A cytoarchitectonic and histochemical study of nucleus basalis and associated cell groups in the normal human brain
Identifieur interne : 002150 ( Main/Corpus ); précédent : 002149; suivant : 002151A cytoarchitectonic and histochemical study of nucleus basalis and associated cell groups in the normal human brain
Auteurs : C. B. Saper ; T. C. ChelimskySource :
- Neuroscience [ 0306-4522 ] ; 1984.
English descriptors
Abstract
Several recent studies have reported loss of neurons in the nucleus basalis in Alzheimer's disease. However, few detailed studies of the normal distribution of these neurons in the human brain have appeared. We have used Nissl staining and acetylcholinesterase histochemical staining of the human basal forebrain, alone or in combination to identify the organization of the nucleus basalis and associated cell groups, (or collectively, the magnocellular basal nucleus) in the normal human brain. The magnocellular basal nucleus includes a series of clusters of neurons and scattered perikarya extending from the medial septum and diagonal band nucleus rostrally, through the substantia innominata to the furthest caudal extent of the globus pallidus. This distribution is similar to that which has been described in the monkey. Furthermore, acetylcholinesterase-positive fibers in the human brain are seen in the two major pathways that have been identified as carrying magnocellular basal nucleus axons to the cerebral cortex in other species.These observations suggest that the topographic organization of the magnocellular basal projection to cerebral cortex in other species probably exists in man as well. It will therefore be important in future studies of the fate of these neurons in neurological degenerative diseases to assess the loss of neurons in the different components of the magnocellular basal nucleus in relation to the clinical evidence for dysfunction in the cortical areas which they innervate.
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DOI: 10.1016/0306-4522(84)90286-0
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">A cytoarchitectonic and histochemical study of nucleus basalis and associated cell groups in the normal human brain</title><author><name sortKey="Saper, C B" sort="Saper, C B" uniqKey="Saper C" first="C. B." last="Saper">C. B. Saper</name><affiliation><mods:affiliation>Departments of Neurology and Neurological Surgery (Neurology), and Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, U.S.A.</mods:affiliation></affiliation></author><author><name sortKey="Chelimsky, T C" sort="Chelimsky, T C" uniqKey="Chelimsky T" first="T. C." last="Chelimsky">T. C. Chelimsky</name><affiliation><mods:affiliation>Departments of Neurology and Neurological Surgery (Neurology), and Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, U.S.A.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:89F3B219906223165AD2AAEA087EE8083D9124B3</idno><date when="1984" year="1984">1984</date><idno type="doi">10.1016/0306-4522(84)90286-0</idno><idno type="url">https://api.istex.fr/document/89F3B219906223165AD2AAEA087EE8083D9124B3/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002150</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">A cytoarchitectonic and histochemical study of nucleus basalis and associated cell groups in the normal human brain</title><author><name sortKey="Saper, C B" sort="Saper, C B" uniqKey="Saper C" first="C. B." last="Saper">C. B. Saper</name><affiliation><mods:affiliation>Departments of Neurology and Neurological Surgery (Neurology), and Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, U.S.A.</mods:affiliation></affiliation></author><author><name sortKey="Chelimsky, T C" sort="Chelimsky, T C" uniqKey="Chelimsky T" first="T. C." last="Chelimsky">T. C. Chelimsky</name><affiliation><mods:affiliation>Departments of Neurology and Neurological Surgery (Neurology), and Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, U.S.A.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Neuroscience</title><title level="j" type="abbrev">NSC</title><idno type="ISSN">0306-4522</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1984">1984</date><biblScope unit="volume">13</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="1023">1023</biblScope><biblScope unit="page" to="1037">1037</biblScope></imprint><idno type="ISSN">0306-4522</idno></series><idno type="istex">89F3B219906223165AD2AAEA087EE8083D9124B3</idno><idno type="DOI">10.1016/0306-4522(84)90286-0</idno><idno type="PII">0306-4522(84)90286-0</idno><idno type="ArticleID">84902860</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0306-4522</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AChE</term><term>MBN</term><term>iso-OMPA</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several recent studies have reported loss of neurons in the nucleus basalis in Alzheimer's disease. However, few detailed studies of the normal distribution of these neurons in the human brain have appeared. We have used Nissl staining and acetylcholinesterase histochemical staining of the human basal forebrain, alone or in combination to identify the organization of the nucleus basalis and associated cell groups, (or collectively, the magnocellular basal nucleus) in the normal human brain. The magnocellular basal nucleus includes a series of clusters of neurons and scattered perikarya extending from the medial septum and diagonal band nucleus rostrally, through the substantia innominata to the furthest caudal extent of the globus pallidus. This distribution is similar to that which has been described in the monkey. Furthermore, acetylcholinesterase-positive fibers in the human brain are seen in the two major pathways that have been identified as carrying magnocellular basal nucleus axons to the cerebral cortex in other species.These observations suggest that the topographic organization of the magnocellular basal projection to cerebral cortex in other species probably exists in man as well. It will therefore be important in future studies of the fate of these neurons in neurological degenerative diseases to assess the loss of neurons in the different components of the magnocellular basal nucleus in relation to the clinical evidence for dysfunction in the cortical areas which they innervate.