Blood pressure and heart rate in parkinsonian patients with and without wearing‐off
Identifieur interne : 001B17 ( Main/Corpus ); précédent : 001B16; suivant : 001B18Blood pressure and heart rate in parkinsonian patients with and without wearing‐off
Auteurs : V. Pursiainen ; J. T. Korpelainen ; T. H. Haapaniemi ; K. A. Sotaniemi ; V. V. MyllylSource :
- European Journal of Neurology [ 1351-5101 ] ; 2007-04.
English descriptors
Abstract
Our study aimed to investigate the cardiovascular autonomic regulation related to the wearing‐off phenomenon in Parkinson's disease (PD). We measured blood pressure (BP) and heart rate (HR) at rest and during orthostatic test in 16 patients with PD with wearing‐off and in 15 patients with PD without wearing‐off both before (baseline) and repetitively at 1‐h intervals for up to 4 h after the morning PD medication dose. The patients with wearing‐off had fluctuation of BP during the observation period, BP increasing when the motor performance worsened and vice versa. The mean supine BP was at its highest at the baseline measurement (patients with wearing‐off, 145 ± 18 mmHg; patients without wearing‐off, 138 ± 17 mmHg), fell during the first hour (patients with wearing‐off, 119 ± 17 mmHg; patients without wearing‐off, 126 ± 18 mmHg), and then rose again toward the end of the observation period (patients with wearing‐off, 136 ± 15 mmHg; patients without wearing‐off, 138 ± 18 mmHg). This BP change was statistically significant only in PD patients with wearing‐off (P < 0.001). In conclusion, BP seems to fluctuate with motor impairment in PD patients with wearing‐off. This fluctuation may represent autonomic dysfunction caused by the PD process itself, the effect of PD medication, or both.
Url:
DOI: 10.1111/j.1468-1331.2007.01672.x
Links to Exploration step
ISTEX:3F9376B4E7F2BF2A724930D5775EB0CAA8DEAD41Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Blood pressure and heart rate in parkinsonian patients with and without wearing‐off</title><author><name sortKey="Pursiainen, V" sort="Pursiainen, V" uniqKey="Pursiainen V" first="V." last="Pursiainen">V. Pursiainen</name><affiliation><mods:affiliation>Department of Neurology and Peijas Hospital, Vantaa, Finland</mods:affiliation></affiliation></author><author><name sortKey="Korpelainen, J T" sort="Korpelainen, J T" uniqKey="Korpelainen J" first="J. T." last="Korpelainen">J. T. Korpelainen</name><affiliation><mods:affiliation>Department of Neurology, University of Oulu, Oulu, Finland; and</mods:affiliation></affiliation></author><author><name sortKey="Haapaniemi, T H" sort="Haapaniemi, T H" uniqKey="Haapaniemi T" first="T. H." last="Haapaniemi">T. H. Haapaniemi</name><affiliation><mods:affiliation>Department of Neurology, University of Oulu, Oulu, Finland; and</mods:affiliation></affiliation></author><author><name sortKey="Sotaniemi, K A" sort="Sotaniemi, K A" uniqKey="Sotaniemi K" first="K. A." last="Sotaniemi">K. A. Sotaniemi</name><affiliation><mods:affiliation>Department of Neurology, University of Oulu, Oulu, Finland; and</mods:affiliation></affiliation></author><author><name sortKey="Myllyl, V V" sort="Myllyl, V V" uniqKey="Myllyl V" first="V. V." last="Myllyl">V. V. Myllyl</name><affiliation><mods:affiliation>Department of Neurology, University of Oulu, Oulu, Finland; and</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3F9376B4E7F2BF2A724930D5775EB0CAA8DEAD41</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1111/j.1468-1331.2007.01672.x</idno><idno type="url">https://api.istex.fr/document/3F9376B4E7F2BF2A724930D5775EB0CAA8DEAD41/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001B17</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Blood pressure and heart rate in parkinsonian patients with and without wearing‐off</title><author><name sortKey="Pursiainen, V" sort="Pursiainen, V" uniqKey="Pursiainen V" first="V." last="Pursiainen">V. Pursiainen</name><affiliation><mods:affiliation>Department of Neurology and Peijas Hospital, Vantaa, Finland</mods:affiliation></affiliation></author><author><name sortKey="Korpelainen, J T" sort="Korpelainen, J T" uniqKey="Korpelainen J" first="J. T." last="Korpelainen">J. T. Korpelainen</name><affiliation><mods:affiliation>Department of Neurology, University of Oulu, Oulu, Finland; and</mods:affiliation></affiliation></author><author><name sortKey="Haapaniemi, T H" sort="Haapaniemi, T H" uniqKey="Haapaniemi T" first="T. H." last="Haapaniemi">T. H. Haapaniemi</name><affiliation><mods:affiliation>Department of Neurology, University of