Spatial Remapping of Cortico-striatal Connectivity in Parkinson's Disease
Identifieur interne : 002537 ( Main/Corpus ); précédent : 002536; suivant : 002538Spatial Remapping of Cortico-striatal Connectivity in Parkinson's Disease
Auteurs : Rick C. Helmich ; Loes C. Derikx ; Maaike Bakker ; Ren Scheeringa ; Bastiaan R. Bloem ; Ivan ToniSource :
- Cerebral Cortex [ 1047-3211 ] ; 2009-08-26.
Abstract
Parkinson's disease (PD) is characterized by striatal dopamine depletion, especially in the posterior putamen. The dense connectivity profile of the striatum suggests that these local impairments may propagate throughout the whole cortico-striatal network. Here we test the effect of striatal dopamine depletion on cortico-striatal network properties by comparing the functional connectivity profile of the posterior putamen, the anterior putamen, and the caudate nucleus between 41 PD patients and 36 matched controls. We used multiple regression analyses of resting-state functional magnetic resonance imaging data to quantify functional connectivity across different networks. Each region had a distinct connectivity profile that was similarly expressed in patients and controls: the posterior putamen was uniquely coupled to cortical motor areas, the anterior putamen to the presupplementary motor area and anterior cingulate cortex, and the caudate nucleus to the dorsal prefrontal cortex. Differences between groups were specific to the putamen: although PD patients showed decreased coupling between the posterior putamen and the inferior parietal cortex, this region showed increased functional connectivity with the anterior putamen. We conclude that dopamine depletion in PD leads to a remapping of cerebral connectivity that reduces the spatial segregation between different cortico-striatal loops. These alterations of network properties may underlie abnormal sensorimotor integration in PD.
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DOI: 10.1093/cercor/bhp178
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Helmich</name><affiliation><mods:affiliation></mods:affiliation></affiliation><affiliation><mods:affiliation></mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: Rick.Helmich@donders.ru.nl</mods:affiliation></affiliation></author><author><name sortKey="Derikx, Loes C" sort="Derikx, Loes C" uniqKey="Derikx L" first="Loes C." last="Derikx">Loes C. 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Bloem</name><affiliation><mods:affiliation></mods:affiliation></affiliation></author><author><name sortKey="Toni, Ivan" sort="Toni, Ivan" uniqKey="Toni I" first="Ivan" last="Toni">Ivan Toni</name><affiliation><mods:affiliation></mods:affiliation></affiliation><affiliation><mods:affiliation></mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Cerebral Cortex</title><idno type="ISSN">1047-3211</idno><idno type="eISSN">1460-2199</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2009-08-26">2009-08-26</date><biblScope unit="volume">20</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="1175">1175</biblScope><biblScope unit="page" to="1186">1186</biblScope></imprint><idno type="ISSN">1047-3211</idno></series><idno type="istex">EF71BBFD4B1A17C31E4569707D17FA7EC21C6D7D</idno><idno type="DOI">10.1093/cercor/bhp178</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1047-3211</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Parkinson's disease (PD) is characterized by striatal dopamine depletion, especially in the posterior putamen. The dense connectivity profile of the striatum suggests that these local impairments may propagate throughout the whole cortico-striatal network. Here we test the effect of striatal dopamine depletion on cortico-striatal network properties by comparing the functional connectivity profile of the posterior putamen, the anterior putamen, and the caudate nucleus between 41 PD patients and 36 matched controls. We used multiple regression analyses of resting-state functional magnetic resonance imaging data to quantify functional connectivity across different networks. Each region had a distinct connectivity profile that was similarly expressed in patients and controls: the posterior putamen was uniquely coupled to cortical motor areas, the anterior putamen to the presupplementary motor area and anterior cingulate cortex, and the caudate nucleus to the dorsal prefrontal cortex. Differences between groups were specific to the putamen: although PD patients showed decreased coupling between the posterior putamen and the inferior parietal cortex, this region showed increased functional connectivity with the anterior putamen. We conclude that dopamine depletion in PD leads to a remapping of cerebral connectivity that reduces the spatial segregation between different cortico-striatal loops. These alterations of network properties may underlie abnormal sensorimotor integration in PD.