Serveur d'exploration sur la maladie de Parkinson

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Surgical treatment of Parkinson’s disease

Identifieur interne : 002322 ( Main/Corpus ); précédent : 002321; suivant : 002323

Surgical treatment of Parkinson’s disease

Auteurs : William C. Koller ; Rajesh Pahwa ; Kelly E. Lyons ; Alberto Albanese

Source :

RBID : ISTEX:359DF71AC4BA274D93A73FADA1A187822F1E6414

English descriptors

Abstract

Stereotaxtic surgery is an effective therapeutic maneuver in the management of advanced Parkinson’s disease (PD). Thalamotomy is an effective measure to control tremor but other PD symptoms are not changed. Bilateral operations are associated with a risk of severe speech impairment. Deep brain stimulation (DBS) of the thalamus is as effective as thalamotomy and is associated with fewer side effects. Pallidotomy is effective in reducing contralateral dyskinesias and the cardinal symptoms of PD. Bilateral pallidotomy often results in cognitive dysfunction. Deep brain stimulation of the pallidum replicates the positive effects of pallidotomy and appears to be safer than ablative lesions. Subthalamic DBS is currently under investigation. This procedure may control all PD symptoms, and the dose of levodopa can often be dramatically reduced. Neurotransplantation is a promising surgical approach to PD. However, further investigation is needed to optimize this approach.

Url:
DOI: 10.1016/S0022-510X(99)00139-2

Links to Exploration step

ISTEX:359DF71AC4BA274D93A73FADA1A187822F1E6414

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<abstract lang="en">Stereotaxtic surgery is an effective therapeutic maneuver in the management of advanced Parkinson’s disease (PD). Thalamotomy is an effective measure to control tremor but other PD symptoms are not changed. Bilateral operations are associated with a risk of severe speech impairment. Deep brain stimulation (DBS) of the thalamus is as effective as thalamotomy and is associated with fewer side effects. Pallidotomy is effective in reducing contralateral dyskinesias and the cardinal symptoms of PD. Bilateral pallidotomy often results in cognitive dysfunction. Deep brain stimulation of the pallidum replicates the positive effects of pallidotomy and appears to be safer than ablative lesions. Subthalamic DBS is currently under investigation. This procedure may control all PD symptoms, and the dose of levodopa can often be dramatically reduced. Neurotransplantation is a promising surgical approach to PD. However, further investigation is needed to optimize this approach.</abstract>
<note type="content">Section title: Review article</note>
<note type="content">Table 1: Classic stereotaxic operations performed in parkinsonian patients in the pre-levodopa era</note>
<note type="content">Table 2: Thalamotomy in Parkinson’s disease</note>
<note type="content">Table 3: High frequency thalamic stimulation for parkinsonian tremor</note>
<note type="content">Table 4: Pallidotomy for Parkinson’s disease</note>
<note type="content">Table 5: Globus pallidus stimulation for Parkinson’s disease</note>
<note type="content">Table 6: Subthalamic stimulation for Parkinson’s disease</note>
<subject lang="en">
<genre>Keywords</genre>
<topic>Parkinson’s disease</topic>
<topic>Deep brain stimulation</topic>
<topic>Thalamotomy</topic>
<topic>Pallidotomy</topic>
<topic>Subthalamus</topic>
<topic>VIM nucleus</topic>
</subject>
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<title>Journal of the Neurological Sciences</title>
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<title>JNS</title>
</titleInfo>
<genre type="Journal">journal</genre>
<originInfo>
<dateIssued encoding="w3cdtf">19990801</dateIssued>
</originInfo>
<identifier type="ISSN">0022-510X</identifier>
<identifier type="PII">S0022-510X(00)X0076-7</identifier>
<part>
<date>19990801</date>
<detail type="volume">
<number>167</number>
<caption>vol.</caption>
</detail>
<detail type="issue">
<number>1</number>
<caption>no.</caption>
</detail>
<extent unit="issue pages">
<start>1</start>
<end>78</end>
</extent>
<extent unit="pages">
<start>1</start>
<end>10</end>
</extent>
</part>
</relatedItem>
<identifier type="istex">359DF71AC4BA274D93A73FADA1A187822F1E6414</identifier>
<identifier type="DOI">10.1016/S0022-510X(99)00139-2</identifier>
<identifier type="PII">S0022-510X(99)00139-2</identifier>
<accessCondition type="use and reproduction" contentType="">© 1999Elsevier Science B.V.</accessCondition>
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<recordOrigin>Elsevier Science B.V., ©1999</recordOrigin>
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