Oulu, Oulu, Finland; and</mods:affiliation></affiliation></author><author><name sortKey="Sotaniemi, K A" sort="Sotaniemi, K A" uniqKey="Sotaniemi K" first="K. A." last="Sotaniemi">K. A. Sotaniemi</name><affiliation><mods:affiliation>Department of Neurology, University of Oulu, Oulu, Finland; and</mods:affiliation></affiliation></author><author><name sortKey="Myllyl, V V" sort="Myllyl, V V" uniqKey="Myllyl V" first="V. V." last="Myllyl">V. V. Myllyl</name><affiliation><mods:affiliation>Department of Neurology, University of Oulu, Oulu, Finland; and</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2007-04">2007-04</date><biblScope unit="volume">14</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="373">373</biblScope><biblScope unit="page" to="378">378</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">3F9376B4E7F2BF2A724930D5775EB0CAA8DEAD41</idno><idno type="DOI">10.1111/j.1468-1331.2007.01672.x</idno><idno type="ArticleID">ENE1672</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>autonomic nervous system</term><term>blood pressure</term><term>motor fluctuation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Our study aimed to investigate the cardiovascular autonomic regulation related to the wearing‐off phenomenon in Parkinson's disease (PD). We measured blood pressure (BP) and heart rate (HR) at rest and during orthostatic test in 16 patients with PD with wearing‐off and in 15 patients with PD without wearing‐off both before (baseline) and repetitively at 1‐h intervals for up to 4 h after the morning PD medication dose. The patients with wearing‐off had fluctuation of BP during the observation period, BP increasing when the motor performance worsened and vice versa. The mean supine BP was at its highest at the baseline measurement (patients with wearing‐off, 145 ± 18 mmHg; patients without wearing‐off, 138 ± 17 mmHg), fell during the first hour (patients with wearing‐off, 119 ± 17 mmHg; patients without wearing‐off, 126 ± 18 mmHg), and then rose again toward the end of the observation period (patients with wearing‐off, 136 ± 15 mmHg; patients without wearing‐off, 138 ± 18 mmHg). This BP change was statistically significant only in PD patients with wearing‐off (P < 0.001). In conclusion, BP seems to fluctuate with motor impairment in PD patients with wearing‐off. This fluctuation may represent autonomic dysfunction caused by the PD process itself, the effect of PD medication, or both.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>V. Pursiainen</name><affiliations><json:string>Department of Neurology and Peijas Hospital, Vantaa, Finland</json:string></affiliations></json:item><json:item><name>J. T. Korpelainen</name><affiliations><json:string>Department of Neurology, University of Oulu, Oulu, Finland; and</json:string></affiliations></json:item><json:item><name>T. H. Haapaniemi</name><affiliations><json:string>Department of Neurology, University of Oulu, Oulu, Finland; and</json:string></affiliations></json:item><json:item><name>K. A. Sotaniemi</name><affiliations><json:string>Department of Neurology, University of Oulu, Oulu, Finland; and</json:string></affiliations></json:item><json:item><name>V. V. Myllylä</name><affiliations><json:string>Department of Neurology, University of Oulu, Oulu, Finland; and</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>autonomic nervous system</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>blood pressure</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>motor fluctuation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item></subject><articleId><json:string>ENE1672</json:string></articleId><language><json:string>eng</json:string></language><abstract>Our study aimed to investigate the cardiovascular autonomic regulation related to the wearing‐off phenomenon in Parkinson's disease (PD). We measured blood pressure (BP) and heart rate (HR) at rest and during orthostatic test in 16 patients with PD with wearing‐off and in 15 patients with PD without wearing‐off both before (baseline) and repetitively at 1‐h intervals for up to 4 h after the morning PD medication dose. The patients with wearing‐off had fluctuation of BP during the observation period, BP increasing when the motor performance worsened and vice versa. The mean supine BP was at its highest at the baseline measurement (patients with wearing‐off, 145 ± 18 mmHg; patients without wearing‐off, 138 ± 17 mmHg), fell during the first hour (patients with wearing‐off, 119 ± 17 mmHg; patients without wearing‐off, 126 ± 18 mmHg), and then rose again toward the end of the observation period (patients with wearing‐off, 136 ± 15 mmHg; patients without wearing‐off, 138 ± 18 mmHg). This BP change was statistically significant only in PD patients with wearing‐off (P > 0.001). In conclusion, BP seems to fluctuate with motor impairment in PD patients with wearing‐off. This fluctuation may represent autonomic dysfunction caused by the PD process itself, the effect of PD medication, or both.