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>C.B. Saper</name><affiliations><json:string>Departments of Neurology and Neurological Surgery (Neurology), and Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, U.S.A.</json:string></affiliations></json:item><json:item><name>T.C. Chelimsky</name><affiliations><json:string>Departments of Neurology and Neurological Surgery (Neurology), and Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, U.S.A.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>AChE : acetylcholinesterase</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>iso-OMPA : N,N-bis(1-methyl ethyl) pyrophosphorodiamidic anhydride</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MBN : magnocellular basal nucleus</value></json:item></subject><articleId><json:string>84902860</json:string></articleId><language><json:string>eng</json:string></language><abstract>Several recent studies have reported loss of neurons in the nucleus basalis in Alzheimer's disease. However, few detailed studies of the normal distribution of these neurons in the human brain have appeared. We have used Nissl staining and acetylcholinesterase histochemical staining of the human basal forebrain, alone or in combination to identify the organization of the nucleus basalis and associated cell groups, (or collectively, the magnocellular basal nucleus) in the normal human brain. The magnocellular basal nucleus includes a series of clusters of neurons and scattered perikarya extending from the medial septum and diagonal band nucleus rostrally, through the substantia innominata to the furthest caudal extent of the globus pallidus. This distribution is similar to that which has been described in the monkey. Furthermore, acetylcholinesterase-positive fibers in the human brain are seen in the two major pathways that have been identified as carrying magnocellular basal nucleus axons to the cerebral cortex in other species.These observations suggest that the topographic organization of the magnocellular basal projection to cerebral cortex in other species probably exists in man as well. It will therefore be important in future studies of the fate of these neurons in neurological degenerative diseases to assess the loss of neurons in the different components of the magnocellular basal nucleus in relation to the clinical evidence for dysfunction in the cortical areas which they innervate.</abstract><qualityIndicators><score>7.7</score><pdfVersion>1.3</pdfVersion><pdfPageSize>576 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>3</keywordCount><abstractCharCount>1516</abstractCharCount><pdfWordCount>6833</pdfWordCount><pdfCharCount>43256</pdfCharCount><pdfPageCount>15</pdfPageCount><abstractWordCount>225</abstractWordCount></qualityIndicators><title>A cytoarchitectonic and histochemical study of nucleus basalis and associated cell groups in the normal human brain</title><pii><json:string>0306-4522(84)90286-0</json:string></pii><genre><json:string>research-article</json:string></genre><serie><volume>76</volume><pages><last>5396</last><first>5392</first></pages><genre></genre><language><json:string>unknown</json:string></language><title>Proc. natn. 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B. Saper, Department of Neurology, Box 8111, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, U.S.A.</affiliation><affiliation>Departments of Neurology and Neurological Surgery (Neurology), and Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, U.S.A.</affiliation></author><author><persName><forename type="first">T.C.</forename><surname>Chelimsky</surname></persName><affiliation>Departments of Neurology and Neurological Surgery (Neurology), and Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, U.S.A.</affiliation></author></analytic><monogr><title level="j">Neuroscience</title><title level="j" type="abbrev">NSC</title><idno type="pISSN">0306-4522</idno><idno type="PII">S0306-4522(00)X0616-1</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1984"></date><biblScope unit="volume">13</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="1023">1023</biblScope><biblScope unit="page" to="1037">1037</biblScope></imprint></monogr><idno type="istex">89F3B219906223165AD2AAEA087EE8083D9124B3</idno><idno type="DOI">10.1016/0306-4522(84)90286-0</idno><idno type="PII">0306-4522(84)90286-0</idno><idno type="ArticleID">84902860</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1984</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Several recent studies have reported loss of neurons in the nucleus basalis in Alzheimer's disease. However, few detailed studies of the normal distribution of these neurons