Safety and Tolerability Assessment of Intrastriatal Neural Allografts in Five Patients with Huntington's Disease
Identifieur interne : 002012 ( Main/Corpus ); précédent : 002011; suivant : 002013Safety and Tolerability Assessment of Intrastriatal Neural Allografts in Five Patients with Huntington's Disease
Auteurs : A.-C. Bachoud-Lévi ; C. Bourdet ; P. Brugières ; J.-P. Nguyen ; T. Grandmougin ; B. Haddad ; R. Jény ; P. Bartolomeo ; M.-F. Boissé ; G. Dalla Barba ; J.-D. Degos ; A.-M. Ergis ; J.-P. Lefaucheur ; F. Lisovoski ; E. Pailhous ; P. Rémy ; S. Palfi ; G. L. Defer ; P. Cesaro ; P. Hantraye ; M. PeschanskiSource :
- Experimental Neurology [ 0014-4886 ] ; 1999.
English descriptors
Abstract
This study describes issues related to the safety and tolerability of fetal striatal neural allografts as assessed in five patients with Huntington's disease. Huntington's disease (HD) is characterized by motor, cognitive, and behavioral disturbances. The latter include psychological disturbances and, as a consequence, we took particular care to analyze behavioral changes, in addition to the usual “safety” follow-up. We conducted multidisciplinary follow-up at least 2 years before and 1 year after grafting. Psychological care extended to close relatives. The grafting procedure itself was altogether safe and uneventful, and there were no apparent clinical deleterious effects for 1 year. The immunosuppressive treatment, however, was complicated by various problems (irregular compliance, errors of handling, side effects). Direct psychological consequences of the transplantation procedure were rare and not worrisome, although mood alteration requiring treatment was observed in one patient. Indirectly, however, the procedure required patients and relatives to accept constraints that tended to complicate familial situations already marred by aggressivity and depression. All patients and close relatives expressed major expectations, in spite of our strong and repeated cautioning. It is clearly important to be aware of these particular conditions since they may eventually translate into psychological difficulties in coping with the long-term clinical outcome of the procedure, if not beneficial. Despite an overall good tolerance, therefore, this follow-up calls for caution regarding the involvement of HD patients in experimental surgical protocols.
Url:
DOI: 10.1006/exnr.1999.7239
Links to Exploration step
ISTEX:D64682DFDD7E38D56E3B9F94E88EDC0FA406447ELe document en format XML
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Bachoud-Lévi</name><affiliation><mods:affiliation>Faculté de Médecine, INSERM U. 421/IM3, 94010, Créteil, France</mods:affiliation></affiliation></author><author><name sortKey="Bourdet, C" sort="Bourdet, C" uniqKey="Bourdet C" first="C." last="Bourdet">C. Bourdet</name><affiliation><mods:affiliation>Service de Psychiatrie, Hôpital Albert Chenevier-AP/HP, 94010, Créteil, France</mods:affiliation></affiliation></author><author><name sortKey="Brugieres, P" sort="Brugieres, P" uniqKey="Brugieres P" first="P." last="Brugières">P. Brugières</name><affiliation><mods:affiliation>Service de Neuroradiologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</mods:affiliation></affiliation></author><author><name sortKey="Nguyen, J P" sort="Nguyen, J P" uniqKey="Nguyen J" first="J.-P." last="Nguyen">J.-P. Nguyen</name><affiliation><mods:affiliation>Service de Neurochirurgie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</mods:affiliation></affiliation></author><author><name sortKey="Grandmougin, T" sort="Grandmougin, T" uniqKey="Grandmougin T" first="T." last="Grandmougin">T. Grandmougin</name><affiliation><mods:affiliation>Service de Psychiatrie, Hôpital Albert Chenevier-AP/HP, 94010, Créteil, France</mods:affiliation></affiliation></author><author><name sortKey="Haddad, B" sort="Haddad, B" uniqKey="Haddad B" first="B." last="Haddad">B. Haddad</name><affiliation><mods:affiliation>Service de Gynécologie, Centre Hospitalier Intercommunal de Créteil, 94010, Créteil, France</mods:affiliation></affiliation></author><author><name sortKey="Jeny, R" sort="Jeny, R" uniqKey="Jeny R" first="R." last="Jény">R. Jény</name><affiliation><mods:affiliation>Service de Gynécologie, Hôpital Esquirol, 94 Saint-Maurice, France</mods:affiliation></affiliation></author><author><name sortKey="Bartolomeo, P" sort="Bartolomeo, P" uniqKey="Bartolomeo P" first="P." last="Bartolomeo">P. Bartolomeo</name><affiliation><mods:affiliation>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</mods:affiliation></affiliation></author><author><name sortKey="Boisse, M F" sort="Boisse, M F" uniqKey="Boisse M" first="M.-F." last="Boissé">M.