Restoration of locomotive function in Parkinson’s disease by spinal cord stimulation: mechanistic approach
Identifieur interne : 002295 ( Main/Corpus ); précédent : 002294; suivant : 002296Restoration of locomotive function in Parkinson’s disease by spinal cord stimulation: mechanistic approach
Auteurs : Romulo Fuentes ; Per Petersson ; Miguel A. L. NicolelisSource :
- European Journal of Neuroscience [ 0953-816X ] ; 2010-10.
English descriptors
Abstract
Specific motor symptoms of Parkinson’s disease (PD) can be treated effectively with direct electrical stimulation of deep nuclei in the brain. However, this is an invasive procedure, and the fraction of eligible patients is rather low according to currently used criteria. Spinal cord stimulation (SCS), a minimally invasive method, has more recently been proposed as a therapeutic approach to alleviate PD akinesia, in light of its proven ability to rescue locomotion in rodent models of PD. The mechanisms accounting for this effect are unknown but, from accumulated experience with the use of SCS in the management of chronic pain, it is known that the pathways most probably activated by SCS are the superficial fibers of the dorsal columns. We suggest that the prokinetic effect of SCS results from direct activation of ascending pathways reaching thalamic nuclei and the cerebral cortex. The afferent stimulation may, in addition, activate brainstem nuclei, contributing to the initiation of locomotion. On the basis of the striking change in the corticostriatal oscillatory mode of neuronal activity induced by SCS, we propose that, through activation of lemniscal and brainstem pathways, the locomotive increase is achieved by disruption of antikinetic low‐frequency (<30 Hz) oscillatory synchronization in the corticobasal ganglia circuits.
Url:
DOI: 10.1111/j.1460-9568.2010.07417.x
Links to Exploration step
ISTEX:6FA0006D6F54663C55939D0CA33AA28CE8A7EBD8Le document en format XML
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L.</forename><surname>Nicolelis</surname></persName><affiliation>Department of Neurobiology, Duke Medical Center, 311 Research Drive, Durham, NC 27710, USA</affiliation><affiliation>Center for Neuroengineering, Duke University, Durham, NC, USA</affiliation><affiliation>Department of Biomedical Engineering, Duke University, Durham, NC, USA</affiliation><affiliation>Department of Psychology and Neuroscience, Duke University, Durham, NC, USA</affiliation><affiliation>Edmond and Lily Safra International Institute of Neuroscience of Natal (ELS‐IINN), Natal RN, Brazil</affiliation></author></analytic><monogr><title level="j">European Journal of Neuroscience</title><idno type="pISSN">0953-816X</idno><idno type="eISSN">1460-9568</idno><idno type="DOI">10.1111/(ISSN)1460-9568</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-10"></date><biblScope unit="volume">32</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1100">1100</biblScope><biblScope unit="page" to="1108">1108</biblScope></imprint></monogr><idno type="istex">6FA0006D6F54663C55939D0CA33AA28CE8A7EBD8</idno><idno type="DOI">10.1111/j.1460-9568.2010.07417.x</idno><idno type="ArticleID">EJN7417</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Specific motor symptoms of Parkinson’s disease (PD) can be treated effectively with direct electrical stimulation of deep nuclei in the brain. However, this is an invasive procedure, and the fraction of eligible patients is rather low according to currently used criteria. Spinal cord stimulation (SCS), a minimally invasive method, has more recently been proposed as a therapeutic approach to alleviate PD akinesia, in light of its proven ability to rescue locomotion in rodent models of PD. The mechanisms accounting for this effect are unknown but, from accumulated experience with the use of SCS in the management of chronic pain, it is known that the pathways most probably activated by SCS are the superficial fibers of the dorsal columns. We suggest that the prokinetic effect of SCS results from direct activation of ascending pathways reaching thalamic nuclei and the cerebral cortex. The afferent stimulation may, in addition, activate brainstem nuclei, contributing to the initiation of locomotion. On the basis of the striking change in the corticostriatal oscillatory mode of neuronal activity induced by SCS, we propose that, through activation of lemniscal and brainstem pathways, the locomotive increase is achieved by disruption of antikinetic low‐frequency (<30 Hz) oscillatory synchronization in the corticobasal ganglia circuits.