Brain perfusion and markers of neurodegeneration in rapid eye movement sleep behavior disorder
Identifieur interne : 001877 ( Main/Corpus ); précédent : 001876; suivant : 001878Brain perfusion and markers of neurodegeneration in rapid eye movement sleep behavior disorder
Auteurs : Mélanie Vendette ; Jean-François Gagnon ; Jean-Paul Soucy ; Nadia Gosselin ; Ronald B. Postuma ; Maria Tuineag ; Isabelle Godin ; Jacques MontplaisirSource :
- Movement Disorders [ 0885-3185 ] ; 2011-08-01.
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Abstract
Potential early markers of neurodegeneration such as subtle motor signs, reduced color discrimination, olfactory impairment, and brain perfusion abnormalities have been reported in idiopathic rapid eye movement sleep behavior disorder, a risk factor for Parkinson's disease and Lewy body dementia. The aim of this study was to reproduce observations of regional cerebral blood flow abnormalities in a larger independent sample of patients and to explore correlations between regional cerebral blood flow and markers of neurodegeneration. Twenty patients with idiopathic rapid eye movement sleep behavior disorder and 20 healthy controls were studied by single‐photon emission computerized tomography. Motor examination, color discrimination, and olfactory identification were examined. Patients with rapid eye movement sleep behavior disorder showed decreased regional cerebral blood flow in the frontal cortex and in medial parietal areas and increased regional cerebral blood flow in subcortical regions including the bilateral pons, putamen, and hippocampus. In rapid eye movement sleep behavior disorder, brain perfusion in the frontal cortex and occipital areas was associated with poorer performance in the color discrimination test. Moreover, a relationship between loss of olfactory discrimination and regional cerebral blood flow reduction in the bilateral anterior parahippocampal gyrus, a region known to be involved in olfactory functions, was found. This study provides further evidence of regional cerebral blood flow abnormalities in rapid eye movement sleep behavior disorder that are similar to those seen in Parkinson's disease and Lewy body dementia. Moreover, regional cerebral blood flow anomalies were associated with markers of neurodegeneration. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23721
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ISTEX:3236139A4D2A2CE02F01B7BBB994D6F1E84CAA12Le document en format XML
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The aim of this study was to reproduce observations of regional cerebral blood flow abnormalities in a larger independent sample of patients and to explore correlations between regional cerebral blood flow and markers of neurodegeneration. Twenty patients with idiopathic rapid eye movement sleep behavior disorder and 20 healthy controls were studied by single‐photon emission computerized tomography. Motor examination, color discrimination, and olfactory identification were examined. Patients with rapid eye movement sleep behavior disorder showed decreased regional cerebral blood flow in the frontal cortex and in medial parietal areas and increased regional cerebral blood flow in subcortical regions including the bilateral pons, putamen, and hippocampus. In rapid eye movement sleep behavior disorder, brain perfusion in the frontal cortex and occipital areas was associated with poorer performance in the color discrimination test. Moreover, a relationship between loss of olfactory discrimination and regional cerebral blood flow reduction in the bilateral anterior parahippocampal gyrus, a region known to be involved in olfactory functions, was found. This study provides further evidence of regional cerebral blood flow abnormalities in rapid eye movement sleep behavior disorder that are similar to those seen in Parkinson's disease and Lewy body dementia. Moreover, regional cerebral blood flow anomalies were associated with markers of neurodegeneration. © 2011 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Mélanie Vendette MSc</name><affiliations><json:string>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré‐Cœur de Montréal, Montreal, Quebec, Canada</json:string><json:string>Department of Psychology, University of Montreal, Montreal, Quebec, Canada</json:string></affiliations></json:item><json:item><name>Jean‐François Gagnon PhD</name><affiliations><json:string>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré‐Cœur de Montréal, Montreal, Quebec, Canada</json:string><json:string>Department of Psychology, Université du Québec à Montréal, Montreal, Quebec, Canada</json:string></affiliations></json:item><json:item><name>Jean‐Paul Soucy MD, MSc</name><affiliations><json:string>Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada</json:string><json:string>Department of Nuclear Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada</json:string></affiliations></json:item><json:item><name>Nadia Gosselin PhD</name><affiliations><json:string>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré‐Cœur de Montréal, Montreal, Quebec, Canada</json:string><json:string>Department of Psychiatry, University of Montreal, Montreal, Quebec, Canada</json:string></affiliations></json:item><json:item><name>Ronald B. 