Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options
Identifieur interne : 002684 ( Main/Corpus ); précédent : 002683; suivant : 002685Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options
Auteurs : A. C. Ludolph ; J. Kassubek ; B. G. Landwehrmeyer ; E. Mandelkow ; E. Mandelkow ; D. J. Burn ; D. Caparros-Lefebvre ; K. A. Frey ; J. G. De Yebenes ; T. Gasser ; P. Heutink ; G. Höglinger ; Z. Jamrozik ; K. A. Jellinger ; A. Kazantsev ; H. Kretzschmar ; A. E. Lang ; I. Litvan ; J. J. Lucas ; P. L. Mcgeer ; S. Melquist ; W. Oertel ; M. Otto ; D. Paviour ; T. Reum ; A. Saint-Raymond ; J. C. Steele ; M. Tolnay ; H. Tumani ; J. C. Van Swieten ; M. T. Vanier ; J. Vonsattel ; S. Wagner ; Z. K. WszolekSource :
- European Journal of Neurology [ 1351-5101 ] ; 2009-03.
English descriptors
- KwdEn :
Abstract
Tauopathies with parkinsonism represent a spectrum of disease entities unified by the pathologic accumulation of hyperphosphorylated tau protein fragments within the central nervous system. These pathologic characteristics suggest shared pathogenetic pathways and possible molecular targets for disease‐modifying therapeutic interventions. Natural history studies, for instance, in progressive supranuclear palsy, frontotemporal dementia with parkinsonism linked to chromosome 17, corticobasal degeneration, and Niemann‐Pick disease type C as well as in amyotrophic lateral sclerosis/Parkinson–dementia complex permit clinical characterization of the disease phenotypes and are crucial to the development and validation of biological markers for differential diagnostics and disease monitoring, for example, by use of neuroimaging or proteomic approaches. The wide pathologic and clinical spectrum of the tauopathies with parkinsonism is reviewed in this article, and perspectives on future advances in the understanding of the pathogenesis are given, together with potential therapeutic strategies.
Url:
DOI: 10.1111/j.1468-1331.2008.02513.x
Links to Exploration step
ISTEX:46DA66675464C537825E2DA84B0B1D58DE536F61Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options</title><author><name sortKey="Ludolph, A C" sort="Ludolph, A C" uniqKey="Ludolph A" first="A. C." last="Ludolph">A. C. Ludolph</name><affiliation><mods:affiliation>Department of Neurology, University of Ulm, Ulm, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kassubek, J" sort="Kassubek, J" uniqKey="Kassubek J" first="J." last="Kassubek">J. Kassubek</name><affiliation><mods:affiliation>Department of Neurology, University of Ulm, Ulm, Germany</mods:affiliation></affiliation></author><author><name sortKey="Landwehrmeyer, B G" sort="Landwehrmeyer, B G" uniqKey="Landwehrmeyer B" first="B. G." last="Landwehrmeyer">B. G. Landwehrmeyer</name><affiliation><mods:affiliation>Department of Neurology, University of Ulm, Ulm, Germany</mods:affiliation></affiliation></author><author><name sortKey="Mandelkow, E" sort="Mandelkow, E" uniqKey="Mandelkow E" first="E." last="Mandelkow">E. Mandelkow</name><affiliation><mods:affiliation>Max Planck Unit for Structural Molecular Biology, c/o DESY, Notkestr, Hamburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Mandelkow, E" sort="Mandelkow, E" uniqKey="Mandelkow E" first="E." last="Mandelkow">E. Mandelkow</name><affiliation><mods:affiliation>Max Planck Unit for Structural Molecular Biology, c/o DESY, Notkestr, Hamburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Burn, D J" sort="Burn, D J" uniqKey="Burn D" first="D. J." last="Burn">D. J. Burn</name><affiliation><mods:affiliation>Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK</mods:affiliation></affiliation></author><author><name sortKey="Caparros Efebvre, D" sort="Caparros Efebvre, D" uniqKey="Caparros Efebvre D" first="D." last="Caparros-Lefebvre">D. Caparros-Lefebvre</name><affiliation><mods:affiliation>Centre Hospitalier de Valenciennes, Résidence du Val d’Escaut, Avenue Desandrouin, Valenciennes, France</mods:affiliation></affiliation></author><author><name sortKey="Frey, K A" sort="Frey, K A" uniqKey="Frey K" first="K. A." last="Frey">K. A. Frey</name><affiliation><mods:affiliation>University of Michigan Medical Center, 1500 E Medical Center Dr, Ann Arbor, MI, USA</mods:affiliation></affiliation></author><author><name sortKey="De Yebenes, J G" sort="De Yebenes, J G" uniqKey="De Yebenes J" first="J. G." last="De Yebenes">J. G. De Yebenes</name><affiliation><mods:affiliation>Hospital Ramon y Cajal, Neurology, Carretera Colmenar, Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Gasser, T" sort="Gasser, T" uniqKey="Gasser T" first="T." last="Gasser">T. Gasser</name><affiliation><mods:affiliation>Universitätsklinikum Tübingen, Zentrum für Neurologie, Hoppe‐Seyler‐Strasse, Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Heutink, P" sort="Heutink, P" uniqKey="Heutink P" first="P." last="Heutink">P. Heutink</name><affiliation><mods:affiliation>VU University Medical Center, Department of Clinical Genetics and Anthropogenet, van der Boechorststraat, Amsterdam, the Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Hoglinger, G" sort="Hoglinger, G" uniqKey="Hoglinger G" first="G." last="Höglinger">G. Höglinger</name><affiliation><mods:affiliation>Philipps‐Universität, Neurologie, Rudolf‐Bultmann‐Strasse, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Jamrozik, Z" sort="Jamrozik, Z" uniqKey="Jamrozik Z" first="Z." last="Jamrozik">Z. Jamrozik</name><affiliation><mods:affiliation>Medical University of Warsaw, Neurology, Banacha, Warsaw, Poland</mods:affiliation></affiliation></author><author><name sortKey="Jellinger, K A" sort="Jellinger, K A" uniqKey="Jellinger K" first="K. A." last="Jellinger">K. A. Jellinger</name><affiliation><mods:affiliation>Institute of Clinical Neurobiology, Kenyongasse, Vienna, Austria</mods:affiliation></affiliation></author><author><name sortKey="Kazantsev, A" sort="Kazantsev, A" uniqKey="Kazantsev A" first="A." last="Kazantsev">A. Kazantsev</name><affiliation><mods:affiliation>Massachusetts General Hospital, MIND/Harvard Medical School, Charlestown, MA, USA</mods:affiliation></affiliation></author><author><name sortKey="Kretzschmar, H" sort="Kretzschmar, H" uniqKey="Kretzschmar H" first="H." last="Kretzschmar">H. Kretzschmar</name><affiliation><mods:affiliation>Institut für Neuropathologie, BrainNet (German Brain Bank), Feodor‐Lynen‐Strasse, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name><affiliation><mods:affiliation>Toronto Western Hospital, Movement Disorders Center, Toronto, ON, Canada</mods:affiliation></affiliation></author><author><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I." last="Litvan">I. Litvan</name><affiliation><mods:affiliation>University of Louisville, School of Medicine/Department of Neurology, Louisville, KY, USA</mods:affiliation></affiliation></author><author><name sortKey="Lucas, J J" sort="Lucas, J J" uniqKey="Lucas J" first="J. J." last="Lucas">J. J. Lucas</name><affiliation><mods:affiliation>Centro de Biologica Molecular “Severo Ochoa,” Universidad Autonoma de Madrid and CiberNed, Cantoblanco, Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Mcgeer, P L" sort="Mcgeer, P L" uniqKey="Mcgeer P" first="P. L." last="Mcgeer">P. L. Mcgeer</name><affiliation><mods:affiliation>University of British Columbia, Kinsmen Laboratory of Neurological Research, Vancouver, BC, Canada</mods:affiliation></affiliation></author><author><name sortKey="Melquist, S" sort="Melquist, S" uniqKey="Melquist S" first="S." last="Melquist">S. Melquist</name><affiliation><mods:affiliation>Mayo Clinic, Department of Neuroscience, Jacksonville, FL, USA</mods:affiliation></affiliation></author><author><name sortKey="Oertel, W" sort="Oertel, W" uniqKey="Oertel W" first="W." last="Oertel">W. Oertel</name><affiliation><mods:affiliation>Philipps‐Universität, Neurologie, Rudolf‐Bultmann‐Strasse, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Otto, M" sort="Otto, M" uniqKey="Otto M" first="M." last="Otto">M. Otto</name><affiliation><mods:affiliation>Department of Neurology, University of Ulm, Ulm, Germany</mods:affiliation></affiliation></author><author><name sortKey="Paviour, D" sort="Paviour, D" uniqKey="Paviour D" first="D." last="Paviour">D. Paviour</name><affiliation><mods:affiliation>National Hospital for Neurology, Dementia Research Centre, London, England</mods:affiliation></affiliation></author><author><name sortKey="Reum, T" sort="Reum, T" uniqKey="Reum T" first="T." last="Reum">T. Reum</name><affiliation><mods:affiliation>Bundesinstitut für Arzneimittel & Medizinprodukte, Wissenschaftlicher