-F. Boissé</name><affiliation><mods:affiliation>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</mods:affiliation></affiliation></author><author><name sortKey="Barba, G Dalla" sort="Barba, G Dalla" uniqKey="Barba G" first="G. Dalla" last="Barba">G. Dalla Barba</name><affiliation><mods:affiliation>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</mods:affiliation></affiliation></author><author><name sortKey="Degos, J D" sort="Degos, J D" uniqKey="Degos J" first="J.-D." last="Degos">J.-D. Degos</name><affiliation><mods:affiliation>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</mods:affiliation></affiliation></author><author><name sortKey="Ergis, A M" sort="Ergis, A M" uniqKey="Ergis A" first="A.-M." last="Ergis">A.-M. Ergis</name><affiliation><mods:affiliation>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</mods:affiliation></affiliation></author><author><name sortKey="Lefaucheur, J P" sort="Lefaucheur, J P" uniqKey="Lefaucheur J" first="J.-P." last="Lefaucheur">J.-P. Lefaucheur</name><affiliation><mods:affiliation>Service de Physiologie–Explorations Fonctionnelles, CHU Henri Mondor-AP/HP, 94010, Créteil, France</mods:affiliation></affiliation></author><author><name sortKey="Lisovoski, F" sort="Lisovoski, F" uniqKey="Lisovoski F" first="F." last="Lisovoski">F. Lisovoski</name><affiliation><mods:affiliation>Faculté de Médecine, INSERM U. 421/IM3, 94010, Créteil, France</mods:affiliation></affiliation></author><author><name sortKey="Pailhous, E" sort="Pailhous, E" uniqKey="Pailhous E" first="E." last="Pailhous">E. Pailhous</name><affiliation><mods:affiliation>Service de Psychiatrie, Hôpital Albert Chenevier-AP/HP, 94010, Créteil, France</mods:affiliation></affiliation></author><author><name sortKey="Remy, P" sort="Remy, P" uniqKey="Remy P" first="P." last="Rémy">P. Rémy</name><affiliation><mods:affiliation>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</mods:affiliation></affiliation></author><author><name sortKey="Palfi, S" sort="Palfi, S" uniqKey="Palfi S" first="S." last="Palfi">S. Palfi</name><affiliation><mods:affiliation>CEA, CNRS URA 2210, SHFJ, 91406, Orsay, France</mods:affiliation></affiliation></author><author><name sortKey="Defer, G L" sort="Defer, G L" uniqKey="Defer G" first="G. L." last="Defer">G. L. Defer</name><affiliation><mods:affiliation>Service de Neurologie, CHU Côte de Nâcre, 14000, Caen, France</mods:affiliation></affiliation></author><author><name sortKey="Cesaro, P" sort="Cesaro, P" uniqKey="Cesaro P" first="P." last="Cesaro">P. Cesaro</name><affiliation><mods:affiliation>Faculté de Médecine, INSERM U. 421/IM3, 94010, Créteil, France</mods:affiliation></affiliation></author><author><name sortKey="Hantraye, P" sort="Hantraye, P" uniqKey="Hantraye P" first="P." last="Hantraye">P. Hantraye</name><affiliation><mods:affiliation>CEA, CNRS URA 2210, SHFJ, 91406, Orsay, France</mods:affiliation></affiliation></author><author><name sortKey="Peschanski, M" sort="Peschanski, M" uniqKey="Peschanski M" first="M." last="Peschanski">M. Peschanski</name><affiliation><mods:affiliation>Faculté de Médecine, INSERM U. 421/IM3, 94010, Créteil, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Experimental Neurology</title><title level="j" type="abbrev">YEXNR</title><idno type="ISSN">0014-4886</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">161</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="194">194</biblScope><biblScope unit="page" to="202">202</biblScope></imprint><idno type="ISSN">0014-4886</idno></series><idno type="istex">D64682DFDD7E38D56E3B9F94E88EDC0FA406447E</idno><idno type="DOI">10.1006/exnr.1999.7239</idno><idno type="PII">S0014-4886(99)97239-4</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-4886</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Huntington's disease</term><term>fetal neural transplants.</term><term>safety and tolerability</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study describes issues related to the safety and tolerability of fetal striatal neural allografts as assessed in five patients with Huntington's disease. Huntington's disease (HD) is characterized by motor, cognitive, and behavioral disturbances. The latter include psychological disturbances and, as a consequence, we took particular care to analyze behavioral changes, in addition to the usual “safety” follow-up. We conducted multidisciplinary follow-up at least 2 years before and 1 year after grafting. Psychological care extended to close relatives. The grafting procedure itself was altogether safe and uneventful, and there were no apparent clinical deleterious effects for 1 year. The immunosuppressive treatment, however, was complicated by various