Diagnostic value of brain MRI and 18F‐FDG PET in the differentiation of parkinsonian type multiple system atrophy from Parkinson’s disease
Identifieur interne : 001E25 ( Main/Corpus ); précédent : 001E24; suivant : 001E26Diagnostic value of brain MRI and 18F‐FDG PET in the differentiation of parkinsonian type multiple system atrophy from Parkinson’s disease
Auteurs : K. Kwon ; C. G. Choi ; J. S. Kim ; M. C. Lee ; S. J. ChungSource :
- European Journal of Neurology [ 1351-5101 ] ; 2008-10.
English descriptors
- KwdEn :
Abstract
Background and purpose: Differentiation between parkinsonian type multiple system atrophy (MSA‐P) and Parkinson’s disease (PD) is important but often difficult. We investigated the diagnostic value of brain magnetic resonance imaging (MRI) and 18F‐fluorodeoxyglucose positron emission tomography (18F‐FDG PET) in differentiating MSA‐P from PD. Methods: Twenty‐four patients with MSA‐P (16 probable and 8 possible) and eight patients with PD were included in this study. Results: For analysis using the putaminal findings, the sensitivities were 58.3% by visual analysis of brain MRI, 95.8% by visual analysis of 18F‐FDG PET, and 79.2% by statistical parametric mapping (SPM) analysis of 18F‐FDG PET in differentiating MSA‐P from PD; the specificity was 100% for each analysis. Using the putaminal findings, visual analysis of 18F‐FDG PET had a higher sensitivity compared with brain MRI (P = 0.004) and SPM analysis of 18F‐FDG PET revealed a tendency towards higher sensitivity compared with brain MRI (P = 0.063). For analysis using both putaminal and infratentorial findings, the sensitivities were 79.2% by visual analysis of brain MRI, 95.8% by visual analysis of 18F‐FDG PET, 95.8% by SPM analysis of 18F‐FDG PET in differentiating MSA‐P from PD; the specificity was 100% for each analysis. Conclusion: Both brain MRI and 18F‐FDG PET showed diagnostic usefulness in differentiating MSA‐P from PD, with 18F‐FDG PET being more sensitive than brain MRI.
Url:
DOI: 10.1111/j.1468-1331.2008.02235.x
Links to Exploration step
ISTEX:C524F8DED52BBB1DD6DC0A6A462FE3CDEE0DEFB6Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diagnostic value of brain MRI and 18F‐FDG PET in the differentiation of parkinsonian type multiple system atrophy from Parkinson’s disease</title><author><name sortKey="Kwon, K" sort="Kwon, K" uniqKey="Kwon K" first="K." last="Kwon">K. Kwon</name><affiliation><mods:affiliation>Department of Neurology, Center for Parkinsonism and Other Movement Disorders</mods:affiliation></affiliation></author><author><name sortKey="Choi, C G" sort="Choi, C G" uniqKey="Choi C" first="C. G." last="Choi">C. G. Choi</name><affiliation><mods:affiliation>Departments of Radiology</mods:affiliation></affiliation></author><author><name sortKey="Kim, J S" sort="Kim, J S" uniqKey="Kim J" first="J. S." last="Kim">J. S. Kim</name><affiliation><mods:affiliation>Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Lee, M C" sort="Lee, M C" uniqKey="Lee M" first="M. C." last="Lee">M. C. Lee</name><affiliation><mods:affiliation>Department of Neurology, Center for Parkinsonism and Other Movement Disorders</mods:affiliation></affiliation></author><author><name sortKey="Chung, S J" sort="Chung, S J" uniqKey="Chung S" first="S. J." last="Chung">S. J. Chung</name><affiliation><mods:affiliation>Department of Neurology, Center for Parkinsonism and Other Movement Disorders</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C524F8DED52BBB1DD6DC0A6A462FE3CDEE0DEFB6</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1111/j.1468-1331.2008.02235.x</idno><idno type="url">https://api.istex.fr/document/C524F8DED52BBB1DD6DC0A6A462FE3CDEE0DEFB6/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001E25</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Diagnostic value of brain MRI and 18F‐FDG PET in the differentiation of parkinsonian type multiple system atrophy from Parkinson’s disease</title><author><name sortKey="Kwon, K" sort="Kwon, K" uniqKey="Kwon K" first="K." last="Kwon">K. Kwon</name><affiliation><mods:affiliation>Department of Neurology, Center for Parkinsonism and Other Movement Disorders</mods:affiliation></affiliation></author><author><name sortKey="Choi, C G" sort="Choi, C G" uniqKey="Choi