Service/Klinische Prüfungen, Georg‐Kiesinger‐Allee, Bonn, Germany</mods:affiliation></affiliation></author><author><name sortKey="Saint Aymond, A" sort="Saint Aymond, A" uniqKey="Saint Aymond A" first="A." last="Saint-Raymond">A. Saint-Raymond</name><affiliation><mods:affiliation>European Medicines Agency (EMEA), Scientific Advice and Orphan Drugs Sector, 7 Westferry Circus, Canary Wharf, London, England</mods:affiliation></affiliation></author><author><name sortKey="Steele, J C" sort="Steele, J C" uniqKey="Steele J" first="J. C." last="Steele">J. C. Steele</name><affiliation><mods:affiliation>Guam Memorial Hospital, Neurology, Carlos Camacho Way, Tamuning, Guam</mods:affiliation></affiliation></author><author><name sortKey="Tolnay, M" sort="Tolnay, M" uniqKey="Tolnay M" first="M." last="Tolnay">M. Tolnay</name><affiliation><mods:affiliation>Institut für Pathologie, Schönbeinstrasse, Basel, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Tumani, H" sort="Tumani, H" uniqKey="Tumani H" first="H." last="Tumani">H. Tumani</name><affiliation><mods:affiliation>Department of Neurology, University of Ulm, Ulm, Germany</mods:affiliation></affiliation></author><author><name sortKey="Van Swieten, J C" sort="Van Swieten, J C" uniqKey="Van Swieten J" first="J. C." last="Van Swieten">J. C. Van Swieten</name><affiliation><mods:affiliation>University Hospital Rotterdam, Department of Neurology, Erasmus MC, Dr Molewaterplein, GD Rotterdam, the Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Vanier, M T" sort="Vanier, M T" uniqKey="Vanier M" first="M. T." last="Vanier">M. T. Vanier</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 820, Laënnec Medical School, Lyon, France</mods:affiliation></affiliation></author><author><name sortKey="Vonsattel, J" sort="Vonsattel, J" uniqKey="Vonsattel J" first="J." last="Vonsattel">J. Vonsattel</name><affiliation><mods:affiliation>New York Brain Bank, Columbia University, Pathology, Babies Hospital, New York, NY, USA</mods:affiliation></affiliation></author><author><name sortKey="Wagner, S" sort="Wagner, S" uniqKey="Wagner S" first="S." last="Wagner">S. Wagner</name><affiliation><mods:affiliation>Deutsche PSP‐Gesellschaft e.V. (PSP Germany), c/o S. Wagner, Könneritzstrasse, Leipzig, Germany</mods:affiliation></affiliation></author><author><name sortKey="Wszolek, Z K" sort="Wszolek, Z K" uniqKey="Wszolek Z" first="Z. K." last="Wszolek">Z. K. Wszolek</name><affiliation><mods:affiliation>Mayo Clinic, Department of Neurology, Jacksonville, FL, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:46DA66675464C537825E2DA84B0B1D58DE536F61</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1111/j.1468-1331.2008.02513.x</idno><idno type="url">https://api.istex.fr/document/46DA66675464C537825E2DA84B0B1D58DE536F61/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002684</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options</title><author><name sortKey="Ludolph, A C" sort="Ludolph, A C" uniqKey="Ludolph A" first="A. C." last="Ludolph">A. C. Ludolph</name><affiliation><mods:affiliation>Department of Neurology, University of Ulm, Ulm, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kassubek, J" sort="Kassubek, J" uniqKey="Kassubek J" first="J." last="Kassubek">J. Kassubek</name><affiliation><mods:affiliation>Department of Neurology, University of Ulm, Ulm, Germany</mods:affiliation></affiliation></author><author><name sortKey="Landwehrmeyer, B G" sort="Landwehrmeyer, B G" uniqKey="Landwehrmeyer B" first="B. G." last="Landwehrmeyer">B. G. Landwehrmeyer</name><affiliation><mods:affiliation>Department of Neurology, University of Ulm, Ulm, Germany</mods:affiliation></affiliation></author><author><name sortKey="Mandelkow, E" sort="Mandelkow, E" uniqKey="Mandelkow E" first="E." last="Mandelkow">E. Mandelkow</name><affiliation><mods:affiliation>Max Planck Unit for Structural Molecular Biology, c/o DESY, Notkestr, Hamburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Mandelkow, E" sort="Mandelkow, E" uniqKey="Mandelkow E" first="E." last="Mandelkow">E. Mandelkow</name><affiliation><mods:affiliation>Max Planck Unit for Structural Molecular Biology, c/o DESY, Notkestr, Hamburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Burn, D J" sort="Burn, D J" uniqKey="Burn D" first="D. J." last="Burn">D. J. Burn</name><affiliation><mods:affiliation>Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK</mods:affiliation></affiliation></author><author><name sortKey="Caparros Efebvre, D" sort="Caparros Efebvre, D" uniqKey="Caparros Efebvre D" first="D." last="Caparros-Lefebvre">D. Caparros-Lefebvre</name><affiliation><mods:affiliation>Centre Hospitalier de Valenciennes, Résidence du Val d’Escaut, Avenue Desandrouin, Valenciennes, France</mods:affiliation></affiliation></author><author><name sortKey="Frey, K A" sort="Frey, K A" uniqKey="Frey K" first="K. A." last="Frey">K. A. Frey</name><affiliation><mods:affiliation>University of Michigan Medical Center, 1500 E Medical Center Dr, Ann Arbor, MI, USA</mods:affiliation></affiliation></author><author><name sortKey="De Yebenes, J G" sort="De Yebenes, J G" uniqKey="De Yebenes J" first="J. G." last="De Yebenes">J. G. De Yebenes</name><affiliation><mods:affiliation>Hospital Ramon y Cajal, Neurology, Carretera Colmenar, Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Gasser, T" sort="Gasser, T" uniqKey="Gasser T" first="T." last="Gasser">T. Gasser</name><affiliation><mods:affiliation>Universitätsklinikum Tübingen, Zentrum für Neurologie, Hoppe‐Seyler‐Strasse, Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Heutink, P" sort="Heutink, P" uniqKey="Heutink P" first="P." last="Heutink">P. Heutink</name><affiliation><mods:affiliation>VU University Medical Center, Department of Clinical Genetics and Anthropogenet, van der Boechorststraat, Amsterdam, the Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Hoglinger, G" sort="Hoglinger, G" uniqKey="Hoglinger G" first="G." last="Höglinger">G. Höglinger</name><affiliation><mods:affiliation>Philipps‐Universität, Neurologie, Rudolf‐Bultmann‐Strasse, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Jamrozik, Z" sort="Jamrozik, Z" uniqKey="Jamrozik Z" first="Z." last="Jamrozik">Z. Jamrozik</name><affiliation><mods:affiliation>Medical University of Warsaw, Neurology, Banacha, Warsaw, Poland</mods:affiliation></affiliation></author><author><name sortKey="Jellinger, K A" sort="Jellinger, K A" uniqKey="Jellinger K" first="K. A." last="Jellinger">K. A. Jellinger</name><affiliation><mods:affiliation>Institute of Clinical Neurobiology, Kenyongasse, Vienna, Austria</mods:affiliation></affiliation></author><author><name sortKey="Kazantsev, A" sort="Kazantsev, A" uniqKey="Kazantsev A" first="A." last="Kazantsev">A. Kazantsev</name><affiliation><mods:affiliation>Massachusetts General Hospital, MIND/Harvard Medical School, Charlestown, MA, USA</mods:affiliation></affiliation></author><author><name sortKey="Kretzschmar, H" sort="Kretzschmar, H" uniqKey="Kretzschmar H" first="H." last="Kretzschmar">H. Kretzschmar</name><affiliation><mods:affiliation>Institut für Neuropathologie, BrainNet (German Brain Bank), Feodor‐Lynen‐Strasse, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name><affiliation><mods:affiliation>Toronto Western Hospital, Movement Disorders Center, Toronto, ON, Canada</mods:affiliation></affiliation></author><author><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I." last="Litvan">I. Litvan</name><affiliation><mods:affiliation>University of Louisville, School of Medicine/Department of Neurology, Louisville, KY, USA</mods:affiliation></affiliation></author><author><name sortKey="Lucas, J J" sort="Lucas, J J" uniqKey="Lucas J" first="J. J." last="Lucas">J. J. Lucas</name><affiliation><mods:affiliation>Centro de Biologica Molecular “Severo Ochoa,” Universidad Autonoma de Madrid and CiberNed, Cantoblanco, Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Mcgeer, P L" sort="Mcgeer, P L" uniqKey="Mcgeer P" first="P. L." last="Mcgeer">P. L. Mcgeer</name><affiliation><mods:affiliation>University of British Columbia, Kinsmen Laboratory of Neurological Research, Vancouver, BC, Canada</mods:affiliation></affiliation></author><author><name sortKey="Melquist, S" sort="Melquist, S" uniqKey="Melquist S" first="S." last="Melquist">S. Melquist</name><affiliation><mods:affiliation>Mayo Clinic, Department of Neuroscience, Jacksonville, FL, USA</mods:affiliation></affiliation></author><author><name sortKey="Oertel, W" sort="Oertel, W" uniqKey="Oertel