Correlation between neuromorphometry in the substantia nigra and clinical features in Parkinson's disease using disector counts
Identifieur interne : 001687 ( Main/Corpus ); précédent : 001686; suivant : 001688Correlation between neuromorphometry in the substantia nigra and clinical features in Parkinson's disease using disector counts
Auteurs : Shuang Yong Ma ; Matias Röytt ; Juha O. Rinne ; Yrjö Collan ; Urpo K. RinneSource :
- Journal of the Neurological Sciences [ 0022-510X ] ; 1997.
Abstract
Previous studies based on single sections have suggested a significant correlation between pigmented neuronal loss in the substantia nigra (SN) and clinical features in Parkinson's disease (PD). However, disector (DS) counts - unbiased and accurate stereological estimates have not been available. To evaluate total neuron numbers in the pars compacta of the substantia nigra (SNpc) in relation to clinical features, we estimated the neuron counts in the SNpc by the DS method in brain samples from 12 controls and 12 PD patients. The total number of pigmented neurons in the whole SNpc was significantly reduced in PD patients (to 45% of the control mean, P<0.001). The density of pigmented neurons (neuron/mm3) was reduced to 51% of the average control value (P<0.001). No significant difference was seen in the volume (mm3) of the SNpc between PD patients and controls. Furthermore, the total number of pigmented neurons in the SNpc showed a significant negative correlation with the duration of disease (r=−0.86, P<0.001) and with the stage of disease (r=−0.58, P<0.05) in PD patients. Using an unbiased neuron counting method, these relationships, for the first time, demonstrate that the more severe pigmented neuronal loss in the SNpc is associated with the longer duration and the more severe stage of disease in PD patients.
Url:
DOI: 10.1016/S0022-510X(97)00100-7
Links to Exploration step
ISTEX:CD8B3911CDE6D368B4C34D54B8753B5D9626A5A6Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Correlation between neuromorphometry in the substantia nigra and clinical features in Parkinson's disease using disector counts</title><author><name sortKey="Ma, Shuang Yong" sort="Ma, Shuang Yong" uniqKey="Ma S" first="Shuang Yong" last="Ma">Shuang Yong Ma</name><affiliation><mods:affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation></affiliation></author><author><name sortKey="Roytt, Matias" sort="Roytt, Matias" uniqKey="Roytt M" first="Matias" last="Röytt">Matias Röytt</name><affiliation><mods:affiliation>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation></affiliation></author><author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O" last="Rinne">Juha O. Rinne</name><affiliation><mods:affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation></affiliation></author><author><name sortKey="Collan, Yrjo" sort="Collan, Yrjo" uniqKey="Collan Y" first="Yrjö" last="Collan">Yrjö Collan</name><affiliation><mods:affiliation>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation></affiliation></author><author><name sortKey="Rinne, Urpo K" sort="Rinne, Urpo K" uniqKey="Rinne U" first="Urpo K" last="Rinne">Urpo K. Rinne</name><affiliation><mods:affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation></affiliation><affiliation><mods:affiliation>Corresponding author. Tel: +358 2 2611700; Fax: +358 2 2611709.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:CD8B3911CDE6D368B4C34D54B8753B5D9626A5A6</idno><date when="1997" year="1997">1997</date><idno type="doi">10.1016/S0022-510X(97)00100-7</idno><idno type="url">https://api.istex.fr/document/CD8B3911CDE6D368B4C34D54B8753B5D9626A5A6/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001687</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Correlation between neuromorphometry in the substantia nigra and clinical features in Parkinson's disease using disector counts</title><author><name sortKey="Ma, Shuang Yong" sort="Ma, Shuang Yong" uniqKey="Ma S" first="Shuang Yong" last="Ma">Shuang Yong Ma</name><affiliation><mods:affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation></affiliation></author><author><name sortKey="Roytt, Matias" sort="Roytt, Matias" uniqKey="Roytt M" first="Matias" last="Röytt">Matias Röytt</name><affiliation><mods:affiliation>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation></affiliation></author><author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O" last="Rinne">Juha O. Rinne</name><affiliation><mods:affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation></affiliation></author><author><name sortKey="Collan, Yrjo" sort="Collan, Yrjo" uniqKey="Collan Y" first="Yrjö" last="Collan">Yrjö Collan</name><affiliation><mods:affiliation>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation></affiliation></author><author><name sortKey="Rinne, Urpo K" sort="Rinne, Urpo K" uniqKey="Rinne U" first="Urpo K" last="Rinne">Urpo K. Rinne</name><affiliation><mods:affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</mods:affiliation></affiliation><affiliation><mods:affiliation>Corresponding author. Tel: +358 2 2611700; Fax: +358 2 2611709.