Demographic and motor features associated with the occurrence of neuropsychiatric and sleep complications of Parkinson's disease
Identifieur interne : 002222 ( Main/Corpus ); précédent : 002221; suivant : 002223Demographic and motor features associated with the occurrence of neuropsychiatric and sleep complications of Parkinson's disease
Auteurs : Renato Puppi Munhoz ; Hélio A. Teive ; Hariklia Eleftherohorinou ; Lachlan J. Coin ; Andrew J. Lees ; Laura Silveira-MoriyamaSource :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2013-08.
Abstract
Objective To determine whether four key neuropsychiatric and sleep related features associated with Parkinson's disease (PD) are associated with the motor handicap and demographic data. Background The growing number of recognised non-motor features of PD makes routine screening of all these symptoms impractical. Here, we investigated the hypothesis that standard demographic data and the routine assessment of motor signs is associated with the presence of dementia, psychosis, clinically probable rapid eye movement (REM) sleep behavior disorder (cpRBD) and restless legs syndrome (RLS). Methods 775 patients with PD underwent standardised assessment of motor features and the presence of dementia, psychosis, cpRBD and RLS. A stepwise feature elimination procedure with fitted logistic regression models was applied to identify which/if any combination of demographic and motor factors is associated with each of the four studied non-motor features. A within-study out-of-sample estimate of the power of the predicted values of the models was calculated using standard evaluation procedures. Results Age and Hoehn&Yahr (H&Y) stage were strongly associated with the presence of dementia (p value<0.001 for both factors in the final selected model) while a combination of age, disease duration, H&Y stage, dopamine agonists and catechol-O-methyltransferase (COMT) inhibitors was associated with the presence of psychosis. Disease duration and H&Y stage were the significant indicators of cpRBD, and the lack of significant motor asymmetry was the only significant feature associated with RLS-type symptoms but the evidence of association was weak. Conclusions Demographic and motor features routinely collected in patients with PD can estimate the occurrence of neuropsychiatric and sleep-related features of PD.
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DOI: 10.1136/jnnp-2012-304440
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Teive</name><affiliation><mods:affiliation>Department of Neurology, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Eleftherohorinou, Hariklia" sort="Eleftherohorinou, Hariklia" uniqKey="Eleftherohorinou H" first="Hariklia" last="Eleftherohorinou">Hariklia Eleftherohorinou</name><affiliation><mods:affiliation>Department of Epidemiology and Public Health, Centre for Biostatistics, Imperial College St Mary's Campus, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Coin, Lachlan J" sort="Coin, Lachlan J" uniqKey="Coin L" first="Lachlan J" last="Coin">Lachlan J. Coin</name><affiliation><mods:affiliation>Department of Epidemiology and Public Health, Centre for Biostatistics, Imperial College St Mary's Campus, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name><affiliation><mods:affiliation>Reta Lila Weston Institute, UCL Institute of Neurology, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Silveira Moriyama, Laura" sort="Silveira Moriyama, Laura" uniqKey="Silveira Moriyama L" first="Laura" last="Silveira-Moriyama">Laura Silveira-Moriyama</name><affiliation><mods:affiliation>Reta Lila Weston Institute, UCL Institute of Neurology, London, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, FCM, University of Campinas, Campinas, UNICAMP, Brazil</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AA6673435D5D050C24ADEBE4E5189ACE4C110471</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1136/jnnp-2012-304440</idno><idno type="url">https://api.istex.fr/document/AA6673435D5D050C24ADEBE4E5189ACE4C110471/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002222</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Demographic and motor features associated with the occurrence of neuropsychiatric and sleep complications of Parkinson's disease</title><author><name sortKey="Munhoz, Renato Puppi" sort="Munhoz, Renato Puppi" uniqKey="Munhoz R" first="Renato Puppi" last="Munhoz">Renato Puppi Munhoz</name><affiliation><mods:affiliation>Department of Neurology, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil</mods:affiliation></affiliation><affiliation><mods:affiliation>Associacao Paranaense dos Portadores de Parkinsonismo, Curitiba, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Teive, Helio A" sort="Teive, Helio A" uniqKey="Teive