A new diagnostic test to distinguish tremulous Parkinson's disease from advanced essential tremor
Identifieur interne : 001869 ( Main/Corpus ); précédent : 001868; suivant : 001870A new diagnostic test to distinguish tremulous Parkinson's disease from advanced essential tremor
Auteurs : Muthuraman Muthuraman ; Abdulnasir Hossen ; Ulrich Heute ; Günther Deuschl ; Jan RaethjenSource :
- Movement Disorders [ 0885-3185 ] ; 2011-07.
English descriptors
Abstract
Background:: Clinical distinction between advanced essential tremor and tremulous Parkinson's disease can be difficult. Methods:: In selected power spectra of accelerometric postural tremor recordings on the more affected side of 41 patients with essential tremor and 39 patients with tremulous Parkinson's disease being indistinguishable by tremor frequency, peak power or number of harmonic peaks, waveform asymmetry (autocorrelation decay), and mean peak power of all harmonic peaks were computed. Cutoff for essential tremor–Parkinson's disease distinction was determined by receiver operating characteristics. Diagnostic yield was tested in 12 clinically unclear patients with monosymptomatic tremor, subsequently definitively diagnosed with essential tremor (n = 2) or Parkinson's disease (n = 10) by 123‐I FP‐CIT–single‐photon emission computed tomography, fluorodopa‐positron emission tomography, or clinical course. Results:: By autocorrelation decay 64%, by mean harmonic peak power 94% (Parkinson's disease > essential tremor) of patients with a definite clinical diagnosis, and 11 of 12 clinically unclear patients were classified correctly. Conclusions:: Mean harmonic power is a useful measure to separate clinically difficult cases of advanced essential tremor from tremulous Parkinson's disease. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23672
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-07">2011-07</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1548">1548</biblScope><biblScope unit="page" to="1552">1552</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">DEAD6AE06D22C93EB0AB604B51515EB4B33020C7</idno><idno type="DOI">10.1002/mds.23672</idno><idno type="ArticleID">MDS23672</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>accelerometry</term><term>differential diagnosis</term><term>essential tremor</term><term>parkinsonian tremor</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: Clinical distinction between advanced essential tremor and tremulous Parkinson's disease can be difficult. Methods:: In selected power spectra of accelerometric postural tremor recordings on the more affected side of 41 patients with essential tremor and 39 patients with tremulous Parkinson's disease being indistinguishable by tremor frequency, peak power or number of harmonic peaks, waveform asymmetry (autocorrelation decay), and mean peak power of all harmonic peaks were computed. Cutoff for essential tremor–Parkinson's disease distinction was determined by receiver operating characteristics. Diagnostic yield was tested in 12 clinically unclear patients with monosymptomatic tremor, subsequently definitively diagnosed with essential tremor (n = 2) or Parkinson's disease (n = 10) by 123‐I FP‐CIT–single‐photon emission computed tomography, fluorodopa‐positron emission tomography, or clinical course. Results:: By autocorrelation decay 64%, by mean harmonic peak power 94% (Parkinson's disease > essential tremor) of patients with a definite clinical diagnosis, and 11 of 12 clinically unclear patients were classified correctly. Conclusions:: Mean harmonic power is a useful measure to separate clinically difficult cases of advanced essential tremor from tremulous Parkinson's disease. © 2011 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Muthuraman Muthuraman PhD</name><affiliations><json:string>Department of Neurology, University of Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Abdulnasir Hossen PhD</name><affiliations><json:string>Department of Electrical and Computer Engineering, Sultan Qaboos University, Muscat, Oman</json:string></affiliations></json:item><json:item><name>Ulrich Heute PhD</name><affiliations><json:string>Institute for Circuit and System Theory, Faculty of Engineering, University of Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Günther Deuschl MD</name><affiliations><json:string>Department of Neurology, University of Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Jan Raethjen MD</name><affiliations><json:string>Department of Neurology, University of Kiel, Kiel, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>parkinsonian tremor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>essential tremor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>accelerometry</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>differential diagnosis</value></json:item></subject><articleId><json:string>MDS23672</json:string></articleId><language><json:string>eng</json:string></language><abstract>Background:: Clinical distinction between advanced essential tremor and tremulous Parkinson's disease can be