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The aim of this study was to reproduce observations of regional cerebral blood flow abnormalities in a larger independent sample of patients and to explore correlations between regional cerebral blood flow and markers of neurodegeneration. Twenty patients with idiopathic rapid eye movement sleep behavior disorder and 20 healthy controls were studied by single‐photon emission computerized tomography. Motor examination, color discrimination, and olfactory identification were examined. Patients with rapid eye movement sleep behavior disorder showed decreased regional cerebral blood flow in the frontal cortex and in medial parietal areas and increased regional cerebral blood flow in subcortical regions including the bilateral pons, putamen, and hippocampus. In rapid eye movement sleep behavior disorder, brain perfusion in the frontal cortex and occipital areas was associated with poorer performance in the color discrimination test. Moreover, a relationship between loss of olfactory discrimination and regional cerebral blood flow reduction in the bilateral anterior parahippocampal gyrus, a region known to be involved in olfactory functions, was found. This study provides further evidence of regional cerebral blood flow abnormalities in rapid eye movement sleep behavior disorder that are similar to those seen in Parkinson's disease and Lewy body dementia. 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Postuma, and Jacques Montplaisir.</note><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Brain perfusion and markers of neurodegeneration in rapid eye movement sleep behavior disorder</title><author><persName><forename type="first">Mélanie</forename><surname>Vendette</surname></persName><roleName type="degree">MSc</roleName><affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré‐Cœur de Montréal, Montreal, Quebec, Canada</affiliation><affiliation>Department of Psychology, University of Montreal, Montreal, Quebec, Canada</affiliation></author><author><persName><forename type="first">Jean‐François</forename><surname>Gagnon</surname></persName><roleName type="degree">PhD</roleName><affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré‐Cœur de Montréal, Montreal, Quebec, Canada</affiliation><affiliation>Department of Psychology, Université du Québec à Montréal, Montreal, Quebec, Canada</affiliation></author><author><persName><forename type="first">Jean‐Paul</forename><surname>Soucy</surname></persName><roleName type="degree">MD, MSc</roleName><affiliation>Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada</affiliation><affiliation>Department of Nuclear Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada</affiliation></author><author><persName><forename type="first">Nadia</forename><surname>Gosselin</surname></persName><roleName type="degree">PhD</roleName><affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré‐Cœur de Montréal, Montreal, Quebec, Canada</affiliation><affiliation>Department of Psychiatry, University of Montreal, Montreal, Quebec, Canada</affiliation></author><author><persName><forename type="first">Ronald B.</forename><surname>Postuma</surname></persName><roleName type="degree">MD, MSc</roleName><affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré‐Cœur de Montréal, Montreal, Quebec, Canada</affiliation><affiliation>Department of Neurology, Montreal General Hospital, Montreal, Quebec, Canada</affiliation></author><author><persName><forename type="first">Maria</forename><surname>Tuineag</surname></persName><roleName type="degree">MD</roleName><affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré‐Cœur de Montréal, Montreal, Quebec, Canada</affiliation><affiliation>Department of Psychiatry, University of Montreal, Montreal, Quebec, Canada</affiliation></author><author><persName><forename type="first">Isabelle</forename><surname>Godin</surname></persName><roleName type="degree">BSc</roleName><affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré‐Cœur de Montréal, Montreal, Quebec, Canada</affiliation><affiliation>Department of Psychology, University of Montreal, Montreal, Quebec, Canada</affiliation></author><author><persName><forename type="first">Jacques</forename><surname>Montplaisir</surname></persName><roleName type="degree">MD, PhD, CRCPc</roleName><note type="correspondence"><p>Correspondence: Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré‐Cœur de Montréal, 5400 boul. Gouin Ouest, Montréal, Québec, Canada H4J 1C5</p></note><affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré‐Cœur de Montréal, Montreal, Quebec, Canada</affiliation><affiliation>Department of Psychiatry, University of Montreal, Montreal, Quebec, Canada</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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The aim of this study was to reproduce observations of regional cerebral blood flow abnormalities in a larger independent sample of patients and to explore correlations between regional cerebral blood flow and markers of neurodegeneration. Twenty