Subthreshold depression in patients with Parkinson's disease and dementia––clinical and demographic correlates
Identifieur interne : 001764 ( Main/Corpus ); précédent : 001763; suivant : 001765Subthreshold depression in patients with Parkinson's disease and dementia––clinical and demographic correlates
Auteurs : Uwe Ehrt ; Kolbj Rn Br Nnick ; Peter Paul De Deyn ; Murat Emre ; Sibel Tekin ; Roger Lane ; Dag AarslandSource :
- International Journal of Geriatric Psychiatry [ 0885-6230 ] ; 2007-10.
English descriptors
Abstract
Background: About 40% of the patients with Parkinson's disease (PD) have depressive symptoms, either major depression (MD) or subthreshold depression. Depression was found to be associated with age and age at onset of PD, female gender, more severe parkinsonism, in particular with left‐sided and akinetic‐rigid symptoms, more functional impairment and cognitive impairment. However, the findings are inconsistent and partly contradictory and most of the studies focused on major depression in PD without dementia. The aim of this study was to examine the relationship between subthreshold depression and other clinical features in 538 PD patients with dementia but without MD drawn from a randomized, placebo‐controlled multicentre trial of rivastigmine in PD. Results: One hundred and sixteen patients (21%) had subthreshold depression. Depression was associated with a younger age and age at onset and female gender, but not with severity of parkinsonism, cognition or activities of daily living or laterality of motor symptoms. However, in male patients, an association between depression and left‐sided parkinsonism was found. Conclusion: In contrast to previous findings in PD patients with major depression but without dementia, we found no relationship between subthreshold depression and other clinical symptoms in patients with PDD. Copyright © 2007 John Wiley & Sons, Ltd.
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DOI: 10.1002/gps.1774
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ISTEX:45E7245938BDB5B2F43CB99B3BA82367E42A25EBLe document en format XML
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Hospital, Laboratory of Neurochemistry and Behaviour, Born‐Bunge Foundation, University of Antwerp, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Emre, Murat" sort="Emre, Murat" uniqKey="Emre M" first="Murat" last="Emre">Murat Emre</name><affiliation><mods:affiliation>Istanbul Faculty of Medicine, Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Capa Istanbul, Turkey</mods:affiliation></affiliation></author><author><name sortKey="Tekin, Sibel" sort="Tekin, Sibel" uniqKey="Tekin S" first="Sibel" last="Tekin">Sibel Tekin</name><affiliation><mods:affiliation>Novartis Pharmaceuticals Corporation Clinical Research and Development East Hanover, NJ, USA</mods:affiliation></affiliation></author><author><name sortKey="Lane, Roger" sort="Lane, Roger" uniqKey="Lane R" first="Roger" last="Lane">Roger Lane</name><affiliation><mods:affiliation>Novartis Pharmaceuticals Corporation Clinical Research and Development East Hanover, NJ, USA</mods:affiliation></affiliation></author><author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name><affiliation><mods:affiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Clinical Medicine, University of Bergen, Norway</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:45E7245938BDB5B2F43CB99B3BA82367E42A25EB</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1002/gps.1774</idno><idno type="url">https://api.istex.fr/document/45E7245938BDB5B2F43CB99B3BA82367E42A25EB/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001764</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Subthreshold depression in patients with Parkinson's disease and dementia––clinical and demographic correlates</title><author><name sortKey="Ehrt, Uwe" sort="Ehrt, Uwe" uniqKey="Ehrt U" first="Uwe" last="Ehrt">Uwe Ehrt</name><affiliation><mods:affiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Norway</mods:affiliation></affiliation></author><author><name sortKey="Br Nnick, Kolbj Rn" sort="Br Nnick, Kolbj Rn" uniqKey="Br Nnick K" first="Kolbj Rn" last="Br Nnick">Kolbj Rn Br Nnick</name><affiliation><mods:affiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Norway</mods:affiliation></affiliation></author><author><name sortKey="De Deyn, Peter Paul" sort="De Deyn, Peter Paul" uniqKey="De Deyn P" first="Peter Paul" last="De Deyn">Peter Paul De Deyn</name><affiliation><mods:affiliation>Department of Neurology, Middelheim Hospital, Laboratory of Neurochemistry and Behaviour, Born‐Bunge Foundation, University of Antwerp, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Emre, Murat" sort="Emre, Murat" uniqKey="Emre M" first="Murat" last="Emre">Murat Emre</name><affiliation><mods:affiliation>Istanbul Faculty of Medicine, Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Capa Istanbul, Turkey</mods:affiliation></affiliation></author><author><name sortKey="Tekin, Sibel" sort="Tekin, Sibel" uniqKey="Tekin S" first="Sibel" last="Tekin">Sibel Tekin</name><affiliation><mods:affiliation>Novartis Pharmaceuticals Corporation Clinical Research and Development East Hanover, NJ, USA</mods:affiliation></affiliation></author><author><name sortKey="Lane, Roger" sort="Lane, Roger" uniqKey="Lane R" first="Roger" last="Lane">Roger Lane</name><affiliation><mods:affiliation>Novartis Pharmaceuticals Corporation Clinical Research and Development East