problems (irregular compliance, errors of handling, side effects). Direct psychological consequences of the transplantation procedure were rare and not worrisome, although mood alteration requiring treatment was observed in one patient. Indirectly, however, the procedure required patients and relatives to accept constraints that tended to complicate familial situations already marred by aggressivity and depression. All patients and close relatives expressed major expectations, in spite of our strong and repeated cautioning. It is clearly important to be aware of these particular conditions since they may eventually translate into psychological difficulties in coping with the long-term clinical outcome of the procedure, if not beneficial. Despite an overall good tolerance, therefore, this follow-up calls for caution regarding the involvement of HD patients in experimental surgical protocols.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>A.-C. Bachoud-Lévi</name><affiliations><json:string>Faculté de Médecine, INSERM U. 421/IM3, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>C. Bourdet</name><affiliations><json:string>Service de Psychiatrie, Hôpital Albert Chenevier-AP/HP, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>P. Brugières</name><affiliations><json:string>Service de Neuroradiologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>J.-P. Nguyen</name><affiliations><json:string>Service de Neurochirurgie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>T. Grandmougin</name><affiliations><json:string>Service de Psychiatrie, Hôpital Albert Chenevier-AP/HP, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>B. Haddad</name><affiliations><json:string>Service de Gynécologie, Centre Hospitalier Intercommunal de Créteil, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>R. Jény</name><affiliations><json:string>Service de Gynécologie, Hôpital Esquirol, 94 Saint-Maurice, France</json:string></affiliations></json:item><json:item><name>P. Bartolomeo</name><affiliations><json:string>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>M.-F. Boissé</name><affiliations><json:string>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>G.Dalla Barba</name><affiliations><json:string>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>J.-D. Degos</name><affiliations><json:string>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>A.-M. Ergis</name><affiliations><json:string>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>J.-P. Lefaucheur</name><affiliations><json:string>Service de Physiologie–Explorations Fonctionnelles, CHU Henri Mondor-AP/HP, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>F. Lisovoski</name><affiliations><json:string>Faculté de Médecine, INSERM U. 421/IM3, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>E. Pailhous</name><affiliations><json:string>Service de Psychiatrie, Hôpital Albert Chenevier-AP/HP, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>P. Rémy</name><affiliations><json:string>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>S. Palfi</name><affiliations><json:string>CEA, CNRS URA 2210, SHFJ, 91406, Orsay, France</json:string></affiliations></json:item><json:item><name>G.L. Defer</name><affiliations><json:string>Service de Neurologie, CHU Côte de Nâcre, 14000, Caen, France</json:string></affiliations></json:item><json:item><name>P. Cesaro</name><affiliations><json:string>Faculté de Médecine, INSERM U. 421/IM3, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>P. Hantraye</name><affiliations><json:string>CEA, CNRS URA 2210, SHFJ, 91406, Orsay, France</json:string></affiliations></json:item><json:item><name>M. Peschanski</name><affiliations><json:string>Faculté de Médecine, INSERM U. 421/IM3, 94010, Créteil, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Huntington's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>safety and tolerability</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>fetal neural transplants.</value></json:item></subject><language><json:string>eng</json:string></language><abstract>This study describes issues related to the safety and tolerability of fetal striatal neural allografts as assessed in five patients with Huntington's disease. Huntington's disease (HD) is characterized by motor, cognitive, and behavioral disturbances. The latter include psychological disturbances and, as a consequence, we took particular care to analyze behavioral changes, in addition to the usual “safety” follow-up. We conducted multidisciplinary follow-up at least 2 years before and 1 year after grafting. Psychological care extended to close relatives. The grafting procedure itself was altogether safe and uneventful, and