Regional cortical grey matter loss in Parkinson's disease without dementia is independent from visual hallucinations
Identifieur interne : 002708 ( Main/Corpus ); précédent : 002707; suivant : 002709Regional cortical grey matter loss in Parkinson's disease without dementia is independent from visual hallucinations
Auteurs : Anne Marthe Meppelink ; Bauke M. De Jong ; Laura K. Teune ; Teus Van LaarSource :
- Movement Disorders [ 0885-3185 ] ; 2011-01.
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Abstract
In our previous functional magnetic resonance imaging study, Parkinson's disease (PD) patients with visual hallucinations (VH) showed reduced activations in ventral/lateral visual association cortices preceding image recognition, compared with both PD patients without VH and healthy controls. The primary aim of the current study was to investigate whether functional deficits are associated with grey matter volume changes. In addition, possible grey matter differences between all PD patients and healthy controls were assessed. By using 3‐Tesla magnetic resonance imaging (MRI) and voxel‐based morphometry (VBM), we found no differences between PD patients with (n = 11) and without VH (n = 13). However, grey matter decreases of the bilateral prefrontal and parietal cortex, left anterior superior temporal, and left middle occipital gyrus were found in the total group of PD patients, compared with controls (n = 14). This indicates that previously demonstrated functional deficits in PD patients with VH are not associated with grey matter loss. The strong left parietal reduction in both nondemented patient groups was hemisphere specific and independent of the side of PD symptoms. © 2010Movement Disorder Society.
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DOI: 10.1002/mds.23375
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ISTEX:50455B9A5E317247F64F06A86E9464677ED8BF98Le document en format XML
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The primary aim of the current study was to investigate whether functional deficits are associated with grey matter volume changes. In addition, possible grey matter differences between all PD patients and healthy controls were assessed. By using 3‐Tesla magnetic resonance imaging (MRI) and voxel‐based morphometry (VBM), we found no differences between PD patients with (n = 11) and without VH (n = 13). However, grey matter decreases of the bilateral prefrontal and parietal cortex, left anterior superior temporal, and left middle occipital gyrus were found in the total group of PD patients, compared with controls (n = 14). This indicates that previously demonstrated functional deficits in PD patients with VH are not associated with grey matter loss. The strong left parietal reduction in both nondemented patient groups was hemisphere specific and independent of the side of PD symptoms. © 2010Movement Disorder Society.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Anne Marthe Meppelink MD</name><affiliations><json:string>Department of Neurology, University Medical Center Groningen, University of Groningen, The Netherlands</json:string><json:string>School of Behavioral and Cognitive Neurosciences, University of Groningen, The Netherlands</json:string><json:string>Neuro Imaging Center (NIC) Groningen, University of Groningen, The Netherlands</json:string></affiliations></json:item><json:item><name>Bauke M. de Jong MD, PhD</name><affiliations><json:string>Department of Neurology, University Medical Center Groningen, University of Groningen, The Netherlands</json:string><json:string>School of Behavioral and Cognitive Neurosciences, University of Groningen, The Netherlands</json:string><json:string>Neuro Imaging Center (NIC) Groningen, University of Groningen, The Netherlands</json:string></affiliations></json:item><json:item><name>Laura K. 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The primary aim of the current study was to investigate whether functional deficits are associated with grey matter volume changes. In addition, possible grey matter differences between all PD patients and healthy controls were assessed. By using 3‐Tesla magnetic resonance imaging (MRI) and voxel‐based morphometry (VBM), we found no differences between PD patients with (n = 11) and without VH (n = 13). However, grey matter decreases of the bilateral prefrontal and parietal cortex, left anterior superior temporal, and left middle occipital gyrus were found in the total group of PD patients, compared with controls (n = 14). This indicates that previously demonstrated functional deficits in PD patients with VH are not associated with grey matter loss. 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Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="10"><doi origin="wiley" registered="yes">10.1002/mds.v26.1</doi><numberingGroup><numbering type="journalVolume" number="26">26</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="2011-01">January 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="260" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.23375</doi><idGroup><id type="unit" value="MDS23375"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="articleCategory">Brief Report</title><title type="tocHeading1">Brief Reports</title></titleGroup><copyright ownership="thirdParty">Copyright © 2010 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2010-04-23"></event><event type="manuscriptRevised" date="2010-05-15"></event><event type="manuscriptAccepted" date="2010-07-06"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.1.6 mode:FullText" date="2012-07-17"></event><event type="publishedOnlineEarlyUnpaginated" date="2010-10-04"></event><event type="publishedOnlineFinalForm" date="2011-02-14"></event><event type="firstOnline" date="2010-10-04"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">142</numbering><numbering type="pageLast">147</numbering></numberingGroup><correspondenceTo>Department of Neurology, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS23375.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="46"></count><count type="wordTotal" number="4413"></count></countGroup><titleGroup><title type="main" xml:lang="en">Regional cortical grey matter loss in Parkinson's disease without dementia is independent from visual hallucinations<link href="#fn1"></link></title><title type="short" xml:lang="en">Cortical Grey Matter Changes in PD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2 #af3" corresponding="yes"><personName><givenNames>Anne Marthe</givenNames><familyName>Meppelink</familyName><degrees>MD</degrees></personName><contactDetails><email>A.M.Meppelink@neuro.umcg.nl</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1 #af2 #af3"><personName><givenNames>Bauke M.