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>Rick C. Helmich</name><affiliations><json:string>Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6500 HB Nijmegen, the Netherlands</json:string><json:string>Department of Neurology and Parkinson Centre Nijmegen (ParC), Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, the Netherlands</json:string><json:string>E-mail: Rick.Helmich@donders.ru.nl</json:string></affiliations></json:item><json:item><name>Loes C. Derikx</name><affiliations><json:string>Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6500 HB Nijmegen, the Netherlands</json:string></affiliations></json:item><json:item><name>Maaike Bakker</name><affiliations><json:string>Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6500 HB Nijmegen, the Netherlands</json:string><json:string>Department of Neurology and Parkinson Centre Nijmegen (ParC), Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, the Netherlands</json:string></affiliations></json:item><json:item><name>Ren Scheeringa</name><affiliations><json:string>Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6500 HB Nijmegen, the Netherlands</json:string></affiliations></json:item><json:item><name>Bastiaan R. Bloem</name><affiliations><json:string>Department of Neurology and Parkinson Centre Nijmegen (ParC), Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, the Netherlands</json:string></affiliations></json:item><json:item><name>Ivan Toni</name><affiliations><json:string>Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6500 HB Nijmegen, the Netherlands</json:string><json:string>Donders Institute for Brain, Cognition and Behaviour, Centre for Cognition, Radboud University Nijmegen, 6500 HB Nijmegen, the Netherlands</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Articles</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>compensation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>functional connectivity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>magnetic resonance imaging</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>resting state</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>striatum</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Parkinson's disease (PD) is characterized by striatal dopamine depletion, especially in the posterior putamen. The dense connectivity profile of the striatum suggests that these local impairments may propagate throughout the whole cortico-striatal network. Here we test the effect of striatal dopamine depletion on cortico-striatal network properties by comparing the functional connectivity profile of the posterior putamen, the anterior putamen, and the caudate nucleus between 41 PD patients and 36 matched controls. We used multiple regression analyses of resting-state functional magnetic resonance imaging data to quantify functional connectivity across different networks. Each region had a distinct connectivity profile that was similarly expressed in patients and controls: the posterior putamen was uniquely coupled to cortical motor areas, the anterior putamen to the presupplementary motor area and anterior cingulate cortex, and the caudate nucleus to the dorsal prefrontal cortex. Differences between groups were specific to the putamen: although PD patients showed decreased coupling between the posterior putamen and the inferior parietal cortex, this region showed increased functional connectivity with the anterior putamen. We conclude that dopamine depletion in PD leads to a remapping of cerebral connectivity that reduces the spatial segregation between different cortico-striatal loops. 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The dense connectivity profile of the striatum suggests that these local impairments may propagate throughout the whole cortico-striatal network. Here we test the effect of striatal dopamine depletion on cortico-striatal network properties by comparing the functional connectivity profile of the posterior putamen, the anterior putamen, and the caudate nucleus between 41 PD patients and 36 matched controls. We used multiple regression analyses of resting-state functional magnetic resonance imaging data to quantify functional connectivity across different networks. Each region had a distinct connectivity profile that was similarly expressed in patients and controls: the posterior putamen was uniquely coupled to cortical motor areas, the anterior putamen to the presupplementary motor area and anterior cingulate cortex, and the caudate nucleus to the dorsal prefrontal cortex. Differences between groups were specific to the putamen: although PD patients showed decreased coupling between the posterior putamen and the inferior parietal cortex, this region showed increased functional connectivity with the anterior putamen. We conclude that dopamine depletion in PD leads to a remapping of cerebral connectivity that reduces the spatial segregation between different cortico-striatal loops. 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Email: <email>Rick.Helmich@donders.ru.nl</email>.</corresp></author-notes><pub-date pub-type="epub-ppub"><month>5</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>26</day><month>8</month><year>2009</year></pub-date><volume>20</volume><issue>5</issue><fpage>1175</fpage><lpage>1186</lpage><permissions><copyright-statement>© The Author 2009. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org</copyright-statement><copyright-year>2010</copyright-year></permissions><abstract><p>Parkinson's disease (PD) is characterized by striatal dopamine depletion, especially in the posterior putamen. The dense connectivity profile of the striatum suggests that these local impairments may propagate throughout the whole cortico-striatal network. Here we test the effect of striatal dopamine depletion on cortico-striatal network properties by comparing the functional connectivity profile of the posterior putamen, the anterior putamen, and the caudate nucleus between 41 PD patients and 36 matched controls. We used multiple regression analyses of resting-state functional magnetic resonance imaging data to quantify functional connectivity across different networks. Each region had a distinct connectivity profile that was similarly expressed in patients and controls: the posterior putamen was uniquely coupled to cortical motor areas, the anterior putamen to the pre–supplementary motor area and anterior cingulate cortex, and the caudate nucleus to the dorsal prefrontal cortex. Differences between groups were specific to the putamen: although PD patients showed decreased coupling between the posterior putamen and the inferior parietal cortex, this region showed increased functional connectivity with the anterior putamen. We conclude that dopamine depletion in PD leads to a remapping of cerebral connectivity that reduces the spatial segregation between different cortico-striatal loops. These alterations of network properties may underlie abnormal sensorimotor integration in PD.</p></abstract><kwd-group><kwd>compensation</kwd><kwd>functional connectivity</kwd><kwd>magnetic resonance imaging</kwd><kwd>resting state</kwd><kwd>striatum</kwd></kwd-group></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Spatial Remapping of Cortico-striatal Connectivity in Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Spatial Remapping of Cortico-striatal Connectivity in Parkinson's Disease</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Rick C.</namePart><namePart type="family">Helmich</namePart><affiliation></affiliation><affiliation></affiliation><affiliation>E-mail: Rick.Helmich@donders.ru.nl</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Loes C.</namePart><namePart type="family">Derikx</namePart><affiliation></affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maaike</namePart><namePart type="family">Bakker</namePart><affiliation></affiliation><affiliation></affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ren</namePart><namePart type="family">Scheeringa</namePart><affiliation></affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bastiaan R.</namePart><namePart type="family">Bloem</namePart><affiliation></affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ivan</namePart><namePart type="family">Toni</namePart><affiliation></affiliation><affiliation></affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><subject><topic>Articles</topic></subject><originInfo><publisher>Oxford University Press</publisher><dateIssued encoding="w3cdtf">2009-08-26</dateIssued><dateCreated encoding="w3cdtf">2009-08-26</dateCreated><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Parkinson's disease (PD) is characterized by striatal dopamine depletion, especially in the posterior putamen. The dense connectivity profile of the striatum suggests that these local impairments may propagate throughout the whole cortico-striatal network. Here we test the effect of striatal dopamine depletion on cortico-striatal network properties by comparing the functional connectivity profile of the posterior putamen, the anterior putamen, and the caudate nucleus between 41 PD patients and 36 matched controls. We used multiple regression analyses of resting-state functional magnetic resonance imaging data to quantify functional connectivity across different networks. Each region had a distinct connectivity profile that was similarly expressed in patients and controls: the posterior putamen was uniquely coupled to cortical motor areas, the anterior putamen to the presupplementary motor area and anterior cingulate cortex, and the caudate nucleus to the dorsal prefrontal cortex. Differences between groups were specific to the putamen: although PD patients showed decreased coupling between the posterior putamen and the inferior parietal cortex, this region showed increased functional connectivity with the anterior putamen. We conclude that dopamine depletion in PD leads to a remapping of cerebral connectivity that reduces the spatial segregation between different cortico-striatal loops. These alterations of network properties may underlie abnormal sensorimotor integration in PD.</abstract><subject><genre>Keywords</genre><topic>compensation</topic><topic>functional connectivity</topic><topic>magnetic resonance imaging</topic><topic>resting state</topic><topic>striatum</topic></subject><relatedItem type="host"><titleInfo><title>Cerebral Cortex</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">1047-3211</identifier><identifier type="eISSN">1460-2199</identifier><identifier type="PublisherID">cercor</identifier><identifier type="PublisherID-hwp">cercor</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>1175</start><end>1186</end></extent></part></relatedItem><identifier type="istex">EF71BBFD4B1A17C31E4569707D17FA7EC21C6D7D</identifier><identifier type="DOI">10.1093/cercor/bhp178</identifier><accessCondition type="use and reproduction" contentType="copyright">The Author 2009. Published by Oxford University Press. All rights reserved. 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