Chronic pain in Parkinson's disease: The cross‐sectional French DoPaMiP survey
Identifieur interne : 001B26 ( Main/Corpus ); précédent : 001B25; suivant : 001B27Chronic pain in Parkinson's disease: The cross‐sectional French DoPaMiP survey
Auteurs : Laurence Nègre-Pagès ; Wafa Regragui ; Didier Bouhassira ; Héléne Grandjean ; Olivier RascolSource :
- Movement Disorders [ 0885-3185 ] ; 2008-07-30.
English descriptors
Abstract
Pain is a frequent, but poorly studied symptom of Parkinson's disease (PD). DoPaMiP survey aimed to assess the prevalence of chronic pain in PD, to describe PD patients with chronic pain, and to record analgesic consumption. About 450 parkinsonian patients underwent structured standardized clinical examination and completed self‐reported questionnaires in a cross sectional survey. Pains related or unrelated to PD were identified according to predefined criteria. About 98 patients with other chronic disorders than PD were examined to assess if pain was more frequent in PD than in this population. Two thirds parkinsonian patients (278 of 450) had chronic pain. Twenty‐five patients with non‐chronic pain (<3‐month duration) were excluded from subsequent analysis. Twenty six percent (111 of 425) parkinsonian patients had pain unrelated to PD (“non‐PD‐pain”, caused mainly by osteoarthritis), while 39.3% (167 of 425) had chronic pain related to PD (“PD‐pain”). In this last group, PD was the sole cause of pain in 103 and indirectly aggravated pain of another origin (mainly osteoarthritis) in 64. Parkinsonian patients with “PD‐pain” were younger at PD onset, had more motor complications, more severe depressive symptoms than those without pain or with “non‐PD pain.” “PD‐pain” was more intense (P = 0.03), but was less frequently reported to doctors (P = 0.02), and was associated with less frequent analgesic consumption than “non‐PD‐pain.” Pain was twice more frequent in PD patients than in patients without PD after adjustment for osteo‐articular comorbidities (OR = 1.9; 95% CI 1.2–3.2). Chronic pain is frequent but underreported in PD. Awareness of this problem should be increased and the assessment of analgesic strategies improved. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22142
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ISTEX:DF0136402B0B038462C4D33E390F808C494627BALe document en format XML
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DoPaMiP survey aimed to assess the prevalence of chronic pain in PD, to describe PD patients with chronic pain, and to record analgesic consumption. About 450 parkinsonian patients underwent structured standardized clinical examination and completed self‐reported questionnaires in a cross sectional survey. Pains related or unrelated to PD were identified according to predefined criteria. About 98 patients with other chronic disorders than PD were examined to assess if pain was more frequent in PD than in this population. Two thirds parkinsonian patients (278 of 450) had chronic pain. Twenty‐five patients with non‐chronic pain (<3‐month duration) were excluded from subsequent analysis. Twenty six percent (111 of 425) parkinsonian patients had pain unrelated to PD (“non‐PD‐pain”, caused mainly by osteoarthritis), while 39.3% (167 of 425) had chronic pain related to PD (“PD‐pain”). In this last group, PD was the sole cause of pain in 103 and indirectly aggravated pain of another origin (mainly osteoarthritis) in 64. Parkinsonian patients with “PD‐pain” were younger at PD onset, had more motor complications, more severe depressive symptoms than those without pain or with “non‐PD pain.” “PD‐pain” was more intense (P = 0.03), but was less frequently reported to doctors (P = 0.02), and was associated with less frequent analgesic consumption than “non‐PD‐pain.” Pain was twice more frequent in PD patients than in patients without PD after adjustment for osteo‐articular comorbidities (OR = 1.9; 95% CI 1.2–3.2). Chronic pain is frequent but underreported in PD. Awareness of this problem should be increased and the assessment of analgesic strategies improved. © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Laurence Nègre‐Pagès PhD</name><affiliations><json:string>Department of Clinical Pharmacology, University Hospital, Toulouse, France, and LN‐Pharma, Toulouse, France</json:string></affiliations></json:item><json:item><name>Wafa Regragui MD</name><affiliations><json:string>Department of Neurology, University of Rabat, Morocco</json:string></affiliations></json:item><json:item><name>Didier Bouhassira MD</name><affiliations><json:string>INSERM U‐792, CHU Ambroise Paré, APHP, Boulogne‐Billancourt, France and Université Versailles‐Saint‐Quentin, Versailles, France</json:string></affiliations></json:item><json:item><name>Héléne Grandjean MD</name><affiliations><json:string>INSERM U‐558, Faculty of Medicine, Toulouse, France</json:string></affiliations></json:item><json:item><name>Olivier Rascol MD, PhD</name><affiliations><json:string>Department of Clinical Pharmacology, University Hospital, Toulouse, France</json:string><json:string>Department of Neurosciences, University Hospital, Toulouse, France</json:string><json:string>INSERM U‐825/CIC, Hôpital Purpan, Toulouse, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>chronic pain</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cross sectional survey</value></json:item></subject><articleId><json:string>MDS22142</json:string></articleId><language><json:string>eng</json:string></language><abstract>Pain is a frequent, but poorly studied symptom of Parkinson's disease (PD). 