Coexistence of Pick bodies and atypical Lewy bodies in the locus ceruleus neurons of Pick's disease
Identifieur interne : 001D66 ( Main/Corpus ); précédent : 001D65; suivant : 001D67Coexistence of Pick bodies and atypical Lewy bodies in the locus ceruleus neurons of Pick's disease
Auteurs : S. Takauchi ; S. Yamauchi ; Y. Morimura ; K. Ohara ; Y. Morita ; S. Hayashi ; K. MiyoshiSource :
- Acta Neuropathologica [ 0001-6322 ] ; 1995-07-01.
Abstract
Abstract: We observed abundant Pick argentophilic inclusion bodies (PBs) as well as some atypical Lewy bodies (LBs) in the locus ceruleus (LC) from a patient with Pick's disease. In addition, there were a few neurons which contained both PBs and LBs. PBs in the LC frequently appeared multiple and had lobulated or irregular shapes, though their ultrastructural elements were the same as those of the PBs appearing in the cerebral cortex, and consisted of randomly arranged smooth-surfaced straight tubules of 15 nm in diameter, mixed with a small number of long-period constricted fibrils. The ultrastructure of the LB coexisting with PB was identical with that previously reported; a dense core was surrounded by concentric layers of radially oriented 10-nm filaments and was clearly distinguishable from the PB. Immunohistochemical examination with various antibodies related to neurofibrillar pathology demonstrated that anti-tau antibodies reacted positively with both PB and the rim portion of LB in the present case; an unusual finding for LB. The anti-neurofilament 200-kDa protein stained only LBs, even when PBs and LBs coexisted in the same neuron. These findings show that two kinds of neuronal fibrillar inclusions, whose underlying cytoskeletal abnormalities are thought to be different, can coexist in the same neuron. In addition, the formation of multiple, lobulated PBs may suggest some particularity of cytoskeletal composition of the LC neurons.
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DOI: 10.1007/BF00294465
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In addition, there were a few neurons which contained both PBs and LBs. PBs in the LC frequently appeared multiple and had lobulated or irregular shapes, though their ultrastructural elements were the same as those of the PBs appearing in the cerebral cortex, and consisted of randomly arranged smooth-surfaced straight tubules of 15 nm in diameter, mixed with a small number of long-period constricted fibrils. The ultrastructure of the LB coexisting with PB was identical with that previously reported; a dense core was surrounded by concentric layers of radially oriented 10-nm filaments and was clearly distinguishable from the PB. Immunohistochemical examination with various antibodies related to neurofibrillar pathology demonstrated that anti-tau antibodies reacted positively with both PB and the rim portion of LB in the present case; an unusual finding for LB. The anti-neurofilament 200-kDa protein stained only LBs, even when PBs and LBs coexisted in the same neuron. These findings show that two kinds of neuronal fibrillar inclusions, whose underlying cytoskeletal abnormalities are thought to be different, can coexist in the same neuron. In addition, the formation of multiple, lobulated PBs may suggest some particularity of cytoskeletal composition of the LC neurons.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>S. Takauchi</name><affiliations><json:string>Department of Neuropsychiatry, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663, Nishinomiya, Japan</json:string><json:string>Laboratory of Neuropathology, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan</json:string></affiliations></json:item><json:item><name>S. Yamauchi</name><affiliations><json:string>Department of Neuropsychiatry, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663, Nishinomiya, Japan</json:string></affiliations></json:item><json:item><name>Y. 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Miyoshi</name><affiliations><json:string>Department of Psychiatry, Kyoto University, School of Medicine, Kyoto, Japan</json:string></affiliations></json:item></author><articleId><json:string>Art14</json:string><json:string>BF00294465</json:string></articleId><language><json:string>eng</json:string></language><abstract>Abstract: We observed abundant Pick argentophilic inclusion bodies (PBs) as well as some atypical Lewy bodies (LBs) in the locus ceruleus (LC) from a patient with Pick's disease. In addition, there were a few neurons which contained both PBs and LBs. PBs in the LC frequently appeared multiple and had lobulated or irregular shapes, though their ultrastructural elements were the same as those of the PBs appearing in the cerebral cortex, and consisted of randomly arranged smooth-surfaced straight tubules of 15 nm in diameter, mixed with a small number of long-period constricted fibrils. The ultrastructure of the LB coexisting with PB was identical with that previously reported; a dense core was surrounded by concentric layers of radially oriented 10-nm filaments and was clearly distinguishable from the PB. Immunohistochemical examination with various antibodies related to neurofibrillar pathology demonstrated that anti-tau antibodies reacted positively with both PB and the rim portion of LB in the present case; an unusual finding for LB. The anti-neurofilament 200-kDa protein stained only LBs, even when PBs and LBs coexisted in the same neuron. These findings show that two kinds of neuronal fibrillar inclusions, whose underlying cytoskeletal abnormalities are thought to be different, can coexist in the same neuron. In addition, the formation of multiple, lobulated PBs may suggest some particularity of cytoskeletal composition of the LC neurons.