MIBG scintigraphy for differentiating Parkinson's disease with autonomic dysfunction from Parkinsonism‐predominant multiple system atrophy
Identifieur interne : 002186 ( Main/Corpus ); précédent : 002185; suivant : 002187MIBG scintigraphy for differentiating Parkinson's disease with autonomic dysfunction from Parkinsonism‐predominant multiple system atrophy
Auteurs : Eun Joo Chung ; Won Yong Lee ; Won Tae Yoon ; Byeong Joon Kim ; Gyeong Han LeeSource :
- Movement Disorders [ 0885-3185 ] ; 2009-08-15.
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Abstract
Parkinson's disease (PD) with autonomic dysfunction is difficult to differentiate from Parkinsonism‐predominant multiple system atrophy (MSA‐p). This study aimed to analyze the validity of MIBG scintigraphy for PD with autonomic dysfunction and MSA‐p. Thirty‐nine patients (PD: 27 patients, MSA‐p type: 12) and 12 age‐matched controls were prospectively enrolled and underwent MIBG scintigraphy and autonomic function test (AFT). We separately calculated early and delayed heart‐to‐mediastinal (H/M) ratio and washout rates (WRs). AFT was composed of sympathetic skin reflex and parasympathetic tests based on heart rate variability. Abnormal AFT was observed in 17 (63%) of PD and 10 (83%) of MSA‐p. On comparing PD with abnormal AFT with MSA‐p, either the early or delayed H/M ratio in PD was not different from that in MSA‐p (P > 0.05). Only the WR could differentiate PD with abnormal AFT from MSA‐p (47.07 ± 57.48 vs. 31.39 ± 31.52, respectively) (P = 0.026). According to the results, WR may be more useful than the early and delayed H/M ratio to distinguish MSA‐p from PD with abnormal AFT. Furthermore, the MIBG uptake did not reflect the disease duration or severity. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22649
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-08-15">2009-08-15</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1650">1650</biblScope><biblScope unit="page" to="1655">1655</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">85DD3D3795A4A246C55B100870EF0ACAA50A2EAD</idno><idno type="DOI">10.1002/mds.22649</idno><idno type="ArticleID">MDS22649</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>MIBG scintigraphy</term><term>MSA‐p</term><term>Parkinson's disease</term><term>autonomic dysfunction</term><term>autonomic function test</term><term>multiple system atrophy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) with autonomic dysfunction is difficult to differentiate from Parkinsonism‐predominant multiple system atrophy (MSA‐p). This study aimed to analyze the validity of MIBG scintigraphy for PD with autonomic dysfunction and MSA‐p. Thirty‐nine patients (PD: 27 patients, MSA‐p type: 12) and 12 age‐matched controls were prospectively enrolled and underwent MIBG scintigraphy and autonomic function test (AFT). We separately calculated early and delayed heart‐to‐mediastinal (H/M) ratio and washout rates (WRs). AFT was composed of sympathetic skin reflex and parasympathetic tests based on heart rate variability. Abnormal AFT was observed in 17 (63%) of PD and 10 (83%) of MSA‐p. On comparing PD with abnormal AFT with MSA‐p, either the early or delayed H/M ratio in PD was not different from that in MSA‐p (P > 0.05). Only the WR could differentiate PD with abnormal AFT from MSA‐p (47.07 ± 57.48 vs. 31.39 ± 31.52, respectively) (P = 0.026). According to the results, WR may be more useful than the early and delayed H/M ratio to distinguish MSA‐p from PD with abnormal AFT. Furthermore, the MIBG uptake did not reflect the disease duration or severity. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Eun Joo Chung MD, PhD</name><affiliations><json:string>Department of Neurology, Inje University Pusan Baik Hospital, Pusan, Korea</json:string></affiliations></json:item><json:item><name>Won Yong Lee MD, PhD</name><affiliations><json:string>Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Won Tae Yoon MD</name><affiliations><json:string>Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Byeong Joon Kim MD, PhD</name><affiliations><json:string>Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Gyeong Han Lee MD, PhD</name><affiliations><json:string>Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>autonomic dysfunction</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>multiple system atrophy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MSA‐p</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>autonomic function test</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MIBG scintigraphy</value></json:item></subject><articleId><json:string>MDS22649</json:string></articleId><language><json:string>eng</json:string></language><abstract>Parkinson's disease (PD) with autonomic dysfunction is difficult to differentiate from Parkinsonism‐predominant multiple system atrophy (MSA‐p). This study aimed to analyze the validity of MIBG scintigraphy for PD with autonomic dysfunction and MSA‐p. Thirty‐nine patients (PD: 27 patients, MSA‐p type: 12) and 12 age‐matched controls were prospectively enrolled and underwent MIBG scintigraphy and autonomic function test (AFT). We separately calculated early and delayed heart‐to‐mediastinal (H/M) ratio and washout rates (WRs). AFT was composed of sympathetic skin reflex and parasympathetic tests based on heart rate variability. Abnormal AFT was observed in 17 (63%) of PD and 10 (83%) of MSA‐p. On comparing PD with abnormal AFT with MSA‐p, either the early or delayed H/M ratio in PD was not different from that in MSA‐p (P > 0.05). Only the WR could differentiate PD with abnormal AFT from MSA‐p (47.07 ± 57.48 vs. 31.39 ± 31.52, respectively) (P = 0.026). According to the results, WR may be more useful than the early and delayed H/M ratio to distinguish MSA‐p from PD with abnormal AFT. 