in the human brain have appeared. We have used Nissl staining and acetylcholinesterase histochemical staining of the human basal forebrain, alone or in combination to identify the organization of the nucleus basalis and associated cell groups, (or collectively, the magnocellular basal nucleus) in the normal human brain. The magnocellular basal nucleus includes a series of clusters of neurons and scattered perikarya extending from the medial septum and diagonal band nucleus rostrally, through the substantia innominata to the furthest caudal extent of the globus pallidus. This distribution is similar to that which has been described in the monkey. Furthermore, acetylcholinesterase-positive fibers in the human brain are seen in the two major pathways that have been identified as carrying magnocellular basal nucleus axons to the cerebral cortex in other species.These observations suggest that the topographic organization of the magnocellular basal projection to cerebral cortex in other species probably exists in man as well. It will therefore be important in future studies of the fate of these neurons in neurological degenerative diseases to assess the loss of neurons in the different components of the magnocellular basal nucleus in relation to the clinical evidence for dysfunction in the cortical areas which they innervate.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>AChE</term><term>acetylcholinesterase</term></item><item><term>iso-OMPA</term><term>N,N-bis(1-methyl ethyl) pyrophosphorodiamidic anhydride</term></item><item><term>MBN</term><term>magnocellular basal nucleus</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1984-05-14">Registration</change><change when="1984">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.0.1//EN//XML" URI="art501.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.0" xml:lang="en" docsubtype="fla"><item-info><jid>NSC</jid><aid>84902860</aid><ce:pii>0306-4522(84)90286-0</ce:pii><ce:doi>10.1016/0306-4522(84)90286-0</ce:doi><ce:copyright type="unknown" year="1984">Pergamon Press Ltd.</ce:copyright></item-info><head><ce:title>A cytoarchitectonic and histochemical study of nucleus basalis and associated cell groups in the normal human brain</ce:title><ce:author-group><ce:author><ce:given-name>C.B.</ce:given-name><ce:surname>Saper</ce:surname><ce:cross-ref refid="cor1"><ce:sup>*</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>T.C.</ce:given-name><ce:surname>Chelimsky</ce:surname></ce:author><ce:affiliation><ce:textfn>Departments of Neurology and Neurological Surgery (Neurology), and Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, U.S.A.</ce:textfn></ce:affiliation><ce:correspondence id="cor1"><ce:label>*</ce:label><ce:text>Please address all correspondence to: Dr. C. B. Saper, Department of Neurology, Box 8111, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, U.S.A.</ce:text></ce:correspondence></ce:author-group><ce:date-accepted day="14" month="5" year="1984"></ce:date-accepted><ce:abstract id="ab1" class="author" xml:lang="en"><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Several recent studies have reported loss of neurons in the nucleus basalis in Alzheimer's disease. However, few detailed studies of the normal distribution of these neurons in the human brain have appeared. We have used Nissl staining and acetylcholinesterase histochemical staining of the human basal forebrain, alone or in combination to identify the organization of the nucleus basalis and associated cell groups, (or collectively, the magnocellular basal nucleus) in the normal human brain. The magnocellular basal nucleus includes a series of clusters of neurons and scattered perikarya extending from the medial septum and diagonal band nucleus rostrally, through the substantia innominata to the furthest caudal extent of the globus pallidus. This distribution is similar to that which has been described in the monkey. Furthermore, acetylcholinesterase-positive fibers in the human brain are seen in the two major pathways that have been identified as carrying magnocellular basal nucleus axons to the cerebral cortex in other species.</ce:simple-para><ce:simple-para>These observations suggest that the topographic organization of the magnocellular basal projection to cerebral cortex in other species probably exists in man as well. It will therefore be important in future studies of the fate of these neurons in neurological degenerative diseases to assess the loss of neurons in the different components of the magnocellular basal nucleus in relation to the clinical evidence for dysfunction in the cortical areas which they innervate.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword" xml:lang="en"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>AChE</ce:text><ce:keyword><ce:text>acetylcholinesterase</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>iso-OMPA</ce:text><ce:keyword><ce:text><ce:italic>N,N</ce:italic>-bis(1-methyl ethyl) pyrophosphorodiamidic anhydride</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>MBN</ce:text><ce:keyword><ce:text>magnocellular basal nucleus</ce:text></ce:keyword></ce:keyword></ce:keywords></head><tail><ce:bibliography><ce:section-title>References</ce:section-title><ce:bibliography-sec><ce:bib-reference id="bib1"><ce:label>1.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Adams</ce:surname><ce:given-name>R.D.