there were no apparent clinical deleterious effects for 1 year. The immunosuppressive treatment, however, was complicated by various problems (irregular compliance, errors of handling, side effects). Direct psychological consequences of the transplantation procedure were rare and not worrisome, although mood alteration requiring treatment was observed in one patient. Indirectly, however, the procedure required patients and relatives to accept constraints that tended to complicate familial situations already marred by aggressivity and depression. All patients and close relatives expressed major expectations, in spite of our strong and repeated cautioning. It is clearly important to be aware of these particular conditions since they may eventually translate into psychological difficulties in coping with the long-term clinical outcome of the procedure, if not beneficial. Despite an overall good tolerance, therefore, this follow-up calls for caution regarding the involvement of HD patients in experimental surgical protocols.</abstract><qualityIndicators><score>7.736</score><pdfVersion>1.2</pdfVersion><pdfPageSize>554 x 734 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>3</keywordCount><abstractCharCount>1667</abstractCharCount><pdfWordCount>5480</pdfWordCount><pdfCharCount>34207</pdfCharCount><pdfPageCount>9</pdfPageCount><abstractWordCount>228</abstractWordCount></qualityIndicators><title>Safety and Tolerability Assessment of Intrastriatal Neural Allografts in Five Patients with Huntington's Disease</title><pii><json:string>S0014-4886(99)97239-4</json:string></pii><genre><json:string>research-article</json:string></genre><host><volume>161</volume><pii><json:string>S0014-4886(00)X0025-8</json:string></pii><pages><last>202</last><first>194</first></pages><issn><json:string>0014-4886</json:string></issn><issue>1</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>Experimental Neurology</title><publicationDate>2000</publicationDate></host><categories><wos><json:string>NEUROSCIENCES</json:string></wos></categories><publicationDate>1999</publicationDate><copyrightDate>2000</copyrightDate><doi><json:string>10.1006/exnr.1999.7239</json:string></doi><id>D64682DFDD7E38D56E3B9F94E88EDC0FA406447E</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/D64682DFDD7E38D56E3B9F94E88EDC0FA406447E/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/D64682DFDD7E38D56E3B9F94E88EDC0FA406447E/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/D64682DFDD7E38D56E3B9F94E88EDC0FA406447E/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Safety and Tolerability Assessment of Intrastriatal Neural Allografts in Five Patients with Huntington's Disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>2000</date></publicationStmt><notesStmt><note type="content">Section title: Regular Article</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Safety and Tolerability Assessment of Intrastriatal Neural Allografts in Five Patients with Huntington's Disease</title><author><persName><forename type="first">A.-C.</forename><surname>Bachoud-Lévi</surname></persName><affiliation>Faculté de Médecine, INSERM U. 421/IM3, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">C.</forename><surname>Bourdet</surname></persName><affiliation>Service de Psychiatrie, Hôpital Albert Chenevier-AP/HP, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">P.</forename><surname>Brugières</surname></persName><affiliation>Service de Neuroradiologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">J.-P.</forename><surname>Nguyen</surname></persName><affiliation>Service de Neurochirurgie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">T.</forename><surname>Grandmougin</surname></persName><affiliation>Service de Psychiatrie, Hôpital Albert Chenevier-AP/HP, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">B.</forename><surname>Haddad</surname></persName><affiliation>Service de Gynécologie, Centre Hospitalier Intercommunal de Créteil, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">R.</forename><surname>Jény</surname></persName><affiliation>Service de Gynécologie, Hôpital Esquirol, 94 Saint-Maurice, France</affiliation></author><author><persName><forename type="first">P.</forename><surname>Bartolomeo</surname></persName><affiliation>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">M.-F.</forename><surname>Boissé</surname></persName><affiliation>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">G.Dalla</forename><surname>Barba</surname></persName><affiliation>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">J.-D.</forename><surname>Degos</surname></persName><affiliation>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">A.