Hanover, NJ, USA</mods:affiliation></affiliation></author><author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name><affiliation><mods:affiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Clinical Medicine, University of Bergen, Norway</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">International Journal of Geriatric Psychiatry</title><title level="j" type="sub">A journal of the psychiatry of late life and allied sciences</title><title level="j" type="abbrev">Int. J. Geriat. Psychiatry</title><idno type="ISSN">0885-6230</idno><idno type="eISSN">1099-1166</idno><imprint><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2007-10">2007-10</date><biblScope unit="volume">22</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="980">980</biblScope><biblScope unit="page" to="985">985</biblScope></imprint><idno type="ISSN">0885-6230</idno></series><idno type="istex">45E7245938BDB5B2F43CB99B3BA82367E42A25EB</idno><idno type="DOI">10.1002/gps.1774</idno><idno type="ArticleID">GPS1774</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-6230</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>dementia</term><term>depression</term><term>minor depression</term><term>subthreshold depression</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: About 40% of the patients with Parkinson's disease (PD) have depressive symptoms, either major depression (MD) or subthreshold depression. Depression was found to be associated with age and age at onset of PD, female gender, more severe parkinsonism, in particular with left‐sided and akinetic‐rigid symptoms, more functional impairment and cognitive impairment. However, the findings are inconsistent and partly contradictory and most of the studies focused on major depression in PD without dementia. The aim of this study was to examine the relationship between subthreshold depression and other clinical features in 538 PD patients with dementia but without MD drawn from a randomized, placebo‐controlled multicentre trial of rivastigmine in PD. Results: One hundred and sixteen patients (21%) had subthreshold depression. Depression was associated with a younger age and age at onset and female gender, but not with severity of parkinsonism, cognition or activities of daily living or laterality of motor symptoms. However, in male patients, an association between depression and left‐sided parkinsonism was found. Conclusion: In contrast to previous findings in PD patients with major depression but without dementia, we found no relationship between subthreshold depression and other clinical symptoms in patients with PDD. Copyright © 2007 John Wiley & Sons, Ltd.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Uwe Ehrt</name><affiliations><json:string>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Norway</json:string></affiliations></json:item><json:item><name>Kolbjørn Brønnick</name><affiliations><json:string>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Norway</json:string></affiliations></json:item><json:item><name>Peter Paul De Deyn</name><affiliations><json:string>Department of Neurology, Middelheim Hospital, Laboratory of Neurochemistry and Behaviour, Born‐Bunge Foundation, University of Antwerp, Belgium</json:string></affiliations></json:item><json:item><name>Murat Emre</name><affiliations><json:string>Istanbul Faculty of Medicine, Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Capa Istanbul, Turkey</json:string></affiliations></json:item><json:item><name>Sibel Tekin</name><affiliations><json:string>Novartis Pharmaceuticals Corporation Clinical Research and Development East Hanover, NJ, USA</json:string></affiliations></json:item><json:item><name>Roger Lane</name><affiliations><json:string>Novartis Pharmaceuticals Corporation Clinical Research and Development East Hanover, NJ, USA</json:string></affiliations></json:item><json:item><name>Dag Aarsland</name><affiliations><json:string>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Norway</json:string><json:string>Institute of Clinical Medicine, University of Bergen, Norway</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>subthreshold depression</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>minor depression</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>depression</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dementia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item></subject><articleId><json:string>GPS1774</json:string></articleId><language><json:string>eng</json:string></language><abstract>Background: About 40% of the patients with Parkinson's disease (PD) have depressive symptoms, either major depression (MD) or subthreshold depression. Depression was found to be associated with age and age at onset of PD, female gender, more severe parkinsonism, in particular with left‐sided and akinetic‐rigid symptoms, more functional impairment and cognitive impairment. However, the findings are inconsistent and partly contradictory and most of the studies focused on major depression in PD without dementia. The aim of this study was to examine the relationship between subthreshold depression and other clinical features in 538 PD patients with dementia but without MD drawn from a randomized, placebo‐controlled multicentre trial of rivastigmine in PD. Results: One hundred and sixteen patients (21%) had subthreshold depression. Depression was associated with a younger age and age at onset and female gender, but not with severity of parkinsonism, cognition or activities of daily living or laterality of motor symptoms. However, in male patients, an association between depression and left‐sided parkinsonism was found. Conclusion: In contrast to previous findings in PD patients with major depression but without dementia, we found no relationship between subthreshold depression and other clinical symptoms in patients with PDD. Copyright © 2007 John Wiley & Sons, Ltd.