C" first="C. G." last="Choi">C. G. Choi</name><affiliation><mods:affiliation>Departments of Radiology</mods:affiliation></affiliation></author><author><name sortKey="Kim, J S" sort="Kim, J S" uniqKey="Kim J" first="J. S." last="Kim">J. S. Kim</name><affiliation><mods:affiliation>Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Lee, M C" sort="Lee, M C" uniqKey="Lee M" first="M. C." last="Lee">M. C. Lee</name><affiliation><mods:affiliation>Department of Neurology, Center for Parkinsonism and Other Movement Disorders</mods:affiliation></affiliation></author><author><name sortKey="Chung, S J" sort="Chung, S J" uniqKey="Chung S" first="S. J." last="Chung">S. J. Chung</name><affiliation><mods:affiliation>Department of Neurology, Center for Parkinsonism and Other Movement Disorders</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-10">2008-10</date><biblScope unit="volume">15</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1043">1043</biblScope><biblScope unit="page" to="1049">1049</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">C524F8DED52BBB1DD6DC0A6A462FE3CDEE0DEFB6</idno><idno type="DOI">10.1111/j.1468-1331.2008.02235.x</idno><idno type="ArticleID">ENE2235</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>18F‐fluorodeoxyglucose positron emission tomography</term><term>Parkinson’s disease</term><term>magnetic resonance imaging</term><term>parkinsonian type multiple system atrophy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background and purpose: Differentiation between parkinsonian type multiple system atrophy (MSA‐P) and Parkinson’s disease (PD) is important but often difficult. We investigated the diagnostic value of brain magnetic resonance imaging (MRI) and 18F‐fluorodeoxyglucose positron emission tomography (18F‐FDG PET) in differentiating MSA‐P from PD. Methods: Twenty‐four patients with MSA‐P (16 probable and 8 possible) and eight patients with PD were included in this study. Results: For analysis using the putaminal findings, the sensitivities were 58.3% by visual analysis of brain MRI, 95.8% by visual analysis of 18F‐FDG PET, and 79.2% by statistical parametric mapping (SPM) analysis of 18F‐FDG PET in differentiating MSA‐P from PD; the specificity was 100% for each analysis. Using the putaminal findings, visual analysis of 18F‐FDG PET had a higher sensitivity compared with brain MRI (P = 0.004) and SPM analysis of 18F‐FDG PET revealed a tendency towards higher sensitivity compared with brain MRI (P = 0.063). For analysis using both putaminal and infratentorial findings, the sensitivities were 79.2% by visual analysis of brain MRI, 95.8% by visual analysis of 18F‐FDG PET, 95.8% by SPM analysis of 18F‐FDG PET in differentiating MSA‐P from PD; the specificity was 100% for each analysis. Conclusion: Both brain MRI and 18F‐FDG PET showed diagnostic usefulness in differentiating MSA‐P from PD, with 18F‐FDG PET being more sensitive than brain MRI.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>K.‐Y. Kwon</name><affiliations><json:string>Department of Neurology, Center for Parkinsonism and Other Movement Disorders</json:string></affiliations></json:item><json:item><name>C. G. Choi</name><affiliations><json:string>Departments of Radiology</json:string></affiliations></json:item><json:item><name>J. S. Kim</name><affiliations><json:string>Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>M. C. Lee</name><affiliations><json:string>Department of Neurology, Center for Parkinsonism and Other Movement Disorders</json:string></affiliations></json:item><json:item><name>S. J. Chung</name><affiliations><json:string>Department of Neurology, Center for Parkinsonism and Other Movement Disorders</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>18F‐fluorodeoxyglucose positron emission tomography</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>magnetic resonance imaging</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson’s disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>parkinsonian type multiple system atrophy</value></json:item></subject><articleId><json:string>ENE2235</json:string></articleId><language><json:string>eng</json:string></language><abstract>Background and purpose: Differentiation between parkinsonian type multiple system