H" first="Hélio A" last="Teive">Hélio A. Teive</name><affiliation><mods:affiliation>Department of Neurology, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Eleftherohorinou, Hariklia" sort="Eleftherohorinou, Hariklia" uniqKey="Eleftherohorinou H" first="Hariklia" last="Eleftherohorinou">Hariklia Eleftherohorinou</name><affiliation><mods:affiliation>Department of Epidemiology and Public Health, Centre for Biostatistics, Imperial College St Mary's Campus, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Coin, Lachlan J" sort="Coin, Lachlan J" uniqKey="Coin L" first="Lachlan J" last="Coin">Lachlan J. Coin</name><affiliation><mods:affiliation>Department of Epidemiology and Public Health, Centre for Biostatistics, Imperial College St Mary's Campus, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name><affiliation><mods:affiliation>Reta Lila Weston Institute, UCL Institute of Neurology, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Silveira Moriyama, Laura" sort="Silveira Moriyama, Laura" uniqKey="Silveira Moriyama L" first="Laura" last="Silveira-Moriyama">Laura Silveira-Moriyama</name><affiliation><mods:affiliation>Reta Lila Weston Institute, UCL Institute of Neurology, London, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, FCM, University of Campinas, Campinas, UNICAMP, Brazil</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2013-08">2013-08</date><biblScope unit="volume">84</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="883">883</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">AA6673435D5D050C24ADEBE4E5189ACE4C110471</idno><idno type="DOI">10.1136/jnnp-2012-304440</idno><idno type="href">jnnp-84-883.pdf</idno><idno type="ArticleID">jnnp-2012-304440</idno><idno type="PMID">23463867</idno><idno type="local">jnnp;84/8/883</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Objective To determine whether four key neuropsychiatric and sleep related features associated with Parkinson's disease (PD) are associated with the motor handicap and demographic data. Background The growing number of recognised non-motor features of PD makes routine screening of all these symptoms impractical. Here, we investigated the hypothesis that standard demographic data and the routine assessment of motor signs is associated with the presence of dementia, psychosis, clinically probable rapid eye movement (REM) sleep behavior disorder (cpRBD) and restless legs syndrome (RLS). Methods 775 patients with PD underwent standardised assessment of motor features and the presence of dementia, psychosis, cpRBD and RLS. A stepwise feature elimination procedure with fitted logistic regression models was applied to identify which/if any combination of demographic and motor factors is associated with each of the four studied non-motor features. A within-study out-of-sample estimate of the power of the predicted values of the models was calculated using standard evaluation procedures. Results Age and Hoehn&Yahr (H&Y) stage were strongly associated with the presence of dementia (p value<0.001 for both factors in the final selected model) while a combination of age, disease duration, H&Y stage, dopamine agonists and catechol-O-methyltransferase (COMT) inhibitors was associated with the presence of psychosis. Disease duration and H&Y stage were the significant indicators of cpRBD, and the lack of significant motor asymmetry was the only significant feature associated with RLS-type symptoms but the evidence of association was weak. Conclusions Demographic and motor features routinely collected in patients with PD can estimate the occurrence of neuropsychiatric and sleep-related features of PD.</div></front></TEI><istex><corpusName>bmj</corpusName><author><json:item><name>Renato Puppi Munhoz</name><affiliations><json:string>Department of Neurology, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil</json:string><json:string>Associacao Paranaense dos Portadores de Parkinsonismo, Curitiba, Brazil</json:string></affiliations></json:item><json:item><name>Hélio A Teive</name><affiliations><json:string>Department of Neurology, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil</json:string></affiliations></json:item><json:item><name>Hariklia Eleftherohorinou</name><affiliations><json:string>Department of Epidemiology and Public Health, Centre for Biostatistics, Imperial College St Mary's Campus, London, UK</json:string></affiliations></json:item><json:item><name>Lachlan J Coin</name><affiliations><json:string>Department of Epidemiology and Public Health, Centre for Biostatistics, Imperial College St Mary's Campus, London, UK</json:string></affiliations></json:item><json:item><name>Andrew J Lees</name><affiliations><json:string>Reta Lila Weston Institute, UCL Institute of