difficult. Methods:: In selected power spectra of accelerometric postural tremor recordings on the more affected side of 41 patients with essential tremor and 39 patients with tremulous Parkinson's disease being indistinguishable by tremor frequency, peak power or number of harmonic peaks, waveform asymmetry (autocorrelation decay), and mean peak power of all harmonic peaks were computed. Cutoff for essential tremor–Parkinson's disease distinction was determined by receiver operating characteristics. Diagnostic yield was tested in 12 clinically unclear patients with monosymptomatic tremor, subsequently definitively diagnosed with essential tremor (n = 2) or Parkinson's disease (n = 10) by 123‐I FP‐CIT–single‐photon emission computed tomography, fluorodopa‐positron emission tomography, or clinical course. Results:: By autocorrelation decay 64%, by mean harmonic peak power 94% (Parkinson's disease > essential tremor) of patients with a definite clinical diagnosis, and 11 of 12 clinically unclear patients were classified correctly. Conclusions:: Mean harmonic power is a useful measure to separate clinically difficult cases of advanced essential tremor from tremulous Parkinson's disease. © 2011 Movement Disorder Society</abstract><qualityIndicators><score>7.136</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1344</abstractCharCount><pdfWordCount>16185</pdfWordCount><pdfCharCount>106799</pdfCharCount><pdfPageCount>27</pdfPageCount><abstractWordCount>178</abstractWordCount></qualityIndicators><title>A new diagnostic test to distinguish tremulous Parkinson's disease from advanced essential tremor</title><genre><json:string>article</json:string></genre><host><volume>26</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>5</total><last>1552</last><first>1548</first></pages><issn><json:string>0885-3185</json:string></issn><issue>8</issue><subject><json:item><value>Brief Report</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/mds.23672</json:string></doi><id>DEAD6AE06D22C93EB0AB604B51515EB4B33020C7</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/DEAD6AE06D22C93EB0AB604B51515EB4B33020C7/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/DEAD6AE06D22C93EB0AB604B51515EB4B33020C7/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/DEAD6AE06D22C93EB0AB604B51515EB4B33020C7/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">A new diagnostic test to distinguish tremulous Parkinson's disease from advanced essential tremor</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2011</date></publicationStmt><notesStmt><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report. Muthuraman Muthuraman, Günther Deuschl, and Jan Raethjen received research support from the German Research Council (Deutsche Forschungsgemeinschaft [DFG]: SFB 855) Project D2. Abdulnasir Hossen received research support from the DAAD (German Academic Exchange Service) through a research scholarship. Ulrich Heute received support from the German Research Council (DFG: SFB 855) Project C3. Full financial disclosures and author roles may be found in the online version of this article.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">A new diagnostic test to distinguish tremulous Parkinson's disease from advanced essential tremor</title><author><persName><forename type="first">Muthuraman</forename><surname>Muthuraman</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neurology, University of Kiel, Kiel, Germany</affiliation></author><author><persName><forename type="first">Abdulnasir</forename><surname>Hossen</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Electrical and Computer Engineering, Sultan Qaboos University, Muscat, Oman</affiliation></author><author><persName><forename type="first">Ulrich</forename><surname>Heute</surname></persName><roleName type="degree">PhD</roleName><affiliation>Institute for Circuit and System Theory, Faculty of Engineering, University of Kiel, Kiel, Germany</affiliation></author><author><persName><forename type="first">Günther</forename><surname>Deuschl</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, University of Kiel, Kiel, Germany</affiliation></author><author><persName><forename type="first">Jan</forename><surname>Raethjen</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Department of Neurology, University of Kiel, Schittenhelmstrasse 10, 24105 Kiel, Germany</p></note><affiliation>Department of Neurology, University of Kiel, Kiel, Germany</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-07"></date><biblScope unit="volume">26</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1548">1548</biblScope><biblScope unit="page" to="1552">1552</biblScope></imprint></monogr><idno type="istex">DEAD6AE06D22C93EB0AB604B51515EB4B33020C7</idno><idno type="DOI">10.1002/mds.23672</idno><idno type="ArticleID">MDS23672</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background:: Clinical distinction between advanced essential tremor and tremulous Parkinson's disease can be difficult. Methods:: In selected power spectra of accelerometric postural tremor recordings on the more