-M.</forename><surname>Ergis</surname></persName><affiliation>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">J.-P.</forename><surname>Lefaucheur</surname></persName><affiliation>Service de Physiologie–Explorations Fonctionnelles, CHU Henri Mondor-AP/HP, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">F.</forename><surname>Lisovoski</surname></persName><affiliation>Faculté de Médecine, INSERM U. 421/IM3, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">E.</forename><surname>Pailhous</surname></persName><affiliation>Service de Psychiatrie, Hôpital Albert Chenevier-AP/HP, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">P.</forename><surname>Rémy</surname></persName><affiliation>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">S.</forename><surname>Palfi</surname></persName><affiliation>CEA, CNRS URA 2210, SHFJ, 91406, Orsay, France</affiliation></author><author><persName><forename type="first">G.L.</forename><surname>Defer</surname></persName><affiliation>Service de Neurologie, CHU Côte de Nâcre, 14000, Caen, France</affiliation></author><author><persName><forename type="first">P.</forename><surname>Cesaro</surname></persName><affiliation>Faculté de Médecine, INSERM U. 421/IM3, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">P.</forename><surname>Hantraye</surname></persName><affiliation>CEA, CNRS URA 2210, SHFJ, 91406, Orsay, France</affiliation></author><author><persName><forename type="first">M.</forename><surname>Peschanski</surname></persName><affiliation>Faculté de Médecine, INSERM U. 421/IM3, 94010, Créteil, France</affiliation></author></analytic><monogr><title level="j">Experimental Neurology</title><title level="j" type="abbrev">YEXNR</title><idno type="pISSN">0014-4886</idno><idno type="PII">S0014-4886(00)X0025-8</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999"></date><biblScope unit="volume">161</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="194">194</biblScope><biblScope unit="page" to="202">202</biblScope></imprint></monogr><idno type="istex">D64682DFDD7E38D56E3B9F94E88EDC0FA406447E</idno><idno type="DOI">10.1006/exnr.1999.7239</idno><idno type="PII">S0014-4886(99)97239-4</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2000</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>This study describes issues related to the safety and tolerability of fetal striatal neural allografts as assessed in five patients with Huntington's disease. Huntington's disease (HD) is characterized by motor, cognitive, and behavioral disturbances. The latter include psychological disturbances and, as a consequence, we took particular care to analyze behavioral changes, in addition to the usual “safety” follow-up. We conducted multidisciplinary follow-up at least 2 years before and 1 year after grafting. Psychological care extended to close relatives. The grafting procedure itself was altogether safe and uneventful, and there were no apparent clinical deleterious effects for 1 year. The immunosuppressive treatment, however, was complicated by various problems (irregular compliance, errors of handling, side effects). Direct psychological consequences of the transplantation procedure were rare and not worrisome, although mood alteration requiring treatment was observed in one patient. Indirectly, however, the procedure required patients and relatives to accept constraints that tended to complicate familial situations already marred by aggressivity and depression. All patients and close relatives expressed major expectations, in spite of our strong and repeated cautioning. It is clearly important to be aware of these particular conditions since they may eventually translate into psychological difficulties in coping with the long-term clinical outcome of the procedure, if not beneficial. Despite an overall good tolerance, therefore, this follow-up calls for caution regarding the involvement of HD patients in experimental surgical protocols.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Huntington's disease</term></item><item><term>safety and tolerability</term></item><item><term>fetal neural transplants.</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1999-09-10">Registration</change><change when="1999">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/D64682DFDD7E38D56E3B9F94E88EDC0FA406447E/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>YEXNR</jid><aid>97239</aid><ce:pii>S0014-4886(99)97239-4</ce:pii><ce:doi>10.1006/exnr.1999.7239</ce:doi><ce:copyright type="full-transfer" year="2000">Academic Press</ce:copyright></item-info><head><ce:dochead><ce:textfn>Regular Article</ce:textfn></ce:dochead><ce:title>Safety and Tolerability Assessment of Intrastriatal Neural Allografts in Five Patients with Huntington's Disease</ce:title><ce:author-group><ce:author><ce:given-name>A.