Mild Parkinsonian signs are associated with lower olfactory test scores in the community‐dwelling elderly
Identifieur interne : 002039 ( Main/Corpus ); précédent : 002038; suivant : 002040Mild Parkinsonian signs are associated with lower olfactory test scores in the community‐dwelling elderly
Auteurs : Elan D. Louis ; Karen Marder ; Matthias H. Tabert ; Devangere P. DevanandSource :
- Movement Disorders [ 0885-3185 ] ; 2008-03-15.
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Abstract
Mild Parkinsonian signs (MPS, impaired gait, rigidity, bradykinesia, rest tremor) are commonly found during the clinical examination of older people and may be a precursor to Parkinson's disease (PD) or Alzheimer's disease (AD). Marked deficits in olfaction occur in PD and AD. The objective of this study was to determine whether University of Pennsylvania Smell Test (UPSIT) scores were lower in nondemented community‐dwelling elderly with versus without MPS. Nondemented persons age ≥65 years without PD in Washington Heights‐Inwood, NY were evaluated with an abbreviated motor Unified PD Rating Scale and a 40‐item UPSIT. Lower UPSIT and higher transformed UPSIT score (square root [UPSIT ‐ 41]) indicated greater olfactory dysfunction. One‐hundred‐seventy‐seven (16.4%) of 1,078 participants had MPS. Mean UPSIT scores (MPS vs. without MPS) were 24.3 ± 7.1 versus 26.4 ± 6.8, P < 0.001. In a logistic regression analysis adjusting for age and education, transformed UPSIT score was associated with MPS (OR 1.25, 95% CI 1.04–1.52, P = 0.02). In an adjusted logistic regression analysis, participants with higher transformed UPSIT scores (based on a median split) were 1.55 times more likely to have MPS than were those with lower scores (P = 0.01). Within transformed UPSIT score quartiles, the odds of having MPS were 1.0 (reference), 1.35, 2.02, and 2.20 (P < 0.05). The association with transformed UPSIT scores was similar across MPS subtypes (axial dysfunction, rigidity, tremor).MPS were associated with a mild reduction in olfactory function. These observations further support the view of MPS as a marker of emerging degenerative brain pathologies. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21777
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Marked deficits in olfaction occur in PD and AD. The objective of this study was to determine whether University of Pennsylvania Smell Test (UPSIT) scores were lower in nondemented community‐dwelling elderly with versus without MPS. Nondemented persons age ≥65 years without PD in Washington Heights‐Inwood, NY were evaluated with an abbreviated motor Unified PD Rating Scale and a 40‐item UPSIT. Lower UPSIT and higher transformed UPSIT score (square root [UPSIT ‐ 41]) indicated greater olfactory dysfunction. One‐hundred‐seventy‐seven (16.4%) of 1,078 participants had MPS. Mean UPSIT scores (MPS vs. without MPS) were 24.3 ± 7.1 versus 26.4 ± 6.8, P < 0.001. In a logistic regression analysis adjusting for age and education, transformed UPSIT score was associated with MPS (OR 1.25, 95% CI 1.04–1.52, P = 0.02). In an adjusted logistic regression analysis, participants with higher transformed UPSIT scores (based on a median split) were 1.55 times more likely to have MPS than were those with lower scores (P = 0.01). Within transformed UPSIT score quartiles, the odds of having MPS were 1.0 (reference), 1.35, 2.02, and 2.20 (P < 0.05). The association with transformed UPSIT scores was similar across MPS subtypes (axial dysfunction, rigidity, tremor).MPS were associated with a mild reduction in olfactory function. These observations further support the view of MPS as a marker of emerging degenerative brain pathologies. © 2007 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Elan D. Louis MD, MSc</name><affiliations><json:string>The Gertrude H. 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Marked deficits in olfaction occur in PD and AD. The objective of this study was to determine whether University of Pennsylvania Smell Test (UPSIT) scores were lower in nondemented community‐dwelling elderly with versus without MPS. Nondemented persons age ≥65 years without PD in Washington Heights‐Inwood, NY were evaluated with an abbreviated motor Unified PD Rating Scale and a 40‐item UPSIT. Lower UPSIT and higher transformed UPSIT score (square root [UPSIT ‐ 41]) indicated greater olfactory dysfunction. One‐hundred‐seventy‐seven (16.4%) of 1,078 participants had MPS. Mean UPSIT scores (MPS vs. without MPS) were 24.3 ± 7.1 versus 26.4 ± 6.8, P > 0.001. In a logistic regression analysis adjusting for age and education, transformed UPSIT score was associated with MPS (OR 1.25, 95% CI 1.04–1.52, P = 0.02). In an adjusted logistic regression analysis, participants with higher transformed UPSIT scores (based on a median split) were 1.55 times more likely to have MPS than were those with lower scores (P = 0.01). Within transformed UPSIT score quartiles, the odds of having MPS were 1.0 (reference), 1.35, 2.02, and 2.20 (P > 0.05). The association with transformed UPSIT scores was similar across MPS subtypes (axial dysfunction, rigidity, tremor).MPS were associated with a mild reduction in olfactory function. 