="degree">MD</roleName><affiliation>Movement Disorders Unit, Neurology Service, Internal Medicine Department Hospital de Clínicas, Federal University of Paraná, Curitiba‐PR, Brazil</affiliation></author><author><persName><forename type="first">Andrew J.</forename><surname>Lees</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, 1 Wakefield St, London, WC1N 1PJ, United Kingdom</p></note><affiliation>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-12-15"></date><biblScope unit="volume">25</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="page" from="2879">2879</biblScope><biblScope unit="page" to="2883">2883</biblScope></imprint></monogr><idno type="istex">812BDDD70A7C5A82FA206880E00F606B2AC14CD9</idno><idno type="DOI">10.1002/mds.23325</idno><idno type="ArticleID">MDS23325</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>LRRK2 mutations can cause familial and sporadic Parkinson's disease (PD) with Lewy‐body pathology at post‐mortem. Studies of olfaction in LRRK2 are sparse and incongruent. We applied a previously validated translation of the 16 item smell identification test from Sniffin' Sticks (SS‐16) to 14 parkinsonian carriers of heterozygous G2019S LRRK2 mutation and compared with 106 PD patients and 118 healthy controls. The mean SS‐16 score in LRRK2 was higher than in PD (p < 0.001, 95% CI for β = −4.7 to −1.7) and lower than in controls (p = 0.007, 95% CI for β = +0.6 to +3.6). In the LRRK2 group, subjects with low scores had significantly more dyskinesia. They also had younger age of onset, longer disease duration, and reported less frequently a family history of PD, but none of these other differences reached significance. Odor identification is diminished in LRRK2 parkinsonism but not to the same extent as in idiopathic PD. © 2010 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>olfaction</term></item><item><term>smell</term></item><item><term>LRRK2</term></item><item><term>PARK8</term></item><item><term>parkinsonism</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-02-24">Received</change><change when="2010-06-01">Registration</change><change when="2010-12-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/812BDDD70A7C5A82FA206880E00F606B2AC14CD9/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="160"><doi origin="wiley" registered="yes">10.1002/mds.v25.16</doi><numberingGroup><numbering type="journalVolume" number="25">25</numbering><numbering type="journalIssue">16</numbering></numberingGroup><coverDate startDate="2010-12-15">15 December 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="270" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.23325</doi><idGroup><id type="unit" value="MDS23325"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="articleCategory">Brief Report</title><title type="tocHeading1">Brief Reports</title></titleGroup><copyright ownership="thirdParty">Copyright © 2010 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2010-02-24"></event><event type="manuscriptRevised" date="2010-05-02"></event><event type="manuscriptAccepted" date="2010-06-01"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.4 mode:FullText" date="2010-12-16"></event><event type="publishedOnlineEarlyUnpaginated" date="2010-09-03"></event><event type="firstOnline" date="2010-09-03"></event><event type="publishedOnlineFinalForm" date="2010-12-16"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">2879</numbering><numbering type="pageLast">2883</numbering></numberingGroup><correspondenceTo>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, 1 Wakefield St, London, WC1N 1PJ, United Kingdom</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS23325.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="36"></count><count type="wordTotal" number="3625"></count></countGroup><titleGroup><title type="main" xml:lang="en">Olfactory heterogeneity in <i>LRRK2</i> related Parkinsonism<link href="#fn3"></link></title><title type="short" xml:lang="en">Olfaction in <fi>LRRK2</fi></title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Laura</givenNames><familyName>Silveira‐Moriyama</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Renato Pupi</givenNames><familyName>Munhoz</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Margarete</givenNames><familyName>de J. 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Aguiar</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af5 #af6"><personName><givenNames>Rodrigo A.</givenNames><familyName>Bressan</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af5 #af6 #af7"><personName><givenNames>Andre C.</givenNames><familyName>Felicio</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af7"><personName><givenNames>Orlando G.P.</givenNames><familyName>Barsottini</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Luiz Augusto F.</givenNames><familyName>Andrade</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Hsin F.