</givenNames><familyName>de Jong</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1 #af2 #af3"><personName><givenNames>Laura K.</givenNames><familyName>Teune</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1 #af2 #af3"><personName><givenNames>Teus</givenNames><familyName>van Laar</familyName><degrees>MD, PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="NL" type="organization"><unparsedAffiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, The Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="NL" type="organization"><unparsedAffiliation>School of Behavioral and Cognitive Neurosciences, University of Groningen, The Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="NL" type="organization"><unparsedAffiliation>Neuro Imaging Center (NIC) Groningen, University of Groningen, The Netherlands</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">MRI</keyword><keyword xml:id="kwd2">VBM</keyword><keyword xml:id="kwd3">Parkinson's disease</keyword><keyword xml:id="kwd4">visual hallucinations</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>In our previous functional magnetic resonance imaging study, Parkinson's disease (PD) patients with visual hallucinations (VH) showed reduced activations in ventral/lateral visual association cortices preceding image recognition, compared with both PD patients without VH and healthy controls. The primary aim of the current study was to investigate whether functional deficits are associated with grey matter volume changes. In addition, possible grey matter differences between all PD patients and healthy controls were assessed. By using 3‐Tesla magnetic resonance imaging (MRI) and voxel‐based morphometry (VBM), we found no differences between PD patients with (n = 11) and without VH (n = 13). However, grey matter decreases of the bilateral prefrontal and parietal cortex, left anterior superior temporal, and left middle occipital gyrus were found in the total group of PD patients, compared with controls (n = 14). This indicates that previously demonstrated functional deficits in PD patients with VH are not associated with grey matter loss. The strong left parietal reduction in both nondemented patient groups was hemisphere specific and independent of the side of PD symptoms. © 2010Movement Disorder Society.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: Nothing to report.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Regional cortical grey matter loss in Parkinson's disease without dementia is independent from visual hallucinations</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Cortical Grey Matter Changes in PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Regional cortical grey matter loss in Parkinson's disease without dementia is independent from visual hallucinations</title></titleInfo><name type="personal"><namePart type="given">Anne Marthe</namePart><namePart type="family">Meppelink</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, The Netherlands</affiliation><affiliation>School of Behavioral and Cognitive Neurosciences, University of Groningen, The Netherlands</affiliation><affiliation>Neuro Imaging Center (NIC) Groningen, University of Groningen, The Netherlands</affiliation><description>Correspondence: Department of Neurology, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bauke M.</namePart><namePart type="family">de Jong</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, The Netherlands</affiliation><affiliation>School of Behavioral and Cognitive Neurosciences, University of Groningen, The Netherlands</affiliation><affiliation>Neuro Imaging Center (NIC) Groningen, University of Groningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Laura K.</namePart><namePart type="family">Teune</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, The Netherlands</affiliation><affiliation>School of Behavioral and Cognitive Neurosciences, University of Groningen, The Netherlands</affiliation><affiliation>Neuro Imaging Center (NIC) Groningen, University of Groningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Teus</namePart><namePart type="family">van Laar</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, The Netherlands</affiliation><affiliation>School of Behavioral and Cognitive Neurosciences, University of Groningen, The Netherlands</affiliation><affiliation>Neuro Imaging Center (NIC) Groningen, University of Groningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-01</dateIssued><dateCaptured encoding="w3cdtf">2010-04-23</dateCaptured><dateValid encoding="w3cdtf">2010-07-06</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">1</extent><extent unit="references">46</extent><extent unit="words">4413</extent></physicalDescription><abstract lang="en">In our previous functional magnetic resonance imaging study, Parkinson's disease (PD) patients with visual hallucinations (VH) showed reduced activations in ventral/lateral visual association cortices preceding image recognition, compared with both PD patients without VH and healthy controls. The primary aim of the current study was to investigate whether functional deficits are associated with grey matter volume changes. In addition, possible grey matter differences between all PD patients and healthy controls were assessed. By using 3‐Tesla magnetic resonance imaging (MRI) and voxel‐based morphometry (VBM), we found no differences between PD patients with (n = 11) and without VH (n = 13). However, grey matter decreases of the bilateral prefrontal and parietal cortex, left anterior superior temporal, and left middle occipital gyrus were found in the total group of PD patients, compared with controls (n = 14). This indicates that previously demonstrated functional deficits in PD patients with VH are not associated with grey matter loss. The strong left parietal reduction in both nondemented patient groups was hemisphere specific and independent of the side of PD symptoms. © 2010Movement Disorder Society.</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><subject lang="en"><genre>Keywords</genre><topic>MRI</topic><topic>VBM</topic><topic>Parkinson's disease</topic><topic>visual hallucinations</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>142</start><end>147</end><total>6</total></extent></part></relatedItem><identifier type="istex">50455B9A5E317247F64F06A86E9464677ED8BF98</identifier><identifier type="DOI">10.1002/mds.23375</identifier><identifier type="ArticleID">MDS23375</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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