affected side of 41 patients with essential tremor and 39 patients with tremulous Parkinson's disease being indistinguishable by tremor frequency, peak power or number of harmonic peaks, waveform asymmetry (autocorrelation decay), and mean peak power of all harmonic peaks were computed. Cutoff for essential tremor–Parkinson's disease distinction was determined by receiver operating characteristics. Diagnostic yield was tested in 12 clinically unclear patients with monosymptomatic tremor, subsequently definitively diagnosed with essential tremor (n = 2) or Parkinson's disease (n = 10) by 123‐I FP‐CIT–single‐photon emission computed tomography, fluorodopa‐positron emission tomography, or clinical course. Results:: By autocorrelation decay 64%, by mean harmonic peak power 94% (Parkinson's disease > essential tremor) of patients with a definite clinical diagnosis, and 11 of 12 clinically unclear patients were classified correctly. Conclusions:: Mean harmonic power is a useful measure to separate clinically difficult cases of advanced essential tremor from tremulous Parkinson's disease. © 2011 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>parkinsonian tremor</term></item><item><term>essential tremor</term></item><item><term>accelerometry</term></item><item><term>differential diagnosis</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-11-08">Received</change><change when="2011-01-13">Registration</change><change when="2011-07">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/DEAD6AE06D22C93EB0AB604B51515EB4B33020C7/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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number="2"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="18"></count><count type="wordTotal" number="3531"></count></countGroup><titleGroup><title type="main" xml:lang="en">A new diagnostic test to distinguish tremulous Parkinson's disease from advanced essential tremor<link href="#fn1"></link></title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Muthuraman</givenNames><familyName>Muthuraman</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Abdulnasir</givenNames><familyName>Hossen</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Ulrich</givenNames><familyName>Heute</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Günther</givenNames><familyName>Deuschl</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Jan</givenNames><familyName>Raethjen</familyName><degrees>MD</degrees></personName><contactDetails><email normalForm="j.raethjen@neurologie.uni-kiel.de">j.raethjen@neurologie.uni‐kiel.de</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, University of Kiel, Kiel, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="OM" type="organization"><unparsedAffiliation>Department of Electrical and Computer Engineering, Sultan Qaboos University, Muscat, Oman</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="DE" type="organization"><unparsedAffiliation>Institute for Circuit and System Theory, Faculty of Engineering, University of Kiel, Kiel, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">parkinsonian tremor</keyword><keyword xml:id="kwd2">essential tremor</keyword><keyword xml:id="kwd3">accelerometry</keyword><keyword xml:id="kwd4">differential diagnosis</keyword></keywordGroup><supportingInformation><p> Additional Supporting Information may be found in the online version of this article. </p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds23672:MDS_23672_sm_suppinfo"></mediaResource><caption>Supporting Information</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main">Background:</title><p>Clinical distinction between advanced essential tremor and tremulous Parkinson's disease can be difficult.</p></section><section xml:id="abs1-2"><title type="main">Methods:</title><p>In selected power spectra of accelerometric postural tremor recordings on the more affected side of 41 patients with essential tremor and 39 patients with tremulous Parkinson's disease being indistinguishable by tremor frequency, peak power or number of harmonic peaks, waveform asymmetry (autocorrelation decay), and mean peak power of all harmonic peaks were computed. Cutoff for essential tremor–Parkinson's disease distinction was determined by receiver operating characteristics. Diagnostic yield was tested in 12 clinically unclear patients with monosymptomatic tremor, subsequently definitively diagnosed with essential tremor (n = 2) or Parkinson's disease (n = 10) by 123‐I FP‐CIT–single‐photon emission computed tomography, fluorodopa‐positron emission tomography, or clinical course.</p></section><section xml:id="abs1-3"><title type="main">Results:</title><p>By autocorrelation decay 64%, by mean harmonic peak power 94% (Parkinson's disease > essential tremor) of patients with a definite clinical diagnosis, and 11 of 12 clinically unclear patients were classified correctly.