Immunogenicity of a Heptavalent Pneumococcal Conjugate Vaccine in Apache and Navajo Indian, Alaska Native, and Non-Native American Children Aged <2 Years
Identifieur interne : 002235 ( Main/Corpus ); précédent : 002234; suivant : 002236Immunogenicity of a Heptavalent Pneumococcal Conjugate Vaccine in Apache and Navajo Indian, Alaska Native, and Non-Native American Children Aged <2 Years
Auteurs : Karen M. Miernyk ; Alan J. Parkinson ; Karen M. Rudolph ; Kenneth M. Petersen ; Lisa R. Bulkow ; David P. Greenberg ; Joel I. Ward ; George Brenneman ; Ray Reid ; Mathuram SantoshamSource :
- Clinical Infectious Diseases [ 1058-4838 ] ; 2000-07.
Abstract
High rates of invasive pneumococcal disease have been described among infants living in various Native American communities. In this study, we evaluated the immunogenicity of a 7-valent pneumococcal vaccine consisting of serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F covalently linked to the outer membrane protein complex of Neisseria meningitidis in Apache and Navajo Indian, Alaska Native, and non-Native American children. The vaccine was administered at ages 2, 4, and 6 months; a booster dose was given at age 15 months. Levels of serotype-specific immunoglobulin G (IgG) were measured by a standardized enzyme-linked immunosorbent assay. The responses after 3 primary doses of vaccine were similar in all 3 groups of children, except for those to serotypes 14 and 23F. One month after the booster dose, geometric mean concentrations (GMCs) of serotype-specific IgG antibodies increased significantly in all 3 groups of children, compared with GMCs of IgG antibodies to pneumo-coccal serotypes before the booster dose.
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DOI: 10.1086/313907
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Ward</name><affiliation><mods:affiliation></mods:affiliation></affiliation></author><author><name sortKey="Brenneman, George" sort="Brenneman, George" uniqKey="Brenneman G" first="George" last="Brenneman">George Brenneman</name><affiliation><mods:affiliation></mods:affiliation></affiliation></author><author><name sortKey="Reid, Ray" sort="Reid, Ray" uniqKey="Reid R" first="Ray" last="Reid">Ray Reid</name><affiliation><mods:affiliation></mods:affiliation></affiliation></author><author><name sortKey="Santosham, Mathuram" sort="Santosham, Mathuram" uniqKey="Santosham M" first="Mathuram" last="Santosham">Mathuram Santosham</name><affiliation><mods:affiliation></mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Clinical Infectious Diseases</title><title level="j" type="abbrev">Clinical Infectious Diseases</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published" when="2000-07">2000-07</date><biblScope unit="volume">31</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="34">34</biblScope><biblScope unit="page" to="41">41</biblScope></imprint><idno type="ISSN">1058-4838</idno></series><idno type="istex">EDE682815AB9EEBF3A68407B8BE60A7B518B7074</idno><idno type="DOI">10.1086/313907</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1058-4838</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">High rates of invasive pneumococcal disease have been described among infants living in various Native American communities. In this study, we evaluated the immunogenicity of a 7-valent pneumococcal vaccine consisting of serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F covalently linked to the outer membrane protein complex of Neisseria meningitidis in Apache and Navajo Indian, Alaska Native, and non-Native American children. The vaccine was administered at ages 2, 4, and 6 months; a booster dose was given at age 15 months. Levels of serotype-specific immunoglobulin G (IgG) were measured by a standardized enzyme-linked immunosorbent assay. The responses after 3 primary doses of vaccine were similar in all 3 groups of children, except for those to serotypes 14 and 23F. One month after the booster dose, geometric mean concentrations (GMCs) of serotype-specific IgG antibodies increased significantly in all 3 groups of children, compared with GMCs of IgG antibodies to pneumo-coccal serotypes before the booster dose.