W" first="W." last="Oertel">W. Oertel</name><affiliation><mods:affiliation>Philipps‐Universität, Neurologie, Rudolf‐Bultmann‐Strasse, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Otto, M" sort="Otto, M" uniqKey="Otto M" first="M." last="Otto">M. Otto</name><affiliation><mods:affiliation>Department of Neurology, University of Ulm, Ulm, Germany</mods:affiliation></affiliation></author><author><name sortKey="Paviour, D" sort="Paviour, D" uniqKey="Paviour D" first="D." last="Paviour">D. Paviour</name><affiliation><mods:affiliation>National Hospital for Neurology, Dementia Research Centre, London, England</mods:affiliation></affiliation></author><author><name sortKey="Reum, T" sort="Reum, T" uniqKey="Reum T" first="T." last="Reum">T. Reum</name><affiliation><mods:affiliation>Bundesinstitut für Arzneimittel & Medizinprodukte, Wissenschaftlicher Service/Klinische Prüfungen, Georg‐Kiesinger‐Allee, Bonn, Germany</mods:affiliation></affiliation></author><author><name sortKey="Saint Aymond, A" sort="Saint Aymond, A" uniqKey="Saint Aymond A" first="A." last="Saint-Raymond">A. Saint-Raymond</name><affiliation><mods:affiliation>European Medicines Agency (EMEA), Scientific Advice and Orphan Drugs Sector, 7 Westferry Circus, Canary Wharf, London, England</mods:affiliation></affiliation></author><author><name sortKey="Steele, J C" sort="Steele, J C" uniqKey="Steele J" first="J. C." last="Steele">J. C. Steele</name><affiliation><mods:affiliation>Guam Memorial Hospital, Neurology, Carlos Camacho Way, Tamuning, Guam</mods:affiliation></affiliation></author><author><name sortKey="Tolnay, M" sort="Tolnay, M" uniqKey="Tolnay M" first="M." last="Tolnay">M. Tolnay</name><affiliation><mods:affiliation>Institut für Pathologie, Schönbeinstrasse, Basel, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Tumani, H" sort="Tumani, H" uniqKey="Tumani H" first="H." last="Tumani">H. Tumani</name><affiliation><mods:affiliation>Department of Neurology, University of Ulm, Ulm, Germany</mods:affiliation></affiliation></author><author><name sortKey="Van Swieten, J C" sort="Van Swieten, J C" uniqKey="Van Swieten J" first="J. C." last="Van Swieten">J. C. Van Swieten</name><affiliation><mods:affiliation>University Hospital Rotterdam, Department of Neurology, Erasmus MC, Dr Molewaterplein, GD Rotterdam, the Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Vanier, M T" sort="Vanier, M T" uniqKey="Vanier M" first="M. T." last="Vanier">M. T. Vanier</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 820, Laënnec Medical School, Lyon, France</mods:affiliation></affiliation></author><author><name sortKey="Vonsattel, J" sort="Vonsattel, J" uniqKey="Vonsattel J" first="J." last="Vonsattel">J. Vonsattel</name><affiliation><mods:affiliation>New York Brain Bank, Columbia University, Pathology, Babies Hospital, New York, NY, USA</mods:affiliation></affiliation></author><author><name sortKey="Wagner, S" sort="Wagner, S" uniqKey="Wagner S" first="S." last="Wagner">S. Wagner</name><affiliation><mods:affiliation>Deutsche PSP‐Gesellschaft e.V. (PSP Germany), c/o S. Wagner, Könneritzstrasse, Leipzig, Germany</mods:affiliation></affiliation></author><author><name sortKey="Wszolek, Z K" sort="Wszolek, Z K" uniqKey="Wszolek Z" first="Z. K." last="Wszolek">Z. K. Wszolek</name><affiliation><mods:affiliation>Mayo Clinic, Department of Neurology, Jacksonville, FL, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2009-03">2009-03</date><biblScope unit="volume">16</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="297">297</biblScope><biblScope unit="page" to="309">309</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">46DA66675464C537825E2DA84B0B1D58DE536F61</idno><idno type="DOI">10.1111/j.1468-1331.2008.02513.x</idno><idno type="ArticleID">ENE2513</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson disease</term><term>corticobasal degeneration</term><term>frontotemporal dementia with parkinsonism linked to chromosome 17</term><term>microtubule‐associated protein tau</term><term>multiple system atrophy</term><term>parkinsonism</term><term>progressive supranuclear palsy</term><term>tauopathies</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Tauopathies with parkinsonism represent a spectrum of disease entities unified by the pathologic accumulation of hyperphosphorylated tau protein fragments within the central nervous system. These pathologic characteristics suggest shared pathogenetic pathways and possible molecular targets for disease‐modifying therapeutic interventions. Natural history studies, for instance, in progressive supranuclear palsy, frontotemporal dementia with parkinsonism linked to chromosome 17, corticobasal degeneration, and Niemann‐Pick disease type C as well as in amyotrophic lateral sclerosis/Parkinson–dementia complex permit clinical characterization of the disease phenotypes and are crucial to the development and validation of biological markers for differential diagnostics and disease monitoring, for example, by use of neuroimaging or proteomic approaches. The wide pathologic and clinical spectrum of the tauopathies with parkinsonism is reviewed in this article, and perspectives on future advances in the understanding of the pathogenesis are given, together with potential therapeutic strategies.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>A. C. Ludolph</name><affiliations><json:string>Department of Neurology, University of Ulm, Ulm, Germany</json:string></affiliations></json:item><json:item><name>J. Kassubek</name><affiliations><json:string>Department of Neurology, University of Ulm, Ulm, Germany</json:string></affiliations></json:item><json:item><name>B. G. Landwehrmeyer</name><affiliations><json:string>Department of Neurology, University of Ulm, Ulm, Germany</json:string></affiliations></json:item><json:item><name>E. Mandelkow</name><affiliations><json:string>Max Planck Unit for Structural Molecular Biology, c/o DESY, Notkestr, Hamburg, Germany</json:string></affiliations></json:item><json:item><name>E.‐M. Mandelkow</name><affiliations><json:string>Max Planck Unit for Structural Molecular Biology, c/o DESY, Notkestr, Hamburg, Germany</json:string></affiliations></json:item><json:item><name>D. J. Burn</name><affiliations><json:string>Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK</json:string></affiliations></json:item><json:item><name>D. Caparros‐Lefebvre</name><affiliations><json:string>Centre Hospitalier de Valenciennes, Résidence du Val d’Escaut, Avenue Desandrouin, Valenciennes, France</json:string></affiliations></json:item><json:item><name>K. A. Frey</name><affiliations><json:string>University of Michigan Medical Center, 1500 E Medical Center Dr, Ann Arbor, MI, USA</json:string></affiliations></json:item><json:item><name>J. G. De Yebenes</name><affiliations><json:string>Hospital Ramon y Cajal, Neurology, Carretera Colmenar, Madrid, Spain</json:string></affiliations></json:item><json:item><name>T. Gasser</name><affiliations><json:string>Universitätsklinikum Tübingen, Zentrum für Neurologie, Hoppe‐Seyler‐Strasse, Tübingen, Germany</json:string></affiliations></json:item><json:item><name>P. Heutink</name><affiliations><json:string>VU University Medical Center, Department of Clinical Genetics and Anthropogenet, van der Boechorststraat, Amsterdam, the Netherlands</json:string></affiliations></json:item><json:item><name>G. Höglinger</name><affiliations><json:string>Philipps‐Universität, Neurologie, Rudolf‐Bultmann‐Strasse, Marburg, Germany</json:string></affiliations></json:item><json:item><name>Z. Jamrozik</name><affiliations><json:string>Medical University of Warsaw, Neurology, Banacha, Warsaw, Poland</json:string></affiliations></json:item><json:item><name>K. A. Jellinger</name><affiliations><json:string>Institute of Clinical Neurobiology, Kenyongasse, Vienna, Austria</json:string></affiliations></json:item><json:item><name>A. Kazantsev</name><affiliations><json:string>Massachusetts General Hospital, MIND/Harvard Medical School, Charlestown, MA, USA</json:string></affiliations></json:item><json:item><name>H. Kretzschmar</name><affiliations><json:string>Institut für Neuropathologie, BrainNet (German Brain Bank), Feodor‐Lynen‐Strasse, Munich, Germany</json:string></affiliations></json:item><json:item><name>A. E. Lang</name><affiliations><json:string>Toronto Western Hospital, Movement Disorders Center, Toronto, ON, Canada</json:string></affiliations></json:item><json:item><name>I. Litvan</name><affiliations><json:string>University of Louisville, School of Medicine/Department of