Diet supplement CoQ10 delays brain atrophy in aged transgenic mice with mutations in the amyloid precursor protein: An in vivo volume MRI study
Identifieur interne : 002073 ( Main/Corpus ); précédent : 002072; suivant : 002074Diet supplement CoQ10 delays brain atrophy in aged transgenic mice with mutations in the amyloid precursor protein: An in vivo volume MRI study
Auteurs : Li ; Clifford R. Jack ; Xi-Fei Yang ; Edward S. YangSource :
- BioFactors [ 0951-6433 ] ; 2008.
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- KwdEn :
Abstract
We tested the hypotheses that supplemental intake of the diet supplement Coenzyme Q10 (CoQ10) could delay brain atrophy in double transgenic amyloid precursor protein (APP) / presenilin 1 (PS1), single transgenic APP and PS1 as well as wild type mice by volume MR image in vivo. One hundred and twelve mice (28 APP/PS1, 28 APP, 28 PS1 and 28 wild types) were studied. Half of each genotype group (n = 14 per group) was treated with CoQ10 2400 mg/kg/day, and the other half with placebo for 60 days. Magnetic resonance (MR) images were used to obtain the volumes of the hemispheres and hippocampi. APP / PS1, APP, PS1 and wild type mice treated with CoQ10 exhibited significantly less atrophy in hemisphere and hippocampus than those receiving placebo. The neuro‐protective effect of the CoQ10 on hemispheric volume, and hippocampal volume was related to genotype; greater in APP/PS1 than APP and PS1 mice and less in wild type mice. Our result indicated that CoQ10 may have therapeutic potential in the prevention and treatment of MCI and AD.
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DOI: 10.1002/biof.5520320120
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One hundred and twelve mice (28 APP/PS1, 28 APP, 28 PS1 and 28 wild types) were studied. Half of each genotype group (n = 14 per group) was treated with CoQ10 2400 mg/kg/day, and the other half with placebo for 60 days. Magnetic resonance (MR) images were used to obtain the volumes of the hemispheres and hippocampi. APP / PS1, APP, PS1 and wild type mice treated with CoQ10 exhibited significantly less atrophy in hemisphere and hippocampus than those receiving placebo. The neuro‐protective effect of the CoQ10 on hemispheric volume, and hippocampal volume was related to genotype; greater in APP/PS1 than APP and PS1 mice and less in wild type mice. Our result indicated that CoQ10 may have therapeutic potential in the prevention and treatment of MCI and AD.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Dr. Li</name><affiliations><json:string>Hong Kong Applied Science and Technology Research Institute Company Limited, Hong Kong, HKSAR, China</json:string></affiliations></json:item><json:item><name>Clifford R. Jack</name><affiliations><json:string>Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA</json:string></affiliations></json:item><json:item><name>Xi‐Fei Yang</name><affiliations><json:string>Hong Kong Applied Science and Technology Research Institute Company Limited, Hong Kong, HKSAR, China</json:string></affiliations></json:item><json:item><name>Edward S. Yang</name><affiliations><json:string>Hong Kong Applied Science and Technology Research Institute Company Limited, Hong Kong, HKSAR, China</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>APP/PS1 double transgenic mice</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>antioxidant</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Alzheimer's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hippocampal volume</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hemispheric volume</value></json:item></subject><articleId><json:string>BIOF5520320120</json:string></articleId><language><json:string>eng</json:string></language><abstract>We tested the hypotheses that supplemental intake of the diet supplement Coenzyme Q10 (CoQ10) could delay brain atrophy in double transgenic amyloid precursor protein (APP) / presenilin 1 (PS1), single transgenic APP and PS1 as well as wild type mice by volume MR image in vivo. One hundred and twelve mice (28 APP/PS1, 28 APP, 28 PS1 and 28 wild types) were studied. Half of each genotype group (n = 14 per group) was treated with CoQ10 2400 mg/kg/day, and the other half with placebo for 60 days. Magnetic resonance (MR) images were used to obtain the volumes of the hemispheres and hippocampi. APP / PS1, APP, PS1 and wild type mice treated with CoQ10 exhibited significantly less atrophy in hemisphere and hippocampus than those receiving placebo. The neuro‐protective effect of the CoQ10 on hemispheric volume, and hippocampal volume was related to genotype; greater in APP/PS1 than APP and PS1 mice and less in wild type mice. 