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="ISSN">0022-510X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">151</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="83">83</biblScope><biblScope unit="page" to="87">87</biblScope></imprint><idno type="ISSN">0022-510X</idno></series><idno type="istex">CD8B3911CDE6D368B4C34D54B8753B5D9626A5A6</idno><idno type="DOI">10.1016/S0022-510X(97)00100-7</idno><idno type="PII">S0022-510X(97)00100-7</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-510X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous studies based on single sections have suggested a significant correlation between pigmented neuronal loss in the substantia nigra (SN) and clinical features in Parkinson's disease (PD). However, disector (DS) counts - unbiased and accurate stereological estimates have not been available. To evaluate total neuron numbers in the pars compacta of the substantia nigra (SNpc) in relation to clinical features, we estimated the neuron counts in the SNpc by the DS method in brain samples from 12 controls and 12 PD patients. The total number of pigmented neurons in the whole SNpc was significantly reduced in PD patients (to 45% of the control mean, P<0.001). The density of pigmented neurons (neuron/mm3) was reduced to 51% of the average control value (P<0.001). No significant difference was seen in the volume (mm3) of the SNpc between PD patients and controls. Furthermore, the total number of pigmented neurons in the SNpc showed a significant negative correlation with the duration of disease (r=−0.86, P<0.001) and with the stage of disease (r=−0.58, P<0.05) in PD patients. Using an unbiased neuron counting method, these relationships, for the first time, demonstrate that the more severe pigmented neuronal loss in the SNpc is associated with the longer duration and the more severe stage of disease in PD patients.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Shuang Yong Ma</name><affiliations><json:string>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</json:string></affiliations></json:item><json:item><name>Matias Röyttä</name><affiliations><json:string>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</json:string></affiliations></json:item><json:item><name>Juha O Rinne</name><affiliations><json:string>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</json:string></affiliations></json:item><json:item><name>Yrjö Collan</name><affiliations><json:string>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</json:string></affiliations></json:item><json:item><name>Urpo K Rinne</name><affiliations><json:string>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</json:string><json:string>Corresponding author. Tel: +358 2 2611700; Fax: +358 2 2611709.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Disector counts</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Substantia nigra</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Correlation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Clinical features</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Previous studies based on single sections have suggested a significant correlation between pigmented neuronal loss in the substantia nigra (SN) and clinical features in Parkinson's disease (PD). However, disector (DS) counts - unbiased and accurate stereological estimates have not been available. To evaluate total neuron numbers in the pars compacta of the substantia nigra (SNpc) in relation to clinical features, we estimated the neuron counts in the SNpc by the DS method in brain samples from 12 controls and 12 PD patients. The total number of pigmented neurons in the whole SNpc was significantly reduced in PD patients (to 45% of the control mean, P>0.001). The density of pigmented neurons (neuron/mm3) was reduced to 51% of the average control value (P>0.001). No significant difference was seen in the volume (mm3) of the SNpc between PD patients and controls. Furthermore, the total number of pigmented neurons in the SNpc showed a significant negative correlation with the duration of disease (r=−0.86, P>0.001) and with the stage of disease (r=−0.58, P>0.05) in PD patients. Using an unbiased neuron counting method, these relationships, for the first time, demonstrate that the more severe pigmented neuronal loss in the SNpc is associated with the longer duration and the more severe stage of disease in PD patients.