</abstract><qualityIndicators><score>5.78</score><pdfVersion>1.3</pdfVersion><pdfPageSize>567 x 737 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1383</abstractCharCount><pdfWordCount>3356</pdfWordCount><pdfCharCount>22254</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>202</abstractWordCount></qualityIndicators><title>Subthreshold depression in patients with Parkinson's disease and dementia––clinical and demographic correlates</title><genre><json:string>article</json:string></genre><host><volume>22</volume><publisherId><json:string>GPS</json:string></publisherId><pages><total>6</total><last>985</last><first>980</first></pages><issn><json:string>0885-6230</json:string></issn><issue>10</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1099-1166</json:string></eissn><title>International Journal of Geriatric Psychiatry</title><doi><json:string>10.1002/(ISSN)1099-1166</json:string></doi></host><publicationDate>2007</publicationDate><copyrightDate>2007</copyrightDate><doi><json:string>10.1002/gps.1774</json:string></doi><id>45E7245938BDB5B2F43CB99B3BA82367E42A25EB</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/45E7245938BDB5B2F43CB99B3BA82367E42A25EB/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/45E7245938BDB5B2F43CB99B3BA82367E42A25EB/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/45E7245938BDB5B2F43CB99B3BA82367E42A25EB/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Subthreshold depression in patients with Parkinson's disease and dementia––clinical and demographic correlates</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><availability><p>WILEY</p></availability><date>2007</date></publicationStmt><notesStmt><note>Novartis Pharma AG, Basel, Switzerland</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Subthreshold depression in patients with Parkinson's disease and dementia––clinical and demographic correlates</title><author><persName><forename type="first">Uwe</forename><surname>Ehrt</surname></persName><note type="correspondence"><p>Correspondence: Research Centre for Clinical Neuroscience, Stavanger University Hospital, Psychiatric Clinic, PO Box 1163, Hillevåg, 4095 Stavanger, Norway.</p></note><affiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Norway</affiliation></author><author><persName><forename type="first">Kolbjørn</forename><surname>Brønnick</surname></persName><affiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Norway</affiliation></author><author><persName><forename type="first">Peter Paul</forename><surname>De Deyn</surname></persName><affiliation>Department of Neurology, Middelheim Hospital, Laboratory of Neurochemistry and Behaviour, Born‐Bunge Foundation, University of Antwerp, Belgium</affiliation></author><author><persName><forename type="first">Murat</forename><surname>Emre</surname></persName><affiliation>Istanbul Faculty of Medicine, Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Capa Istanbul, Turkey</affiliation></author><author><persName><forename type="first">Sibel</forename><surname>Tekin</surname></persName><affiliation>Novartis Pharmaceuticals Corporation Clinical Research and Development East Hanover, NJ, USA</affiliation></author><author><persName><forename type="first">Roger</forename><surname>Lane</surname></persName><affiliation>Novartis Pharmaceuticals Corporation Clinical Research and Development East Hanover, NJ, USA</affiliation></author><author><persName><forename type="first">Dag</forename><surname>Aarsland</surname></persName><affiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Norway</affiliation><affiliation>Institute of Clinical Medicine, University of Bergen, Norway</affiliation></author></analytic><monogr><title level="j">International Journal of Geriatric Psychiatry</title><title level="j" type="sub">A journal of the psychiatry of late life and allied sciences</title><title level="j" type="abbrev">Int. J. Geriat. Psychiatry</title><idno type="pISSN">0885-6230</idno><idno type="eISSN">1099-1166</idno><idno type="DOI">10.1002/(ISSN)1099-1166</idno><imprint><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2007-10"></date><biblScope unit="volume">22</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="980">980</biblScope><biblScope unit="page" to="985">985</biblScope></imprint></monogr><idno type="istex">45E7245938BDB5B2F43CB99B3BA82367E42A25EB</idno><idno type="DOI">10.1002/gps.1774</idno><idno type="ArticleID">GPS1774</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2007</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background: About 40% of the patients with Parkinson's disease (PD) have depressive symptoms, either major depression (MD) or subthreshold depression. Depression was found to be associated with age and age at onset of PD, female gender, more severe parkinsonism, in particular with left‐sided and akinetic‐rigid symptoms, more functional impairment and cognitive impairment. However, the findings are inconsistent and partly contradictory and most of the studies focused on major depression in PD without dementia. The aim of this study was to examine the relationship between subthreshold depression and other clinical features in 538 PD patients with dementia but without MD drawn from a randomized, placebo‐controlled multicentre trial of rivastigmine in PD. Results: One hundred and sixteen patients (21%) had subthreshold depression. Depression was associated with a younger age and age at onset and female gender, but not with severity of parkinsonism, cognition or activities of daily living or laterality of motor symptoms. However, in male patients, an association between depression and left‐sided parkinsonism was found. Conclusion: In contrast to previous findings in PD patients with major depression but without dementia, we found no relationship between subthreshold depression and other clinical symptoms in patients with PDD. Copyright © 2007 John Wiley & Sons, Ltd.