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In this last group, PD was the sole cause of pain in 103 and indirectly aggravated pain of another origin (mainly osteoarthritis) in 64. Parkinsonian patients with “PD‐pain” were younger at PD onset, had more motor complications, more severe depressive symptoms than those without pain or with “non‐PD pain.” “PD‐pain” was more intense (P = 0.03), but was less frequently reported to doctors (P = 0.02), and was associated with less frequent analgesic consumption than “non‐PD‐pain.” Pain was twice more frequent in PD patients than in patients without PD after adjustment for osteo‐articular comorbidities (OR = 1.9; 95% CI 1.2–3.2). Chronic pain is frequent but underreported in PD. 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DoPaMiP survey aimed to assess the prevalence of chronic pain in PD, to describe PD patients with chronic pain, and to record analgesic consumption. About 450 parkinsonian patients underwent structured standardized clinical examination and completed self‐reported questionnaires in a cross sectional survey. Pains related or unrelated to PD were identified according to predefined criteria. About 98 patients with other chronic disorders than PD were examined to assess if pain was more frequent in PD than in this population. Two thirds parkinsonian patients (278 of 450) had chronic pain. Twenty‐five patients with non‐chronic pain (<3‐month duration) were excluded from subsequent analysis. Twenty six percent (111 of 425) parkinsonian patients had pain unrelated to PD (“non‐PD‐pain”, caused mainly by osteoarthritis), while 39.3% (167 of 425) had chronic pain related to PD (“PD‐pain”). In this last group, PD was the sole cause of pain in 103 and indirectly aggravated pain of another origin (mainly osteoarthritis) in 64. Parkinsonian patients with “PD‐pain” were younger at PD onset, had more motor complications, more severe depressive symptoms than those without pain or with “non‐PD pain.” “PD‐pain” was more intense (P = 0.03), but was less frequently reported to doctors (P = 0.02), and was associated with less frequent analgesic consumption than “non‐PD‐pain.” Pain was twice more frequent in PD patients than in patients without PD after adjustment for osteo‐articular comorbidities (OR = 1.9; 95% CI 1.2–3.2). Chronic pain is frequent but underreported in PD. 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France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">parkinson's disease</keyword><keyword xml:id="kwd2">chronic pain</keyword><keyword xml:id="kwd3">cross sectional survey</keyword></keywordGroup><fundingInfo><fundingAgency>Programme Regional Hospitalier de Recherche Clinique (PHRC)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Boehringer Ingelheim</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Eisai</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Faust Pharmaceuticals</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Fertizin</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Euthérapie</fundingAgency></fundingInfo><fundingInfo><fundingAgency>GlaxoSmithKline</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Pierre Fabre Médicaments</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Solvay Pharma</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Wyeth Lederlé</fundingAgency></fundingInfo><fundingInfo><fundingAgency>UPSA Pain Institute</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Pain is a frequent, but poorly studied symptom of Parkinson's disease (PD). DoPaMiP survey aimed to assess the prevalence of chronic pain in PD, to describe PD patients with chronic pain, and to record analgesic consumption. About 450 parkinsonian patients underwent structured standardized clinical examination and completed self‐reported questionnaires in a cross sectional survey. Pains related or unrelated to PD were identified according to predefined criteria. About 98 patients with other chronic disorders than PD were examined to assess if pain was more frequent in PD than in this population. Two thirds parkinsonian patients (278 of 450) had chronic pain. Twenty‐five patients with non‐chronic pain (<3‐month duration) were excluded from subsequent analysis. Twenty six percent (111 of 425) parkinsonian patients had pain unrelated to PD (“non‐PD‐pain”, caused mainly by osteoarthritis), while 39.3% (167 of 425) had chronic pain related to PD (“PD‐pain”). In this last group, PD was the sole cause of pain in 103 and indirectly aggravated pain of another origin (mainly osteoarthritis) in 64. Parkinsonian patients with “PD‐pain” were younger at PD onset, had more motor complications, more severe depressive symptoms than those without pain or with “non‐PD pain.” “PD‐pain” was more intense (<i>P</i> = 0.03), but was less frequently reported to doctors (<i>P</i> = 0.02), and was associated with less frequent analgesic consumption than “non‐PD‐pain.” Pain was twice more