patients with idiopathic rapid eye movement sleep behavior disorder and 20 healthy controls were studied by single‐photon emission computerized tomography. Motor examination, color discrimination, and olfactory identification were examined. Patients with rapid eye movement sleep behavior disorder showed decreased regional cerebral blood flow in the frontal cortex and in medial parietal areas and increased regional cerebral blood flow in subcortical regions including the bilateral pons, putamen, and hippocampus. In rapid eye movement sleep behavior disorder, brain perfusion in the frontal cortex and occipital areas was associated with poorer performance in the color discrimination test. Moreover, a relationship between loss of olfactory discrimination and regional cerebral blood flow reduction in the bilateral anterior parahippocampal gyrus, a region known to be involved in olfactory functions, was found. This study provides further evidence of regional cerebral blood flow abnormalities in rapid eye movement sleep behavior disorder that are similar to those seen in Parkinson's disease and Lewy body dementia. Moreover, regional cerebral blood flow anomalies were associated with markers of neurodegeneration. © 2011 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>rapid eye movement sleep behavior disorder</term></item><item><term>single‐photon emission computerized tomography (regional cerebral blood flow)</term></item><item><term>Parkinson's disease</term></item><item><term>Lewy body dementia</term></item><item><term>markers of neurodegeneration</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-09-23">Received</change><change when="2011-02-24">Registration</change><change when="2011-08-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/3236139A4D2A2CE02F01B7BBB994D6F1E84CAA12/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="90"><doi origin="wiley" registered="yes">10.1002/mds.v26.9</doi><numberingGroup><numbering type="journalVolume" number="26">26</numbering><numbering type="journalIssue">9</numbering></numberingGroup><coverDate startDate="2011-08-01">1 August 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="220" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.23721</doi><idGroup><id type="unit" value="MDS23721"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2011 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2010-09-23"></event><event type="manuscriptRevised" date="2011-02-04"></event><event type="manuscriptAccepted" date="2011-02-24"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.0.1 mode:FullText" date="2011-12-16"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-05-03"></event><event type="publishedOnlineFinalForm" date="2011-08-09"></event><event type="firstOnline" date="2011-05-03"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">1717</numbering><numbering type="pageLast">1724</numbering></numberingGroup><correspondenceTo>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré‐Cœur de Montréal, 5400 boul. Gouin Ouest, Montréal, Québec, Canada H4J 1C5</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS23721.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="43"></count><count type="wordTotal" number="5978"></count></countGroup><titleGroup><title type="main" xml:lang="en">Brain perfusion and markers of neurodegeneration in rapid eye movement sleep behavior disorder<link href="#fn1"></link><link href="#fn2"></link><link href="#fn3"></link></title><title type="short" xml:lang="en">rCBF in Idiopathic RBD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Mélanie</givenNames><familyName>Vendette</familyName><degrees>MSc</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1 #af3"><personName><givenNames>Jean‐François</givenNames><familyName>Gagnon</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af4 #af5"><personName><givenNames>Jean‐Paul</givenNames><familyName>Soucy</familyName><degrees>MD, MSc</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1 #af6"><personName><givenNames>Nadia</givenNames><familyName>Gosselin</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1 #af7"><personName><givenNames>Ronald B.</givenNames><familyName>Postuma</familyName><degrees>MD, MSc</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1 #af6"><personName><givenNames>Maria</givenNames><familyName>Tuineag</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Isabelle</givenNames><familyName>Godin</familyName><degrees>BSc</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1 #af6" corresponding="yes"><personName><givenNames>Jacques</givenNames><familyName>Montplaisir</familyName><degrees>MD, PhD, CRCPc</degrees></personName><contactDetails><email>JY.Montplaisir@UMontreal.CA</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="CA" type="organization"><unparsedAffiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré‐Cœur de Montréal, Montreal, Quebec, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="CA" type="organization"><unparsedAffiliation>Department of Psychology, University of Montreal, Montreal, Quebec, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="CA" type="organization"><unparsedAffiliation>Department of