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>subthreshold depression</term></item><item><term>minor depression</term></item><item><term>depression</term></item><item><term>dementia</term></item><item><term>Parkinson's disease</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2006-08-18">Received</change><change when="2007-01-03">Registration</change><change when="2007-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/45E7245938BDB5B2F43CB99B3BA82367E42A25EB/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Ltd.</publisherName><publisherLoc>Chichester, UK</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1099-1166</doi><issn type="print">0885-6230</issn><issn type="electronic">1099-1166</issn><idGroup><id type="product" value="GPS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY">International Journal of Geriatric Psychiatry</title><title type="subtitle">A journal of the psychiatry of late life and allied sciences</title><title type="short">Int. 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href="file:GPS.GPS1774.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="40"></count></countGroup><titleGroup><title type="main" xml:lang="en">Subthreshold depression in patients with Parkinson's disease and dementia––clinical and demographic correlates</title><title type="short" xml:lang="en">SUBTHRESHOLD DEPRESSION IN PATIENTS WITH PD AND DEMENTIA</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Uwe</givenNames><familyName>Ehrt</familyName></personName><contactDetails><email>uehr@sir.no</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Kolbjørn</givenNames><familyName>Brønnick</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Peter Paul</givenNames><familyName>De Deyn</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Murat</givenNames><familyName>Emre</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Sibel</givenNames><familyName>Tekin</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Roger</givenNames><familyName>Lane</familyName></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1 #af5"><personName><givenNames>Dag</givenNames><familyName>Aarsland</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="NO" type="organization"><unparsedAffiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="BE" type="organization"><unparsedAffiliation>Department of Neurology, Middelheim Hospital, Laboratory of Neurochemistry and Behaviour, Born‐Bunge Foundation, University of Antwerp, Belgium</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="TR" type="organization"><unparsedAffiliation>Istanbul Faculty of Medicine, Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Capa Istanbul, Turkey</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="US" type="organization"><unparsedAffiliation>Novartis Pharmaceuticals Corporation Clinical Research and Development East Hanover, NJ, USA</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="NO" type="organization"><unparsedAffiliation>Institute of Clinical Medicine, University of Bergen, Norway</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">subthreshold depression</keyword><keyword xml:id="kwd2">minor depression</keyword><keyword xml:id="kwd3">depression</keyword><keyword xml:id="kwd4">dementia</keyword><keyword xml:id="kwd5">Parkinson's disease</keyword></keywordGroup><fundingInfo><fundingAgency>Novartis Pharma AG, Basel, Switzerland</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main">Background</title><p>About 40% of the patients with Parkinson's disease (PD) have depressive symptoms, either major depression (MD) or subthreshold depression. Depression was found to be associated with age and age at onset of PD, female gender, more severe parkinsonism, in particular with left‐sided and akinetic‐rigid symptoms, more functional impairment and cognitive impairment.</p><p>However, the findings are inconsistent and partly contradictory and most of the studies focused on major depression in PD without dementia.</p><p>The aim of this study was to examine the relationship between subthreshold depression and other clinical features in 538 PD patients with dementia but without MD drawn from a randomized, placebo‐controlled multicentre trial of rivastigmine in PD.</p></section><section xml:id="abs1-2"><title type="main">Results</title><p>One hundred and sixteen patients (21%) had subthreshold depression. Depression was associated with a younger age and age at onset and female gender, but not with severity of parkinsonism, cognition or activities of daily living or laterality of motor symptoms. However, in male patients, an association between depression and left‐sided parkinsonism was found.