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>Karen M. Miernyk</name><affiliations><json:string>Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, US Department of Health and Human Services, Anchorage, Alaska</json:string><json:string>E-mail: kcm4@cdc.gov</json:string></affiliations></json:item><json:item><name>Alan J. Parkinson</name><affiliations><json:string>Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, US Department of Health and Human Services, Anchorage, Alaska</json:string></affiliations></json:item><json:item><name>Karen M. Rudolph</name><affiliations><json:string>Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, US Department of Health and Human Services, Anchorage, Alaska</json:string></affiliations></json:item><json:item><name>Kenneth M. Petersen</name><affiliations><json:string>Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, US Department of Health and Human Services, Anchorage, Alaska</json:string></affiliations></json:item><json:item><name>Lisa R. Bulkow</name><affiliations><json:string>Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, US Department of Health and Human Services, Anchorage, Alaska</json:string></affiliations></json:item><json:item><name>David P. Greenberg</name><affiliations><json:string>University of California at Los Angeles Center for Vaccine Research, Torrance</json:string></affiliations></json:item><json:item><name>Joel I. Ward</name><affiliations><json:string>University of California at Los Angeles Center for Vaccine Research, Torrance</json:string></affiliations></json:item><json:item><name>George Brenneman</name><affiliations><json:string>Center for American Indian and Alaskan Native Health, Department of International Health, Johns Hopkins University, Baltimore, Maryland</json:string></affiliations></json:item><json:item><name>Ray Reid</name><affiliations><json:string>Center for American Indian and Alaskan Native Health, Department of International Health, Johns Hopkins University, Baltimore, Maryland</json:string></affiliations></json:item><json:item><name>Mathuram Santosham</name><affiliations><json:string>Center for American Indian and Alaskan Native Health, Department of International Health, Johns Hopkins University, Baltimore, Maryland</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Clinical Articles</value></json:item></subject><language><json:string>eng</json:string></language><abstract>High rates of invasive pneumococcal disease have been described among infants living in various Native American communities. In this study, we evaluated the immunogenicity of a 7-valent pneumococcal vaccine consisting of serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F covalently linked to the outer membrane protein complex of Neisseria meningitidis in Apache and Navajo Indian, Alaska Native, and non-Native American children. The vaccine was administered at ages 2, 4, and 6 months; a booster dose was given at age 15 months. Levels of serotype-specific immunoglobulin G (IgG) were measured by a standardized enzyme-linked immunosorbent assay. The responses after 3 primary doses of vaccine were similar in all 3 groups of children, except for those to serotypes 14 and 23F. One month after the booster dose, geometric mean concentrations (GMCs) of serotype-specific IgG antibodies increased significantly in all 3 groups of children, compared with GMCs of IgG antibodies to pneumo-coccal serotypes before the booster dose.</abstract><qualityIndicators><score>6.86</score><pdfVersion>1.2</pdfVersion><pdfPageSize>612 x 792 pts (letter)</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>1</keywordCount><abstractCharCount>1021</abstractCharCount><pdfWordCount>5052</pdfWordCount><pdfCharCount>33539</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>155</abstractWordCount></qualityIndicators><title>Immunogenicity of a Heptavalent Pneumococcal Conjugate Vaccine in Apache and Navajo Indian, Alaska Native, and Non-Native American Children Aged >2 Years</title><genre><json:string>research-article</json:string></genre><host><volume>31</volume><pages><last>41</last><first>34</first></pages><issn><json:string>1058-4838</json:string></issn><issue>1</issue><genre></genre><language><json:string>unknown</json:string></language><eissn><json:string>1537-6591</json:string></eissn><title>Clinical Infectious Diseases</title></host><categories><wos><json:string>IMMUNOLOGY</json:string><json:string>INFECTIOUS DISEASES</json:string><json:string>MICROBIOLOGY</json:string></wos></categories><publicationDate>2000</publicationDate><copyrightDate>2000</copyrightDate><doi><json:string>10.1086/313907</json:string></doi><id>EDE682815AB9EEBF3A68407B8BE60A7B518B7074</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/EDE682815AB9EEBF3A68407B8BE60A7B518B7074/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/EDE682815AB9EEBF3A68407B8BE60A7B518B7074/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/EDE682815AB9EEBF3A68407B8BE60A7B518B7074/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Immunogenicity