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>dorsal column</term></item><item><term>electrical stimulation</term></item><item><term>Parkinson’s disease</term></item><item><term>spinal cord</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/6FA0006D6F54663C55939D0CA33AA28CE8A7EBD8/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1460-9568</doi><issn type="print">0953-816X</issn><issn type="electronic">1460-9568</issn><idGroup><id type="product" value="EJN"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF NEUROSCIENCE">European Journal of Neuroscience</title></titleGroup></publicationMeta><publicationMeta level="part" position="10107"><doi origin="wiley">10.1111/ejn.2010.32.issue-7</doi><titleGroup><title type="specialIssueTitle">Special Feature: Deep Brain Stimulation</title></titleGroup><numberingGroup><numbering type="journalVolume" number="32">32</numbering><numbering type="journalIssue">7</numbering></numberingGroup><coverDate startDate="2010-10">October 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="5" status="forIssue"><doi origin="wiley">10.1111/j.1460-9568.2010.07417.x</doi><idGroup><id type="unit" value="EJN7417"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="tocHeading1">DEEP BRAIN STIMULATION</title></titleGroup><copyright>© 2010 The Authors. European Journal of Neuroscience © 2010 Federation of European Neuroscience Societies and Blackwell Publishing Ltd</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.22 mode:FullText" date="2010-10-06"></event><event type="firstOnline" date="2010-10-06"></event><event type="publishedOnlineFinalForm" date="2010-10-06"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-12"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-17"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="1100">1100</numbering><numbering type="pageLast" number="1108">1108</numbering></numberingGroup><correspondenceTo>Romulo Fuentes, as above.
E‐mail: <email>fuentes@neuro.duke.edu</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:EJN.EJN7417.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 22 April 2010, revised 9 July 2010, accepted 20 July 2010</unparsedEditorialHistory><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="0"></count></countGroup><titleGroup><title type="main">Restoration of locomotive function in Parkinson’s disease by spinal cord stimulation: mechanistic approach</title><title type="shortAuthors">R. Fuentes <i>et al.</i></title><title type="short">Spinal stimulation for Parkinson’s disease</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" noteRef="#fn1"><personName><givenNames>Romulo</givenNames><familyName>Fuentes</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2" noteRef="#fn1"><personName><givenNames>Per</givenNames><familyName>Petersson</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1 #a3 #a4 #a5 #a6"><personName><givenNames>Miguel A. L.</givenNames><familyName>Nicolelis</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="US"><unparsedAffiliation>Department of Neurobiology, Duke Medical Center, 311 Research Drive, Durham, NC 27710, USA</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="SE"><unparsedAffiliation>Department of Experimental Medical Science, NRC, Lund University, Lund, Sweden</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="US"><unparsedAffiliation>Center for Neuroengineering, Duke University, Durham, NC, USA</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="US"><unparsedAffiliation>Department of Biomedical Engineering, Duke University, Durham, NC, USA</unparsedAffiliation></affiliation><affiliation xml:id="a5" countryCode="US"><unparsedAffiliation>Department of Psychology and Neuroscience, Duke University, Durham, NC, USA</unparsedAffiliation></affiliation><affiliation xml:id="a6" countryCode="BR"><unparsedAffiliation>Edmond and Lily Safra International Institute of Neuroscience of Natal (ELS‐IINN), Natal RN, Brazil</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">dorsal column</keyword><keyword xml:id="k2">electrical stimulation</keyword><keyword xml:id="k3">Parkinson’s disease</keyword><keyword xml:id="k4">spinal cord</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Specific motor symptoms of Parkinson’s disease (PD) can be treated effectively with direct electrical stimulation of deep nuclei in the brain. However, this is an invasive procedure, and the fraction of eligible patients is rather low according to currently used criteria. Spinal cord stimulation (SCS), a minimally invasive method, has more recently been proposed as a therapeutic approach to alleviate PD akinesia, in light of its proven ability to rescue locomotion in rodent models of PD. The mechanisms accounting for this effect are unknown but, from accumulated experience with the use of SCS in the management of chronic pain, it is known that the pathways most probably activated by SCS are the superficial fibers of the dorsal columns. We suggest that the prokinetic effect of SCS results from direct activation of ascending pathways reaching thalamic nuclei and the cerebral cortex. The afferent stimulation may, in addition, activate brainstem nuclei, contributing to the initiation of locomotion. On the basis of the striking change in the corticostriatal oscillatory mode of neuronal activity induced by SCS, we propose that, through activation of lemniscal and brainstem pathways, the locomotive increase is achieved by disruption of antikinetic low‐frequency (<30 Hz) oscillatory synchronization in the corticobasal ganglia circuits.