</abstract><qualityIndicators><score>5.255</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1302</abstractCharCount><pdfWordCount>3023</pdfWordCount><pdfCharCount>19298</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>186</abstractWordCount></qualityIndicators><title>Blood pressure and heart rate in parkinsonian patients with and without wearing‐off</title><genre><json:string>article</json:string></genre><host><volume>14</volume><publisherId><json:string>ENE</json:string></publisherId><pages><total>6</total><last>378</last><first>373</first></pages><issn><json:string>1351-5101</json:string></issn><issue>4</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1468-1331</json:string></eissn><title>European Journal of Neurology</title><doi><json:string>10.1111/(ISSN)1468-1331</json:string></doi></host><publicationDate>2007</publicationDate><copyrightDate>2007</copyrightDate><doi><json:string>10.1111/j.1468-1331.2007.01672.x</json:string></doi><id>3F9376B4E7F2BF2A724930D5775EB0CAA8DEAD41</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/3F9376B4E7F2BF2A724930D5775EB0CAA8DEAD41/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/3F9376B4E7F2BF2A724930D5775EB0CAA8DEAD41/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/3F9376B4E7F2BF2A724930D5775EB0CAA8DEAD41/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Blood pressure and heart rate in parkinsonian patients with and without wearing‐off</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>2007</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Blood pressure and heart rate in parkinsonian patients with and without wearing‐off</title><author><persName><forename type="first">V.</forename><surname>Pursiainen</surname></persName><affiliation>Department of Neurology and Peijas Hospital, Vantaa, Finland</affiliation></author><author><persName><forename type="first">J. T.</forename><surname>Korpelainen</surname></persName><affiliation>Department of Neurology, University of Oulu, Oulu, Finland; and</affiliation></author><author><persName><forename type="first">T. H.</forename><surname>Haapaniemi</surname></persName><affiliation>Department of Neurology, University of Oulu, Oulu, Finland; and</affiliation></author><author><persName><forename type="first">K. A.</forename><surname>Sotaniemi</surname></persName><affiliation>Department of Neurology, University of Oulu, Oulu, Finland; and</affiliation></author><author><persName><forename type="first">V. V.</forename><surname>Myllylä</surname></persName><affiliation>Department of Neurology, University of Oulu, Oulu, Finland; and</affiliation></author></analytic><monogr><title level="j">European Journal of Neurology</title><idno type="pISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><idno type="DOI">10.1111/(ISSN)1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2007-04"></date><biblScope unit="volume">14</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="373">373</biblScope><biblScope unit="page" to="378">378</biblScope></imprint></monogr><idno type="istex">3F9376B4E7F2BF2A724930D5775EB0CAA8DEAD41</idno><idno type="DOI">10.1111/j.1468-1331.2007.01672.x</idno><idno type="ArticleID">ENE1672</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2007</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Our study aimed to investigate the cardiovascular autonomic regulation related to the wearing‐off phenomenon in Parkinson's disease (PD). We measured blood pressure (BP) and heart rate (HR) at rest and during orthostatic test in 16 patients with PD with wearing‐off and in 15 patients with PD without wearing‐off both before (baseline) and repetitively at 1‐h intervals for up to 4 h after the morning PD medication dose. The patients with wearing‐off had fluctuation of BP during the observation period, BP increasing when the motor performance worsened and vice versa. The mean supine BP was at its highest at the baseline measurement (patients with wearing‐off, 145 ± 18 mmHg; patients without wearing‐off, 138 ± 17 mmHg), fell during the first hour (patients with wearing‐off, 119 ± 17 mmHg; patients without wearing‐off, 126 ± 18 mmHg), and then rose again toward the end of the observation period (patients with wearing‐off, 136 ± 15 mmHg; patients without wearing‐off, 138 ± 18 mmHg). This BP change was statistically significant only in PD patients with wearing‐off (P < 0.001). In conclusion, BP seems to fluctuate with motor impairment in PD patients with wearing‐off. This fluctuation may represent autonomic dysfunction caused by the PD process itself, the effect of PD medication, or both.