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Tel.: +852 3406 2620; Fax: +852 3406 2802</p></note><affiliation>Hong Kong Applied Science and Technology Research Institute Company Limited, Hong Kong, HKSAR, China</affiliation></author><author><persName><forename type="first">Clifford R.</forename><surname>Jack</surname></persName><affiliation>Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA</affiliation></author><author><persName><forename type="first">Xi‐Fei</forename><surname>Yang</surname></persName><affiliation>Hong Kong Applied Science and Technology Research Institute Company Limited, Hong Kong, HKSAR, China</affiliation></author><author><persName><forename type="first">Edward S.</forename><surname>Yang</surname></persName><affiliation>Hong Kong Applied Science and Technology Research Institute Company Limited, Hong Kong, HKSAR, China</affiliation></author></analytic><monogr><title level="j">BioFactors</title><title level="j" type="abbrev">BioFactors</title><idno type="pISSN">0951-6433</idno><idno type="eISSN">1872-8081</idno><idno type="DOI">10.1002/(ISSN)1872-8081</idno><imprint><publisher>IOS Press</publisher><pubPlace>Amsterdam</pubPlace><date type="published" when="2008"></date><biblScope unit="volume">32</biblScope><biblScope unit="issue">1‐4</biblScope><biblScope unit="page" from="169">169</biblScope><biblScope unit="page" to="178">178</biblScope></imprint></monogr><idno type="istex">01DF26D10B0055A77F7430C325DD96A5FEC3D660</idno><idno type="DOI">10.1002/biof.5520320120</idno><idno type="ArticleID">BIOF5520320120</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We tested the hypotheses that supplemental intake of the diet supplement Coenzyme Q10 (CoQ10) could delay brain atrophy in double transgenic amyloid precursor protein (APP) / presenilin 1 (PS1), single transgenic APP and PS1 as well as wild type mice by volume MR image in vivo. One hundred and twelve mice (28 APP/PS1, 28 APP, 28 PS1 and 28 wild types) were studied. Half of each genotype group (n = 14 per group) was treated with CoQ10 2400 mg/kg/day, and the other half with placebo for 60 days. Magnetic resonance (MR) images were used to obtain the volumes of the hemispheres and hippocampi. APP / PS1, APP, PS1 and wild type mice treated with CoQ10 exhibited significantly less atrophy in hemisphere and hippocampus than those receiving placebo. The neuro‐protective effect of the CoQ10 on hemispheric volume, and hippocampal volume was related to genotype; greater in APP/PS1 than APP and PS1 mice and less in wild type mice. 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Tel.: +852 3406 2620; Fax: +852 3406 2802</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:BIOF.BIOF5520320120.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="5"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="57"></count></countGroup><titleGroup><title type="main" xml:lang="en">Diet supplement CoQ<sub>10</sub> delays brain atrophy in aged transgenic mice with mutations in the amyloid precursor protein: An <i>in vivo</i> volume MRI study</title><title type="short" xml:lang="en">Diet supplement CoQ<sub>10</sub> delays brain atrophy in aged transgenic mice</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><honorifics>Dr.</honorifics><givenNames>Geng</givenNames><familyName>Li</familyName></personName><contactDetails><email>gli@astri.org</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Clifford R.</givenNames><familyName>Jack</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Xi‐Fei</givenNames><familyName>Yang</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Edward S.</givenNames><familyName>Yang</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="CN" type="organization"><unparsedAffiliation>Hong Kong Applied Science and Technology Research Institute Company Limited, Hong Kong, HKSAR, China</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">APP/PS1 double transgenic mice</keyword><keyword xml:id="kwd2">antioxidant</keyword><keyword xml:id="kwd3">Alzheimer's disease</keyword><keyword xml:id="kwd4">hippocampal volume</keyword><keyword xml:id="kwd5">hemispheric volume</keyword></keywordGroup><fundingInfo><fundingAgency>Rejuvenis, Hong Kong Jockey Club Charities Trust and RGC Seed Funding Programme for Basic Research 2006–2007</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>We tested the hypotheses that supplemental intake of the diet supplement Coenzyme Q<sub>10</sub> (CoQ<sub>10</sub>) could delay brain atrophy in double transgenic amyloid precursor protein (APP) / presenilin 1 (PS1), single transgenic APP and PS1 as well as wild type mice by volume MR image <i>in vivo</i>. One hundred and twelve mice (28 APP/PS1, 28 APP, 28 PS1 and 28 wild types) were studied. Half of each genotype group (<i>n</i> = 14 per group) was treated with CoQ<sub>10</sub> 2400 mg/kg/day, and the other half with placebo for 60 days. Magnetic resonance (MR) images were used to obtain the volumes of the hemispheres and hippocampi. APP / PS1, APP, PS1 and wild type mice treated with CoQ<sub>10</sub> exhibited significantly less atrophy in hemisphere and hippocampus than those receiving placebo. The neuro‐protective effect of the CoQ<sub>10</sub> on hemispheric volume, and hippocampal volume was related to genotype; greater in APP/PS1 than APP and PS1 mice and less in wild type mice. Our result indicated that CoQ<sub>10</sub> may have therapeutic potential in the prevention and treatment of MCI and AD.