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p> R.F. and P.P. contributed equally to this work.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Restoration of locomotive function in Parkinson’s disease by spinal cord stimulation: mechanistic approach</title></titleInfo><titleInfo type="abbreviated"><title>Spinal stimulation for Parkinson’s disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Restoration of locomotive function in Parkinson’s disease by spinal cord stimulation: mechanistic approach</title></titleInfo><name type="personal"><namePart type="given">Romulo</namePart><namePart type="family">Fuentes</namePart><affiliation>Department of Neurobiology, Duke Medical Center, 311 Research Drive, Durham, NC 27710, USA</affiliation><description>R.F. and P.P. contributed equally to this work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Per</namePart><namePart type="family">Petersson</namePart><affiliation>Department of Experimental Medical Science, NRC, Lund University, Lund, Sweden</affiliation><description>R.F. and P.P. contributed equally to this work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Miguel A. L.</namePart><namePart type="family">Nicolelis</namePart><affiliation>Department of Neurobiology, Duke Medical Center, 311 Research Drive, Durham, NC 27710, USA</affiliation><affiliation>Center for Neuroengineering, Duke University, Durham, NC, USA</affiliation><affiliation>Department of Biomedical Engineering, Duke University, Durham, NC, USA</affiliation><affiliation>Department of Psychology and Neuroscience, Duke University, Durham, NC, USA</affiliation><affiliation>Edmond and Lily Safra International Institute of Neuroscience of Natal (ELS‐IINN), Natal RN, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2010-10</dateIssued><edition>Received 22 April 2010, revised 9 July 2010, accepted 20 July 2010</edition><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent></physicalDescription><abstract lang="en">Specific motor symptoms of Parkinson’s disease (PD) can be treated effectively with direct electrical stimulation of deep nuclei in the brain. However, this is an invasive procedure, and the fraction of eligible patients is rather low according to currently used criteria. Spinal cord stimulation (SCS), a minimally invasive method, has more recently been proposed as a therapeutic approach to alleviate PD akinesia, in light of its proven ability to rescue locomotion in rodent models of PD. The mechanisms accounting for this effect are unknown but, from accumulated experience with the use of SCS in the management of chronic pain, it is known that the pathways most probably activated by SCS are the superficial fibers of the dorsal columns. We suggest that the prokinetic effect of SCS results from direct activation of ascending pathways reaching thalamic nuclei and the cerebral cortex. The afferent stimulation may, in addition, activate brainstem nuclei, contributing to the initiation of locomotion. On the basis of the striking change in the corticostriatal oscillatory mode of neuronal activity induced by SCS, we propose that, through activation of lemniscal and brainstem pathways, the locomotive increase is achieved by disruption of antikinetic low‐frequency (<30 Hz) oscillatory synchronization in the corticobasal ganglia circuits.</abstract><subject lang="en"><genre>Keywords</genre><topic>dorsal column</topic><topic>electrical stimulation</topic><topic>Parkinson’s disease</topic><topic>spinal cord</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neuroscience</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0953-816X</identifier><identifier type="eISSN">1460-9568</identifier><identifier type="DOI">10.1111/(ISSN)1460-9568</identifier><identifier type="PublisherID">EJN</identifier><part><date>2010</date><detail type="title"><title>Special Feature: Deep Brain Stimulation</title></detail><detail type="volume"><caption>vol.</caption><number>32</number></detail><detail type="issue"><caption>no.</caption><number>7</number></detail><extent unit="pages"><start>1100</start><end>1108</end><total>9</total></extent></part></relatedItem><identifier type="istex">6FA0006D6F54663C55939D0CA33AA28CE8A7EBD8</identifier><identifier type="DOI">10.1111/j.1460-9568.2010.07417.x</identifier><identifier type="ArticleID">EJN7417</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2010 The Authors. 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|clé= ISTEX:6FA0006D6F54663C55939D0CA33AA28CE8A7EBD8
|texte= Restoration of locomotive function in Parkinson’s disease by spinal cord stimulation: mechanistic approach
}}
| This area was generated with Dilib version V0.6.23. |  |