of a Heptavalent Pneumococcal Conjugate Vaccine in Apache and Navajo Indian, Alaska Native, and Non-Native American Children Aged <2 Years</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>The University of Chicago Press</publisher><availability><p>OUP</p></availability><date>2000</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Immunogenicity of a Heptavalent Pneumococcal Conjugate Vaccine in Apache and Navajo Indian, Alaska Native, and Non-Native American Children Aged <2 Years</title><author corresp="yes"><persName><forename type="first">Karen M.</forename><surname>Miernyk</surname></persName><email>kcm4@cdc.gov</email><affiliation></affiliation></author><author><persName><forename type="first">Alan J.</forename><surname>Parkinson</surname></persName><affiliation></affiliation></author><author><persName><forename type="first">Karen M.</forename><surname>Rudolph</surname></persName><affiliation></affiliation></author><author><persName><forename type="first">Kenneth M.</forename><surname>Petersen</surname></persName><affiliation></affiliation></author><author><persName><forename type="first">Lisa R.</forename><surname>Bulkow</surname></persName><affiliation></affiliation></author><author><persName><forename type="first">David P.</forename><surname>Greenberg</surname></persName><affiliation></affiliation></author><author><persName><forename type="first">Joel I.</forename><surname>Ward</surname></persName><affiliation></affiliation></author><author><persName><forename type="first">George</forename><surname>Brenneman</surname></persName><affiliation></affiliation></author><author><persName><forename type="first">Ray</forename><surname>Reid</surname></persName><affiliation></affiliation></author><author><persName><forename type="first">Mathuram</forename><surname>Santosham</surname></persName><affiliation></affiliation></author></analytic><monogr><title level="j">Clinical Infectious Diseases</title><title level="j" type="abbrev">Clinical Infectious Diseases</title><idno type="pISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published" when="2000-07"></date><biblScope unit="volume">31</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="34">34</biblScope><biblScope unit="page" to="41">41</biblScope></imprint></monogr><idno type="istex">EDE682815AB9EEBF3A68407B8BE60A7B518B7074</idno><idno type="DOI">10.1086/313907</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2000</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>High rates of invasive pneumococcal disease have been described among infants living in various Native American communities. In this study, we evaluated the immunogenicity of a 7-valent pneumococcal vaccine consisting of serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F covalently linked to the outer membrane protein complex of Neisseria meningitidis in Apache and Navajo Indian, Alaska Native, and non-Native American children. The vaccine was administered at ages 2, 4, and 6 months; a booster dose was given at age 15 months. Levels of serotype-specific immunoglobulin G (IgG) were measured by a standardized enzyme-linked immunosorbent assay. The responses after 3 primary doses of vaccine were similar in all 3 groups of children, except for those to serotypes 14 and 23F. One month after the booster dose, geometric mean concentrations (GMCs) of serotype-specific IgG antibodies increased significantly in all 3 groups of children, compared with GMCs of IgG antibodies to pneumo-coccal serotypes before the booster dose.</p></abstract></profileDesc><revisionDesc><change when="2000-07">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/EDE682815AB9EEBF3A68407B8BE60A7B518B7074/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">cid</journal-id><journal-id journal-id-type="publisher-id">cid</journal-id><journal-title>Clinical Infectious Diseases</journal-title><abbrev-journal-title>Clinical Infectious Diseases</abbrev-journal-title><issn pub-type="ppub">1058-4838</issn><issn pub-type="epub">1537-6591</issn><publisher><publisher-name>The University of Chicago Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.1086/313907</article-id><article-categories><subj-group subj-group-type="heading"><subject>Clinical Articles</subject></subj-group></article-categories><title-group><article-title>Immunogenicity of a Heptavalent Pneumococcal Conjugate Vaccine in Apache and Navajo Indian, Alaska Native, and Non-Native American Children Aged <2 Years</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Miernyk</surname><given-names>Karen M.