</p></section><section xml:id="abs1-4"><title type="main">Conclusions:</title><p>Mean harmonic power is a useful measure to separate clinically difficult cases of advanced essential tremor from tremulous Parkinson's disease. © 2011 Movement Disorder Society</p></section></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p><b>Relevant conflicts of interest/financial disclosures:</b> Nothing to report.</p><p>Muthuraman Muthuraman, Günther Deuschl, and Jan Raethjen received research support from the German Research Council (Deutsche Forschungsgemeinschaft [DFG]: SFB 855) Project D2. Abdulnasir Hossen received research support from the DAAD (German Academic Exchange Service) through a research scholarship. Ulrich Heute received support from the German Research Council (DFG: SFB 855) Project C3.</p><p>Full financial disclosures and author roles may be found in the online version of this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>A new diagnostic test to distinguish tremulous Parkinson's disease from advanced essential tremor</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>A new diagnostic test to distinguish tremulous Parkinson's disease from advanced essential tremor</title></titleInfo><name type="personal"><namePart type="given">Muthuraman</namePart><namePart type="family">Muthuraman</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, University of Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Abdulnasir</namePart><namePart type="family">Hossen</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Electrical and Computer Engineering, Sultan Qaboos University, Muscat, Oman</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ulrich</namePart><namePart type="family">Heute</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Institute for Circuit and System Theory, Faculty of Engineering, University of Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Günther</namePart><namePart type="family">Deuschl</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan</namePart><namePart type="family">Raethjen</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Kiel, Kiel, Germany</affiliation><description>Correspondence: Department of Neurology, University of Kiel, Schittenhelmstrasse 10, 24105 Kiel, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-07</dateIssued><dateCaptured encoding="w3cdtf">2010-11-08</dateCaptured><dateValid encoding="w3cdtf">2011-01-13</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent><extent unit="references">18</extent><extent unit="words">3531</extent></physicalDescription><abstract lang="en">Background:: Clinical distinction between advanced essential tremor and tremulous Parkinson's disease can be difficult. Methods:: In selected power spectra of accelerometric postural tremor recordings on the more affected side of 41 patients with essential tremor and 39 patients with tremulous Parkinson's disease being indistinguishable by tremor frequency, peak power or number of harmonic peaks, waveform asymmetry (autocorrelation decay), and mean peak power of all harmonic peaks were computed. Cutoff for essential tremor–Parkinson's disease distinction was determined by receiver operating characteristics. Diagnostic yield was tested in 12 clinically unclear patients with monosymptomatic tremor, subsequently definitively diagnosed with essential tremor (n = 2) or Parkinson's disease (n = 10) by 123‐I FP‐CIT–single‐photon emission computed tomography, fluorodopa‐positron emission tomography, or clinical course. Results:: By autocorrelation decay 64%, by mean harmonic peak power 94% (Parkinson's disease > essential tremor) of patients with a definite clinical diagnosis, and 11 of 12 clinically unclear patients were classified correctly. Conclusions:: Mean harmonic power is a useful measure to separate clinically difficult cases of advanced essential tremor from tremulous Parkinson's disease. © 2011 Movement Disorder Society</abstract><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report. Muthuraman Muthuraman, Günther Deuschl, and Jan Raethjen received research support from the German Research Council (Deutsche Forschungsgemeinschaft [DFG]: SFB 855) Project D2. Abdulnasir Hossen received research support from the DAAD (German Academic Exchange Service) through a research scholarship. Ulrich Heute received support from the German Research Council (DFG: SFB 855) Project C3. Full financial disclosures and author roles may be found in the online version of this article.</note><subject lang="en"><genre>Keywords</genre><topic>parkinsonian tremor</topic><topic>essential tremor</topic><topic>accelerometry</topic><topic>differential diagnosis</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><note type="content"> Additional Supporting Information may be found in the online version of this article.Supporting Info Item: Supporting Information - </note><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>1548</start><end>1552</end><total>5</total></extent></part></relatedItem><identifier type="istex">DEAD6AE06D22C93EB0AB604B51515EB4B33020C7</identifier><identifier type="DOI">10.1002/mds.23672</identifier><identifier type="ArticleID">MDS23672</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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