Plasma profiles of adrenocorticotropic hormone, cortisol, growth hormone and prolactin in patients with untreated parkinson's disease
Identifieur interne : 001872 ( Main/Corpus ); précédent : 001871; suivant : 001873Plasma profiles of adrenocorticotropic hormone, cortisol, growth hormone and prolactin in patients with untreated parkinson's disease
Auteurs : G. Bellomo ; L. Santambrogio ; M. Fiacconi ; M. Scarponi ; G. CiuffettiSource :
- Journal of Neurology [ 0340-5354 ] ; 1991-02-01.
Abstract
Summary: Plasma profiles of prolactin, growth hormone, adrenocorticotropic hormone (ACTH) and cortisol were evaluated in a group of untreated patients with idiopathic Parkinson's disease and a group of healthy age-matched controls. Plasma integrated concentrations of all hormones except prolactin were significantly lower in the patients as compared with the controls; however, prolactin nocturnal peak concentration was significantly elevated in the patients; nocturnal growth hormone levels were significantly reduced in the Parkinson group; ACTH and cortisol plasma concentrations were also consistently lower during most of the day in the patients with Parkinson's disease. These data confirm the presence of a hypothalamic disturbance in patients with idopathic Parkinson's disease, which can affect pituitary function.
Url:
DOI: 10.1007/BF00319704
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Plasma integrated concentrations of all hormones except prolactin were significantly lower in the patients as compared with the controls; however, prolactin nocturnal peak concentration was significantly elevated in the patients; nocturnal growth hormone levels were significantly reduced in the Parkinson group; ACTH and cortisol plasma concentrations were also consistently lower during most of the day in the patients with Parkinson's disease. These data confirm the presence of a hypothalamic disturbance in patients with idopathic Parkinson's disease, which can affect pituitary function.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>G. Bellomo</name><affiliations><json:string>II Department of Internal Medicine, University of Perugia, Policlinico Monteluce, I-06100, Perugia, Italy</json:string></affiliations></json:item><json:item><name>L. 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Plasma integrated concentrations of all hormones except prolactin were significantly lower in the patients as compared with the controls; however, prolactin nocturnal peak concentration was significantly elevated in the patients; nocturnal growth hormone levels were significantly reduced in the Parkinson group; ACTH and cortisol plasma concentrations were also consistently lower during most of the day in the patients with Parkinson's disease. 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patients with untreated parkinson's disease</ArticleTitle><ArticleCategory>Original Investigations</ArticleCategory><ArticleFirstPage>19</ArticleFirstPage><ArticleLastPage>22</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2004</Year><Month>8</Month><Day>26</Day></RegistrationDate><Received><Year>1990</Year><Month>2</Month><Day>22</Day></Received><Revised><Year>1990</Year><Month>7</Month><Day>26</Day></Revised><Accepted><Year>1990</Year><Month>9</Month><Day>3</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1991</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant 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DisplayOrder="Western"><GivenName>G.</GivenName><FamilyName>Ciuffetti</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>II Department of Internal Medicine</OrgDivision><OrgName>University of Perugia, Policlinico Monteluce</OrgName><OrgAddress><Postcode>I-06100</Postcode><City>Perugia</City><Country>Italy</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Department of Nuclear Medicine</OrgDivision><OrgName>University of Perugia Medical School</OrgName><OrgAddress><Postcode>I-06100</Postcode><City>Perugia</City><Country>Italy</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>Plasma profiles of prolactin, growth hormone, adrenocorticotropic hormone (ACTH) and cortisol were evaluated in a group of untreated patients with idiopathic Parkinson's disease and a group of healthy age-matched controls. Plasma integrated concentrations of all hormones except prolactin were significantly lower in the patients as compared with the controls; however, prolactin nocturnal peak concentration was significantly elevated in the patients; nocturnal growth hormone levels were significantly reduced in the Parkinson group; ACTH and cortisol plasma concentrations were also consistently lower during most of the day in the patients with Parkinson's disease. These data confirm the presence of a hypothalamic disturbance in patients with idopathic Parkinson's disease, which can affect pituitary function.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Parkinson's disease</Keyword><Keyword>Adrenocorticotropic hormone</Keyword><Keyword>Cortisol</Keyword><Keyword>Growth hormone</Keyword><Keyword>Prolactin</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Plasma profiles of adrenocorticotropic hormone, cortisol, growth hormone and prolactin in patients with untreated parkinson's disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Plasma profiles of adrenocorticotropic hormone, cortisol, growth hormone and prolactin in patients with untreated parkinson's disease</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">G.</namePart><namePart type="family">Bellomo</namePart><affiliation>II Department of Internal Medicine, University of Perugia, Policlinico Monteluce, I-06100, Perugia, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Santambrogio</namePart><affiliation>II Department of Internal Medicine, University of Perugia, Policlinico Monteluce, I-06100, Perugia, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Fiacconi</namePart><affiliation>Department of Nuclear Medicine, University of Perugia Medical School, I-06100, Perugia, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="given">M.</namePart><namePart type="family">Scarponi</namePart><affiliation>II Department of Internal Medicine, University of Perugia, Policlinico Monteluce, I-06100, Perugia, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Ciuffetti</namePart><affiliation>II Department of Internal Medicine, University of Perugia, Policlinico Monteluce, I-06100, Perugia, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper"></genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1990-02-22</dateCreated><dateIssued encoding="w3cdtf">1991-02-01</dateIssued><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Summary: Plasma profiles of prolactin, growth hormone, adrenocorticotropic hormone (ACTH) and cortisol were evaluated in a group of untreated patients with idiopathic Parkinson's disease and a group of healthy age-matched controls. Plasma integrated concentrations of all hormones except prolactin were significantly lower in the patients as compared with the controls; however, prolactin nocturnal peak concentration was significantly elevated in the patients; nocturnal growth hormone levels were significantly reduced in the Parkinson group; ACTH and cortisol plasma concentrations were also consistently lower during most of the day in the patients with Parkinson's disease. 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