frequent in PD patients than in patients without PD after adjustment for osteo‐articular comorbidities (OR = 1.9; 95% CI 1.2–3.2). Chronic pain is frequent but underreported in PD. Awareness of this problem should be increased and the assessment of analgesic strategies improved. © 2008 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Chronic pain in Parkinson's disease: The cross‐sectional French DoPaMiP survey</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Chronic Pain in Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Chronic pain in Parkinson's disease: The cross‐sectional French DoPaMiP survey</title></titleInfo><name type="personal"><namePart type="given">Laurence</namePart><namePart type="family">Nègre‐Pagès</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Clinical Pharmacology, University Hospital, Toulouse, France, and LN‐Pharma, Toulouse, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wafa</namePart><namePart type="family">Regragui</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Rabat, Morocco</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Didier</namePart><namePart type="family">Bouhassira</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>INSERM U‐792, CHU Ambroise Paré, APHP, Boulogne‐Billancourt, France and Université Versailles‐Saint‐Quentin, Versailles, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Héléne</namePart><namePart type="family">Grandjean</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>INSERM U‐558, Faculty of Medicine, Toulouse, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Olivier</namePart><namePart type="family">Rascol</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Clinical Pharmacology, University Hospital, Toulouse, France</affiliation><affiliation>Department of Neurosciences, University Hospital, Toulouse, France</affiliation><affiliation>INSERM U‐825/CIC, Hôpital Purpan, Toulouse, France</affiliation><description>Correspondence: Service de Pharmacologie Médicale et Clinique, Faculté de Médecine, 37 allées Jules Guesde, 31 000 Toulouse, France</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-07-30</dateIssued><dateCaptured encoding="w3cdtf">2007-12-10</dateCaptured><dateValid encoding="w3cdtf">2008-04-27</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">6</extent><extent unit="references">43</extent><extent unit="words">7636</extent></physicalDescription><abstract lang="en">Pain is a frequent, but poorly studied symptom of Parkinson's disease (PD). DoPaMiP survey aimed to assess the prevalence of chronic pain in PD, to describe PD patients with chronic pain, and to record analgesic consumption. About 450 parkinsonian patients underwent structured standardized clinical examination and completed self‐reported questionnaires in a cross sectional survey. Pains related or unrelated to PD were identified according to predefined criteria. About 98 patients with other chronic disorders than PD were examined to assess if pain was more frequent in PD than in this population. Two thirds parkinsonian patients (278 of 450) had chronic pain. Twenty‐five patients with non‐chronic pain (<3‐month duration) were excluded from subsequent analysis. Twenty six percent (111 of 425) parkinsonian patients had pain unrelated to PD (“non‐PD‐pain”, caused mainly by osteoarthritis), while 39.3% (167 of 425) had chronic pain related to PD (“PD‐pain”). In this last group, PD was the sole cause of pain in 103 and indirectly aggravated pain of another origin (mainly osteoarthritis) in 64. Parkinsonian patients with “PD‐pain” were younger at PD onset, had more motor complications, more severe depressive symptoms than those without pain or with “non‐PD pain.” “PD‐pain” was more intense (P = 0.03), but was less frequently reported to doctors (P = 0.02), and was associated with less frequent analgesic consumption than “non‐PD‐pain.” Pain was twice more frequent in PD patients than in patients without PD after adjustment for osteo‐articular comorbidities (OR = 1.9; 95% CI 1.2–3.2). Chronic pain is frequent but underreported in PD. Awareness of this problem should be increased and the assessment of analgesic strategies improved. © 2008 Movement Disorder Society</abstract><note type="funding">Programme Regional Hospitalier de Recherche Clinique (PHRC)</note><note type="funding">Boehringer Ingelheim</note><note type="funding">Eisai</note><note type="funding">Faust Pharmaceuticals</note><note type="funding">Fertizin</note><note type="funding">Euthérapie</note><note type="funding">GlaxoSmithKline</note><note type="funding">Pierre Fabre Médicaments</note><note type="funding">Solvay Pharma</note><note type="funding">Wyeth Lederlé</note><note type="funding">UPSA Pain Institute</note><subject lang="en"><genre>Keywords</genre><topic>parkinson's disease</topic><topic>chronic pain</topic><topic>cross sectional survey</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>1361</start><end>1369</end><total>9</total></extent></part></relatedItem><identifier type="istex">DF0136402B0B038462C4D33E390F808C494627BA</identifier><identifier type="DOI">10.1002/mds.22142</identifier><identifier type="ArticleID">MDS22142</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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