Neurology, Louisville, KY, USA</json:string></affiliations></json:item><json:item><name>J. J. Lucas</name><affiliations><json:string>Centro de Biologica Molecular “Severo Ochoa,” Universidad Autonoma de Madrid and CiberNed, Cantoblanco, Madrid, Spain</json:string></affiliations></json:item><json:item><name>P. L. McGeer</name><affiliations><json:string>University of British Columbia, Kinsmen Laboratory of Neurological Research, Vancouver, BC, Canada</json:string></affiliations></json:item><json:item><name>S. Melquist</name><affiliations><json:string>Mayo Clinic, Department of Neuroscience, Jacksonville, FL, USA</json:string></affiliations></json:item><json:item><name>W. Oertel</name><affiliations><json:string>Philipps‐Universität, Neurologie, Rudolf‐Bultmann‐Strasse, Marburg, Germany</json:string></affiliations></json:item><json:item><name>M. Otto</name><affiliations><json:string>Department of Neurology, University of Ulm, Ulm, Germany</json:string></affiliations></json:item><json:item><name>D. Paviour</name><affiliations><json:string>National Hospital for Neurology, Dementia Research Centre, London, England</json:string></affiliations></json:item><json:item><name>T. Reum</name><affiliations><json:string>Bundesinstitut für Arzneimittel & Medizinprodukte, Wissenschaftlicher Service/Klinische Prüfungen, Georg‐Kiesinger‐Allee, Bonn, Germany</json:string></affiliations></json:item><json:item><name>A. Saint‐Raymond</name><affiliations><json:string>European Medicines Agency (EMEA), Scientific Advice and Orphan Drugs Sector, 7 Westferry Circus, Canary Wharf, London, England</json:string></affiliations></json:item><json:item><name>J. C. Steele</name><affiliations><json:string>Guam Memorial Hospital, Neurology, Carlos Camacho Way, Tamuning, Guam</json:string></affiliations></json:item><json:item><name>M. Tolnay</name><affiliations><json:string>Institut für Pathologie, Schönbeinstrasse, Basel, Switzerland</json:string></affiliations></json:item><json:item><name>H. Tumani</name><affiliations><json:string>Department of Neurology, University of Ulm, Ulm, Germany</json:string></affiliations></json:item><json:item><name>J. C. Van Swieten</name><affiliations><json:string>University Hospital Rotterdam, Department of Neurology, Erasmus MC, Dr Molewaterplein, GD Rotterdam, the Netherlands</json:string></affiliations></json:item><json:item><name>M. T. Vanier</name><affiliations><json:string>Institut National de la Santé et de la Recherche Médicale, Unit 820, Laënnec Medical School, Lyon, France</json:string></affiliations></json:item><json:item><name>J.‐P. Vonsattel</name><affiliations><json:string>New York Brain Bank, Columbia University, Pathology, Babies Hospital, New York, NY, USA</json:string></affiliations></json:item><json:item><name>S. Wagner</name><affiliations><json:string>Deutsche PSP‐Gesellschaft e.V. (PSP Germany), c/o S. Wagner, Könneritzstrasse, Leipzig, Germany</json:string></affiliations></json:item><json:item><name>Z. K. Wszolek</name><affiliations><json:string>Mayo Clinic, Department of Neurology, Jacksonville, FL, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>corticobasal degeneration</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>frontotemporal dementia with parkinsonism linked to chromosome 17</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>microtubule‐associated protein tau</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>multiple system atrophy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>parkinsonism</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>progressive supranuclear palsy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>tauopathies</value></json:item></subject><articleId><json:string>ENE2513</json:string></articleId><language><json:string>eng</json:string></language><abstract>Tauopathies with parkinsonism represent a spectrum of disease entities unified by the pathologic accumulation of hyperphosphorylated tau protein fragments within the central nervous system. These pathologic characteristics suggest shared pathogenetic pathways and possible molecular targets for disease‐modifying therapeutic interventions. Natural history studies, for instance, in progressive supranuclear palsy, frontotemporal dementia with parkinsonism linked to chromosome 17, corticobasal degeneration, and Niemann‐Pick disease type C as well as in amyotrophic lateral sclerosis/Parkinson–dementia complex permit clinical characterization of the disease phenotypes and are crucial to the development and validation of biological markers for differential diagnostics and disease monitoring, for example, by use of neuroimaging or proteomic approaches. The wide pathologic and clinical spectrum of the tauopathies with parkinsonism is reviewed in this article, and perspectives on future advances in the understanding of the pathogenesis are given, together with potential therapeutic strategies.</abstract><qualityIndicators><score>6.656</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>8</keywordCount><abstractCharCount>1099</abstractCharCount><pdfWordCount>8002</pdfWordCount><pdfCharCount>56436</pdfCharCount><pdfPageCount>13</pdfPageCount><abstractWordCount>138</abstractWordCount></qualityIndicators><title>Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options</title><corporate><json:item><name>for the Reisensburg Working Group for Tauopathies With Parkinsonism</name></json:item></corporate><genre><json:string>review-article</json:string></genre><host><volume>16</volume><publisherId><json:string>ENE</json:string></publisherId><pages><total>14</total><last>309</last><first>297</first></pages><issn><json:string>1351-5101</json:string></issn><issue>3</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1468-1331</json:string></eissn><title>European Journal of Neurology</title><doi><json:string>10.1111/(ISSN)1468-1331</json:string></doi></host><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1111/j.1468-1331.2008.02513.x</json:string></doi><id>46DA66675464C537825E2DA84B0B1D58DE536F61</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/46DA66675464C537825E2DA84B0B1D58DE536F61/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/46DA66675464C537825E2DA84B0B1D58DE536F61/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/46DA66675464C537825E2DA84B0B1D58DE536F61/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>2009</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options</title><author><orgName>for the Reisensburg Working Group for Tauopathies With Parkinsonism</orgName></author><author><persName><forename type="first">A. C.</forename><surname>Ludolph</surname></persName><note type="biography">These authors contributed equally to the work.</note><affiliation>These authors contributed equally to the work.</affiliation><affiliation>Department of Neurology, University of Ulm, Ulm, Germany</affiliation></author><author><persName><forename type="first">J.</forename><surname>Kassubek</surname></persName><note type="biography">These authors contributed equally to the work.</note><affiliation>These authors contributed equally to the work.</affiliation><affiliation>Department of Neurology, University of Ulm, Ulm, Germany</affiliation></author><author><persName><forename type="first">B. G.</forename><surname>Landwehrmeyer</surname></persName><note type="biography">These authors contributed equally to the work.</note><affiliation>These authors contributed equally to the work.</affiliation><affiliation>Department of Neurology, University of Ulm, Ulm, Germany</affiliation></author><author><persName><forename type="first">E.</forename><surname>Mandelkow</surname></persName><affiliation>Max Planck Unit for Structural Molecular Biology, c/o DESY, Notkestr, Hamburg, Germany</affiliation></author><author><persName><forename type="first">E.‐M.</forename><surname>Mandelkow</surname></persName><affiliation>Max Planck Unit for Structural Molecular Biology, c/o DESY, Notkestr, Hamburg, Germany</affiliation></author><author><persName><forename type="first">D. J.</forename><surname>Burn</surname></persName><affiliation>Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK</affiliation></author><author><persName><forename type="first">D.</forename><surname>Caparros‐Lefebvre</surname></persName><affiliation>Centre Hospitalier de Valenciennes, Résidence du Val d’Escaut, Avenue Desandrouin, Valenciennes, France</affiliation></author><author><persName><forename type="first">K. A.</forename><surname>Frey</surname></persName><affiliation>University of Michigan Medical Center, 1500 E Medical Center Dr, Ann Arbor, MI, USA</affiliation></author><author><persName><forename type="first">J. G.