</abstract><qualityIndicators><score>7.346</score><pdfVersion>1.3</pdfVersion><pdfPageSize>597.28 x 785 pts</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1465</abstractCharCount><pdfWordCount>4694</pdfWordCount><pdfCharCount>20365</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>221</abstractWordCount></qualityIndicators><title>Coexistence of Pick bodies and atypical Lewy bodies in the locus ceruleus neurons of Pick's 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In addition, there were a few neurons which contained both PBs and LBs. PBs in the LC frequently appeared multiple and had lobulated or irregular shapes, though their ultrastructural elements were the same as those of the PBs appearing in the cerebral cortex, and consisted of randomly arranged smooth-surfaced straight tubules of 15 nm in diameter, mixed with a small number of long-period constricted fibrils. The ultrastructure of the LB coexisting with PB was identical with that previously reported; a dense core was surrounded by concentric layers of radially oriented 10-nm filaments and was clearly distinguishable from the PB. Immunohistochemical examination with various antibodies related to neurofibrillar pathology demonstrated that anti-tau antibodies reacted positively with both PB and the rim portion of LB in the present case; an unusual finding for LB. The anti-neurofilament 200-kDa protein stained only LBs, even when PBs and LBs coexisted in the same neuron. These findings show that two kinds of neuronal fibrillar inclusions, whose underlying cytoskeletal abnormalities are thought to be different, can coexist in the same neuron. In addition, the formation of multiple, lobulated PBs may suggest some particularity of cytoskeletal composition of the LC neurons.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>Medicine & Public Health</head><item><term>Pathology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1994-10-05">Created</change><change when="1995-07-01">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-3-15">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/CFA7530367B76A6420D76085A57EF807FBE22FC1/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Springer, Publisher found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" 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Report</ArticleCategory><ArticleFirstPage>93</ArticleFirstPage><ArticleLastPage>100</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2004</Year><Month>8</Month><Day>18</Day></RegistrationDate><Received><Year>1994</Year><Month>10</Month><Day>5</Day></Received><Revised><Year>1995</Year><Month>2</Month><Day>14</Day></Revised><Accepted><Year>1995</Year><Month>2</Month><Day>14</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1995</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>401</JournalID><VolumeIDStart>90</VolumeIDStart><VolumeIDEnd>90</VolumeIDEnd><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1 Aff2" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>S.</GivenName><FamilyName>Takauchi</FamilyName></AuthorName><Contact><Phone>81-798-45-6051</Phone><Fax>81-798-45-6053</Fax></Contact></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>S.</GivenName><FamilyName>Yamauchi</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Y.</GivenName><FamilyName>Morimura</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>K.</GivenName><FamilyName>Ohara</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Y.</GivenName><FamilyName>Morita</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>S.</GivenName><FamilyName>Hayashi</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>K.</GivenName><FamilyName>Miyoshi</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Department of Neuropsychiatry</OrgDivision><OrgName>Hyogo College of Medicine</OrgName><OrgAddress><Street>1-1 Mukogawa-cho</Street><Postcode>663</Postcode><City>Nishinomiya</City><Country>Japan</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Laboratory of Neuropathology</OrgDivision><OrgName>Hyogo Institute for Aging Brain and Cognitive Disorders</OrgName><OrgAddress><City>Himeji</City><Country>Japan</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgDivision>Department of Psychiatry</OrgDivision><OrgName>Kyoto University, School of Medicine</OrgName><OrgAddress><City>Kyoto</City><Country>Japan</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>We observed abundant Pick argentophilic inclusion bodies (PBs) as well as some atypical Lewy bodies (LBs) in the locus ceruleus (LC) from a patient with Pick's disease. In addition, there were a few neurons which contained both PBs and LBs. PBs in the LC frequently appeared multiple and had lobulated or irregular shapes, though their ultrastructural elements were the same as those of the PBs appearing in the cerebral cortex, and consisted of randomly arranged smooth-surfaced straight tubules of 15 nm in diameter, mixed with a small number of long-period constricted fibrils. The ultrastructure of the LB coexisting with PB was identical with that previously reported; a dense core was surrounded by concentric layers of radially oriented 10-nm filaments and was clearly distinguishable from the PB. Immunohistochemical examination with various antibodies related to neurofibrillar pathology demonstrated that anti-tau antibodies reacted positively with both PB and the rim portion of LB in the present case; an unusual finding for LB. The anti-neurofilament 200-kDa protein stained only LBs, even when PBs and LBs coexisted in the same neuron. These findings show that two kinds of neuronal fibrillar inclusions, whose underlying cytoskeletal abnormalities are thought to be different, can coexist in the same neuron. In addition, the formation of multiple, lobulated PBs may suggest some particularity of cytoskeletal composition of the LC neurons.