Hepta-, hexa-, tetra- and dichloronaphthalene congeners as inducers of hepatic microsomal drug-metabolizing enzymes
Identifieur interne : 002231 ( Main/Corpus ); précédent : 002230; suivant : 002232Hepta-, hexa-, tetra- and dichloronaphthalene congeners as inducers of hepatic microsomal drug-metabolizing enzymes
Auteurs : Mary Anne Campbell ; S. Bandiera ; L. Robertson ; A. Parkinson ; S. SafeSource :
- Toxicology [ 0300-483X ] ; 1982.
Abstract
Pretreatment of immature male Wistar rats with 1,2,3,4,5,6,7-hepta-, 1,2,3,4,5,6,8-hepta- and 1,2,3,4,5,6-hexachloronaphthalene resulted in the induction of several hepatic microsomal drug-metabolizing enzymes. The enzymic activities, reduced cytochrome P-450: CO and ethylisocyanide binding difference spectra and electrophoretic mobilities of the induced microsomal proteins were comparable to those observed after administration of the classical inducer of microsomal aryl hydrocarbon hydroxylase, 3-methylcholanthrene. The 1,2,3,4,5,6,7-heptachloronaphthalene congener, which is fully substituted in the lateral 2,3,6 and 7 positions, was more potent than the 1,2,3,4,5,6,8-hepta- and the 1,2,3,4,5,6-hexachloronaphthalene congeners which contain only 3 lateral chloro substituents. 1,2,3,4-Tetra- and several lower chlorinated naphthalenes were inactive as inducers of microsomal aryl hydrocarbon hydroxylase. The effects of structure on the induction activities of the polychlorinated naphthalenes were similar to those observed for other halogenated aryl hydrocarbons.
Url:
DOI: 10.1016/0300-483X(83)90081-1
Links to Exploration step
ISTEX:CC49E438021EB5C75312154D7F889A6D2B4DAE77Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Hepta-, hexa-, tetra- and dichloronaphthalene congeners as inducers of hepatic microsomal drug-metabolizing enzymes</title><author><name sortKey="Campbell, Mary Anne" sort="Campbell, Mary Anne" uniqKey="Campbell M" first="Mary Anne" last="Campbell">Mary Anne Campbell</name><affiliation><mods:affiliation>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</mods:affiliation></affiliation><affiliation><mods:affiliation>The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph Ontario, N1G 2W1 Canada</mods:affiliation></affiliation></author><author><name sortKey="Bandiera, S" sort="Bandiera, S" uniqKey="Bandiera S" first="S." last="Bandiera">S. Bandiera</name><affiliation><mods:affiliation>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</mods:affiliation></affiliation><affiliation><mods:affiliation>The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph Ontario, N1G 2W1 Canada</mods:affiliation></affiliation></author><author><name sortKey="Robertson, L" sort="Robertson, L" uniqKey="Robertson L" first="L." last="Robertson">L. Robertson</name><affiliation><mods:affiliation>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</mods:affiliation></affiliation></author><author><name sortKey="Parkinson, A" sort="Parkinson, A" uniqKey="Parkinson A" first="A." last="Parkinson">A. Parkinson</name><affiliation><mods:affiliation>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</mods:affiliation></affiliation><affiliation><mods:affiliation>The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph Ontario, N1G 2W1 Canada</mods:affiliation></affiliation></author><author><name sortKey="Safe, S" sort="Safe, S" uniqKey="Safe S" first="S." last="Safe">S. Safe</name><affiliation><mods:affiliation>To whom correspondence should be sent.</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:CC49E438021EB5C75312154D7F889A6D2B4DAE77</idno><date when="1983" year="1983">1983</date><idno type="doi">10.1016/0300-483X(83)90081-1</idno><idno type="url">https://api.istex.fr/document/CC49E438021EB5C75312154D7F889A6D2B4DAE77/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002231</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Hepta-, hexa-, tetra- and dichloronaphthalene congeners as inducers of hepatic microsomal drug-metabolizing enzymes</title><author><name sortKey="Campbell, Mary Anne" sort="Campbell, Mary Anne" uniqKey="Campbell M" first="Mary Anne" last="Campbell">Mary Anne Campbell</name><affiliation><mods:affiliation>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</mods:affiliation></affiliation><affiliation><mods:affiliation>The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph Ontario, N1G 2W1 Canada</mods:affiliation></affiliation></author><author><name sortKey="Bandiera, S" sort="Bandiera, S" uniqKey="Bandiera S" first="S." last="Bandiera">S. Bandiera</name><affiliation><mods:affiliation>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</mods:affiliation></affiliation><affiliation><mods:affiliation>The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph Ontario, N1G 2W1 Canada</mods:affiliation></affiliation></author><author><name sortKey="Robertson, L" sort="Robertson, L" uniqKey="Robertson L" first="L." last="Robertson">L. Robertson</name><affiliation><mods:affiliation>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</mods:affiliation></affiliation></author><author><name sortKey="Parkinson, A" sort="Parkinson, A" uniqKey="Parkinson A" first="A." last="Parkinson">A. Parkinson</name><affiliation><mods:affiliation>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</mods:affiliation></affiliation><affiliation><mods:affiliation>The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph Ontario, N1G 2W1 Canada</mods:affiliation></affiliation></author><author><name sortKey="Safe, S" sort="Safe, S" uniqKey="Safe S" first="S." last="Safe">S. Safe</name><affiliation><mods:affiliation>To whom correspondence should be sent.</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Toxicology</title><title level="j" type="abbrev">TOX</title><idno type="ISSN">0300-483X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1982">1982</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">3–4</biblScope><biblScope unit="page" from="193">193</biblScope><biblScope unit="page" to="205">205</biblScope></imprint><idno type="ISSN">0300-483X</idno></series><idno type="istex">CC49E438021EB5C75312154D7F889A6D2B4DAE77</idno><idno type="DOI">10.1016/0300-483X(83)90081-1</idno><idno type="PII">0300-483X(83)90081-1</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0300-483X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pretreatment of immature male Wistar rats with 1,2,3,4,5,6,7-hepta-, 1,2,3,4,5,6,8-hepta- and 1,2,3,4,5,6-hexachloronaphthalene resulted in the induction of several hepatic microsomal drug-metabolizing enzymes. The enzymic activities, reduced cytochrome P-450: CO and ethylisocyanide binding difference spectra and electrophoretic mobilities of the induced microsomal proteins were comparable to those observed after administration of the classical inducer of microsomal aryl hydrocarbon hydroxylase, 3-methylcholanthrene. The 1,2,3,4,5,6,7-heptachloronaphthalene congener, which is fully substituted in the lateral 2,3,6 and 7 positions, was more potent than the 1,2,3,4,5,6,8-hepta- and the 1,2,3,4,5,6-hexachloronaphthalene congeners which contain only 3 lateral chloro substituents. 1,2,3,4-Tetra- and several lower chlorinated naphthalenes were inactive as inducers of microsomal aryl hydrocarbon hydroxylase. The effects of structure on the induction activities of the polychlorinated naphthalenes were similar to those observed for other halogenated aryl hydrocarbons.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Mary Anne Campbell</name><affiliations><json:string>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</json:string><json:string>The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph Ontario, N1G 2W1 Canada</json:string></affiliations></json:item><json:item><name>S. Bandiera</name><affiliations><json:string>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</json:string><json:string>The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph Ontario, N1G 2W1 Canada</json:string></affiliations></json:item><json:item><name>L. Robertson</name><affiliations><json:string>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</json:string></affiliations></json:item><json:item><name>A. Parkinson</name><affiliations><json:string>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</json:string><json:string>The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph Ontario, N1G 2W1 Canada</json:string></affiliations></json:item><json:item><name>S. Safe</name><affiliations><json:string>To whom correspondence should be sent.</json:string><json:string>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Polychlorinated naphthalenes</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Structure-activity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>AHH induction</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>AHH : aryl hydrocarbon hydroxylase</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>B[a]P : benzo[a]pyrene hydroxylase</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>CO : carbon monoxide</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>DMAP : 4-dimethylaminoantipyrine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>EROD : ethoxyresorufin O-deethylase</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>EIC : ethylisocyanide</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>GLC : gas liquid chromatography</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MC : 3-methylcholantherene</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MS : mass spectra</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PB : phenobarbitone</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PBBs : polybrominated biphenyls</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PCBs : polychlorinated biphenyls</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PCDDs : polychlorinated dibenzo-p-dioxins</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PCDFs : polychlorinated dibenzofurans</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PCNs : polychlorinated naphthalenes</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>TCDD : 2,3,7,8-tetrachlorodibenzo-p-dioxin</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>TLC : thin-layer chromatography</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Pretreatment of immature male Wistar rats with 1,2,3,4,5,6,7-hepta-, 1,2,3,4,5,6,8-hepta- and 1,2,3,4,5,6-hexachloronaphthalene resulted in the induction of several hepatic microsomal drug-metabolizing enzymes. The enzymic activities, reduced cytochrome P-450: CO and ethylisocyanide binding difference spectra and electrophoretic mobilities of the induced microsomal proteins were comparable to those observed after administration of the classical inducer of microsomal aryl hydrocarbon hydroxylase, 3-methylcholanthrene. The 1,2,3,4,5,6,7-heptachloronaphthalene congener, which is fully substituted in the lateral 2,3,6 and 7 positions, was more potent than the 1,2,3,4,5,6,8-hepta- and the 1,2,3,4,5,6-hexachloronaphthalene congeners which contain only 3 lateral chloro substituents. 1,2,3,4-Tetra- and several lower chlorinated naphthalenes were inactive as inducers of microsomal aryl hydrocarbon hydroxylase. The effects of structure on the induction activities of the polychlorinated naphthalenes were similar to those observed for other halogenated aryl hydrocarbons.</abstract><qualityIndicators><score>5.937</score><pdfVersion>1.2</pdfVersion><pdfPageSize>512 x 735 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>20</keywordCount><abstractCharCount>1075</abstractCharCount><pdfWordCount>4425</pdfWordCount><pdfCharCount>21996</pdfCharCount><pdfPageCount>13</pdfPageCount><abstractWordCount>126</abstractWordCount></qualityIndicators><title>Hepta-, hexa-, tetra- and dichloronaphthalene congeners as inducers of hepatic microsomal drug-metabolizing enzymes</title><pii><json:string>0300-483X(83)90081-1</json:string></pii><genre><json:string>research-article</json:string></genre><host><volume>26</volume><pii><json:string>S0300-483X(00)X0366-6</json:string></pii><pages><last>205</last><first>193</first></pages><issn><json:string>0300-483X</json:string></issn><issue>3–4</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>Toxicology</title><publicationDate>1983</publicationDate></host><categories><wos><json:string>PHARMACOLOGY & PHARMACY</json:string><json:string>TOXICOLOGY</json:string><json:string>TRANSPLANTATION</json:string></wos></categories><publicationDate>1982</publicationDate><copyrightDate>1983</copyrightDate><doi><json:string>10.1016/0300-483X(83)90081-1</json:string></doi><id>CC49E438021EB5C75312154D7F889A6D2B4DAE77</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/CC49E438021EB5C75312154D7F889A6D2B4DAE77/fulltext/pdf</uri></json:item><json:item><original>true</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/CC49E438021EB5C75312154D7F889A6D2B4DAE77/fulltext/txt</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/CC49E438021EB5C75312154D7F889A6D2B4DAE77/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/CC49E438021EB5C75312154D7F889A6D2B4DAE77/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Hepta-, hexa-, tetra- and dichloronaphthalene congeners as inducers of hepatic microsomal drug-metabolizing enzymes</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1983</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Hepta-, hexa-, tetra- and dichloronaphthalene congeners as inducers of hepatic microsomal drug-metabolizing enzymes</title><author><persName><forename type="first">Mary Anne</forename><surname>Campbell</surname></persName><affiliation>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</affiliation><affiliation>The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph Ontario, N1G 2W1 Canada</affiliation></author><author><persName><forename type="first">S.