</forename><surname>De Yebenes</surname></persName><affiliation>Hospital Ramon y Cajal, Neurology, Carretera Colmenar, Madrid, Spain</affiliation></author><author><persName><forename type="first">T.</forename><surname>Gasser</surname></persName><affiliation>Universitätsklinikum Tübingen, Zentrum für Neurologie, Hoppe‐Seyler‐Strasse, Tübingen, Germany</affiliation></author><author><persName><forename type="first">P.</forename><surname>Heutink</surname></persName><affiliation>VU University Medical Center, Department of Clinical Genetics and Anthropogenet, van der Boechorststraat, Amsterdam, the Netherlands</affiliation></author><author><persName><forename type="first">G.</forename><surname>Höglinger</surname></persName><affiliation>Philipps‐Universität, Neurologie, Rudolf‐Bultmann‐Strasse, Marburg, Germany</affiliation></author><author><persName><forename type="first">Z.</forename><surname>Jamrozik</surname></persName><affiliation>Medical University of Warsaw, Neurology, Banacha, Warsaw, Poland</affiliation></author><author><persName><forename type="first">K. A.</forename><surname>Jellinger</surname></persName><affiliation>Institute of Clinical Neurobiology, Kenyongasse, Vienna, Austria</affiliation></author><author><persName><forename type="first">A.</forename><surname>Kazantsev</surname></persName><affiliation>Massachusetts General Hospital, MIND/Harvard Medical School, Charlestown, MA, USA</affiliation></author><author><persName><forename type="first">H.</forename><surname>Kretzschmar</surname></persName><affiliation>Institut für Neuropathologie, BrainNet (German Brain Bank), Feodor‐Lynen‐Strasse, Munich, Germany</affiliation></author><author><persName><forename type="first">A. E.</forename><surname>Lang</surname></persName><affiliation>Toronto Western Hospital, Movement Disorders Center, Toronto, ON, Canada</affiliation></author><author><persName><forename type="first">I.</forename><surname>Litvan</surname></persName><affiliation>University of Louisville, School of Medicine/Department of Neurology, Louisville, KY, USA</affiliation></author><author><persName><forename type="first">J. J.</forename><surname>Lucas</surname></persName><affiliation>Centro de Biologica Molecular “Severo Ochoa,” Universidad Autonoma de Madrid and CiberNed, Cantoblanco, Madrid, Spain</affiliation></author><author><persName><forename type="first">P. L.</forename><surname>McGeer</surname></persName><affiliation>University of British Columbia, Kinsmen Laboratory of Neurological Research, Vancouver, BC, Canada</affiliation></author><author><persName><forename type="first">S.</forename><surname>Melquist</surname></persName><affiliation>Mayo Clinic, Department of Neuroscience, Jacksonville, FL, USA</affiliation></author><author><persName><forename type="first">W.</forename><surname>Oertel</surname></persName><affiliation>Philipps‐Universität, Neurologie, Rudolf‐Bultmann‐Strasse, Marburg, Germany</affiliation></author><author><persName><forename type="first">M.</forename><surname>Otto</surname></persName><affiliation>Department of Neurology, University of Ulm, Ulm, Germany</affiliation></author><author><persName><forename type="first">D.</forename><surname>Paviour</surname></persName><affiliation>National Hospital for Neurology, Dementia Research Centre, London, England</affiliation></author><author><persName><forename type="first">T.</forename><surname>Reum</surname></persName><affiliation>Bundesinstitut für Arzneimittel & Medizinprodukte, Wissenschaftlicher Service/Klinische Prüfungen, Georg‐Kiesinger‐Allee, Bonn, Germany</affiliation></author><author><persName><forename type="first">A.</forename><surname>Saint‐Raymond</surname></persName><affiliation>European Medicines Agency (EMEA), Scientific Advice and Orphan Drugs Sector, 7 Westferry Circus, Canary Wharf, London, England</affiliation></author><author><persName><forename type="first">J. C.</forename><surname>Steele</surname></persName><affiliation>Guam Memorial Hospital, Neurology, Carlos Camacho Way, Tamuning, Guam</affiliation></author><author><persName><forename type="first">M.</forename><surname>Tolnay</surname></persName><affiliation>Institut für Pathologie, Schönbeinstrasse, Basel, Switzerland</affiliation></author><author><persName><forename type="first">H.</forename><surname>Tumani</surname></persName><affiliation>Department of Neurology, University of Ulm, Ulm, Germany</affiliation></author><author><persName><forename type="first">J. C.</forename><surname>Van Swieten</surname></persName><affiliation>University Hospital Rotterdam, Department of Neurology, Erasmus MC, Dr Molewaterplein, GD Rotterdam, the Netherlands</affiliation></author><author><persName><forename type="first">M. T.</forename><surname>Vanier</surname></persName><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 820, Laënnec Medical School, Lyon, France</affiliation></author><author><persName><forename type="first">J.‐P.</forename><surname>Vonsattel</surname></persName><affiliation>New York Brain Bank, Columbia University, Pathology, Babies Hospital, New York, NY, USA</affiliation></author><author><persName><forename type="first">S.</forename><surname>Wagner</surname></persName><affiliation>Deutsche PSP‐Gesellschaft e.V. (PSP Germany), c/o S. Wagner, Könneritzstrasse, Leipzig, Germany</affiliation></author><author><persName><forename type="first">Z. K.</forename><surname>Wszolek</surname></persName><note type="biography">These authors contributed equally to the work.</note><affiliation>These authors contributed equally to the work.</affiliation><affiliation>Mayo Clinic, Department of Neurology, Jacksonville, FL, USA</affiliation></author></analytic><monogr><title level="j">European Journal of Neurology</title><idno type="pISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><idno type="DOI">10.1111/(ISSN)1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2009-03"></date><biblScope unit="volume">16</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="297">297</biblScope><biblScope unit="page" to="309">309</biblScope></imprint></monogr><idno type="istex">46DA66675464C537825E2DA84B0B1D58DE536F61</idno><idno type="DOI">10.1111/j.1468-1331.2008.02513.x</idno><idno type="ArticleID">ENE2513</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Tauopathies with parkinsonism represent a spectrum of disease entities unified by the pathologic accumulation of hyperphosphorylated tau protein fragments within the central nervous system. These pathologic characteristics suggest shared pathogenetic pathways and possible molecular targets for disease‐modifying therapeutic interventions. Natural history studies, for instance, in progressive supranuclear palsy, frontotemporal dementia with parkinsonism linked to chromosome 17, corticobasal degeneration, and Niemann‐Pick disease type C as well as in amyotrophic lateral sclerosis/Parkinson–dementia complex permit clinical characterization of the disease phenotypes and are crucial to the development and validation of biological markers for differential diagnostics and disease monitoring, for example, by use of neuroimaging or proteomic approaches. The wide pathologic and clinical spectrum of the tauopathies with parkinsonism is reviewed in this article, and perspectives on future advances in the understanding of the pathogenesis are given, together with potential therapeutic strategies.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>corticobasal degeneration</term></item><item><term>frontotemporal dementia with parkinsonism linked to chromosome 17</term></item><item><term>microtubule‐associated protein tau</term></item><item><term>multiple system atrophy</term></item><item><term>Parkinson disease</term></item><item><term>parkinsonism</term></item><item><term>progressive supranuclear palsy</term></item><item><term>tauopathies</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-03">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/46DA66675464C537825E2DA84B0B1D58DE536F61/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1468-1331</doi><issn type="print">1351-5101</issn><issn type="electronic">1468-1331</issn><idGroup><id type="product" value="ENE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF NEUROLOGY">European Journal of Neurology</title></titleGroup></publicationMeta><publicationMeta level="part" position="03003"><doi origin="wiley">10.1111/ene.2009.16.issue-3</doi><numberingGroup><numbering type="journalVolume" number="16">16</numbering><numbering type="journalIssue" number="3">3</numbering></numberingGroup><coverDate startDate="2009-03">March 2009</coverDate></publicationMeta><publicationMeta level="unit" type="reviewArticle" position="5" status="forIssue"><doi origin="wiley">10.1111/j.1468-1331.2008.02513.x</doi><idGroup><id type="unit" value="ENE2513"></id></idGroup><countGroup><count type="pageTotal" number="14"></count></countGroup><titleGroup><title type="tocHeading1">Review Article</title></titleGroup><copyright>© 2009 The Author(s). Journal compilation © 2009 EFNS</copyright><eventGroup><event type="firstOnline" date="2009-02-05"></event><event type="publishedOnlineFinalForm" date="2009-02-05"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-06"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-24"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="297">297</numbering><numbering type="pageLast" number="309">309</numbering></numberingGroup><correspondenceTo>Prof Dr Albert C. Ludolph, Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany (tel.: +49 731 1771200; fax: +49 731 1771202; e‐mail: <email>albert.ludolph@rku.de</email>.).