-C.</ce:given-name><ce:surname>Bachoud-Lévi</ce:surname><ce:cross-ref refid="A1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="A2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="A3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>C.</ce:given-name><ce:surname>Bourdet</ce:surname><ce:cross-ref refid="A4"><ce:sup>d</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>P.</ce:given-name><ce:surname>Brugières</ce:surname><ce:cross-ref refid="A5"><ce:sup>e</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.-P.</ce:given-name><ce:surname>Nguyen</ce:surname><ce:cross-ref refid="A6"><ce:sup>f</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>T.</ce:given-name><ce:surname>Grandmougin</ce:surname><ce:cross-ref refid="A4"><ce:sup>d</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>B.</ce:given-name><ce:surname>Haddad</ce:surname><ce:cross-ref refid="A7"><ce:sup>g</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>R.</ce:given-name><ce:surname>Jény</ce:surname><ce:cross-ref refid="A8"><ce:sup>h</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>P.</ce:given-name><ce:surname>Bartolomeo</ce:surname><ce:cross-ref refid="A2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="A9"><ce:sup>i</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>M.-F.</ce:given-name><ce:surname>Boissé</ce:surname><ce:cross-ref refid="A2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>G.Dalla</ce:given-name><ce:surname>Barba</ce:surname><ce:cross-ref refid="A2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="A9"><ce:sup>i</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.-D.</ce:given-name><ce:surname>Degos</ce:surname><ce:cross-ref refid="A2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>A.-M.</ce:given-name><ce:surname>Ergis</ce:surname><ce:cross-ref refid="A2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="A9"><ce:sup>i</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.-P.</ce:given-name><ce:surname>Lefaucheur</ce:surname><ce:cross-ref refid="A10"><ce:sup>j</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>F.</ce:given-name><ce:surname>Lisovoski</ce:surname><ce:cross-ref refid="A1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="A11"><ce:sup>k</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>E.</ce:given-name><ce:surname>Pailhous</ce:surname><ce:cross-ref refid="A4"><ce:sup>d</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>P.</ce:given-name><ce:surname>Rémy</ce:surname><ce:cross-ref refid="A2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="A12"><ce:sup>l</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>S.</ce:given-name><ce:surname>Palfi</ce:surname><ce:cross-ref refid="A13"><ce:sup>m</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>G.L.</ce:given-name><ce:surname>Defer</ce:surname><ce:cross-ref refid="A14"><ce:sup>n</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>P.</ce:given-name><ce:surname>Cesaro</ce:surname><ce:cross-ref refid="A1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="A2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>P.</ce:given-name><ce:surname>Hantraye</ce:surname><ce:cross-ref refid="A13"><ce:sup>m</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>M.</ce:given-name><ce:surname>Peschanski</ce:surname><ce:cross-ref refid="A1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="A1"><ce:label>a</ce:label><ce:textfn>Faculté de Médecine, INSERM U. 421/IM3, 94010, Créteil, France</ce:textfn></ce:affiliation><ce:affiliation id="A2"><ce:label>b</ce:label><ce:textfn>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</ce:textfn></ce:affiliation><ce:affiliation id="A5"><ce:label>e</ce:label><ce:textfn>Service de Neuroradiologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</ce:textfn></ce:affiliation><ce:affiliation id="A6"><ce:label>f</ce:label><ce:textfn>Service de Neurochirurgie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</ce:textfn></ce:affiliation><ce:affiliation id="A10"><ce:label>j</ce:label><ce:textfn>Service de Physiologie–Explorations Fonctionnelles, CHU Henri Mondor-AP/HP, 94010, Créteil, France</ce:textfn></ce:affiliation><ce:affiliation id="A3"><ce:label>c</ce:label><ce:textfn>LSCP (CNRS, EHESS), 75006, Paris, France</ce:textfn></ce:affiliation><ce:affiliation id="A4"><ce:label>d</ce:label><ce:textfn>Service de Psychiatrie, Hôpital Albert Chenevier-AP/HP, 94010, Créteil, France</ce:textfn></ce:affiliation><ce:affiliation id="A7"><ce:label>g</ce:label><ce:textfn>Service de Gynécologie, Centre Hospitalier Intercommunal de