</given-names></name><xref ref-type="aff" rid="AU1">1</xref><xref ref-type="corresp" rid="COR1"></xref></contrib><contrib contrib-type="author"><name><surname>Parkinson</surname><given-names>Alan J.</given-names></name><xref ref-type="aff" rid="AU1">1</xref></contrib><contrib contrib-type="author"><name><surname>Rudolph</surname><given-names>Karen M.</given-names></name><xref ref-type="aff" rid="AU1">1</xref></contrib><contrib contrib-type="author"><name><surname>Petersen</surname><given-names>Kenneth M.</given-names></name><xref ref-type="aff" rid="AU1">1</xref></contrib><contrib contrib-type="author"><name><surname>Bulkow</surname><given-names>Lisa R.</given-names></name><xref ref-type="aff" rid="AU1">1</xref></contrib><contrib contrib-type="author"><name><surname>Greenberg</surname><given-names>David P.</given-names></name><xref ref-type="aff" rid="AU2">2</xref></contrib><contrib contrib-type="author"><name><surname>Ward</surname><given-names>Joel I.</given-names></name><xref ref-type="aff" rid="AU2">2</xref></contrib><contrib contrib-type="author"><name><surname>Brenneman</surname><given-names>George</given-names></name><xref ref-type="aff" rid="AU3">3</xref></contrib><contrib contrib-type="author"><name><surname>Reid</surname><given-names>Ray</given-names></name><xref ref-type="aff" rid="AU3">3</xref></contrib><contrib contrib-type="author"><name><surname>Santosham</surname><given-names>Mathuram</given-names></name><xref ref-type="aff" rid="AU3">3</xref></contrib><aff id="AU1"><label>1</label><institution>Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, US Department of Health and Human Services</institution>, <addr-line>Anchorage, Alaska</addr-line></aff><aff id="AU2"><label>2</label><institution>University of California at Los Angeles Center for Vaccine Research</institution>, <addr-line>Torrance</addr-line></aff><aff id="AU3"><label>3</label><institution>Center for American Indian and Alaskan Native Health, Department of International Health, Johns Hopkins University</institution>, <addr-line>Baltimore, Maryland</addr-line></aff></contrib-group><author-notes><corresp id="COR1">Reprints or correspondence: Karen M. Miernyk, Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 4055 Tudor Centre Dr., Anchorage, AK 99508 (<email>kcm4@cdc.gov</email>).</corresp></author-notes><pub-date pub-type="ppub"><month>7</month><year>2000</year></pub-date><volume>31</volume><issue>1</issue><fpage>34</fpage><lpage>41</lpage><history><date date-type="received"><day>12</day><month>7</month><year>1999</year></date><date date-type="rev-recd"><day>30</day><month>11</month><year>1999</year></date></history><copyright-statement>© 2000 by the Infectious Diseases Society of America</copyright-statement><copyright-year>2000</copyright-year><abstract><p>High rates of invasive pneumococcal disease have been described among infants living in various Native American communities. In this study, we evaluated the immunogenicity of a 7-valent pneumococcal vaccine consisting of serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F covalently linked to the outer membrane protein complex of <italic>Neisseria meningitidis</italic> in Apache and Navajo Indian, Alaska Native, and non-Native American children. The vaccine was administered at ages 2, 4, and 6 months; a booster dose was given at age 15 months. Levels of serotype-specific immunoglobulin G (IgG) were measured by a standardized enzyme-linked immunosorbent assay. The responses after 3 primary doses of vaccine were similar in all 3 groups of children, except for those to serotypes 14 and 23F. One month after the booster dose, geometric mean concentrations (GMCs) of serotype-specific IgG antibodies increased significantly in all 3 groups of children, compared with GMCs of IgG antibodies to pneumo-coccal serotypes before the booster dose.</p></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Immunogenicity of a Heptavalent Pneumococcal Conjugate Vaccine in Apache and Navajo Indian, Alaska Native, and Non-Native American Children Aged <2 Years</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Immunogenicity of a Heptavalent Pneumococcal Conjugate Vaccine in Apache and Navajo Indian, Alaska Native, and Non-Native American Children Aged <2 Years</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Karen M.