</p></section><section xml:id="abs1-3"><title type="main">Conclusion</title><p>In contrast to previous findings in PD patients with major depression but without dementia, we found no relationship between subthreshold depression and other clinical symptoms in patients with PDD. Copyright © 2007 John Wiley & Sons, Ltd.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Subthreshold depression in patients with Parkinson's disease and dementia––clinical and demographic correlates</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>SUBTHRESHOLD DEPRESSION IN PATIENTS WITH PD AND DEMENTIA</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Subthreshold depression in patients with Parkinson's disease and dementia––clinical and demographic correlates</title></titleInfo><name type="personal"><namePart type="given">Uwe</namePart><namePart type="family">Ehrt</namePart><affiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Norway</affiliation><description>Correspondence: Research Centre for Clinical Neuroscience, Stavanger University Hospital, Psychiatric Clinic, PO Box 1163, Hillevåg, 4095 Stavanger, Norway.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kolbjørn</namePart><namePart type="family">Brønnick</namePart><affiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Peter Paul</namePart><namePart type="family">De Deyn</namePart><affiliation>Department of Neurology, Middelheim Hospital, Laboratory of Neurochemistry and Behaviour, Born‐Bunge Foundation, University of Antwerp, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Murat</namePart><namePart type="family">Emre</namePart><affiliation>Istanbul Faculty of Medicine, Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Capa Istanbul, Turkey</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sibel</namePart><namePart type="family">Tekin</namePart><affiliation>Novartis Pharmaceuticals Corporation Clinical Research and Development East Hanover, NJ, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roger</namePart><namePart type="family">Lane</namePart><affiliation>Novartis Pharmaceuticals Corporation Clinical Research and Development East Hanover, NJ, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dag</namePart><namePart type="family">Aarsland</namePart><affiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Norway</affiliation><affiliation>Institute of Clinical Medicine, University of Bergen, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>John Wiley & Sons, Ltd.</publisher><place><placeTerm type="text">Chichester, UK</placeTerm></place><dateIssued encoding="w3cdtf">2007-10</dateIssued><dateCaptured encoding="w3cdtf">2006-08-18</dateCaptured><dateValid encoding="w3cdtf">2007-01-03</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">1</extent><extent unit="references">40</extent></physicalDescription><abstract lang="en">Background: About 40% of the patients with Parkinson's disease (PD) have depressive symptoms, either major depression (MD) or subthreshold depression. Depression was found to be associated with age and age at onset of PD, female gender, more severe parkinsonism, in particular with left‐sided and akinetic‐rigid symptoms, more functional impairment and cognitive impairment. However, the findings are inconsistent and partly contradictory and most of the studies focused on major depression in PD without dementia. The aim of this study was to examine the relationship between subthreshold depression and other clinical features in 538 PD patients with dementia but without MD drawn from a randomized, placebo‐controlled multicentre trial of rivastigmine in PD. Results: One hundred and sixteen patients (21%) had subthreshold depression. Depression was associated with a younger age and age at onset and female gender, but not with severity of parkinsonism, cognition or activities of daily living or laterality of motor symptoms. However, in male patients, an association between depression and left‐sided parkinsonism was found. Conclusion: In contrast to previous findings in PD patients with major depression but without dementia, we found no relationship between subthreshold depression and other clinical symptoms in patients with PDD. Copyright © 2007 John Wiley & Sons, Ltd.</abstract><note type="funding">Novartis Pharma AG, Basel, Switzerland</note><subject lang="en"><genre>Keywords</genre><topic>subthreshold depression</topic><topic>minor depression</topic><topic>depression</topic><topic>dementia</topic><topic>Parkinson's disease</topic></subject><relatedItem type="host"><titleInfo><title>International Journal of Geriatric Psychiatry</title><subTitle>A journal of the psychiatry of late life and allied sciences</subTitle></titleInfo><titleInfo type="abbreviated"><title>Int. J. Geriat. Psychiatry</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-6230</identifier><identifier type="eISSN">1099-1166</identifier><identifier type="DOI">10.1002/(ISSN)1099-1166</identifier><identifier type="PublisherID">GPS</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>980</start><end>985</end><total>6</total></extent></part></relatedItem><identifier type="istex">45E7245938BDB5B2F43CB99B3BA82367E42A25EB</identifier><identifier type="DOI">10.1002/gps.1774</identifier><identifier type="ArticleID">GPS1774</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 John Wiley & Sons, Ltd.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>John Wiley & Sons, Ltd.</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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