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Pick body</Keyword><Keyword>Lewy body</Keyword><Keyword>Locus ceruleus</Keyword><Keyword>Pick's disease</Keyword><Keyword>Immunohistochemistry</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Coexistence of Pick bodies and atypical Lewy bodies in the locus ceruleus neurons of Pick's disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Coexistence of Pick bodies and atypical Lewy bodies in the locus ceruleus neurons of Pick's disease</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">S.</namePart><namePart type="family">Takauchi</namePart><affiliation>Department of Neuropsychiatry, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663, Nishinomiya, Japan</affiliation><affiliation>Laboratory of Neuropathology, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Yamauchi</namePart><affiliation>Department of Neuropsychiatry, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663, Nishinomiya, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Morimura</namePart><affiliation>Department of Neuropsychiatry, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663, Nishinomiya, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Ohara</namePart><affiliation>Department of Neuropsychiatry, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663, Nishinomiya, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Morita</namePart><affiliation>Department of Neuropsychiatry, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663, Nishinomiya, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Hayashi</namePart><affiliation>Department of Neuropsychiatry, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663, Nishinomiya, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Miyoshi</namePart><affiliation>Department of Psychiatry, Kyoto University, School of Medicine, Kyoto, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper"></genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1994-10-05</dateCreated><dateIssued encoding="w3cdtf">1995-07-01</dateIssued><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Abstract: We observed abundant Pick argentophilic inclusion bodies (PBs) as well as some atypical Lewy bodies (LBs) in the locus ceruleus (LC) from a patient with Pick's disease. In addition, there were a few neurons which contained both PBs and LBs. PBs in the LC frequently appeared multiple and had lobulated or irregular shapes, though their ultrastructural elements were the same as those of the PBs appearing in the cerebral cortex, and consisted of randomly arranged smooth-surfaced straight tubules of 15 nm in diameter, mixed with a small number of long-period constricted fibrils. The ultrastructure of the LB coexisting with PB was identical with that previously reported; a dense core was surrounded by concentric layers of radially oriented 10-nm filaments and was clearly distinguishable from the PB. Immunohistochemical examination with various antibodies related to neurofibrillar pathology demonstrated that anti-tau antibodies reacted positively with both PB and the rim portion of LB in the present case; an unusual finding for LB. The anti-neurofilament 200-kDa protein stained only LBs, even when PBs and LBs coexisted in the same neuron. These findings show that two kinds of neuronal fibrillar inclusions, whose underlying cytoskeletal abnormalities are thought to be different, can coexist in the same neuron. In addition, the formation of multiple, lobulated PBs may suggest some particularity of cytoskeletal composition of the LC neurons.</abstract><note>Case Report</note><relatedItem type="host"><titleInfo><title>Acta Neuropathologica</title></titleInfo><titleInfo type="abbreviated"><title>Acta Neuropathol</title></titleInfo><genre type="Journal" displayLabel="Archive Journal"></genre><originInfo><dateIssued encoding="w3cdtf">1995-07-01</dateIssued><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Pathology</topic></subject><identifier type="ISSN">0001-6322</identifier><identifier type="eISSN">1432-0533</identifier><identifier type="JournalID">401</identifier><identifier type="IssueArticleCount">17</identifier><identifier type="VolumeIssueCount">6</identifier><part><date>1995</date><detail type="volume"><number>90</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="pages"><start>93</start><end>100</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1995</recordOrigin></recordInfo></relatedItem><identifier type="istex">CFA7530367B76A6420D76085A57EF807FBE22FC1</identifier><identifier type="DOI">10.1007/BF00294465</identifier><identifier type="ArticleID">BF00294465</identifier><identifier type="ArticleID">Art14</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 1995</accessCondition><recordInfo><recordContentSource>SPRINGER</recordContentSource><recordOrigin>Springer-Verlag, 1995</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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