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>autonomic nervous system</term></item><item><term>blood pressure</term></item><item><term>motor fluctuation</term></item><item><term>Parkinson's disease</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-04">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/3F9376B4E7F2BF2A724930D5775EB0CAA8DEAD41/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1468-1331</doi><issn type="print">1351-5101</issn><issn type="electronic">1468-1331</issn><idGroup><id type="product" value="ENE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF NEUROLOGY">European Journal of Neurology</title></titleGroup></publicationMeta><publicationMeta level="part" position="04004"><doi origin="wiley">10.1111/ene.2007.14.issue-4</doi><numberingGroup><numbering type="journalVolume" number="14">14</numbering><numbering type="journalIssue" number="4">4</numbering></numberingGroup><coverDate startDate="2007-04">April 2007</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="3" status="forIssue"><doi origin="wiley">10.1111/j.1468-1331.2007.01672.x</doi><idGroup><id type="unit" value="ENE1672"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><eventGroup><event type="firstOnline" date="2007-03-23"></event><event type="publishedOnlineFinalForm" date="2007-03-23"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-06"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-24"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="373">373</numbering><numbering type="pageLast" number="378">378</numbering></numberingGroup><correspondenceTo>Ville Pursiainen, Department of Neurology, University of Oulu, PO Box 5000, FIN‐90014, Oulu, Finland (tel.: +358 41 504 7337; fax: +358 8 315 4544; e‐mail: <email>ville.pursiainen@sci.fi</email>).</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ENE.ENE1672.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 11 April 2006 Accepted 6 October 2006</unparsedEditorialHistory><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="1"></count></countGroup><titleGroup><title type="main">Blood pressure and heart rate in parkinsonian patients with and without wearing‐off</title><title type="shortAuthors">V. Pursiainen <i>et al.</i></title><title type="short">BP and HR in parkinsonian patients</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a2"><personName><givenNames>V.</givenNames><familyName>Pursiainen</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>J. T.</givenNames><familyName>Korpelainen</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>T. H.</givenNames><familyName>Haapaniemi</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>K. A.</givenNames><familyName>Sotaniemi</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>V. V.</givenNames><familyName>Myllylä</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="FI"><unparsedAffiliation>Department of Neurology, University of Oulu, Oulu, Finland; and</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="FI"><unparsedAffiliation>Department of Neurology and Peijas Hospital, Vantaa, Finland</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">autonomic nervous system</keyword><keyword xml:id="k2">blood pressure</keyword><keyword xml:id="k3">motor fluctuation</keyword><keyword xml:id="k4">Parkinson's disease</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>Our study aimed to investigate the cardiovascular autonomic regulation related to the wearing‐off phenomenon in Parkinson's disease (PD). We measured blood pressure (BP) and heart rate (HR) at rest and during orthostatic test in 16 patients with PD with wearing‐off and in 15 patients with PD without wearing‐off both before (baseline) and repetitively at 1‐h intervals for up to 4 h after the morning PD medication dose.