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Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-08-15"></date><biblScope unit="volume">24</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1650">1650</biblScope><biblScope unit="page" to="1655">1655</biblScope></imprint></monogr><idno type="istex">85DD3D3795A4A246C55B100870EF0ACAA50A2EAD</idno><idno type="DOI">10.1002/mds.22649</idno><idno type="ArticleID">MDS22649</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Parkinson's disease (PD) with autonomic dysfunction is difficult to differentiate from Parkinsonism‐predominant multiple system atrophy (MSA‐p). This study aimed to analyze the validity of MIBG scintigraphy for PD with autonomic dysfunction and MSA‐p. Thirty‐nine patients (PD: 27 patients, MSA‐p type: 12) and 12 age‐matched controls were prospectively enrolled and underwent MIBG scintigraphy and autonomic function test (AFT). We separately calculated early and delayed heart‐to‐mediastinal (H/M) ratio and washout rates (WRs). AFT was composed of sympathetic skin reflex and parasympathetic tests based on heart rate variability. Abnormal AFT was observed in 17 (63%) of PD and 10 (83%) of MSA‐p. On comparing PD with abnormal AFT with MSA‐p, either the early or delayed H/M ratio in PD was not different from that in MSA‐p (P > 0.05). Only the WR could differentiate PD with abnormal AFT from MSA‐p (47.07 ± 57.48 vs. 31.39 ± 31.52, respectively) (P = 0.026). According to the results, WR may be more useful than the early and delayed H/M ratio to distinguish MSA‐p from PD with abnormal AFT. Furthermore, the MIBG uptake did not reflect the disease duration or severity. © 2009 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>autonomic dysfunction</term></item><item><term>multiple system atrophy</term></item><item><term>MSA‐p</term></item><item><term>autonomic function test</term></item><item><term>MIBG scintigraphy</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-12-05">Received</change><change when="2009-04-07">Registration</change><change when="2009-08-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/85DD3D3795A4A246C55B100870EF0ACAA50A2EAD/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="110"><doi origin="wiley" registered="yes">10.1002/mds.v24:11</doi><numberingGroup><numbering type="journalVolume" number="24">24</numbering><numbering type="journalIssue">11</numbering></numberingGroup><coverDate startDate="2009-08-15">15 August 2009</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="130" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22649</doi><idGroup><id type="unit" value="MDS22649"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2009 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2008-12-05"></event><event type="manuscriptRevised" date="2009-03-30"></event><event type="manuscriptAccepted" date="2009-04-07"></event><event type="publishedOnlineEarlyUnpaginated" date="2009-06-09"></event><event type="firstOnline" date="2009-06-09"></event><event type="publishedOnlineFinalForm" date="2009-08-26"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">1650</numbering><numbering type="pageLast">1655</numbering></numberingGroup><correspondenceTo>Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Irwon‐Dong, Gangnam‐Gu, Seoul 135‐710, Korea</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22649.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="34"></count><count type="wordTotal" number="4069"></count></countGroup><titleGroup><title type="main" xml:lang="en">MIBG scintigraphy for differentiating Parkinson's disease with autonomic dysfunction from Parkinsonism‐predominant multiple system atrophy<link href="#fn2"></link></title><title type="short" xml:lang="en">MIBG Analysis in PD With Dysautonomia and MSA‐p</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Eun Joo</givenNames><familyName>Chung</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2" corresponding="yes"><personName><givenNames>Won Yong</givenNames><familyName>Lee</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email>neurolwy@skku.edu</email></contactDetails></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Won Tae</givenNames><familyName>Yoon</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Byeong Joon</givenNames><familyName>Kim</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Gyeong Han</givenNames><familyName>Lee</familyName><degrees>MD, PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="KR" type="organization"><unparsedAffiliation>Department of Neurology, Inje University Pusan Baik Hospital, Pusan, Korea</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="KR" type="organization"><unparsedAffiliation>Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="KR" type="organization"><unparsedAffiliation>Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">autonomic dysfunction</keyword><keyword xml:id="kwd3">multiple