atrophy (MSA‐P) and Parkinson’s disease (PD) is important but often difficult. We investigated the diagnostic value of brain magnetic resonance imaging (MRI) and 18F‐fluorodeoxyglucose positron emission tomography (18F‐FDG PET) in differentiating MSA‐P from PD. Methods: Twenty‐four patients with MSA‐P (16 probable and 8 possible) and eight patients with PD were included in this study. Results: For analysis using the putaminal findings, the sensitivities were 58.3% by visual analysis of brain MRI, 95.8% by visual analysis of 18F‐FDG PET, and 79.2% by statistical parametric mapping (SPM) analysis of 18F‐FDG PET in differentiating MSA‐P from PD; the specificity was 100% for each analysis. Using the putaminal findings, visual analysis of 18F‐FDG PET had a higher sensitivity compared with brain MRI (P = 0.004) and SPM analysis of 18F‐FDG PET revealed a tendency towards higher sensitivity compared with brain MRI (P = 0.063). For analysis using both putaminal and infratentorial findings, the sensitivities were 79.2% by visual analysis of brain MRI, 95.8% by visual analysis of 18F‐FDG PET, 95.8% by SPM analysis of 18F‐FDG PET in differentiating MSA‐P from PD; the specificity was 100% for each analysis. Conclusion: Both brain MRI and 18F‐FDG PET showed diagnostic usefulness in differentiating MSA‐P from PD, with 18F‐FDG PET being more sensitive than brain MRI.</abstract><qualityIndicators><score>6.583</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1459</abstractCharCount><pdfWordCount>4027</pdfWordCount><pdfCharCount>26680</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>213</abstractWordCount></qualityIndicators><title>Diagnostic value of brain MRI and 18F‐FDG PET in the differentiation of parkinsonian type multiple system atrophy from Parkinson’s disease</title><genre><json:string>article</json:string></genre><host><volume>15</volume><publisherId><json:string>ENE</json:string></publisherId><pages><total>7</total><last>1049</last><first>1043</first></pages><issn><json:string>1351-5101</json:string></issn><issue>10</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1468-1331</json:string></eissn><title>European Journal of Neurology</title><doi><json:string>10.1111/(ISSN)1468-1331</json:string></doi></host><publicationDate>2008</publicationDate><copyrightDate>2008</copyrightDate><doi><json:string>10.1111/j.1468-1331.2008.02235.x</json:string></doi><id>C524F8DED52BBB1DD6DC0A6A462FE3CDEE0DEFB6</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/C524F8DED52BBB1DD6DC0A6A462FE3CDEE0DEFB6/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/C524F8DED52BBB1DD6DC0A6A462FE3CDEE0DEFB6/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/C524F8DED52BBB1DD6DC0A6A462FE3CDEE0DEFB6/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Diagnostic value of brain MRI and 18F‐FDG PET in the differentiation of parkinsonian type multiple system atrophy from Parkinson’s disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>2008</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Diagnostic value of brain MRI and 18F‐FDG PET in the differentiation of parkinsonian type multiple system atrophy from Parkinson’s disease</title><author><persName><forename type="first">K.‐Y.</forename><surname>Kwon</surname></persName><affiliation>Department of Neurology, Center for Parkinsonism and Other Movement Disorders</affiliation></author><author><persName><forename type="first">C. G.</forename><surname>Choi</surname></persName><affiliation>Departments of Radiology</affiliation></author><author><persName><forename type="first">J. S.</forename><surname>Kim</surname></persName><affiliation>Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</affiliation></author><author><persName><forename type="first">M. C.</forename><surname>Lee</surname></persName><affiliation>Department of Neurology, Center for Parkinsonism and Other Movement Disorders</affiliation></author><author><persName><forename type="first">S. J.