</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ENE.ENE2513.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 29 September 2008 Accepted 28 November 2008</unparsedEditorialHistory><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="5"></count></countGroup><titleGroup><title type="main">Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options</title><title type="shortAuthors">A. C. Ludolph <i>et al.</i></title><title type="short">Tauopathies with parkinsonism</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" noteRef="#fn1"><personName><givenNames>A. C.</givenNames><familyName>Ludolph</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1" noteRef="#fn1"><personName><givenNames>J.</givenNames><familyName>Kassubek</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1" noteRef="#fn1"><personName><givenNames>B. G.</givenNames><familyName>Landwehrmeyer</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a2"><personName><givenNames>E.</givenNames><familyName>Mandelkow</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a2"><personName><givenNames>E.‐M.</givenNames><familyName>Mandelkow</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a3"><personName><givenNames>D. J.</givenNames><familyName>Burn</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a4"><personName><givenNames>D.</givenNames><familyName>Caparros‐Lefebvre</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a5"><personName><givenNames>K. A.</givenNames><familyName>Frey</familyName></personName></creator><creator creatorRole="author" xml:id="cr9" affiliationRef="#a6"><personName><givenNames>J. G.</givenNames><familyName>De Yebenes</familyName></personName></creator><creator creatorRole="author" xml:id="cr10" affiliationRef="#a7"><personName><givenNames>T.</givenNames><familyName>Gasser</familyName></personName></creator><creator creatorRole="author" xml:id="cr11" affiliationRef="#a8"><personName><givenNames>P.</givenNames><familyName>Heutink</familyName></personName></creator><creator creatorRole="author" xml:id="cr12" affiliationRef="#a9"><personName><givenNames>G.</givenNames><familyName>Höglinger</familyName></personName></creator><creator creatorRole="author" xml:id="cr13" affiliationRef="#a10"><personName><givenNames>Z.</givenNames><familyName>Jamrozik</familyName></personName></creator><creator creatorRole="author" xml:id="cr14" affiliationRef="#a11"><personName><givenNames>K. A.</givenNames><familyName>Jellinger</familyName></personName></creator><creator creatorRole="author" xml:id="cr15" affiliationRef="#a12"><personName><givenNames>A.</givenNames><familyName>Kazantsev</familyName></personName></creator><creator creatorRole="author" xml:id="cr16" affiliationRef="#a13"><personName><givenNames>H.</givenNames><familyName>Kretzschmar</familyName></personName></creator><creator creatorRole="author" xml:id="cr17" affiliationRef="#a14"><personName><givenNames>A. E.</givenNames><familyName>Lang</familyName></personName></creator><creator creatorRole="author" xml:id="cr18" affiliationRef="#a15"><personName><givenNames>I.</givenNames><familyName>Litvan</familyName></personName></creator><creator creatorRole="author" xml:id="cr19" affiliationRef="#a16"><personName><givenNames>J. J.</givenNames><familyName>Lucas</familyName></personName></creator><creator creatorRole="author" xml:id="cr20" affiliationRef="#a17"><personName><givenNames>P. L.</givenNames><familyName>McGeer</familyName></personName></creator><creator creatorRole="author" xml:id="cr21" affiliationRef="#a18"><personName><givenNames>S.</givenNames><familyName>Melquist</familyName></personName></creator><creator creatorRole="author" xml:id="cr22" affiliationRef="#a9"><personName><givenNames>W.</givenNames><familyName>Oertel</familyName></personName></creator><creator creatorRole="author" xml:id="cr23" affiliationRef="#a1"><personName><givenNames>M.</givenNames><familyName>Otto</familyName></personName></creator><creator creatorRole="author" xml:id="cr24" affiliationRef="#a19"><personName><givenNames>D.</givenNames><familyName>Paviour</familyName></personName></creator><creator creatorRole="author" xml:id="cr25" affiliationRef="#a20"><personName><givenNames>T.</givenNames><familyName>Reum</familyName></personName></creator><creator creatorRole="author" xml:id="cr26" affiliationRef="#a21"><personName><givenNames>A.</givenNames><familyName>Saint‐Raymond</familyName></personName></creator><creator creatorRole="author" xml:id="cr27" affiliationRef="#a22"><personName><givenNames>J. C.</givenNames><familyName>Steele</familyName></personName></creator><creator creatorRole="author" xml:id="cr28" affiliationRef="#a23"><personName><givenNames>M.</givenNames><familyName>Tolnay</familyName></personName></creator><creator creatorRole="author" xml:id="cr29" affiliationRef="#a1"><personName><givenNames>H.</givenNames><familyName>Tumani</familyName></personName></creator><creator creatorRole="author" xml:id="cr30" affiliationRef="#a24"><personName><givenNames>J. C.</givenNames><familyName>Van Swieten</familyName></personName></creator><creator creatorRole="author" xml:id="cr31" affiliationRef="#a25"><personName><givenNames>M. T.</givenNames><familyName>Vanier</familyName></personName></creator><creator creatorRole="author" xml:id="cr32" affiliationRef="#a26"><personName><givenNames>J.‐P.</givenNames><familyName>Vonsattel</familyName></personName></creator><creator creatorRole="author" xml:id="cr33" affiliationRef="#a27"><personName><givenNames>S.</givenNames><familyName>Wagner</familyName></personName></creator><creator creatorRole="author" xml:id="cr34" affiliationRef="#a28" noteRef="#fn1"><personName><givenNames>Z. K.</givenNames><familyName>Wszolek</familyName></personName></creator><creator creatorRole="author" xml:id="cr35" affiliationRef="#a1"><groupName>for the Reisensburg Working Group for Tauopathies With Parkinsonism</groupName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="DE"><unparsedAffiliation>Department of Neurology, University of Ulm, Ulm, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="DE"><unparsedAffiliation>Max Planck Unit for Structural Molecular Biology, c/o DESY, Notkestr, Hamburg, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="GB"><unparsedAffiliation>Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="FR"><unparsedAffiliation>Centre Hospitalier de Valenciennes, Résidence du Val d’Escaut, Avenue Desandrouin, Valenciennes, France</unparsedAffiliation></affiliation><affiliation xml:id="a5" countryCode="US"><unparsedAffiliation>University of Michigan Medical Center, 1500 E Medical Center Dr, Ann Arbor, MI, USA</unparsedAffiliation></affiliation><affiliation xml:id="a6" countryCode="ES"><unparsedAffiliation>Hospital Ramon y Cajal, Neurology, Carretera Colmenar, Madrid, Spain</unparsedAffiliation></affiliation><affiliation xml:id="a7" countryCode="DE"><unparsedAffiliation>Universitätsklinikum Tübingen, Zentrum für Neurologie, Hoppe‐Seyler‐Strasse, Tübingen, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a8" countryCode="NL"><unparsedAffiliation>VU University Medical Center, Department of Clinical Genetics and Anthropogenet, van der Boechorststraat, Amsterdam, the Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="a9" countryCode="DE"><unparsedAffiliation>Philipps‐Universität, Neurologie, Rudolf‐Bultmann‐Strasse, Marburg, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a10" countryCode="PL"><unparsedAffiliation>Medical University of