system atrophy</keyword><keyword xml:id="kwd4">MSA‐p</keyword><keyword xml:id="kwd5">autonomic function test</keyword><keyword xml:id="kwd6">MIBG scintigraphy</keyword></keywordGroup><fundingInfo><fundingAgency>Samsung Medical Center Clinical Research Development Program</fundingAgency><fundingNumber># CRS105‐11‐1</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Parkinson's disease (PD) with autonomic dysfunction is difficult to differentiate from Parkinsonism‐predominant multiple system atrophy (MSA‐p). This study aimed to analyze the validity of MIBG scintigraphy for PD with autonomic dysfunction and MSA‐p. Thirty‐nine patients (PD: 27 patients, MSA‐p type: 12) and 12 age‐matched controls were prospectively enrolled and underwent MIBG scintigraphy and autonomic function test (AFT). We separately calculated early and delayed heart‐to‐mediastinal (<i>H</i>/<i>M</i>) ratio and washout rates (WRs). AFT was composed of sympathetic skin reflex and parasympathetic tests based on heart rate variability. Abnormal AFT was observed in 17 (63%) of PD and 10 (83%) of MSA‐p. On comparing PD with abnormal AFT with MSA‐p, either the early or delayed <i>H</i>/<i>M</i> ratio in PD was not different from that in MSA‐p (<i>P</i> > 0.05). Only the WR could differentiate PD with abnormal AFT from MSA‐p (47.07 ± 57.48 vs. 31.39 ± 31.52, respectively) (<i>P</i> = 0.026). According to the results, WR may be more useful than the early and delayed <i>H</i>/<i>M</i> ratio to distinguish MSA‐p from PD with abnormal AFT. Furthermore, the MIBG uptake did not reflect the disease duration or severity. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn2"><p>Potential conflict of interest: None reported.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>MIBG scintigraphy for differentiating Parkinson's disease with autonomic dysfunction from Parkinsonism‐predominant multiple system atrophy</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>MIBG Analysis in PD With Dysautonomia and MSA‐p</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>MIBG scintigraphy for differentiating Parkinson's disease with autonomic dysfunction from Parkinsonism‐predominant multiple system atrophy</title></titleInfo><name type="personal"><namePart type="given">Eun Joo</namePart><namePart type="family">Chung</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Inje University Pusan Baik Hospital, Pusan, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Won Yong</namePart><namePart type="family">Lee</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</affiliation><description>Correspondence: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Irwon‐Dong, Gangnam‐Gu, Seoul 135‐710, Korea</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Won Tae</namePart><namePart type="family">Yoon</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Byeong Joon</namePart><namePart type="family">Kim</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gyeong Han</namePart><namePart type="family">Lee</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-08-15</dateIssued><dateCaptured encoding="w3cdtf">2008-12-05</dateCaptured><dateValid encoding="w3cdtf">2009-04-07</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent><extent unit="references">34</extent><extent unit="words">4069</extent></physicalDescription><abstract lang="en">Parkinson's disease (PD) with autonomic dysfunction is difficult to differentiate from Parkinsonism‐predominant multiple system atrophy (MSA‐p). This study aimed to analyze the validity of MIBG scintigraphy for PD with autonomic dysfunction and MSA‐p. Thirty‐nine patients (PD: 27 patients, MSA‐p type: 12) and 12 age‐matched controls were prospectively enrolled and underwent MIBG scintigraphy and autonomic function test (AFT). We separately calculated early and delayed heart‐to‐mediastinal (H/M) ratio and washout rates (WRs). AFT was composed of sympathetic skin reflex and parasympathetic tests based on heart rate variability. Abnormal AFT was observed in 17 (63%) of PD and 10 (83%) of MSA‐p. On comparing PD with abnormal AFT with MSA‐p, either the early or delayed H/M ratio in PD was not different from that in MSA‐p (P > 0.05). Only the WR could differentiate PD with abnormal AFT from MSA‐p (47.07 ± 57.48 vs. 31.39 ± 31.52, respectively) (P = 0.026). According to the results, WR may be more useful than the early and delayed H/M ratio to distinguish MSA‐p from PD with abnormal AFT. Furthermore, the MIBG uptake did not reflect the disease duration or severity. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None reported.</note><note type="funding">Samsung Medical Center Clinical Research Development Program - No. # CRS105‐11‐1; </note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>autonomic dysfunction</topic><topic>multiple system atrophy</topic><topic>MSA‐p</topic><topic>autonomic function test</topic><topic>MIBG scintigraphy</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>11</number></detail><extent unit="pages"><start>1650</start><end>1655</end><total>6</total></extent></part></relatedItem><identifier type="istex">85DD3D3795A4A246C55B100870EF0ACAA50A2EAD</identifier><identifier type="DOI">10.1002/mds.22649</identifier><identifier type="ArticleID">MDS22649</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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