Ventricular enlargement and mild cognitive impairment in early Parkinson's disease
Identifieur interne : 001674 ( Main/Corpus ); précédent : 001673; suivant : 001675Ventricular enlargement and mild cognitive impairment in early Parkinson's disease
Auteurs : Turi O. Dalaker ; Robert Zivadinov ; Deepa Preeti Ramasamy ; Mona K. Beyer ; Guido Alves ; Kolbjorn S. Bronnick ; Ole-Bjorn Tysnes ; Dag Aarsland ; Jan P. LarsenSource :
- Movement Disorders [ 0885-3185 ] ; 2011-02-01.
English descriptors
Abstract
Mild cognitive impairment (MCI) may predict future development of dementia in Parkinson's disease (PD). We aimed to examine the extent of subcortical brain atrophy in patients with early PD with and without MCI compared to normal controls (NC). Participating in a population‐based study were 43 early, drug‐naïve PD patients and 41 NC. Eleven patients were classified with MCI (MCI PD) and 32 patients without (non‐MCI PD). Volumetric segmentation of 3D‐T1 weighted brain MRI was performed using FreeSurfer. Groups were compared applying MANCOVA corrected for total intracranial volume, age, and sex. Results showed that left inferior lateral ventricle and third ventricle volumes were significantly larger in MCI PD than in non‐MCI PD and NC. Fourth ventricular size in MCI PD was significantly different from NC and highly correlated with memory performance in MCI PD patients. This suggests that cognitive dysfunction in early PD may be associated with ventricular enlargement. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23443
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We aimed to examine the extent of subcortical brain atrophy in patients with early PD with and without MCI compared to normal controls (NC). Participating in a population‐based study were 43 early, drug‐naïve PD patients and 41 NC. Eleven patients were classified with MCI (MCI PD) and 32 patients without (non‐MCI PD). Volumetric segmentation of 3D‐T1 weighted brain MRI was performed using FreeSurfer. Groups were compared applying MANCOVA corrected for total intracranial volume, age, and sex. Results showed that left inferior lateral ventricle and third ventricle volumes were significantly larger in MCI PD than in non‐MCI PD and NC. Fourth ventricular size in MCI PD was significantly different from NC and highly correlated with memory performance in MCI PD patients. This suggests that cognitive dysfunction in early PD may be associated with ventricular enlargement. © 2010 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Turi O. Dalaker MD</name><affiliations><json:string>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</json:string><json:string>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</json:string><json:string>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</json:string></affiliations></json:item><json:item><name>Robert Zivadinov MD, PhD</name><affiliations><json:string>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</json:string><json:string>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</json:string></affiliations></json:item><json:item><name>Deepa Preeti Ramasamy MD</name><affiliations><json:string>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</json:string></affiliations></json:item><json:item><name>Mona K. Beyer MD, PhD</name><affiliations><json:string>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</json:string><json:string>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Guido Alves MD, PhD</name><affiliations><json:string>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</json:string><json:string>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Kolbjorn S. Bronnick PhD</name><affiliations><json:string>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Ole‐Bjorn Tysnes MD, PhD</name><affiliations><json:string>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</json:string><json:string>Department of Neurology, Haukeland University Hospital, Bergen, Norway</json:string></affiliations></json:item><json:item><name>Dag Aarsland MD, PhD</name><affiliations><json:string>Division of Psychiatry, Stavanger University Hospital, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Jan P. Larsen MD, PhD</name><affiliations><json:string>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</json:string><json:string>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</json:string><json:string>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MRI</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>volumetric MRI</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MCI (mild cognitive impairment)</value></json:item></subject><articleId><json:string>MDS23443</json:string></articleId><language><json:string>eng</json:string></language><abstract>Mild cognitive impairment (MCI) may predict future development of dementia in Parkinson's disease (PD). We aimed to examine the extent of subcortical brain atrophy in patients with early PD with and without MCI compared to normal controls (NC). Participating in a population‐based study were 43 early, drug‐naïve PD patients and 41 NC. Eleven patients were classified with MCI (MCI PD) and 32 patients without (non‐MCI PD). Volumetric segmentation of 3D‐T1 weighted brain MRI was performed using FreeSurfer. Groups were compared applying MANCOVA corrected for total intracranial volume, age, and sex. Results showed that left inferior lateral ventricle and third ventricle volumes were significantly larger in MCI PD than in non‐MCI PD and NC. Fourth ventricular size in MCI PD was significantly different from NC and highly correlated with memory performance in MCI PD patients. This suggests that cognitive dysfunction in early PD may be associated with ventricular enlargement. © 2010 Movement Disorder Society</abstract><qualityIndicators><score>4.713</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1013</abstractCharCount><pdfWordCount>2877</pdfWordCount><pdfCharCount>19608</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>153</abstractWordCount></qualityIndicators><title>Ventricular enlargement and mild cognitive impairment in early Parkinson's disease</title><genre><json:string>article</json:string></genre><host><volume>26</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>5</total><last>301</last><first>297</first></pages><issn><json:string>0885-3185</json:string></issn><issue>2</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/mds.23443</json:string></doi><id>BFFCD73D1AA85D14FB940CCE57AE9592AA4E7CB5</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/BFFCD73D1AA85D14FB940CCE57AE9592AA4E7CB5/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/BFFCD73D1AA85D14FB940CCE57AE9592AA4E7CB5/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/BFFCD73D1AA85D14FB940CCE57AE9592AA4E7CB5/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Ventricular enlargement and mild cognitive impairment in early Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2011</date></publicationStmt><notesStmt><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles can be found in the online version of this article.</note><note>Dr. Larry D. Jacobs Fellowship, the Research Council of Norway - No. 186966;</note><note>Norwegian Society of Radiology</note><note>Western Norway Regional Health Authority - No. 911218;</note><note>Research Council of Norway - No. 177966;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Ventricular enlargement and mild cognitive impairment in early Parkinson's disease</title><author><persName><forename type="first">Turi O.