Warsaw, Neurology, Banacha, Warsaw, Poland</unparsedAffiliation></affiliation><affiliation xml:id="a11" countryCode="AT"><unparsedAffiliation>Institute of Clinical Neurobiology, Kenyongasse, Vienna, Austria</unparsedAffiliation></affiliation><affiliation xml:id="a12" countryCode="US"><unparsedAffiliation>Massachusetts General Hospital, MIND/Harvard Medical School, Charlestown, MA, USA</unparsedAffiliation></affiliation><affiliation xml:id="a13" countryCode="DE"><unparsedAffiliation>Institut für Neuropathologie, BrainNet (German Brain Bank), Feodor‐Lynen‐Strasse, Munich, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a14" countryCode="CA"><unparsedAffiliation>Toronto Western Hospital, Movement Disorders Center, Toronto, ON, Canada</unparsedAffiliation></affiliation><affiliation xml:id="a15" countryCode="US"><unparsedAffiliation>University of Louisville, School of Medicine/Department of Neurology, Louisville, KY, USA</unparsedAffiliation></affiliation><affiliation xml:id="a16" countryCode="ES"><unparsedAffiliation>Centro de Biologica Molecular “Severo Ochoa,” Universidad Autonoma de Madrid and CiberNed, Cantoblanco, Madrid, Spain</unparsedAffiliation></affiliation><affiliation xml:id="a17" countryCode="CA"><unparsedAffiliation>University of British Columbia, Kinsmen Laboratory of Neurological Research, Vancouver, BC, Canada</unparsedAffiliation></affiliation><affiliation xml:id="a18" countryCode="US"><unparsedAffiliation>Mayo Clinic, Department of Neuroscience, Jacksonville, FL, USA</unparsedAffiliation></affiliation><affiliation xml:id="a19"><unparsedAffiliation>National Hospital for Neurology, Dementia Research Centre, London, England</unparsedAffiliation></affiliation><affiliation xml:id="a20" countryCode="DE"><unparsedAffiliation>Bundesinstitut für Arzneimittel & Medizinprodukte, Wissenschaftlicher Service/Klinische Prüfungen, Georg‐Kiesinger‐Allee, Bonn, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a21"><unparsedAffiliation>European Medicines Agency (EMEA), Scientific Advice and Orphan Drugs Sector, 7 Westferry Circus, Canary Wharf, London, England</unparsedAffiliation></affiliation><affiliation xml:id="a22" countryCode="GU"><unparsedAffiliation>Guam Memorial Hospital, Neurology, Carlos Camacho Way, Tamuning, Guam</unparsedAffiliation></affiliation><affiliation xml:id="a23" countryCode="CH"><unparsedAffiliation>Institut für Pathologie, Schönbeinstrasse, Basel, Switzerland</unparsedAffiliation></affiliation><affiliation xml:id="a24" countryCode="NL"><unparsedAffiliation>University Hospital Rotterdam, Department of Neurology, Erasmus MC, Dr Molewaterplein, GD Rotterdam, the Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="a25" countryCode="FR"><unparsedAffiliation>Institut National de la Santé et de la Recherche Médicale, Unit 820, Laënnec Medical School, Lyon, France</unparsedAffiliation></affiliation><affiliation xml:id="a26" countryCode="US"><unparsedAffiliation>New York Brain Bank, Columbia University, Pathology, Babies Hospital, New York, NY, USA</unparsedAffiliation></affiliation><affiliation xml:id="a27" countryCode="DE"><unparsedAffiliation>Deutsche PSP‐Gesellschaft e.V. (PSP Germany), c/o S. Wagner, Könneritzstrasse, Leipzig, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a28" countryCode="US"><unparsedAffiliation>Mayo Clinic, Department of Neurology, Jacksonville, FL, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">corticobasal degeneration</keyword><keyword xml:id="k2">frontotemporal dementia with parkinsonism linked to chromosome 17</keyword><keyword xml:id="k3">microtubule‐associated protein tau</keyword><keyword xml:id="k4">multiple system atrophy</keyword><keyword xml:id="k5">Parkinson disease</keyword><keyword xml:id="k6">parkinsonism</keyword><keyword xml:id="k7">progressive supranuclear palsy</keyword><keyword xml:id="k8">tauopathies</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>Tauopathies with parkinsonism represent a spectrum of disease entities unified by the pathologic accumulation of hyperphosphorylated tau protein fragments within the central nervous system. These pathologic characteristics suggest shared pathogenetic pathways and possible molecular targets for disease‐modifying therapeutic interventions. Natural history studies, for instance, in progressive supranuclear palsy, frontotemporal dementia with parkinsonism linked to chromosome 17, corticobasal degeneration, and Niemann‐Pick disease type C as well as in amyotrophic lateral sclerosis/Parkinson–dementia complex permit clinical characterization of the disease phenotypes and are crucial to the development and validation of biological markers for differential diagnostics and disease monitoring, for example, by use of neuroimaging or proteomic approaches. The wide pathologic and clinical spectrum of the tauopathies with parkinsonism is reviewed in this article, and perspectives on future advances in the understanding of the pathogenesis are given, together with potential therapeutic strategies.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><label>*</label><p> These authors contributed equally to the work.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options</title></titleInfo><titleInfo type="abbreviated"><title>Tauopathies with parkinsonism</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options</title></titleInfo><name type="personal"><namePart type="given">A. C.</namePart><namePart type="family">Ludolph</namePart><affiliation>Department of Neurology, University of Ulm, Ulm, Germany</affiliation><description>These authors contributed equally to the work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kassubek</namePart><affiliation>Department of Neurology, University of Ulm, Ulm, Germany</affiliation><description>These authors contributed equally to the work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B. G.</namePart><namePart type="family">Landwehrmeyer</namePart><affiliation>Department of Neurology, University of Ulm, Ulm, Germany</affiliation><description>These authors contributed equally to the work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Mandelkow</namePart><affiliation>Max Planck Unit for Structural Molecular Biology, c/o DESY, Notkestr, Hamburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.‐M.</namePart><namePart type="family">Mandelkow</namePart><affiliation>Max Planck Unit for Structural Molecular Biology, c/o DESY, Notkestr, Hamburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. J.</namePart><namePart type="family">Burn</namePart><affiliation>Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Caparros‐Lefebvre</namePart><affiliation>Centre Hospitalier de Valenciennes, Résidence du Val d’Escaut, Avenue Desandrouin, Valenciennes, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. A.</namePart><namePart type="family">Frey</namePart><affiliation>University of Michigan Medical Center, 1500 E Medical Center Dr, Ann Arbor, MI, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. G.</namePart><namePart type="family">De Yebenes</namePart><affiliation>Hospital Ramon y Cajal, Neurology, Carretera Colmenar, Madrid, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Gasser</namePart><affiliation>Universitätsklinikum Tübingen, Zentrum für Neurologie, Hoppe‐Seyler‐Strasse, Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Heutink</namePart><affiliation>VU University Medical Center, Department of Clinical Genetics and Anthropogenet, van der Boechorststraat, Amsterdam, the Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Höglinger</namePart><affiliation>Philipps‐Universität, Neurologie, Rudolf‐Bultmann‐Strasse, Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z.</namePart><namePart type="family">Jamrozik</namePart><affiliation>Medical University of Warsaw, Neurology, Banacha, Warsaw, Poland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. A.</namePart><namePart type="family">Jellinger</namePart><affiliation>Institute of Clinical Neurobiology, Kenyongasse, Vienna, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Kazantsev</namePart><affiliation>Massachusetts General Hospital, MIND/Harvard Medical School, Charlestown, MA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Kretzschmar</namePart><affiliation>Institut für Neuropathologie, BrainNet (German Brain Bank), Feodor‐Lynen‐Strasse, Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. E.</namePart><namePart type="family">Lang</namePart><affiliation>Toronto Western Hospital, Movement Disorders Center, Toronto, ON, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Litvan</namePart><affiliation>University of Louisville, School of Medicine/Department of Neurology, Louisville, KY, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. J.