</forename><surname>Chung</surname></persName><affiliation>Department of Neurology, Center for Parkinsonism and Other Movement Disorders</affiliation></author></analytic><monogr><title level="j">European Journal of Neurology</title><idno type="pISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><idno type="DOI">10.1111/(ISSN)1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-10"></date><biblScope unit="volume">15</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1043">1043</biblScope><biblScope unit="page" to="1049">1049</biblScope></imprint></monogr><idno type="istex">C524F8DED52BBB1DD6DC0A6A462FE3CDEE0DEFB6</idno><idno type="DOI">10.1111/j.1468-1331.2008.02235.x</idno><idno type="ArticleID">ENE2235</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background and purpose: Differentiation between parkinsonian type multiple system atrophy (MSA‐P) and Parkinson’s disease (PD) is important but often difficult. We investigated the diagnostic value of brain magnetic resonance imaging (MRI) and 18F‐fluorodeoxyglucose positron emission tomography (18F‐FDG PET) in differentiating MSA‐P from PD. Methods: Twenty‐four patients with MSA‐P (16 probable and 8 possible) and eight patients with PD were included in this study. Results: For analysis using the putaminal findings, the sensitivities were 58.3% by visual analysis of brain MRI, 95.8% by visual analysis of 18F‐FDG PET, and 79.2% by statistical parametric mapping (SPM) analysis of 18F‐FDG PET in differentiating MSA‐P from PD; the specificity was 100% for each analysis. Using the putaminal findings, visual analysis of 18F‐FDG PET had a higher sensitivity compared with brain MRI (P = 0.004) and SPM analysis of 18F‐FDG PET revealed a tendency towards higher sensitivity compared with brain MRI (P = 0.063). For analysis using both putaminal and infratentorial findings, the sensitivities were 79.2% by visual analysis of brain MRI, 95.8% by visual analysis of 18F‐FDG PET, 95.8% by SPM analysis of 18F‐FDG PET in differentiating MSA‐P from PD; the specificity was 100% for each analysis. Conclusion: Both brain MRI and 18F‐FDG PET showed diagnostic usefulness in differentiating MSA‐P from PD, with 18F‐FDG PET being more sensitive than brain MRI.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>18F‐fluorodeoxyglucose positron emission tomography</term></item><item><term>magnetic resonance imaging</term></item><item><term>Parkinson’s disease</term></item><item><term>parkinsonian type multiple system atrophy</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/C524F8DED52BBB1DD6DC0A6A462FE3CDEE0DEFB6/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1468-1331</doi><issn type="print">1351-5101</issn><issn type="electronic">1468-1331</issn><idGroup><id type="product" value="ENE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF NEUROLOGY">European Journal of Neurology</title></titleGroup></publicationMeta><publicationMeta level="part" position="10010"><doi origin="wiley">10.1111/ene.2008.15.issue-10</doi><numberingGroup><numbering type="journalVolume" number="15">15</numbering><numbering type="journalIssue" number="10">10</numbering></numberingGroup><coverDate startDate="2008-10">October 2008</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="5" status="forIssue"><doi origin="wiley">10.1111/j.1468-1331.2008.02235.x</doi><idGroup><id type="unit" value="ENE2235"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><copyright>© 2008 The Author(s). Journal compilation © 2008 EFNS</copyright><eventGroup><event type="firstOnline" date="2008-08-20"></event><event type="publishedOnlineFinalForm" date="2008-09-05"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-06"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-24"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="1043">1043</numbering><numbering type="pageLast" number="1049">1049</numbering></numberingGroup><correspondenceTo>Sun Ju Chung, MD, PhD, Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 388‐1, Poongnap‐dong, Songpa‐gu, Seoul 138‐736, South Korea (tel.: +82 2 3010 3988; fax: +82 2 474 4691; e‐mail: <email>sjchung@amc.seoul.kr</email>).</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ENE.ENE2235.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 8 February 2008 Accepted 27 May 2008</unparsedEditorialHistory><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="4"></count></countGroup><titleGroup><title type="main">Diagnostic value of brain MRI and <sup>18</sup>F‐FDG PET in the differentiation of parkinsonian type multiple system atrophy from Parkinson’s disease</title><title type="shortAuthors">K.