Psychology, Université du Québec à Montréal, Montreal, Quebec, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="CA" type="organization"><unparsedAffiliation>Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="CA" type="organization"><unparsedAffiliation>Department of Nuclear Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="CA" type="organization"><unparsedAffiliation>Department of Psychiatry, University of Montreal, Montreal, Quebec, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="CA" type="organization"><unparsedAffiliation>Department of Neurology, Montreal General Hospital, Montreal, Quebec, Canada</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">rapid eye movement sleep behavior disorder</keyword><keyword xml:id="kwd2">single‐photon emission computerized tomography (regional cerebral blood flow)</keyword><keyword xml:id="kwd3">Parkinson's disease</keyword><keyword xml:id="kwd4">Lewy body dementia</keyword><keyword xml:id="kwd5">markers of neurodegeneration</keyword></keywordGroup><supportingInformation><p> Additional Supporting Information may be found in the online version of this article. </p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds23721:MDS_23721_sm_Supptable1"></mediaResource><caption>Supporting Information Table 1.</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds23721:MDS_23721_sm_Supptable2"></mediaResource><caption>Supporting Information Table 2.</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Potential early markers of neurodegeneration such as subtle motor signs, reduced color discrimination, olfactory impairment, and brain perfusion abnormalities have been reported in idiopathic rapid eye movement sleep behavior disorder, a risk factor for Parkinson's disease and Lewy body dementia. The aim of this study was to reproduce observations of regional cerebral blood flow abnormalities in a larger independent sample of patients and to explore correlations between regional cerebral blood flow and markers of neurodegeneration. Twenty patients with idiopathic rapid eye movement sleep behavior disorder and 20 healthy controls were studied by single‐photon emission computerized tomography. Motor examination, color discrimination, and olfactory identification were examined. Patients with rapid eye movement sleep behavior disorder showed decreased regional cerebral blood flow in the frontal cortex and in medial parietal areas and increased regional cerebral blood flow in subcortical regions including the bilateral pons, putamen, and hippocampus. In rapid eye movement sleep behavior disorder, brain perfusion in the frontal cortex and occipital areas was associated with poorer performance in the color discrimination test. Moreover, a relationship between loss of olfactory discrimination and regional cerebral blood flow reduction in the bilateral anterior parahippocampal gyrus, a region known to be involved in olfactory functions, was found. This study provides further evidence of regional cerebral blood flow abnormalities in rapid eye movement sleep behavior disorder that are similar to those seen in Parkinson's disease and Lewy body dementia. Moreover, regional cerebral blood flow anomalies were associated with markers of neurodegeneration. © 2011 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p><b>Funding agencies</b>: This study was supported by grants from the Fonds de la Recherche en Santé du Québec and the Canadian Institutes of Health Research to Jean‐François Gagnon, Jean‐Paul Soucy, Ronald B. Postuma, and Jacques Montplaisir.</p></note><note xml:id="fn2"><p><b>Relevant conflicts of interest/financial disclosures</b>: Nothing to report.</p></note><note xml:id="fn3"><p>Full financial disclosures and author roles may be found in the online version of this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Brain perfusion and markers of neurodegeneration in rapid eye movement sleep behavior disorder</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>rCBF in Idiopathic RBD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Brain perfusion and markers of neurodegeneration in rapid eye movement sleep behavior disorder</title></titleInfo><name type="personal"><namePart type="given">Mélanie</namePart><namePart type="family">Vendette</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré‐Cœur de Montréal, Montreal, Quebec, Canada</affiliation><affiliation>Department of Psychology, University of Montreal, Montreal, Quebec, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐François</namePart><namePart type="family">Gagnon</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré‐Cœur de Montréal, Montreal, Quebec, Canada</affiliation><affiliation>Department of Psychology, Université du Québec à Montréal, Montreal, Quebec, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐Paul</namePart><namePart type="family">Soucy</namePart><namePart type="termsOfAddress">MD, MSc</namePart><affiliation>Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada</affiliation><affiliation>Department of Nuclear Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nadia</namePart><namePart type="family">Gosselin</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré‐Cœur de Montréal, Montreal, Quebec, Canada</affiliation><affiliation>Department of Psychiatry, University of Montreal, Montreal, Quebec, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ronald B.