Neurology, London, UK</json:string></affiliations></json:item><json:item><name>Laura Silveira-Moriyama</name><affiliations><json:string>Reta Lila Weston Institute, UCL Institute of Neurology, London, UK</json:string><json:string>Department of Neurology, FCM, University of Campinas, Campinas, UNICAMP, Brazil</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Movement disorders</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PARKINSON'S DISEASE</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>CLINICAL NEUROLOGY</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MOVEMENT DISORDERS</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Objective To determine whether four key neuropsychiatric and sleep related features associated with Parkinson's disease (PD) are associated with the motor handicap and demographic data. Background The growing number of recognised non-motor features of PD makes routine screening of all these symptoms impractical. Here, we investigated the hypothesis that standard demographic data and the routine assessment of motor signs is associated with the presence of dementia, psychosis, clinically probable rapid eye movement (REM) sleep behavior disorder (cpRBD) and restless legs syndrome (RLS). Methods 775 patients with PD underwent standardised assessment of motor features and the presence of dementia, psychosis, cpRBD and RLS. A stepwise feature elimination procedure with fitted logistic regression models was applied to identify which/if any combination of demographic and motor factors is associated with each of the four studied non-motor features. A within-study out-of-sample estimate of the power of the predicted values of the models was calculated using standard evaluation procedures. Results Age and Hoehn&Yahr (H&Y) stage were strongly associated with the presence of dementia (p value>0.001 for both factors in the final selected model) while a combination of age, disease duration, H&Y stage, dopamine agonists and catechol-O-methyltransferase (COMT) inhibitors was associated with the presence of psychosis. Disease duration and H&Y stage were the significant indicators of cpRBD, and the lack of significant motor asymmetry was the only significant feature associated with RLS-type symptoms but the evidence of association was weak. Conclusions Demographic and motor features routinely collected in patients with PD can estimate the occurrence of neuropsychiatric and sleep-related features of PD.</abstract><qualityIndicators><score>7.079</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 793.701 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1814</abstractCharCount><pdfWordCount>4079</pdfWordCount><pdfCharCount>25778</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>256</abstractWordCount></qualityIndicators><title>Demographic and motor features associated with the occurrence of neuropsychiatric and sleep complications of Parkinson's 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Publishing Group Ltd</publisher><availability><p>BMJ</p></availability><date>2013-03-05</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Demographic and motor features associated with the occurrence of neuropsychiatric and sleep complications of Parkinson's disease</title><author><persName><forename type="first">Renato Puppi</forename><surname>Munhoz</surname></persName><affiliation>Department of Neurology, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil</affiliation><affiliation>Associacao Paranaense dos Portadores de Parkinsonismo, Curitiba, Brazil</affiliation></author><author><persName><forename type="first">Hélio A</forename><surname>Teive</surname></persName><affiliation>Department of Neurology, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil</affiliation></author><author><persName><forename type="first">Hariklia</forename><surname>Eleftherohorinou</surname></persName><affiliation>Department of Epidemiology and Public Health, Centre for Biostatistics, Imperial College St Mary's Campus, London, UK</affiliation></author><author><persName><forename type="first">Lachlan J</forename><surname>Coin</surname></persName><affiliation>Department of Epidemiology and Public Health, Centre for Biostatistics, Imperial College St Mary's Campus, London, UK</affiliation></author><author><persName><forename type="first">Andrew J</forename><surname>Lees</surname></persName><affiliation>Reta Lila Weston Institute, UCL Institute of Neurology, London, UK</affiliation></author><author><persName><forename type="first">Laura</forename><surname>Silveira-Moriyama</surname></persName><affiliation>Reta Lila Weston Institute, UCL Institute of Neurology, London, UK</affiliation><affiliation>Department of Neurology, FCM, University of