‐Y. Kwon <i>et al.</i></title><title type="short">Diagnostic value of brain MRI and <sup>18</sup>F‐FDG PET in differentiating MSA‐P from PD</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>K.‐Y.</givenNames><familyName>Kwon</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>C. G.</givenNames><familyName>Choi</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3"><personName><givenNames>J. S.</givenNames><familyName>Kim</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>M. C.</givenNames><familyName>Lee</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>S. J.</givenNames><familyName>Chung</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Department of Neurology, Center for Parkinsonism and Other Movement Disorders</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>Departments of Radiology</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="KR"><unparsedAffiliation>Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1"><sup>18</sup>F‐fluorodeoxyglucose positron emission tomography</keyword><keyword xml:id="k2">magnetic resonance imaging</keyword><keyword xml:id="k3">Parkinson’s disease</keyword><keyword xml:id="k4">parkinsonian type multiple system atrophy</keyword></keywordGroup><supportingInformation><p><b>Table S1.</b> Neuroimaging based diagnosis in 13 patients with MSA‐P, who showed no cerebellar symptom, and eight patients with PD.</p><p>Please note: Blackwell Publishing are not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing material) should be directed to the corresponding author for the article.</p><supportingInfoItem><mediaResource alt="supporting info item" href="urn-x:wiley:13515101:media:ene2235:ENE_2235_sm_table_Supplement"></mediaResource><caption>Supporting info item</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><p><b>Background and purpose: </b> Differentiation between parkinsonian type multiple system atrophy (MSA‐P) and Parkinson’s disease (PD) is important but often difficult. We investigated the diagnostic value of brain magnetic resonance imaging (MRI) and <sup>18</sup>F‐fluorodeoxyglucose positron emission tomography (<sup>18</sup>F‐FDG PET) in differentiating MSA‐P from PD.</p><p><b>Methods: </b> Twenty‐four patients with MSA‐P (16 probable and 8 possible) and eight patients with PD were included in this study.</p><p><b>Results: </b> For analysis using the putaminal findings, the sensitivities were 58.3% by visual analysis of brain MRI, 95.8% by visual analysis of <sup>18</sup>F‐FDG PET, and 79.2% by statistical parametric mapping (SPM) analysis of <sup>18</sup>F‐FDG PET in differentiating MSA‐P from PD; the specificity was 100% for each analysis. Using the putaminal findings, visual analysis of <sup>18</sup>F‐FDG PET had a higher sensitivity compared with brain MRI (<i>P</i> = 0.004) and SPM analysis of <sup>18</sup>F‐FDG PET revealed a tendency towards higher sensitivity compared with brain MRI (<i>P</i> = 0.063). For analysis using both putaminal and infratentorial findings, the sensitivities were 79.2% by visual analysis of brain MRI, 95.8% by visual analysis of <sup>18</sup>F‐FDG PET, 95.8% by SPM analysis of <sup>18</sup>F‐FDG PET in differentiating MSA‐P from PD; the specificity was 100% for each analysis.</p><p><b>Conclusion: </b> Both brain MRI and <sup>18</sup>F‐FDG PET showed diagnostic usefulness in differentiating MSA‐P from PD, with <sup>18</sup>F‐FDG PET being more sensitive than brain MRI.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Diagnostic value of brain MRI and 18F‐FDG PET in the differentiation of parkinsonian type multiple system atrophy from Parkinson’s disease</title></titleInfo><titleInfo type="abbreviated"><title>Diagnostic value of brain MRI and 18F‐FDG PET in differentiating MSA‐P from PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Diagnostic value of brain MRI and</title></titleInfo><name type="personal"><namePart type="given">K.‐Y.</namePart><namePart type="family">Kwon</namePart><affiliation>Department of Neurology, Center for Parkinsonism and Other Movement Disorders</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. G.</namePart><namePart type="family">Choi</namePart><affiliation>Departments of Radiology</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. S.