</forename><surname>Bandiera</surname></persName><affiliation>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</affiliation><affiliation>The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph Ontario, N1G 2W1 Canada</affiliation></author><author><persName><forename type="first">L.</forename><surname>Robertson</surname></persName><affiliation>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</affiliation></author><author><persName><forename type="first">A.</forename><surname>Parkinson</surname></persName><affiliation>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</affiliation><affiliation>The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph Ontario, N1G 2W1 Canada</affiliation></author><author><persName><forename type="first">S.</forename><surname>Safe</surname></persName><affiliation>To whom correspondence should be sent.</affiliation><affiliation>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</affiliation></author></analytic><monogr><title level="j">Toxicology</title><title level="j" type="abbrev">TOX</title><idno type="pISSN">0300-483X</idno><idno type="PII">S0300-483X(00)X0366-6</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1982"></date><biblScope unit="volume">26</biblScope><biblScope unit="issue">3–4</biblScope><biblScope unit="page" from="193">193</biblScope><biblScope unit="page" to="205">205</biblScope></imprint></monogr><idno type="istex">CC49E438021EB5C75312154D7F889A6D2B4DAE77</idno><idno type="DOI">10.1016/0300-483X(83)90081-1</idno><idno type="PII">0300-483X(83)90081-1</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1983</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Pretreatment of immature male Wistar rats with 1,2,3,4,5,6,7-hepta-, 1,2,3,4,5,6,8-hepta- and 1,2,3,4,5,6-hexachloronaphthalene resulted in the induction of several hepatic microsomal drug-metabolizing enzymes. The enzymic activities, reduced cytochrome P-450: CO and ethylisocyanide binding difference spectra and electrophoretic mobilities of the induced microsomal proteins were comparable to those observed after administration of the classical inducer of microsomal aryl hydrocarbon hydroxylase, 3-methylcholanthrene. The 1,2,3,4,5,6,7-heptachloronaphthalene congener, which is fully substituted in the lateral 2,3,6 and 7 positions, was more potent than the 1,2,3,4,5,6,8-hepta- and the 1,2,3,4,5,6-hexachloronaphthalene congeners which contain only 3 lateral chloro substituents. 1,2,3,4-Tetra- and several lower chlorinated naphthalenes were inactive as inducers of microsomal aryl hydrocarbon hydroxylase. The effects of structure on the induction activities of the polychlorinated naphthalenes were similar to those observed for other halogenated aryl hydrocarbons.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Polychlorinated naphthalenes</term></item><item><term>Structure-activity</term></item><item><term>AHH induction</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>Abbreviations</head><item><term>AHH</term><term>aryl hydrocarbon hydroxylase</term></item><item><term>B[a]P</term><term>benzo[a]pyrene hydroxylase</term></item><item><term>CO</term><term>carbon monoxide</term></item><item><term>DMAP</term><term>4-dimethylaminoantipyrine</term></item><item><term>EROD</term><term>ethoxyresorufin O-deethylase</term></item><item><term>EIC</term><term>ethylisocyanide</term></item><item><term>GLC</term><term>gas liquid chromatography</term></item><item><term>MC</term><term>3-methylcholantherene</term></item><item><term>MS</term><term>mass spectra</term></item><item><term>PB</term><term>phenobarbitone</term></item><item><term>PBBs</term><term>polybrominated biphenyls</term></item><item><term>PCBs</term><term>polychlorinated biphenyls</term></item><item><term>PCDDs</term><term>polychlorinated dibenzo-p-dioxins</term></item><item><term>PCDFs</term><term>polychlorinated dibenzofurans</term></item><item><term>PCNs</term><term>polychlorinated naphthalenes</term></item><item><term>TCDD</term><term>2,3,7,8-tetrachlorodibenzo-p-dioxin</term></item><item><term>TLC</term><term>thin-layer chromatography</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1982-10-05">Registration</change><change when="1982">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>TOX</jid><aid>83900811</aid><ce:pii>0300-483X(83)90081-1</ce:pii><ce:doi>10.1016/0300-483X(83)90081-1</ce:doi><ce:copyright type="unknown" year="1983"></ce:copyright></item-info><head><ce:title>Hepta-, hexa-, tetra- and dichloronaphthalene congeners as inducers of hepatic microsomal drug-metabolizing enzymes</ce:title><ce:author-group><ce:author><ce:given-name>Mary Anne</ce:given-name><ce:surname>Campbell</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>S.</ce:given-name><ce:surname>Bandiera</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>L.