</abstract><qualityIndicators><score>5.422</score><pdfVersion>1.2</pdfVersion><pdfPageSize>600 x 800 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1333</abstractCharCount><pdfWordCount>2902</pdfWordCount><pdfCharCount>17558</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>210</abstractWordCount></qualityIndicators><title>Correlation between neuromorphometry in the substantia nigra and clinical features in Parkinson's disease using disector counts</title><pii><json:string>S0022-510X(97)00100-7</json:string></pii><genre><json:string>research-article</json:string></genre><host><volume>151</volume><pii><json:string>S0022-510X(00)X0032-9</json:string></pii><pages><last>87</last><first>83</first></pages><issn><json:string>0022-510X</json:string></issn><issue>1</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>Journal of the Neurological Sciences</title><publicationDate>1997</publicationDate></host><categories><wos><json:string>CLINICAL NEUROLOGY</json:string><json:string>NEUROIMAGING</json:string><json:string>NEUROSCIENCES</json:string></wos></categories><publicationDate>1997</publicationDate><copyrightDate>1997</copyrightDate><doi><json:string>10.1016/S0022-510X(97)00100-7</json:string></doi><id>CD8B3911CDE6D368B4C34D54B8753B5D9626A5A6</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/CD8B3911CDE6D368B4C34D54B8753B5D9626A5A6/fulltext/pdf</uri></json:item><json:item><original>true</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/CD8B3911CDE6D368B4C34D54B8753B5D9626A5A6/fulltext/txt</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/CD8B3911CDE6D368B4C34D54B8753B5D9626A5A6/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/CD8B3911CDE6D368B4C34D54B8753B5D9626A5A6/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Correlation between neuromorphometry in the substantia nigra and clinical features in Parkinson's disease using disector counts</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1997</date></publicationStmt><notesStmt><note type="content">Fig. 1: The relationship between the total number of pigmented neurons in the SNpc and clinical features of PD patients shows a significant negative correlation with duration of disease (r=−0.86, P<0.001) in (A) and with stage of disease (r=−0.58, P<0.05) in (B).</note><note type="content">Table 1: The mean (SD) and coefficient of error of neuron number, density and volume in the pars compacta of the substantia nigra using disector counts</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Correlation between neuromorphometry in the substantia nigra and clinical features in Parkinson's disease using disector counts</title><author><persName><forename type="first">Shuang Yong</forename><surname>Ma</surname></persName><affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</affiliation></author><author><persName><forename type="first">Matias</forename><surname>Röyttä</surname></persName><affiliation>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</affiliation></author><author><persName><forename type="first">Juha O</forename><surname>Rinne</surname></persName><affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</affiliation></author><author><persName><forename type="first">Yrjö</forename><surname>Collan</surname></persName><affiliation>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</affiliation></author><author><persName><forename type="first">Urpo K</forename><surname>Rinne</surname></persName><affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</affiliation><affiliation>Corresponding author. Tel: +358 2 2611700; Fax: +358 2 2611709.</affiliation></author></analytic><monogr><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="pISSN">0022-510X</idno><idno type="PII">S0022-510X(00)X0032-9</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997"></date><biblScope unit="volume">151</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="83">83</biblScope><biblScope unit="page" to="87">87</biblScope></imprint></monogr><idno type="istex">CD8B3911CDE6D368B4C34D54B8753B5D9626A5A6</idno><idno type="DOI">10.1016/S0022-510X(97)00100-7</idno><idno type="PII">S0022-510X(97)00100-7</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1997</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Previous studies based on single sections have suggested a significant correlation between pigmented neuronal loss in the substantia nigra (SN) and clinical features in Parkinson's disease (PD). However, disector (DS) counts - unbiased and accurate stereological estimates have not been available. To evaluate total neuron numbers in the pars compacta of the substantia nigra (SNpc) in relation to clinical features, we estimated the neuron counts in the SNpc by the DS method in brain samples from 12 controls and 12 PD patients. The total number of pigmented neurons in the whole SNpc was significantly reduced in PD patients (to 45% of the control mean, P<0.001). The density of pigmented neurons (neuron/mm3) was reduced to 51% of the average control value (P<0.001). No significant difference was seen in the volume (mm3) of the SNpc between PD patients and controls. Furthermore, the total number of pigmented neurons in the SNpc showed a significant negative correlation with the duration of disease (r=−0.86, P<0.001) and with the stage of disease (r=−0.58, P<0.05) in PD patients. Using an unbiased neuron counting method, these relationships, for the first time, demonstrate that the more severe pigmented neuronal loss in the SNpc is associated with the longer duration and the more severe stage of disease in PD patients.