Créteil, 94010, Créteil, France</ce:textfn></ce:affiliation><ce:affiliation id="A8"><ce:label>h</ce:label><ce:textfn>Service de Gynécologie, Hôpital Esquirol, 94 Saint-Maurice, France</ce:textfn></ce:affiliation><ce:affiliation id="A9"><ce:label>i</ce:label><ce:textfn>INSERM U 324, Centre Paul Broca, 75014, Paris, France</ce:textfn></ce:affiliation><ce:affiliation id="A11"><ce:label>k</ce:label><ce:textfn>Service de Neurologie, CHU Maison Blanche, 51092, Reims, France</ce:textfn></ce:affiliation><ce:affiliation id="A12"><ce:label>l</ce:label><ce:textfn>SHFJ, 91406, Orsay, France</ce:textfn></ce:affiliation><ce:affiliation id="A13"><ce:label>m</ce:label><ce:textfn>CEA, CNRS URA 2210, SHFJ, 91406, Orsay, France</ce:textfn></ce:affiliation><ce:affiliation id="A14"><ce:label>n</ce:label><ce:textfn>Service de Neurologie, CHU Côte de Nâcre, 14000, Caen, France</ce:textfn></ce:affiliation></ce:author-group><ce:date-received day="1" month="4" year="1999"></ce:date-received><ce:date-accepted day="10" month="9" year="1999"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>This study describes issues related to the safety and tolerability of fetal striatal neural allografts as assessed in five patients with Huntington's disease. Huntington's disease (HD) is characterized by motor, cognitive, and behavioral disturbances. The latter include psychological disturbances and, as a consequence, we took particular care to analyze behavioral changes, in addition to the usual “safety” follow-up. We conducted multidisciplinary follow-up at least 2 years before and 1 year after grafting. Psychological care extended to close relatives. The grafting procedure itself was altogether safe and uneventful, and there were no apparent clinical deleterious effects for 1 year. The immunosuppressive treatment, however, was complicated by various problems (irregular compliance, errors of handling, side effects). Direct psychological consequences of the transplantation procedure were rare and not worrisome, although mood alteration requiring treatment was observed in one patient. Indirectly, however, the procedure required patients and relatives to accept constraints that tended to complicate familial situations already marred by aggressivity and depression. All patients and close relatives expressed major expectations, in spite of our strong and repeated cautioning. It is clearly important to be aware of these particular conditions since they may eventually translate into psychological difficulties in coping with the long-term clinical outcome of the procedure, if not beneficial. Despite an overall good tolerance, therefore, this follow-up calls for caution regarding the involvement of HD patients in experimental surgical protocols.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Huntington's disease</ce:text></ce:keyword><ce:keyword><ce:text>safety and tolerability</ce:text></ce:keyword><ce:keyword><ce:text>fetal neural transplants.</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Safety and Tolerability Assessment of Intrastriatal Neural Allografts in Five Patients with Huntington's Disease</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Safety and Tolerability Assessment of Intrastriatal Neural Allografts in Five Patients with Huntington's Disease</title></titleInfo><name type="personal"><namePart type="given">A.-C.</namePart><namePart type="family">Bachoud-Lévi</namePart><affiliation>Faculté de Médecine, INSERM U. 421/IM3, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Bourdet</namePart><affiliation>Service de Psychiatrie, Hôpital Albert Chenevier-AP/HP, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Brugières</namePart><affiliation>Service de Neuroradiologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.-P.</namePart><namePart type="family">Nguyen</namePart><affiliation>Service de Neurochirurgie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Grandmougin</namePart><affiliation>Service de Psychiatrie, Hôpital Albert Chenevier-AP/HP, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Haddad</namePart><affiliation>Service de Gynécologie, Centre Hospitalier Intercommunal de Créteil, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Jény</namePart><affiliation>Service de Gynécologie, Hôpital Esquirol, 94 Saint-Maurice, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Bartolomeo</namePart><affiliation>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.-F.</namePart><namePart type="family">Boissé</namePart><affiliation>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.Dalla</namePart><namePart type="family">Barba</namePart><affiliation>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.-D.