</namePart><namePart type="family">Lucas</namePart><affiliation>Centro de Biologica Molecular “Severo Ochoa,” Universidad Autonoma de Madrid and CiberNed, Cantoblanco, Madrid, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. L.</namePart><namePart type="family">McGeer</namePart><affiliation>University of British Columbia, Kinsmen Laboratory of Neurological Research, Vancouver, BC, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Melquist</namePart><affiliation>Mayo Clinic, Department of Neuroscience, Jacksonville, FL, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Oertel</namePart><affiliation>Philipps‐Universität, Neurologie, Rudolf‐Bultmann‐Strasse, Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Otto</namePart><affiliation>Department of Neurology, University of Ulm, Ulm, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Paviour</namePart><affiliation>National Hospital for Neurology, Dementia Research Centre, London, England</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Reum</namePart><affiliation>Bundesinstitut für Arzneimittel & Medizinprodukte, Wissenschaftlicher Service/Klinische Prüfungen, Georg‐Kiesinger‐Allee, Bonn, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Saint‐Raymond</namePart><affiliation>European Medicines Agency (EMEA), Scientific Advice and Orphan Drugs Sector, 7 Westferry Circus, Canary Wharf, London, England</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. C.</namePart><namePart type="family">Steele</namePart><affiliation>Guam Memorial Hospital, Neurology, Carlos Camacho Way, Tamuning, Guam</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Tolnay</namePart><affiliation>Institut für Pathologie, Schönbeinstrasse, Basel, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Tumani</namePart><affiliation>Department of Neurology, University of Ulm, Ulm, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. C.</namePart><namePart type="family">Van Swieten</namePart><affiliation>University Hospital Rotterdam, Department of Neurology, Erasmus MC, Dr Molewaterplein, GD Rotterdam, the Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. T.</namePart><namePart type="family">Vanier</namePart><affiliation>Institut National de la Santé et de la Recherche Médicale, Unit 820, Laënnec Medical School, Lyon, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.‐P.</namePart><namePart type="family">Vonsattel</namePart><affiliation>New York Brain Bank, Columbia University, Pathology, Babies Hospital, New York, NY, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Wagner</namePart><affiliation>Deutsche PSP‐Gesellschaft e.V. (PSP Germany), c/o S. Wagner, Könneritzstrasse, Leipzig, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z. K.</namePart><namePart type="family">Wszolek</namePart><affiliation>Mayo Clinic, Department of Neurology, Jacksonville, FL, USA</affiliation><description>These authors contributed equally to the work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="corporate"><namePart>for the Reisensburg Working Group for Tauopathies With Parkinsonism</namePart><description>Department of Neurology, University of Ulm, Ulm, GermanyMax Planck Unit for Structural Molecular Biology, c/o DESY, Notkestr, Hamburg, GermanyInstitute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UKCentre Hospitalier de Valenciennes, Résidence du Val d’Escaut, Avenue Desandrouin, Valenciennes, FranceUniversity of Michigan Medical Center, 1500 E Medical Center Dr, Ann Arbor, MI, USAHospital Ramon y Cajal, Neurology, Carretera Colmenar, Madrid, SpainUniversitätsklinikum Tübingen, Zentrum für Neurologie, Hoppe‐Seyler‐Strasse, Tübingen, GermanyVU University Medical Center, Department of Clinical Genetics and Anthropogenet, van der Boechorststraat, Amsterdam, the NetherlandsPhilipps‐Universität, Neurologie, Rudolf‐Bultmann‐Strasse, Marburg, GermanyMedical University of Warsaw, Neurology, Banacha, Warsaw, PolandInstitute of Clinical Neurobiology, Kenyongasse, Vienna, AustriaMassachusetts General Hospital, MIND/Harvard Medical School, Charlestown, MA, USAInstitut für Neuropathologie, BrainNet (German Brain Bank), Feodor‐Lynen‐Strasse, Munich, GermanyToronto Western Hospital, Movement Disorders Center, Toronto, ON, CanadaUniversity of Louisville, School of Medicine/Department of Neurology, Louisville, KY, USACentro de Biologica Molecular “Severo Ochoa,” Universidad Autonoma de Madrid and CiberNed, Cantoblanco, Madrid, SpainUniversity of British Columbia, Kinsmen Laboratory of Neurological Research, Vancouver, BC, CanadaMayo Clinic, Department of Neuroscience, Jacksonville, FL, USANational Hospital for Neurology, Dementia Research Centre, London, EnglandBundesinstitut für Arzneimittel & Medizinprodukte, Wissenschaftlicher Service/Klinische Prüfungen, Georg‐Kiesinger‐Allee, Bonn, GermanyEuropean Medicines Agency (EMEA), Scientific Advice and Orphan Drugs Sector, 7 Westferry Circus, Canary Wharf, London, EnglandGuam Memorial Hospital, Neurology, Carlos Camacho Way, Tamuning, GuamInstitut für Pathologie, Schönbeinstrasse, Basel, SwitzerlandUniversity Hospital Rotterdam, Department of Neurology, Erasmus MC, Dr Molewaterplein, GD Rotterdam, the NetherlandsInstitut National de la Santé et de la Recherche Médicale, Unit 820, Laënnec Medical School, Lyon, FranceNew York Brain Bank, Columbia University, Pathology, Babies Hospital, New York, NY, USADeutsche PSP‐Gesellschaft e.V. (PSP Germany), c/o S. Wagner, Könneritzstrasse, Leipzig, GermanyMayo Clinic, Department of Neurology, Jacksonville, FL, USA</description></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="reviewArticle"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2009-03</dateIssued><edition>Received 29 September 2008 Accepted 28 November 2008</edition><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">5</extent></physicalDescription><abstract lang="en">Tauopathies with parkinsonism represent a spectrum of disease entities unified by the pathologic accumulation of hyperphosphorylated tau protein fragments within the central nervous system. These pathologic characteristics suggest shared pathogenetic pathways and possible molecular targets for disease‐modifying therapeutic interventions. Natural history studies, for instance, in progressive supranuclear palsy, frontotemporal dementia with parkinsonism linked to chromosome 17, corticobasal degeneration, and Niemann‐Pick disease type C as well as in amyotrophic lateral sclerosis/Parkinson–dementia complex permit clinical characterization of the disease phenotypes and are crucial to the development and validation of biological markers for differential diagnostics and disease monitoring, for example, by use of neuroimaging or proteomic approaches. The wide pathologic and clinical spectrum of the tauopathies with parkinsonism is reviewed in this article, and perspectives on future advances in the understanding of the pathogenesis are given, together with potential therapeutic strategies.</abstract><subject lang="en"><genre>Keywords</genre><topic>corticobasal degeneration</topic><topic>frontotemporal dementia with parkinsonism linked to chromosome 17</topic><topic>microtubule‐associated protein tau</topic><topic>multiple system atrophy</topic><topic>Parkinson disease</topic><topic>parkinsonism</topic><topic>progressive supranuclear palsy</topic><topic>tauopathies</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neurology</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">1351-5101</identifier><identifier type="eISSN">1468-1331</identifier><identifier type="DOI">10.1111/(ISSN)1468-1331</identifier><identifier type="PublisherID">ENE</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>297</start><end>309</end><total>14</total></extent></part></relatedItem><identifier type="istex">46DA66675464C537825E2DA84B0B1D58DE536F61</identifier><identifier type="DOI">10.1111/j.1468-1331.2008.02513.x</identifier><identifier type="ArticleID">ENE2513</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2009 The Author(s). Journal compilation © 2009 EFNS</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002684 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 002684 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:46DA66675464C537825E2DA84B0B1D58DE536F61
|texte= Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options
}}
| This area was generated with Dilib version V0.6.23. |  |