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Disector counts</term></item><item><term>Substantia nigra</term></item><item><term>Parkinson's disease</term></item><item><term>Correlation</term></item><item><term>Clinical features</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1997-04-02">Registration</change><change when="1997">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; body; tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"><istex:entity SYSTEM="gr1" NDATA="IMAGE" name="gr1"></istex:entity></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>JNS</jid><aid>5474</aid><ce:pii>S0022-510X(97)00100-7</ce:pii><ce:doi>10.1016/S0022-510X(97)00100-7</ce:doi><ce:copyright year="1997" type="full-transfer">Elsevier Science B.V.</ce:copyright></item-info><head><ce:title>Correlation between neuromorphometry in the substantia nigra and clinical features in Parkinson's disease using disector counts</ce:title><ce:author-group><ce:author><ce:given-name>Shuang Yong</ce:given-name><ce:surname>Ma</ce:surname><ce:cross-ref refid="AFF1">a</ce:cross-ref></ce:author><ce:author><ce:given-name>Matias</ce:given-name><ce:surname>Röyttä</ce:surname><ce:cross-ref refid="AFF2">b</ce:cross-ref></ce:author><ce:author><ce:given-name>Juha O</ce:given-name><ce:surname>Rinne</ce:surname><ce:cross-ref refid="AFF1">a</ce:cross-ref></ce:author><ce:author><ce:given-name>Yrjö</ce:given-name><ce:surname>Collan</ce:surname><ce:cross-ref refid="AFF2">b</ce:cross-ref></ce:author><ce:author><ce:given-name>Urpo K</ce:given-name><ce:surname>Rinne</ce:surname><ce:cross-ref refid="AFF1">a</ce:cross-ref><ce:cross-ref refid="CORR1">*</ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</ce:textfn></ce:affiliation><ce:correspondence id="CORR1"><ce:label>*</ce:label><ce:text>Corresponding author. Tel: +358 2 2611700; Fax: +358 2 2611709.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="24" month="12" year="1996"></ce:date-received><ce:date-accepted day="2" month="4" year="1997"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Previous studies based on single sections have suggested a significant correlation between pigmented neuronal loss in the substantia nigra (SN) and clinical features in Parkinson's disease (PD). However, disector (DS) counts - unbiased and accurate stereological estimates have not been available. To evaluate total neuron numbers in the pars compacta of the substantia nigra (SNpc) in relation to clinical features, we estimated the neuron counts in the SNpc by the DS method in brain samples from 12 controls and 12 PD patients. The total number of pigmented neurons in the whole SNpc was significantly reduced in PD patients (to 45% of the control mean, <ce:italic>P</ce:italic><0.001). The density of pigmented neurons (neuron/mm<ce:sup>3</ce:sup>) was reduced to 51% of the average control value (<ce:italic>P</ce:italic><0.001). No significant difference was seen in the volume (mm<ce:sup>3</ce:sup>) of the SNpc between PD patients and controls. Furthermore, the total number of pigmented neurons in the SNpc showed a significant negative correlation with the duration of disease (<ce:italic>r</ce:italic>=−0.86, <ce:italic>P</ce:italic><0.001) and with the stage of disease (<ce:italic>r</ce:italic>=−0.58, <ce:italic>P</ce:italic><0.05) in PD patients. Using an unbiased neuron counting method, these relationships, for the first time, demonstrate that the more severe pigmented neuronal loss in the SNpc is associated with the longer duration and the more severe stage of disease in PD patients.