</namePart><namePart type="family">Miernyk</namePart><affiliation></affiliation><affiliation>E-mail: kcm4@cdc.gov</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alan J.</namePart><namePart type="family">Parkinson</namePart><affiliation></affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Karen M.</namePart><namePart type="family">Rudolph</namePart><affiliation></affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kenneth M.</namePart><namePart type="family">Petersen</namePart><affiliation></affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lisa R.</namePart><namePart type="family">Bulkow</namePart><affiliation></affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David P.</namePart><namePart type="family">Greenberg</namePart><affiliation></affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joel I.</namePart><namePart type="family">Ward</namePart><affiliation></affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">George</namePart><namePart type="family">Brenneman</namePart><affiliation></affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ray</namePart><namePart type="family">Reid</namePart><affiliation></affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mathuram</namePart><namePart type="family">Santosham</namePart><affiliation></affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><originInfo><publisher>The University of Chicago Press</publisher><dateIssued encoding="w3cdtf">2000-07</dateIssued><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>High rates of invasive pneumococcal disease have been described among infants living in various Native American communities. In this study, we evaluated the immunogenicity of a 7-valent pneumococcal vaccine consisting of serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F covalently linked to the outer membrane protein complex of Neisseria meningitidis in Apache and Navajo Indian, Alaska Native, and non-Native American children. The vaccine was administered at ages 2, 4, and 6 months; a booster dose was given at age 15 months. Levels of serotype-specific immunoglobulin G (IgG) were measured by a standardized enzyme-linked immunosorbent assay. The responses after 3 primary doses of vaccine were similar in all 3 groups of children, except for those to serotypes 14 and 23F. One month after the booster dose, geometric mean concentrations (GMCs) of serotype-specific IgG antibodies increased significantly in all 3 groups of children, compared with GMCs of IgG antibodies to pneumo-coccal serotypes before the booster dose.</abstract><relatedItem type="host"><titleInfo><title>Clinical Infectious Diseases</title></titleInfo><titleInfo type="abbreviated"><title>Clinical Infectious Diseases</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">1058-4838</identifier><identifier type="eISSN">1537-6591</identifier><identifier type="PublisherID">cid</identifier><identifier type="PublisherID-hwp">cid</identifier><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>34</start><end>41</end></extent></part></relatedItem><identifier type="istex">EDE682815AB9EEBF3A68407B8BE60A7B518B7074</identifier><identifier type="DOI">10.1086/313907</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2000 by the Infectious Diseases Society of America</accessCondition><recordInfo><recordContentSource>OUP</recordContentSource></recordInfo></mods></metadata><annexes><json:item><original>true</original><mimetype>image/jpeg</mimetype><extension>jpeg</extension><uri>https://api.istex.fr/document/EDE682815AB9EEBF3A68407B8BE60A7B518B7074/annexes/jpeg</uri></json:item><json:item><original>true</original><mimetype>image/gif</mimetype><extension>gif</extension><uri>https://api.istex.fr/document/EDE682815AB9EEBF3A68407B8BE60A7B518B7074/annexes/gif</uri></json:item><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/EDE682815AB9EEBF3A68407B8BE60A7B518B7074/annexes/pdf</uri></json:item></annexes><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/EDE682815AB9EEBF3A68407B8BE60A7B518B7074/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">IMMUNOLOGY</classCode><classCode scheme="WOS">INFECTIOUS DISEASES</classCode><classCode scheme="WOS">MICROBIOLOGY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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