</givenNames><familyName>Chien</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af8"><personName><givenNames>Vincenzo</givenNames><familyName>Bonifati</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au13" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Egberto R.</givenNames><familyName>Barbosa</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au14" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Helio A.</givenNames><familyName>Teive</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au15" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Andrew J.</givenNames><familyName>Lees</familyName><degrees>MD</degrees></personName><contactDetails><email>alees@ion.ucl.ac.uk</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="GB" type="organization"><unparsedAffiliation>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="BR" type="organization"><unparsedAffiliation>Movement Disorders Unit, Neurology Service, Internal Medicine Department Hospital de Clínicas, Federal University of Paraná, Curitiba‐PR, Brazil</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="BR" type="organization"><unparsedAffiliation>Department of Neurology, University of Sao Paulo School of Medicine, Sao Paulo‐SP, Brazil</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="CA" type="organization"><unparsedAffiliation>Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="BR" type="organization"><unparsedAffiliation>Instituto do Cérebro ‐ Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="BR" type="organization"><unparsedAffiliation>Laboratório Interdisciplinar de Neurosciencias Clínicas ‐ LiNC, Universidade Federal de Sao Paulo, UNIFESP, São Paulo, Brazil</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="BR" type="organization"><unparsedAffiliation>Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, SP, Brazil</unparsedAffiliation></affiliation><affiliation xml:id="af8" countryCode="NL" type="organization"><unparsedAffiliation>Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">olfaction</keyword><keyword xml:id="kwd2">smell</keyword><keyword xml:id="kwd3"><i>LRRK2</i></keyword><keyword xml:id="kwd4">PARK8</keyword><keyword xml:id="kwd5">parkinsonism</keyword></keywordGroup><fundingInfo><fundingAgency>Reta Lila Weston Trust for Medical Research and Foundation Philantropique Edmond Safra</fundingAgency></fundingInfo><supportingInformation><p> Additional Supporting Information may be found in the online version of this article. </p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds23325:MDS_23325_sm_suppinfo"></mediaResource><caption>Supporting Information</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p><i>LRRK2</i> mutations can cause familial and sporadic Parkinson's disease (PD) with Lewy‐body pathology at post‐mortem. Studies of olfaction in <i>LRRK2</i> are sparse and incongruent. We applied a previously validated translation of the 16 item smell identification test from Sniffin' Sticks (SS‐16) to 14 parkinsonian carriers of heterozygous G2019S <i>LRRK2</i> mutation and compared with 106 PD patients and 118 healthy controls. The mean SS‐16 score in <i>LRRK2</i> was higher than in PD (<i>p</i> < 0.001, 95% CI for β = −4.7 to −1.7) and lower than in controls (<i>p</i> = 0.007, 95% CI for β = +0.6 to +3.6). In the <i>LRRK2</i> group, subjects with low scores had significantly more dyskinesia. They also had younger age of onset, longer disease duration, and reported less frequently a family history of PD, but none of these other differences reached significance. Odor identification is diminished in <i>LRRK2</i> parkinsonism but not to the same extent as in idiopathic PD. © 2010 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn3"><p>Potential conflict of interest: The authors do not have any conflict of interest.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Olfactory heterogeneity in LRRK2 related Parkinsonism</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Olfaction in LRRK2</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Olfactory heterogeneity in</title></titleInfo><name type="personal"><namePart type="given">Laura</namePart><namePart type="family">Silveira‐Moriyama</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Renato Pupi</namePart><namePart type="family">Munhoz</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorders Unit, Neurology Service, Internal Medicine Department Hospital de Clínicas, Federal University of Paraná, Curitiba‐PR, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Margarete</namePart><namePart type="family">de J. Carvalho</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Sao Paulo School of Medicine, Sao Paulo‐SP, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Salmo</namePart><namePart type="family">Raskin</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorders Unit, Neurology Service, Internal Medicine Department Hospital de Clínicas, Federal University of Paraná, Curitiba‐PR, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ekaterina</namePart><namePart type="family">Rogaeva</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Patricia</namePart><namePart type="family">de C. Aguiar</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Instituto do Cérebro ‐ Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rodrigo A.