</ce:given-name></sb:author><sb:author><ce:surname>Victor</ce:surname><ce:given-name>M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Principles of Neurology</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:date>1977</sb:date><sb:publisher><sb:name>McGraw-Hill</sb:name><sb:location>New York</sb:location></sb:publisher></sb:edited-book><sb:pages><sb:first-page>401</sb:first-page><sb:last-page>405</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib2"><ce:label>2.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Arendt</ce:surname><ce:given-name>T.</ce:given-name></sb:author><sb:author><ce:surname>Bigl</ce:surname><ce:given-name>V.</ce:given-name></sb:author><sb:author><ce:surname>Arendt</ce:surname><ce:given-name>A.</ce:given-name></sb:author><sb:author><ce:surname>Tennstedt</ce:surname><ce:given-name>A.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korskakoff's disease</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Acta neuropath. berl.</sb:maintitle></sb:title><sb:volume-nr>61</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>101</sb:first-page><sb:last-page>108</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib3"><ce:label>3.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Armstrong</ce:surname><ce:given-name>D.M.</ce:given-name></sb:author><sb:author><ce:surname>Saper</ce:surname><ce:given-name>C.B.</ce:given-name></sb:author><sb:author><ce:surname>Levey</ce:surname><ce:given-name>A.I.</ce:given-name></sb:author><sb:author><ce:surname>Wainer</ce:surname><ce:given-name>B.H.</ce:given-name></sb:author><sb:author><ce:surname>Terry</ce:surname><ce:given-name>R.D.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Distribution of cholinergic neurons in the rat brain: demonstrated by the immunocytochemical localization of choline acetyltransferase</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. comp. 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B. Saper, Department of Neurology, Box 8111, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, U.S.A.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.C.</namePart><namePart type="family">Chelimsky</namePart><affiliation>Departments of Neurology and Neurological Surgery (Neurology), and Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1984</dateIssued><dateValid encoding="w3cdtf">1984-05-14</dateValid><copyrightDate encoding="w3cdtf">1984</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Several recent studies have reported loss of neurons in the nucleus basalis in Alzheimer's disease. However, few detailed studies of the normal distribution of these neurons in the human brain have appeared. We have used Nissl staining and acetylcholinesterase histochemical staining of the human basal forebrain, alone or in combination to identify the organization of the nucleus basalis and associated cell groups, (or collectively, the magnocellular basal nucleus) in the normal human brain. The magnocellular basal nucleus includes a series of clusters of neurons and scattered perikarya extending from the medial septum and diagonal band nucleus rostrally, through the substantia innominata to the furthest caudal extent of the globus pallidus. This distribution is similar to that which has been described in the monkey. Furthermore, acetylcholinesterase-positive fibers in the human brain are seen in the two major pathways that have been identified as carrying magnocellular basal nucleus axons to the cerebral cortex in other species.These observations suggest that the topographic organization of the magnocellular basal projection to cerebral cortex in other species probably exists in man as well. It will therefore be important in future studies of the fate of these neurons in neurological degenerative diseases to assess the loss of neurons in the different components of the magnocellular basal nucleus in relation to the clinical evidence for dysfunction in the cortical areas which they innervate.</abstract><subject lang="en"><genre>Keywords</genre><topic>AChE : acetylcholinesterase</topic><topic>iso-OMPA : N,N-bis(1-methyl ethyl) pyrophosphorodiamidic anhydride</topic><topic>MBN : magnocellular basal nucleus</topic></subject><relatedItem type="host"><titleInfo><title>Neuroscience</title></titleInfo><titleInfo type="abbreviated"><title>NSC</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">198412</dateIssued></originInfo><identifier type="ISSN">0306-4522</identifier><identifier type="PII">S0306-4522(00)X0616-1</identifier><part><detail type="volume"><number>13</number><caption>vol.</caption></detail><detail type="issue"><number>4</number><caption>no.</caption></detail><extent unit="issue pages"><start>983</start><end>1408</end></extent><extent unit="pages"><start>1023</start><end>1037</end></extent></part></relatedItem><identifier type="istex">89F3B219906223165AD2AAEA087EE8083D9124B3</identifier><identifier type="DOI">10.1016/0306-4522(84)90286-0</identifier><identifier type="PII">0306-4522(84)90286-0</identifier><identifier type="ArticleID">84902860</identifier><accessCondition type="use and reproduction" contentType="">© 1984Pergamon Press Ltd.</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Pergamon Press Ltd., ©1984</recordOrigin></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/89F3B219906223165AD2AAEA087EE8083D9124B3/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">NEUROSCIENCES</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments></istex></record>Pour manipuler ce document sous Unix (Dilib)
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