Campinas, Campinas, UNICAMP, Brazil</affiliation></author></analytic><monogr><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="pISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2013-08"></date><biblScope unit="volume">84</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="883">883</biblScope></imprint></monogr><idno type="istex">AA6673435D5D050C24ADEBE4E5189ACE4C110471</idno><idno type="DOI">10.1136/jnnp-2012-304440</idno><idno type="href">jnnp-84-883.pdf</idno><idno type="ArticleID">jnnp-2012-304440</idno><idno type="PMID">23463867</idno><idno type="local">jnnp;84/8/883</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2013-03-05</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Objective To determine whether four key neuropsychiatric and sleep related features associated with Parkinson's disease (PD) are associated with the motor handicap and demographic data. Background The growing number of recognised non-motor features of PD makes routine screening of all these symptoms impractical. Here, we investigated the hypothesis that standard demographic data and the routine assessment of motor signs is associated with the presence of dementia, psychosis, clinically probable rapid eye movement (REM) sleep behavior disorder (cpRBD) and restless legs syndrome (RLS). Methods 775 patients with PD underwent standardised assessment of motor features and the presence of dementia, psychosis, cpRBD and RLS. A stepwise feature elimination procedure with fitted logistic regression models was applied to identify which/if any combination of demographic and motor factors is associated with each of the four studied non-motor features. A within-study out-of-sample estimate of the power of the predicted values of the models was calculated using standard evaluation procedures. Results Age and Hoehn&Yahr (H&Y) stage were strongly associated with the presence of dementia (p value<0.001 for both factors in the final selected model) while a combination of age, disease duration, H&Y stage, dopamine agonists and catechol-O-methyltransferase (COMT) inhibitors was associated with the presence of psychosis. Disease duration and H&Y stage were the significant indicators of cpRBD, and the lack of significant motor asymmetry was the only significant feature associated with RLS-type symptoms but the evidence of association was weak. Conclusions Demographic and motor features routinely collected in patients with PD can estimate the occurrence of neuropsychiatric and sleep-related features of PD.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>PARKINSON'S DISEASE</term></item><item><term>CLINICAL NEUROLOGY</term></item><item><term>MOVEMENT DISORDERS</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2013-03-05">Created</change><change when="2013-08">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/AA6673435D5D050C24ADEBE4E5189ACE4C110471/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">jnnp</journal-id><journal-id journal-id-type="nlm-ta">J Neurol Neurosurg Psychiatry</journal-id><journal-id journal-id-type="publisher-id">jnnp</journal-id><journal-title>Journal of Neurology, Neurosurgery & Psychiatry</journal-title><abbrev-journal-title abbrev-type="publisher">J Neurol Neurosurg Psychiatry</abbrev-journal-title><abbrev-journal-title>J Neurol Neurosurg Psychiatry</abbrev-journal-title><issn pub-type="ppub">0022-3050</issn><issn pub-type="epub">1468-330X</issn><publisher><publisher-name>BMJ Publishing Group Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">jnnp-2012-304440</article-id><article-id pub-id-type="doi">10.1136/jnnp-2012-304440</article-id><article-id pub-id-type="other">jnnp;84/8/883</article-id><article-id pub-id-type="other">jnnp;jnnp-2012-304440</article-id><article-id pub-id-type="pmid">23463867</article-id><article-id pub-id-type="other">883</article-id><article-id pub-id-type="other">jnnp-2012-304440</article-id><article-categories><subj-group subj-group-type="heading"><subject>Movement disorders</subject></subj-group><series-title>Research paper</series-title></article-categories><title-group><article-title>Demographic and motor features associated with the occurrence of neuropsychiatric and sleep complications of Parkinson's disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Munhoz</surname><given-names>Renato Puppi</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Teive</surname><given-names>Hélio A</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Eleftherohorinou</surname><given-names>Hariklia</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Coin</surname><given-names>Lachlan J</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Lees</surname><given-names>Andrew J</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Silveira-Moriyama</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="af4">4</xref><xref