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Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA</affiliation><affiliation>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA</affiliation><affiliation>Taub Institute for Research of Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA</affiliation><affiliation>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</affiliation></author><author><persName><forename type="first">Karen</forename><surname>Marder</surname></persName><roleName type="degree">MD, MPH</roleName><affiliation>The Gertrude H. 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Marked deficits in olfaction occur in PD and AD. The objective of this study was to determine whether University of Pennsylvania Smell Test (UPSIT) scores were lower in nondemented community‐dwelling elderly with versus without MPS. Nondemented persons age ≥65 years without PD in Washington Heights‐Inwood, NY were evaluated with an abbreviated motor Unified PD Rating Scale and a 40‐item UPSIT. Lower UPSIT and higher transformed UPSIT score (square root [UPSIT ‐ 41]) indicated greater olfactory dysfunction. One‐hundred‐seventy‐seven (16.4%) of 1,078 participants had MPS. Mean UPSIT scores (MPS vs. without MPS) were 24.3 ± 7.1 versus 26.4 ± 6.8, P < 0.001. In a logistic regression analysis adjusting for age and education, transformed UPSIT score was associated with MPS (OR 1.25, 95% CI 1.04–1.52, P = 0.02). In an adjusted logistic regression analysis, participants with higher transformed UPSIT scores (based on a median split) were 1.55 times more likely to have MPS than were those with lower scores (P = 0.01). Within transformed UPSIT score quartiles, the odds of having MPS were 1.0 (reference), 1.35, 2.02, and 2.20 (P < 0.05). The association with transformed UPSIT scores was similar across MPS subtypes (axial dysfunction, rigidity, tremor).MPS were associated with a mild reduction in olfactory function. These observations further support the view of MPS as a marker of emerging degenerative brain pathologies. © 2007 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>mild parkinsonian signs</term></item><item><term>olfaction</term></item><item><term>elderly</term></item><item><term>population</term></item><item><term>epidemiology</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-07-30">Received</change><change when="2007-09-18">Registration</change><change when="2008-03-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/8E1BF07B1A55A38FA97D0A818AAF720FED8E40DD/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>Taub Institute for Research of Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="US" type="organization"><unparsedAffiliation>Department of Geriatric Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="US" type="organization"><unparsedAffiliation>Department of Biological Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="US" type="organization"><unparsedAffiliation>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="US" type="organization"><unparsedAffiliation>New York State Psychiatric Institute, New York, New York, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">mild parkinsonian signs</keyword><keyword xml:id="kwd2">olfaction</keyword><keyword xml:id="kwd3">elderly</keyword><keyword xml:id="kwd4">population</keyword><keyword xml:id="kwd5">epidemiology</keyword></keywordGroup><fundingInfo><fundingAgency>Federal Grants</fundingAgency><fundingNumber>NIH P01 AG07232</fundingNumber><fundingNumber>R01 NS42859</fundingNumber><fundingNumber>RR00645</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Mild Parkinsonian signs (MPS, impaired gait, rigidity, bradykinesia, rest tremor) are commonly found during the clinical examination of older people and may be a precursor to Parkinson's disease (PD) or Alzheimer's disease (AD). Marked deficits in olfaction occur in PD and AD. The objective of this study was to determine whether University of Pennsylvania Smell Test (UPSIT) scores were lower in nondemented community‐dwelling elderly with versus without MPS. Nondemented persons age ≥65 years without PD in Washington Heights‐Inwood, NY were evaluated with an abbreviated motor Unified PD Rating Scale and a 40‐item UPSIT. Lower UPSIT and higher transformed UPSIT score (square root [UPSIT ‐ 41]) indicated greater olfactory dysfunction. One‐hundred‐seventy‐seven (16.4%) of 1,078 participants had MPS. Mean UPSIT scores (MPS vs. without MPS) were 24.3 ± 7.1 versus 26.4 ± 6.8, <i>P</i> < 0.001. In a logistic regression analysis adjusting for age and education, transformed UPSIT score was associated with MPS (OR 1.25, 95% CI 1.04–1.52, <i>P</i> = 0.02). In an adjusted logistic regression analysis, participants with higher