</namePart><namePart type="family">Postuma</namePart><namePart type="termsOfAddress">MD, MSc</namePart><affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré‐Cœur de Montréal, Montreal, Quebec, Canada</affiliation><affiliation>Department of Neurology, Montreal General Hospital, Montreal, Quebec, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maria</namePart><namePart type="family">Tuineag</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré‐Cœur de Montréal, Montreal, Quebec, Canada</affiliation><affiliation>Department of Psychiatry, University of Montreal, Montreal, Quebec, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Isabelle</namePart><namePart type="family">Godin</namePart><namePart type="termsOfAddress">BSc</namePart><affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré‐Cœur de Montréal, Montreal, Quebec, Canada</affiliation><affiliation>Department of Psychology, University of Montreal, Montreal, Quebec, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jacques</namePart><namePart type="family">Montplaisir</namePart><namePart type="termsOfAddress">MD, PhD, CRCPc</namePart><affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré‐Cœur de Montréal, Montreal, Quebec, Canada</affiliation><affiliation>Department of Psychiatry, University of Montreal, Montreal, Quebec, Canada</affiliation><description>Correspondence: Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré‐Cœur de Montréal, 5400 boul. Gouin Ouest, Montréal, Québec, Canada H4J 1C5</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-08-01</dateIssued><dateCaptured encoding="w3cdtf">2010-09-23</dateCaptured><dateValid encoding="w3cdtf">2011-02-24</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">2</extent><extent unit="references">43</extent><extent unit="words">5978</extent></physicalDescription><abstract lang="en">Potential early markers of neurodegeneration such as subtle motor signs, reduced color discrimination, olfactory impairment, and brain perfusion abnormalities have been reported in idiopathic rapid eye movement sleep behavior disorder, a risk factor for Parkinson's disease and Lewy body dementia. The aim of this study was to reproduce observations of regional cerebral blood flow abnormalities in a larger independent sample of patients and to explore correlations between regional cerebral blood flow and markers of neurodegeneration. Twenty patients with idiopathic rapid eye movement sleep behavior disorder and 20 healthy controls were studied by single‐photon emission computerized tomography. Motor examination, color discrimination, and olfactory identification were examined. Patients with rapid eye movement sleep behavior disorder showed decreased regional cerebral blood flow in the frontal cortex and in medial parietal areas and increased regional cerebral blood flow in subcortical regions including the bilateral pons, putamen, and hippocampus. In rapid eye movement sleep behavior disorder, brain perfusion in the frontal cortex and occipital areas was associated with poorer performance in the color discrimination test. Moreover, a relationship between loss of olfactory discrimination and regional cerebral blood flow reduction in the bilateral anterior parahippocampal gyrus, a region known to be involved in olfactory functions, was found. This study provides further evidence of regional cerebral blood flow abnormalities in rapid eye movement sleep behavior disorder that are similar to those seen in Parkinson's disease and Lewy body dementia. Moreover, regional cerebral blood flow anomalies were associated with markers of neurodegeneration. © 2011 Movement Disorder Society</abstract><note type="content">*Funding agencies: This study was supported by grants from the Fonds de la Recherche en Santé du Québec and the Canadian Institutes of Health Research to Jean‐François Gagnon, Jean‐Paul Soucy, Ronald B. Postuma, and Jacques Montplaisir.</note><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note><subject lang="en"><genre>Keywords</genre><topic>rapid eye movement sleep behavior disorder</topic><topic>single‐photon emission computerized tomography (regional cerebral blood flow)</topic><topic>Parkinson's disease</topic><topic>Lewy body dementia</topic><topic>markers of neurodegeneration</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><note type="content"> Additional Supporting Information may be found in the online version of this article.Supporting Info Item: Supporting Information Table 1. - Supporting Information Table 2. - </note><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>9</number></detail><extent unit="pages"><start>1717</start><end>1724</end><total>8</total></extent></part></relatedItem><identifier type="istex">3236139A4D2A2CE02F01B7BBB994D6F1E84CAA12</identifier><identifier type="DOI">10.1002/mds.23721</identifier><identifier type="ArticleID">MDS23721</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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