</namePart><namePart type="family">Degos</namePart><affiliation>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.-M.</namePart><namePart type="family">Ergis</namePart><affiliation>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.-P.</namePart><namePart type="family">Lefaucheur</namePart><affiliation>Service de Physiologie–Explorations Fonctionnelles, CHU Henri Mondor-AP/HP, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Lisovoski</namePart><affiliation>Faculté de Médecine, INSERM U. 421/IM3, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Pailhous</namePart><affiliation>Service de Psychiatrie, Hôpital Albert Chenevier-AP/HP, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Rémy</namePart><affiliation>Service de Neurologie, CHU Henri Mondor-AP/HP, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Palfi</namePart><affiliation>CEA, CNRS URA 2210, SHFJ, 91406, Orsay, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.L.</namePart><namePart type="family">Defer</namePart><affiliation>Service de Neurologie, CHU Côte de Nâcre, 14000, Caen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Cesaro</namePart><affiliation>Faculté de Médecine, INSERM U. 421/IM3, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Hantraye</namePart><affiliation>CEA, CNRS URA 2210, SHFJ, 91406, Orsay, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Peschanski</namePart><affiliation>Faculté de Médecine, INSERM U. 421/IM3, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1999</dateIssued><dateValid encoding="w3cdtf">1999-09-10</dateValid><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">This study describes issues related to the safety and tolerability of fetal striatal neural allografts as assessed in five patients with Huntington's disease. Huntington's disease (HD) is characterized by motor, cognitive, and behavioral disturbances. The latter include psychological disturbances and, as a consequence, we took particular care to analyze behavioral changes, in addition to the usual “safety” follow-up. We conducted multidisciplinary follow-up at least 2 years before and 1 year after grafting. Psychological care extended to close relatives. The grafting procedure itself was altogether safe and uneventful, and there were no apparent clinical deleterious effects for 1 year. The immunosuppressive treatment, however, was complicated by various problems (irregular compliance, errors of handling, side effects). Direct psychological consequences of the transplantation procedure were rare and not worrisome, although mood alteration requiring treatment was observed in one patient. Indirectly, however, the procedure required patients and relatives to accept constraints that tended to complicate familial situations already marred by aggressivity and depression. All patients and close relatives expressed major expectations, in spite of our strong and repeated cautioning. It is clearly important to be aware of these particular conditions since they may eventually translate into psychological difficulties in coping with the long-term clinical outcome of the procedure, if not beneficial. Despite an overall good tolerance, therefore, this follow-up calls for caution regarding the involvement of HD patients in experimental surgical protocols.</abstract><note type="content">Section title: Regular Article</note><subject lang="en"><genre>Keywords</genre><topic>Huntington's disease</topic><topic>safety and tolerability</topic><topic>fetal neural transplants.</topic></subject><relatedItem type="host"><titleInfo><title>Experimental Neurology</title></titleInfo><titleInfo type="abbreviated"><title>YEXNR</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">200001</dateIssued></originInfo><identifier type="ISSN">0014-4886</identifier><identifier type="PII">S0014-4886(00)X0025-8</identifier><part><date>200001</date><detail type="volume"><number>161</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>432</end></extent><extent unit="pages"><start>194</start><end>202</end></extent></part></relatedItem><identifier type="istex">D64682DFDD7E38D56E3B9F94E88EDC0FA406447E</identifier><identifier type="DOI">10.1006/exnr.1999.7239</identifier><identifier type="PII">S0014-4886(99)97239-4</identifier><accessCondition type="use and reproduction" contentType="">© 2000Academic Press</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Academic Press, ©2000</recordOrigin></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/D64682DFDD7E38D56E3B9F94E88EDC0FA406447E/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">NEUROSCIENCES</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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