</namePart><namePart type="family">Kim</namePart><affiliation>Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. C.</namePart><namePart type="family">Lee</namePart><affiliation>Department of Neurology, Center for Parkinsonism and Other Movement Disorders</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. J.</namePart><namePart type="family">Chung</namePart><affiliation>Department of Neurology, Center for Parkinsonism and Other Movement Disorders</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2008-10</dateIssued><edition>Received 8 February 2008 Accepted 27 May 2008</edition><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">4</extent></physicalDescription><abstract lang="en">Background and purpose: Differentiation between parkinsonian type multiple system atrophy (MSA‐P) and Parkinson’s disease (PD) is important but often difficult. We investigated the diagnostic value of brain magnetic resonance imaging (MRI) and 18F‐fluorodeoxyglucose positron emission tomography (18F‐FDG PET) in differentiating MSA‐P from PD. Methods: Twenty‐four patients with MSA‐P (16 probable and 8 possible) and eight patients with PD were included in this study. Results: For analysis using the putaminal findings, the sensitivities were 58.3% by visual analysis of brain MRI, 95.8% by visual analysis of 18F‐FDG PET, and 79.2% by statistical parametric mapping (SPM) analysis of 18F‐FDG PET in differentiating MSA‐P from PD; the specificity was 100% for each analysis. Using the putaminal findings, visual analysis of 18F‐FDG PET had a higher sensitivity compared with brain MRI (P = 0.004) and SPM analysis of 18F‐FDG PET revealed a tendency towards higher sensitivity compared with brain MRI (P = 0.063). For analysis using both putaminal and infratentorial findings, the sensitivities were 79.2% by visual analysis of brain MRI, 95.8% by visual analysis of 18F‐FDG PET, 95.8% by SPM analysis of 18F‐FDG PET in differentiating MSA‐P from PD; the specificity was 100% for each analysis. Conclusion: Both brain MRI and 18F‐FDG PET showed diagnostic usefulness in differentiating MSA‐P from PD, with 18F‐FDG PET being more sensitive than brain MRI.</abstract><subject lang="en"><genre>Keywords</genre><topic>18F‐fluorodeoxyglucose positron emission tomography</topic><topic>magnetic resonance imaging</topic><topic>Parkinson’s disease</topic><topic>parkinsonian type multiple system atrophy</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neurology</title></titleInfo><genre type="Journal">journal</genre><note type="content"> Table S1. Neuroimaging based diagnosis in 13 patients with MSA‐P, who showed no cerebellar symptom, and eight patients with PD. Please note: Blackwell Publishing are not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing material) should be directed to the corresponding author for the article. Table S1. Neuroimaging based diagnosis in 13 patients with MSA‐P, who showed no cerebellar symptom, and eight patients with PD. Please note: Blackwell Publishing are not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing material) should be directed to the corresponding author for the article.Supporting Info Item: Supporting info item - </note><identifier type="ISSN">1351-5101</identifier><identifier type="eISSN">1468-1331</identifier><identifier type="DOI">10.1111/(ISSN)1468-1331</identifier><identifier type="PublisherID">ENE</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>1043</start><end>1049</end><total>7</total></extent></part></relatedItem><identifier type="istex">C524F8DED52BBB1DD6DC0A6A462FE3CDEE0DEFB6</identifier><identifier type="DOI">10.1111/j.1468-1331.2008.02235.x</identifier><identifier type="ArticleID">ENE2235</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2008 The Author(s). Journal compilation © 2008 EFNS</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E25 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 001E25 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:C524F8DED52BBB1DD6DC0A6A462FE3CDEE0DEFB6
|texte= Diagnostic value of brain MRI and 18F‐FDG PET in the differentiation of parkinsonian type multiple system atrophy from Parkinson’s disease
}}
| This area was generated with Dilib version V0.6.23. |  |