High‐frequency deep brain stimulation of the putamen improves bradykinesia in Parkinson's disease
Identifieur interne : 001B67 ( Main/Corpus ); précédent : 001B66; suivant : 001B68High‐frequency deep brain stimulation of the putamen improves bradykinesia in Parkinson's disease
Auteurs : Erwin B. Montgomery Jr. ; He Huang ; Harrison C. Walker ; Barton L. Guthrie ; Ray L. WattsSource :
- Movement Disorders [ 0885-3185 ] ; 2011-10.
English descriptors
Abstract
Deep brain stimulation is effective for a wide range of neurological disorders; however, its mechanisms of action remain unclear. With respect to Parkinson's disease, the existence of multiple effective targets suggests that putamen stimulation also may be effective and raises questions as to the mechanisms of action. Are there as many mechanisms of action as there are effective targets or some single or small set of mechanisms common to all effective targets? During the course of routine surgery of the globus pallidus interna in patients with Parkinson's disease, the deep brain stimulation lead was placed in the putamen en route to the globus pallidus interna. Recordings of hand opening and closing during high‐frequency and no stimulation were made. Speed of the movements, based on the amplitude and frequency of the repetitive hand movements as well as the decay in amplitude, were studied. Hand speed in 6 subjects was statistically significantly faster during active deep brain stimulation than the no‐stimulation condition. There were no statistically significant differences in decay in the amplitude of hand movements. High‐frequency deep brain stimulation of the putamen improves bradykinesia in a hand‐opening and ‐closing task in patients with Parkinson's disease. Consequently, high‐frequency deep brain stimulation of virtually every structure in the basal ganglia‐thalamic‐cortical system improves bradykinesia. These observations, together with microelectrode recordings reported in the literature, argue that deep brain stimulation effects may be system specific and not structure specific. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23842
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There were no statistically significant differences in decay in the amplitude of hand movements. High‐frequency deep brain stimulation of the putamen improves bradykinesia in a hand‐opening and ‐closing task in patients with Parkinson's disease. Consequently, high‐frequency deep brain stimulation of virtually every structure in the basal ganglia‐thalamic‐cortical system improves bradykinesia. These observations, together with microelectrode recordings reported in the literature, argue that deep brain stimulation effects may be system specific and not structure specific. © 2011 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>putamen</term></item><item><term>deep brain stimulation</term></item><item><term>bradykinesia</term></item><item><term>physiology</term></item><item><term>pathophysiology</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2011-02-09">Received</change><change when="2011-05-23">Registration</change><change when="2011-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/49F70A17C7815F69D4C258A31B019E171A6594D3/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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With respect to Parkinson's disease, the existence of multiple effective targets suggests that putamen stimulation also may be effective and raises questions as to the mechanisms of action. Are there as many mechanisms of action as there are effective targets or some single or small set of mechanisms common to all effective targets? During the course of routine surgery of the globus pallidus interna in patients with Parkinson's disease, the deep brain stimulation lead was placed in the putamen en route to the globus pallidus interna. Recordings of hand opening and closing during high‐frequency and no stimulation were made. Speed of the movements, based on the amplitude and frequency of the repetitive hand movements as well as the decay in amplitude, were studied. Hand speed in 6 subjects was statistically significantly faster during active deep brain stimulation than the no‐stimulation condition. There were no statistically significant differences in decay in the amplitude of hand movements. High‐frequency deep brain stimulation of the putamen improves bradykinesia in a hand‐opening and ‐closing task in patients with Parkinson's disease. Consequently, high‐frequency deep brain stimulation of virtually every structure in the basal ganglia‐thalamic‐cortical system improves bradykinesia. These observations, together with microelectrode recordings reported in the literature, argue that deep brain stimulation effects may be system specific and not structure specific. © 2011 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Funding agencies: The research was supported by the Dr. Sigmund Rosen Scholarship fund of the University of Alabama at Birmingham (to E.B.M.), the National Institutes of Health (K23 NS067053‐01; to H.C.W.), the Lanier Family Foundation, and the Charles Ackerman Parkinson Research Fund.</p></note><note xml:id="fn2"><p>Relevant conflicts of interest/financial disclosures: Nothing to report.</p></note><note xml:id="fn3"><p>Full financial disclosures and author roles may be found in the online version of this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>High‐frequency deep brain stimulation of the putamen improves bradykinesia in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Putamen Stimulation and Bradykinesia</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>High‐frequency deep brain stimulation of the putamen improves bradykinesia in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Erwin B.</namePart><namePart type="family">Montgomery Jr.</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA</affiliation><description>Correspondence: Department of Neurology, 360A Sparks Center, 1720 7th Avenue South, University of Alabama at Birmingham, Birmingham, AL 35294, USA</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">He</namePart><namePart type="family">Huang</namePart><namePart type="termsOfAddress">MS</namePart><affiliation>Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Harrison C.</namePart><namePart type="family">Walker</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Barton L.</namePart><namePart type="family">Guthrie</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Division of Neurosurgery, University of Alabama at Birmingham, Birmingham, Alabama, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ray L.</namePart><namePart type="family">Watts</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-10</dateIssued><dateCaptured encoding="w3cdtf">2011-02-09</dateCaptured><dateValid encoding="w3cdtf">2011-05-23</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">4</extent><extent unit="tables">1</extent><extent unit="references">24</extent><extent unit="words">5168</extent></physicalDescription><abstract lang="en">Deep brain stimulation is effective for a wide range of neurological disorders; however, its mechanisms of action remain unclear. With respect to Parkinson's disease, the existence of multiple effective targets suggests that putamen stimulation also may be effective and raises questions as to the mechanisms of action. Are there as many mechanisms of action as there are effective targets or some single or small set of mechanisms common to all effective targets? During the course of routine surgery of the globus pallidus interna in patients with Parkinson's disease, the deep brain stimulation lead was placed in the putamen en route to the globus pallidus interna. Recordings of hand opening and closing during high‐frequency and no stimulation were made. Speed of the movements, based on the amplitude and frequency of the repetitive hand movements as well as the decay in amplitude, were studied. Hand speed in 6 subjects was statistically significantly faster during active deep brain stimulation than the no‐stimulation condition. There were no statistically significant differences in decay in the amplitude of hand movements. High‐frequency deep brain stimulation of the putamen improves bradykinesia in a hand‐opening and ‐closing task in patients with Parkinson's disease. Consequently, high‐frequency deep brain stimulation of virtually every structure in the basal ganglia‐thalamic‐cortical system improves bradykinesia. These observations, together with microelectrode recordings reported in the literature, argue that deep brain stimulation effects may be system specific and not structure specific. © 2011 Movement Disorder Society</abstract><note type="content">*Funding agencies: The research was supported by the Dr. Sigmund Rosen Scholarship fund of the University of Alabama at Birmingham (to E.B.M.), the National Institutes of Health (K23 NS067053‐01; to H.C.W.), the Lanier Family Foundation, and the Charles Ackerman Parkinson Research Fund.</note><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note><subject lang="en"><genre>Keywords</genre><topic>putamen</topic><topic>deep brain stimulation</topic><topic>bradykinesia</topic><topic>physiology</topic><topic>pathophysiology</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>2232</start><end>2238</end><total>7</total></extent></part></relatedItem><identifier type="istex">49F70A17C7815F69D4C258A31B019E171A6594D3</identifier><identifier type="DOI">10.1002/mds.23842</identifier><identifier type="ArticleID">MDS23842</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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