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Disector counts</ce:text></ce:keyword><ce:keyword><ce:text>Substantia nigra</ce:text></ce:keyword><ce:keyword><ce:text>Parkinson's disease</ce:text></ce:keyword><ce:keyword><ce:text>Correlation</ce:text></ce:keyword><ce:keyword><ce:text>Clinical features</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Correlation between neuromorphometry in the substantia nigra and clinical features in Parkinson's disease using disector counts</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Correlation between neuromorphometry in the substantia nigra and clinical features in Parkinson's disease using disector counts</title></titleInfo><name type="personal"><namePart type="given">Shuang Yong</namePart><namePart type="family">Ma</namePart><affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Matias</namePart><namePart type="family">Röyttä</namePart><affiliation>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Juha O</namePart><namePart type="family">Rinne</namePart><affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yrjö</namePart><namePart type="family">Collan</namePart><affiliation>Department of Pathology, University of Turku, FIN-20520, Turku, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Urpo K</namePart><namePart type="family">Rinne</namePart><affiliation>Department of Neurology, University of Turku, FIN-20520, Turku, Finland</affiliation><affiliation>Corresponding author. Tel: +358 2 2611700; Fax: +358 2 2611709.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1997</dateIssued><dateValid encoding="w3cdtf">1997-04-02</dateValid><copyrightDate encoding="w3cdtf">1997</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Previous studies based on single sections have suggested a significant correlation between pigmented neuronal loss in the substantia nigra (SN) and clinical features in Parkinson's disease (PD). However, disector (DS) counts - unbiased and accurate stereological estimates have not been available. To evaluate total neuron numbers in the pars compacta of the substantia nigra (SNpc) in relation to clinical features, we estimated the neuron counts in the SNpc by the DS method in brain samples from 12 controls and 12 PD patients. The total number of pigmented neurons in the whole SNpc was significantly reduced in PD patients (to 45% of the control mean, P<0.001). The density of pigmented neurons (neuron/mm3) was reduced to 51% of the average control value (P<0.001). No significant difference was seen in the volume (mm3) of the SNpc between PD patients and controls. Furthermore, the total number of pigmented neurons in the SNpc showed a significant negative correlation with the duration of disease (r=−0.86, P<0.001) and with the stage of disease (r=−0.58, P<0.05) in PD patients. Using an unbiased neuron counting method, these relationships, for the first time, demonstrate that the more severe pigmented neuronal loss in the SNpc is associated with the longer duration and the more severe stage of disease in PD patients.</abstract><note type="content">Fig. 1: The relationship between the total number of pigmented neurons in the SNpc and clinical features of PD patients shows a significant negative correlation with duration of disease (r=−0.86, P<0.001) in (A) and with stage of disease (r=−0.58, P<0.05) in (B).</note><note type="content">Table 1: The mean (SD) and coefficient of error of neuron number, density and volume in the pars compacta of the substantia nigra using disector counts</note><subject><genre>Keywords</genre><topic>Disector counts</topic><topic>Substantia nigra</topic><topic>Parkinson's disease</topic><topic>Correlation</topic><topic>Clinical features</topic></subject><relatedItem type="host"><titleInfo><title>Journal of the Neurological Sciences</title></titleInfo><titleInfo type="abbreviated"><title>JNS</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">19971003</dateIssued></originInfo><identifier type="ISSN">0022-510X</identifier><identifier type="PII">S0022-510X(00)X0032-9</identifier><part><date>19971003</date><detail type="volume"><number>151</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>120</end></extent><extent unit="pages"><start>83</start><end>87</end></extent></part></relatedItem><identifier type="istex">CD8B3911CDE6D368B4C34D54B8753B5D9626A5A6</identifier><identifier type="DOI">10.1016/S0022-510X(97)00100-7</identifier><identifier type="PII">S0022-510X(97)00100-7</identifier><accessCondition type="use and reproduction" contentType="">© 1997Elsevier Science B.V.</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Elsevier Science B.V., ©1997</recordOrigin></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/CD8B3911CDE6D368B4C34D54B8753B5D9626A5A6/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">CLINICAL NEUROLOGY</classCode><classCode scheme="WOS">NEUROIMAGING</classCode><classCode scheme="WOS">NEUROSCIENCES</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001687 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 001687 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:CD8B3911CDE6D368B4C34D54B8753B5D9626A5A6
|texte= Correlation between neuromorphometry in the substantia nigra and clinical features in Parkinson's disease using disector counts
}}
| This area was generated with Dilib version V0.6.23. |  |