ref-type="aff" rid="af5">5</xref></contrib></contrib-group><aff id="af1"><label>1</label><addr-line>Department of Neurology</addr-line>, <institution>Hospital de Clínicas, Federal University of Paraná</institution>, <addr-line>Curitiba</addr-line>, <country>Brazil</country></aff><aff id="af2"><label>2</label><institution>Associacao Paranaense dos Portadores de Parkinsonismo</institution>, <addr-line>Curitiba</addr-line>, <country>Brazil</country></aff><aff id="af3"><label>3</label><addr-line>Department of Epidemiology and Public Health</addr-line>, <institution>Centre for Biostatistics, Imperial College St Mary's Campus</institution>, <addr-line>London</addr-line>, <country>UK</country></aff><aff id="af4"><label>4</label><institution>Reta Lila Weston Institute, UCL Institute of Neurology</institution>, <addr-line>London</addr-line>, <country>UK</country></aff><aff id="af5"><label>5</label><addr-line>Department of Neurology</addr-line>, <institution>FCM, University of Campinas, Campinas, UNICAMP</institution>, <country>Brazil</country></aff><author-notes><corresp><label>Correspondence to</label> Dr Laura Silveira-Moriyama, Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London WC1N 1PJ, UK; <email>laura.moriyama@ucl.ac.uk</email></corresp></author-notes><pub-date pub-type="ppub"><month>8</month><year>2013</year></pub-date><pub-date pub-type="epub-original"><day>5</day><month>3</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>5</day><month>3</month><year>2013</year></pub-date><volume>84</volume><volume-id pub-id-type="other">84</volume-id><volume-id pub-id-type="other">84</volume-id><issue>8</issue><issue-id pub-id-type="other">jnnp;84/8</issue-id><issue-id pub-id-type="other">8</issue-id><issue-id pub-id-type="other">84/8</issue-id><fpage>883</fpage><history><date date-type="received"><day>25</day><month>10</month><year>2012</year></date><date date-type="rev-recd"><day>7</day><month>2</month><year>2013</year></date><date date-type="accepted"><day>12</day><month>2</month><year>2013</year></date></history><permissions><copyright-statement>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</copyright-statement><copyright-year>2013</copyright-year></permissions><self-uri content-type="pdf" xlink:role="full-text" xlink:href="jnnp-84-883.pdf"></self-uri><abstract><sec><title>Objective</title><p>To determine whether four key neuropsychiatric and sleep related features associated with Parkinson's disease (PD) are associated with the motor handicap and demographic data.</p></sec><sec><title>Background</title><p>The growing number of recognised non-motor features of PD makes routine screening of all these symptoms impractical. Here, we investigated the hypothesis that standard demographic data and the routine assessment of motor signs is associated with the presence of dementia, psychosis, clinically probable rapid eye movement (REM) sleep behavior disorder (cpRBD) and restless legs syndrome (RLS).</p></sec><sec><title>Methods</title><p>775 patients with PD underwent standardised assessment of motor features and the presence of dementia, psychosis, cpRBD and RLS. A stepwise feature elimination procedure with fitted logistic regression models was applied to identify which/if any combination of demographic and motor factors is associated with each of the four studied non-motor features. A within-study out-of-sample estimate of the power of the predicted values of the models was calculated using standard evaluation procedures.</p></sec><sec><title>Results</title><p>Age and Hoehn&Yahr (H&Y) stage were strongly associated with the presence of dementia (p value<0.001 for both factors in the final selected model) while a combination of age, disease duration, H&Y stage, dopamine agonists and catechol-O-methyltransferase (COMT) inhibitors was associated with the presence of psychosis. Disease duration and H&Y stage were the significant indicators of cpRBD, and the lack of significant motor asymmetry was the only significant feature associated with RLS-type symptoms but the evidence of association was weak.</p></sec><sec><title>Conclusions</title><p>Demographic and motor features routinely collected in patients with PD can estimate the occurrence of neuropsychiatric and sleep-related features of PD.