transformed UPSIT scores (based on a median split) were 1.55 times more likely to have MPS than were those with lower scores (<i>P</i> = 0.01). Within transformed UPSIT score quartiles, the odds of having MPS were 1.0 (reference), 1.35, 2.02, and 2.20 (<i>P</i> < 0.05). The association with transformed UPSIT scores was similar across MPS subtypes (axial dysfunction, rigidity, tremor).MPS were associated with a mild reduction in olfactory function. These observations further support the view of MPS as a marker of emerging degenerative brain pathologies. © 2007 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Mild Parkinsonian signs are associated with lower olfactory test scores in the community‐dwelling elderly</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>MPS Associated with Lower Olfactory Test Scores</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Mild Parkinsonian signs are associated with lower olfactory test scores in the community‐dwelling elderly</title></titleInfo><name type="personal"><namePart type="given">Elan D.</namePart><namePart type="family">Louis</namePart><namePart type="termsOfAddress">MD, MSc</namePart><affiliation>The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA</affiliation><affiliation>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA</affiliation><affiliation>Taub Institute for Research of Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA</affiliation><affiliation>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</affiliation><description>Correspondence: Unit 198, Neurological Institute, 710 West 168th Street, New York, NY 10032</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Karen</namePart><namePart type="family">Marder</namePart><namePart type="termsOfAddress">MD, MPH</namePart><affiliation>The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA</affiliation><affiliation>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA</affiliation><affiliation>Taub Institute for Research of Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Matthias H.</namePart><namePart type="family">Tabert</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Geriatric Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA</affiliation><affiliation>New York State Psychiatric Institute, New York, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Devangere P.</namePart><namePart type="family">Devanand</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Biological Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA</affiliation><affiliation>New York State Psychiatric Institute, New York, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-03-15</dateIssued><dateCaptured encoding="w3cdtf">2007-07-30</dateCaptured><dateValid encoding="w3cdtf">2007-09-18</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">34</extent><extent unit="words">5086</extent></physicalDescription><abstract lang="en">Mild Parkinsonian signs (MPS, impaired gait, rigidity, bradykinesia, rest tremor) are commonly found during the clinical examination of older people and may be a precursor to Parkinson's disease (PD) or Alzheimer's disease (AD). Marked deficits in olfaction occur in PD and AD. The objective of this study was to determine whether University of Pennsylvania Smell Test (UPSIT) scores were lower in nondemented community‐dwelling elderly with versus without MPS. Nondemented persons age ≥65 years without PD in Washington Heights‐Inwood, NY were evaluated with an abbreviated motor Unified PD Rating Scale and a 40‐item UPSIT. Lower UPSIT and higher transformed UPSIT score (square root [UPSIT ‐ 41]) indicated greater olfactory dysfunction. One‐hundred‐seventy‐seven (16.4%) of 1,078 participants had MPS. Mean UPSIT scores (MPS vs. without MPS) were 24.3 ± 7.1 versus 26.4 ± 6.8, P < 0.001. In a logistic regression analysis adjusting for age and education, transformed UPSIT score was associated with MPS (OR 1.25, 95% CI 1.04–1.52, P = 0.02). In an adjusted logistic regression analysis, participants with higher transformed UPSIT scores (based on a median split) were 1.55 times more likely to have MPS than were those with lower scores (P = 0.01). Within transformed UPSIT score quartiles, the odds of having MPS were 1.0 (reference), 1.35, 2.02, and 2.20 (P < 0.05). The association with transformed UPSIT scores was similar across MPS subtypes (axial dysfunction, rigidity, tremor).MPS were associated with a mild reduction in olfactory function. These observations further support the view of MPS as a marker of emerging degenerative brain pathologies. © 2007 Movement Disorder Society</abstract><note type="funding">Federal Grants - No. NIH P01 AG07232; No. R01 NS42859; No. RR00645; </note><subject lang="en"><genre>Keywords</genre><topic>mild parkinsonian signs</topic><topic>olfaction</topic><topic>elderly</topic><topic>population</topic><topic>epidemiology</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. 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