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Diet supplement CoQ10 delays brain atrophy in aged transgenic mice with mutations in the amyloid precursor protein: An in vivo volume MRI study</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Diet supplement CoQ10 delays brain atrophy in aged transgenic mice</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Diet supplement CoQ</title></titleInfo><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="family">Li</namePart><affiliation>Hong Kong Applied Science and Technology Research Institute Company Limited, Hong Kong, HKSAR, China</affiliation><description>Correspondence: Hong Kong Applied Science and Technology Research Institute Company Limited, 5th Floor, Photonics Centre, 2 Science Park East Avenue, Hong Kong Science Park, Shatin, New Territories, Hong Kong, HKSAR, China. Tel.: +852 3406 2620; Fax: +852 3406 2802</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Clifford R.</namePart><namePart type="family">Jack</namePart><affiliation>Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Xi‐Fei</namePart><namePart type="family">Yang</namePart><affiliation>Hong Kong Applied Science and Technology Research Institute Company Limited, Hong Kong, HKSAR, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Edward S.</namePart><namePart type="family">Yang</namePart><affiliation>Hong Kong Applied Science and Technology Research Institute Company Limited, Hong Kong, HKSAR, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>IOS Press</publisher><place><placeTerm type="text">Amsterdam</placeTerm></place><dateIssued encoding="w3cdtf">2008</dateIssued><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">5</extent><extent unit="tables">1</extent><extent unit="references">57</extent></physicalDescription><abstract lang="en">We tested the hypotheses that supplemental intake of the diet supplement Coenzyme Q10 (CoQ10) could delay brain atrophy in double transgenic amyloid precursor protein (APP) / presenilin 1 (PS1), single transgenic APP and PS1 as well as wild type mice by volume MR image in vivo. One hundred and twelve mice (28 APP/PS1, 28 APP, 28 PS1 and 28 wild types) were studied. Half of each genotype group (n = 14 per group) was treated with CoQ10 2400 mg/kg/day, and the other half with placebo for 60 days. Magnetic resonance (MR) images were used to obtain the volumes of the hemispheres and hippocampi. APP / PS1, APP, PS1 and wild type mice treated with CoQ10 exhibited significantly less atrophy in hemisphere and hippocampus than those receiving placebo. The neuro‐protective effect of the CoQ10 on hemispheric volume, and hippocampal volume was related to genotype; greater in APP/PS1 than APP and PS1 mice and less in wild type mice. Our result indicated that CoQ10 may have therapeutic potential in the prevention and treatment of MCI and AD.</abstract><note type="funding">Rejuvenis, Hong Kong Jockey Club Charities Trust and RGC Seed Funding Programme for Basic Research 2006–2007</note><subject lang="en"><genre>Keywords</genre><topic>APP/PS1 double transgenic mice</topic><topic>antioxidant</topic><topic>Alzheimer's disease</topic><topic>hippocampal volume</topic><topic>hemispheric volume</topic></subject><relatedItem type="host"><titleInfo><title>BioFactors</title></titleInfo><titleInfo type="abbreviated"><title>BioFactors</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Article</topic></subject><identifier type="ISSN">0951-6433</identifier><identifier type="eISSN">1872-8081</identifier><identifier type="DOI">10.1002/(ISSN)1872-8081</identifier><identifier type="PublisherID">BIOF</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><detail type="issue"><caption>no.</caption><number>1‐4</number></detail><extent unit="pages"><start>169</start><end>178</end><total>10</total></extent></part></relatedItem><identifier type="istex">01DF26D10B0055A77F7430C325DD96A5FEC3D660</identifier><identifier type="DOI">10.1002/biof.5520320120</identifier><identifier type="ArticleID">BIOF5520320120</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 International Union of Biochemistry and Molecular Biology, Inc.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>IOS Press</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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