</p></sec></abstract><kwd-group><kwd>PARKINSON'S DISEASE</kwd><kwd>CLINICAL NEUROLOGY</kwd><kwd>MOVEMENT DISORDERS</kwd></kwd-group></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><partName>Research paper</partName><title>Demographic and motor features associated with the occurrence of neuropsychiatric and sleep complications of Parkinson's disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><partName>Research paper</partName><title>Demographic and motor features associated with the occurrence of neuropsychiatric and sleep complications of Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Renato Puppi</namePart><namePart type="family">Munhoz</namePart><affiliation>Department of Neurology, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil</affiliation><affiliation>Associacao Paranaense dos Portadores de Parkinsonismo, Curitiba, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hélio A</namePart><namePart type="family">Teive</namePart><affiliation>Department of Neurology, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hariklia</namePart><namePart type="family">Eleftherohorinou</namePart><affiliation>Department of Epidemiology and Public Health, Centre for Biostatistics, Imperial College St Mary's Campus, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lachlan J</namePart><namePart type="family">Coin</namePart><affiliation>Department of Epidemiology and Public Health, Centre for Biostatistics, Imperial College St Mary's Campus, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andrew J</namePart><namePart type="family">Lees</namePart><affiliation>Reta Lila Weston Institute, UCL Institute of Neurology, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Laura</namePart><namePart type="family">Silveira-Moriyama</namePart><affiliation>Reta Lila Weston Institute, UCL Institute of Neurology, London, UK</affiliation><affiliation>Department of Neurology, FCM, University of Campinas, Campinas, UNICAMP, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><originInfo><publisher>BMJ Publishing Group Ltd</publisher><dateIssued encoding="w3cdtf">2013-08</dateIssued><dateCreated encoding="w3cdtf">2013-03-05</dateCreated><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Objective To determine whether four key neuropsychiatric and sleep related features associated with Parkinson's disease (PD) are associated with the motor handicap and demographic data. Background The growing number of recognised non-motor features of PD makes routine screening of all these symptoms impractical. Here, we investigated the hypothesis that standard demographic data and the routine assessment of motor signs is associated with the presence of dementia, psychosis, clinically probable rapid eye movement (REM) sleep behavior disorder (cpRBD) and restless legs syndrome (RLS). Methods 775 patients with PD underwent standardised assessment of motor features and the presence of dementia, psychosis, cpRBD and RLS. A stepwise feature elimination procedure with fitted logistic regression models was applied to identify which/if any combination of demographic and motor factors is associated with each of the four studied non-motor features. A within-study out-of-sample estimate of the power of the predicted values of the models was calculated using standard evaluation procedures. Results Age and Hoehn&Yahr (H&Y) stage were strongly associated with the presence of dementia (p value<0.001 for both factors in the final selected model) while a combination of age, disease duration, H&Y stage, dopamine agonists and catechol-O-methyltransferase (COMT) inhibitors was associated with the presence of psychosis. Disease duration and H&Y stage were the significant indicators of cpRBD, and the lack of significant motor asymmetry was the only significant feature associated with RLS-type symptoms but the evidence of association was weak. Conclusions Demographic and motor features routinely collected in patients with PD can estimate the occurrence of neuropsychiatric and sleep-related features of PD.</abstract><subject><genre>Keywords</genre><topic>PARKINSON'S DISEASE</topic><topic>CLINICAL NEUROLOGY</topic><topic>MOVEMENT DISORDERS</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Neurology, Neurosurgery & Psychiatry</title></titleInfo><titleInfo type="abbreviated"><title>J Neurol Neurosurg Psychiatry</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0022-3050</identifier><identifier type="eISSN">1468-330X</identifier><identifier type="PublisherID">jnnp</identifier><identifier type="PublisherID-hwp">jnnp</identifier><identifier type="PublisherID-nlm-ta">J Neurol Neurosurg Psychiatry</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>84</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>883</start></extent></part></relatedItem><identifier type="istex">AA6673435D5D050C24ADEBE4E5189ACE4C110471</identifier><identifier type="DOI">10.1136/jnnp-2012-304440</identifier><identifier type="href">jnnp-84-883.pdf</identifier><identifier type="ArticleID">jnnp-2012-304440</identifier><identifier type="PMID">23463867</identifier><identifier type="local">jnnp;84/8/883</identifier><accessCondition type="use and reproduction" contentType="copyright">Published by the BMJ Publishing Group Limited. 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