</p><p>The patients with wearing‐off had fluctuation of BP during the observation period, BP increasing when the motor performance worsened and vice versa. The mean supine BP was at its highest at the baseline measurement (patients with wearing‐off, 145 ± 18 mmHg; patients without wearing‐off, 138 ± 17 mmHg), fell during the first hour (patients with wearing‐off, 119 ± 17 mmHg; patients without wearing‐off, 126 ± 18 mmHg), and then rose again toward the end of the observation period (patients with wearing‐off, 136 ± 15 mmHg; patients without wearing‐off, 138 ± 18 mmHg). This BP change was statistically significant only in PD patients with wearing‐off (<i>P</i> < 0.001).</p><p>In conclusion, BP seems to fluctuate with motor impairment in PD patients with wearing‐off. This fluctuation may represent autonomic dysfunction caused by the PD process itself, the effect of PD medication, or both.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Blood pressure and heart rate in parkinsonian patients with and without wearing‐off</title></titleInfo><titleInfo type="abbreviated"><title>BP and HR in parkinsonian patients</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Blood pressure and heart rate in parkinsonian patients with and without wearing‐off</title></titleInfo><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Pursiainen</namePart><affiliation>Department of Neurology and Peijas Hospital, Vantaa, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. T.</namePart><namePart type="family">Korpelainen</namePart><affiliation>Department of Neurology, University of Oulu, Oulu, Finland; and</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. H.</namePart><namePart type="family">Haapaniemi</namePart><affiliation>Department of Neurology, University of Oulu, Oulu, Finland; and</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. A.</namePart><namePart type="family">Sotaniemi</namePart><affiliation>Department of Neurology, University of Oulu, Oulu, Finland; and</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V. V.</namePart><namePart type="family">Myllylä</namePart><affiliation>Department of Neurology, University of Oulu, Oulu, Finland; and</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2007-04</dateIssued><edition>Received 11 April 2006 Accepted 6 October 2006</edition><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">1</extent></physicalDescription><abstract lang="en">Our study aimed to investigate the cardiovascular autonomic regulation related to the wearing‐off phenomenon in Parkinson's disease (PD). We measured blood pressure (BP) and heart rate (HR) at rest and during orthostatic test in 16 patients with PD with wearing‐off and in 15 patients with PD without wearing‐off both before (baseline) and repetitively at 1‐h intervals for up to 4 h after the morning PD medication dose. The patients with wearing‐off had fluctuation of BP during the observation period, BP increasing when the motor performance worsened and vice versa. The mean supine BP was at its highest at the baseline measurement (patients with wearing‐off, 145 ± 18 mmHg; patients without wearing‐off, 138 ± 17 mmHg), fell during the first hour (patients with wearing‐off, 119 ± 17 mmHg; patients without wearing‐off, 126 ± 18 mmHg), and then rose again toward the end of the observation period (patients with wearing‐off, 136 ± 15 mmHg; patients without wearing‐off, 138 ± 18 mmHg). This BP change was statistically significant only in PD patients with wearing‐off (P < 0.001). In conclusion, BP seems to fluctuate with motor impairment in PD patients with wearing‐off. This fluctuation may represent autonomic dysfunction caused by the PD process itself, the effect of PD medication, or both.</abstract><subject lang="en"><genre>Keywords</genre><topic>autonomic nervous system</topic><topic>blood pressure</topic><topic>motor fluctuation</topic><topic>Parkinson's disease</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neurology</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">1351-5101</identifier><identifier type="eISSN">1468-1331</identifier><identifier type="DOI">10.1111/(ISSN)1468-1331</identifier><identifier type="PublisherID">ENE</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>373</start><end>378</end><total>6</total></extent></part></relatedItem><identifier type="istex">3F9376B4E7F2BF2A724930D5775EB0CAA8DEAD41</identifier><identifier type="DOI">10.1111/j.1468-1331.2007.01672.x</identifier><identifier type="ArticleID">ENE1672</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B17 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 001B17 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:3F9376B4E7F2BF2A724930D5775EB0CAA8DEAD41
|texte= Blood pressure and heart rate in parkinsonian patients with and without wearing‐off
}}
| This area was generated with Dilib version V0.6.23. |  |