</ce:given-name><ce:surname>Robertson</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>A.</ce:given-name><ce:surname>Parkinson</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>S.</ce:given-name><ce:surname>Safe</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph Ontario, N1G 2W1 Canada</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>To whom correspondence should be sent.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="26" month="7" year="1982"></ce:date-received><ce:date-accepted day="5" month="10" year="1982"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Pretreatment of immature male Wistar rats with 1,2,3,4,5,6,7-hepta-, 1,2,3,4,5,6,8-hepta- and 1,2,3,4,5,6-hexachloronaphthalene resulted in the induction of several hepatic microsomal drug-metabolizing enzymes. The enzymic activities, reduced cytochrome <ce:italic>P</ce:italic>-450: CO and ethylisocyanide binding difference spectra and electrophoretic mobilities of the induced microsomal proteins were comparable to those observed after administration of the classical inducer of microsomal aryl hydrocarbon hydroxylase, 3-methylcholanthrene. The 1,2,3,4,5,6,7-heptachloronaphthalene congener, which is fully substituted in the lateral 2,3,6 and 7 positions, was more potent than the 1,2,3,4,5,6,8-hepta- and the 1,2,3,4,5,6-hexachloronaphthalene congeners which contain only 3 lateral chloro substituents. 1,2,3,4-Tetra- and several lower chlorinated naphthalenes were inactive as inducers of microsomal aryl hydrocarbon hydroxylase. The effects of structure on the induction activities of the polychlorinated naphthalenes were similar to those observed for other halogenated aryl hydrocarbons.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Polychlorinated naphthalenes</ce:text></ce:keyword><ce:keyword><ce:text>Structure-activity</ce:text></ce:keyword><ce:keyword><ce:text>AHH induction</ce:text></ce:keyword></ce:keywords><ce:keywords class="abr"><ce:section-title>Abbreviations</ce:section-title><ce:keyword><ce:text>AHH</ce:text><ce:keyword><ce:text>aryl hydrocarbon hydroxylase</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>B[<ce:italic>a</ce:italic>]P</ce:text><ce:keyword><ce:text>benzo[<ce:italic>a</ce:italic>]pyrene hydroxylase</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>CO</ce:text><ce:keyword><ce:text>carbon monoxide</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>DMAP</ce:text><ce:keyword><ce:text>4-dimethylaminoantipyrine</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>EROD</ce:text><ce:keyword><ce:text>ethoxyresorufin <ce:italic>O</ce:italic>-deethylase</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>EIC</ce:text><ce:keyword><ce:text>ethylisocyanide</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>GLC</ce:text><ce:keyword><ce:text>gas liquid chromatography</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>MC</ce:text><ce:keyword><ce:text>3-methylcholantherene</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>MS</ce:text><ce:keyword><ce:text>mass spectra</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>PB</ce:text><ce:keyword><ce:text>phenobarbitone</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>PBBs</ce:text><ce:keyword><ce:text>polybrominated biphenyls</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>PCBs</ce:text><ce:keyword><ce:text>polychlorinated biphenyls</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>PCDDs</ce:text><ce:keyword><ce:text>polychlorinated dibenzo-<ce:italic>p</ce:italic>-dioxins</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>PCDFs</ce:text><ce:keyword><ce:text>polychlorinated dibenzofurans</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>PCNs</ce:text><ce:keyword><ce:text>polychlorinated naphthalenes</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>TCDD</ce:text><ce:keyword><ce:text>2,3,7,8-tetrachlorodibenzo-<ce:italic>p</ce:italic>-dioxin</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>TLC</ce:text><ce:keyword><ce:text>thin-layer chromatography</ce:text></ce:keyword></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Hepta-, hexa-, tetra- and dichloronaphthalene congeners as inducers of hepatic microsomal drug-metabolizing enzymes</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Hepta-, hexa-, tetra- and dichloronaphthalene congeners as inducers of hepatic microsomal drug-metabolizing enzymes</title></titleInfo><name type="personal"><namePart type="given">Mary Anne</namePart><namePart type="family">Campbell</namePart><affiliation>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</affiliation><affiliation>The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph Ontario, N1G 2W1 Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Bandiera</namePart><affiliation>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</affiliation><affiliation>The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph Ontario, N1G 2W1 Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Robertson</namePart><affiliation>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Parkinson</namePart><affiliation>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</affiliation><affiliation>The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph Ontario, N1G 2W1 Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Safe</namePart><affiliation>To whom correspondence should be sent.</affiliation><affiliation>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station, TX 77843 U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1982</dateIssued><dateValid encoding="w3cdtf">1982-10-05</dateValid><copyrightDate encoding="w3cdtf">1983</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Pretreatment of immature male Wistar rats with 1,2,3,4,5,6,7-hepta-, 1,2,3,4,5,6,8-hepta- and 1,2,3,4,5,6-hexachloronaphthalene resulted in the induction of several hepatic microsomal drug-metabolizing enzymes. The enzymic activities, reduced cytochrome P-450: CO and ethylisocyanide binding difference spectra and electrophoretic mobilities of the induced microsomal proteins were comparable to those observed after administration of the classical inducer of microsomal aryl hydrocarbon hydroxylase, 3-methylcholanthrene. The 1,2,3,4,5,6,7-heptachloronaphthalene congener, which is fully substituted in the lateral 2,3,6 and 7 positions, was more potent than the 1,2,3,4,5,6,8-hepta- and the 1,2,3,4,5,6-hexachloronaphthalene congeners which contain only 3 lateral chloro substituents. 1,2,3,4-Tetra- and several lower chlorinated naphthalenes were inactive as inducers of microsomal aryl hydrocarbon hydroxylase. The effects of structure on the induction activities of the polychlorinated naphthalenes were similar to those observed for other halogenated aryl hydrocarbons.</abstract><subject><genre>Keywords</genre><topic>Polychlorinated naphthalenes</topic><topic>Structure-activity</topic><topic>AHH induction</topic></subject><subject><genre>Abbreviations</genre><topic>AHH : aryl hydrocarbon hydroxylase</topic><topic>B[a]P : benzo[a]pyrene hydroxylase</topic><topic>CO : carbon monoxide</topic><topic>DMAP : 4-dimethylaminoantipyrine</topic><topic>EROD : ethoxyresorufin O-deethylase</topic><topic>EIC : ethylisocyanide</topic><topic>GLC : gas liquid chromatography</topic><topic>MC : 3-methylcholantherene</topic><topic>MS : mass spectra</topic><topic>PB : phenobarbitone</topic><topic>PBBs : polybrominated biphenyls</topic><topic>PCBs : polychlorinated biphenyls</topic><topic>PCDDs : polychlorinated dibenzo-p-dioxins</topic><topic>PCDFs : polychlorinated dibenzofurans</topic><topic>PCNs : polychlorinated naphthalenes</topic><topic>TCDD : 2,3,7,8-tetrachlorodibenzo-p-dioxin</topic><topic>TLC : thin-layer chromatography</topic></subject><relatedItem type="host"><titleInfo><title>Toxicology</title></titleInfo><titleInfo type="abbreviated"><title>TOX</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">198303</dateIssued></originInfo><identifier type="ISSN">0300-483X</identifier><identifier type="PII">S0300-483X(00)X0366-6</identifier><part><date>198303</date><detail type="volume"><number>26</number><caption>vol.</caption></detail><detail type="issue"><number>3–4</number><caption>no.</caption></detail><extent unit="issue pages"><start>181</start><end>359</end></extent><extent unit="pages"><start>193</start><end>205</end></extent></part></relatedItem><identifier type="istex">CC49E438021EB5C75312154D7F889A6D2B4DAE77</identifier><identifier type="DOI">10.1016/0300-483X(83)90081-1</identifier><identifier type="PII">0300-483X(83)90081-1</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/CC49E438021EB5C75312154D7F889A6D2B4DAE77/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">PHARMACOLOGY & PHARMACY</classCode><classCode scheme="WOS">TOXICOLOGY</classCode><classCode scheme="WOS">TRANSPLANTATION</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002231 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 002231 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:CC49E438021EB5C75312154D7F889A6D2B4DAE77
|texte= Hepta-, hexa-, tetra- and dichloronaphthalene congeners as inducers of hepatic microsomal drug-metabolizing enzymes
}}
| This area was generated with Dilib version V0.6.23. |  |