</namePart><namePart type="family">Bressan</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Instituto do Cérebro ‐ Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</affiliation><affiliation>Laboratório Interdisciplinar de Neurosciencias Clínicas ‐ LiNC, Universidade Federal de Sao Paulo, UNIFESP, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andre C.</namePart><namePart type="family">Felicio</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Instituto do Cérebro ‐ Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</affiliation><affiliation>Laboratório Interdisciplinar de Neurosciencias Clínicas ‐ LiNC, Universidade Federal de Sao Paulo, UNIFESP, São Paulo, Brazil</affiliation><affiliation>Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, SP, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Orlando G.P.</namePart><namePart type="family">Barsottini</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, SP, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Luiz Augusto F.</namePart><namePart type="family">Andrade</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Instituto do Cérebro ‐ Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hsin F.</namePart><namePart type="family">Chien</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Sao Paulo School of Medicine, Sao Paulo‐SP, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Vincenzo</namePart><namePart type="family">Bonifati</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Egberto R.</namePart><namePart type="family">Barbosa</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, University of Sao Paulo School of Medicine, Sao Paulo‐SP, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Helio A.</namePart><namePart type="family">Teive</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorders Unit, Neurology Service, Internal Medicine Department Hospital de Clínicas, Federal University of Paraná, Curitiba‐PR, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andrew J.</namePart><namePart type="family">Lees</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom</affiliation><description>Correspondence: Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, 1 Wakefield St, London, WC1N 1PJ, United Kingdom</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-12-15</dateIssued><dateCaptured encoding="w3cdtf">2010-02-24</dateCaptured><dateValid encoding="w3cdtf">2010-06-01</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">1</extent><extent unit="references">36</extent><extent unit="words">3625</extent></physicalDescription><abstract lang="en">LRRK2 mutations can cause familial and sporadic Parkinson's disease (PD) with Lewy‐body pathology at post‐mortem. Studies of olfaction in LRRK2 are sparse and incongruent. We applied a previously validated translation of the 16 item smell identification test from Sniffin' Sticks (SS‐16) to 14 parkinsonian carriers of heterozygous G2019S LRRK2 mutation and compared with 106 PD patients and 118 healthy controls. The mean SS‐16 score in LRRK2 was higher than in PD (p < 0.001, 95% CI for β = −4.7 to −1.7) and lower than in controls (p = 0.007, 95% CI for β = +0.6 to +3.6). In the LRRK2 group, subjects with low scores had significantly more dyskinesia. They also had younger age of onset, longer disease duration, and reported less frequently a family history of PD, but none of these other differences reached significance. Odor identification is diminished in LRRK2 parkinsonism but not to the same extent as in idiopathic PD. © 2010 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: The authors do not have any conflict of interest.</note><note type="funding">Reta Lila Weston Trust for Medical Research and Foundation Philantropique Edmond Safra</note><subject lang="en"><genre>Keywords</genre><topic>olfaction</topic><topic>smell</topic><topic>LRRK2</topic><topic>PARK8</topic><topic>parkinsonism</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><note type="content"> Additional Supporting Information may be found in the online version of this article.Supporting Info Item: Supporting Information - </note><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>16</number></detail><extent unit="pages"><start>2879</start><end>2883</end><total>5</total></extent></part></relatedItem><identifier type="istex">812BDDD70A7C5A82FA206880E00F606B2AC14CD9</identifier><identifier type="DOI">10.1002/mds.23325</identifier><identifier type="ArticleID">MDS23325</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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