</forename><surname>Dalaker</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Department of Radiology, Stavanger University Hospital, PO. Box 8100, N‐4068 Stavanger, Norway</p></note><affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation></author><author><persName><forename type="first">Robert</forename><surname>Zivadinov</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><affiliation>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</affiliation></author><author><persName><forename type="first">Deepa Preeti</forename><surname>Ramasamy</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation></author><author><persName><forename type="first">Mona K.</forename><surname>Beyer</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Guido</forename><surname>Alves</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Kolbjorn S.</forename><surname>Bronnick</surname></persName><roleName type="degree">PhD</roleName><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Ole‐Bjorn</forename><surname>Tysnes</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</affiliation><affiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway</affiliation></author><author><persName><forename type="first">Dag</forename><surname>Aarsland</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Division of Psychiatry, Stavanger University Hospital, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Jan P.</forename><surname>Larsen</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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We aimed to examine the extent of subcortical brain atrophy in patients with early PD with and without MCI compared to normal controls (NC). Participating in a population‐based study were 43 early, drug‐naïve PD patients and 41 NC. Eleven patients were classified with MCI (MCI PD) and 32 patients without (non‐MCI PD). Volumetric segmentation of 3D‐T1 weighted brain MRI was performed using FreeSurfer. Groups were compared applying MANCOVA corrected for total intracranial volume, age, and sex. Results showed that left inferior lateral ventricle and third ventricle volumes were significantly larger in MCI PD than in non‐MCI PD and NC. Fourth ventricular size in MCI PD was significantly different from NC and highly correlated with memory performance in MCI PD patients. This suggests that cognitive dysfunction in early PD may be associated with ventricular enlargement. © 2010 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>MRI</term></item><item><term>volumetric MRI</term></item><item><term>MCI (mild cognitive impairment)</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-04-02">Received</change><change when="2010-08-30">Registration</change><change when="2011-02-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/BFFCD73D1AA85D14FB940CCE57AE9592AA4E7CB5/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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Box 8100, N‐4068 Stavanger, Norway</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS23443.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="31"></count><count type="wordTotal" number="4290"></count></countGroup><titleGroup><title type="main" xml:lang="en">Ventricular enlargement and mild cognitive impairment in early Parkinson's disease<link href="#fn10"></link></title><title type="short" xml:lang="en">Ventricular Size and Cognition in PD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2 #af3" corresponding="yes"><personName><givenNames>Turi O.</givenNames><familyName>Dalaker</familyName><degrees>MD</degrees></personName><contactDetails><email>datu@sus.no</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af3 #af4"><personName><givenNames>Robert</givenNames><familyName>Zivadinov</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Deepa Preeti</givenNames><familyName>Ramasamy</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Mona K.</givenNames><familyName>Beyer</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2 #af5"><personName><givenNames>Guido</givenNames><familyName>Alves</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Kolbjorn S.</givenNames><familyName>Bronnick</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af6 #af7"><personName><givenNames>Ole‐Bjorn</givenNames><familyName>Tysnes</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af8"><personName><givenNames>Dag</givenNames><familyName>Aarsland</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af2 #af5 #af6"><personName><givenNames>Jan P.</givenNames><familyName>Larsen</familyName><degrees>MD, PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="NO" type="organization"><unparsedAffiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="NO" type="organization"><unparsedAffiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="NO" type="organization"><unparsedAffiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="NO" type="organization"><unparsedAffiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="NO" type="organization"><unparsedAffiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af8" countryCode="NO" type="organization"><unparsedAffiliation>Division of Psychiatry, Stavanger University Hospital, Stavanger, Norway</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">MRI</keyword><keyword xml:id="kwd3">volumetric MRI</keyword><keyword xml:id="kwd4">MCI (mild cognitive impairment)</keyword></keywordGroup><fundingInfo><fundingAgency>Dr. Larry D. Jacobs Fellowship, the Research Council of Norway</fundingAgency><fundingNumber>186966</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Norwegian Society of Radiology</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Western Norway Regional Health Authority</fundingAgency><fundingNumber>911218</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Research Council of Norway</fundingAgency><fundingNumber>177966</fundingNumber></fundingInfo><supportingInformation><p> Additional Supporting Information may be found in the online version of this article. </p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds23443:MDS_23443_sm_supptab"></mediaResource><caption>Supporting Table</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Mild cognitive impairment (MCI) may predict future development of dementia in Parkinson's disease (PD). We aimed to examine the extent of subcortical brain atrophy in patients with early PD with and without MCI compared to normal controls (NC). Participating in a population‐based study were 43 early, drug‐naïve PD patients and 41 NC. Eleven patients were classified with MCI (MCI PD) and 32 patients without (non‐MCI PD). Volumetric segmentation of 3D‐T1 weighted brain MRI was performed using FreeSurfer. Groups were compared applying MANCOVA corrected for total intracranial volume, age, and sex. Results showed that left inferior lateral ventricle and third ventricle volumes were significantly larger in MCI PD than in non‐MCI PD and NC. Fourth ventricular size in MCI PD was significantly different from NC and highly correlated with memory performance in MCI PD patients. This suggests that cognitive dysfunction in early PD may be associated with ventricular enlargement. © 2010 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn10"><p><b>Relevant conflicts of interest/financial disclosures</b>: Nothing to report. Full financial disclosures and author roles can be found in the online version of this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Ventricular enlargement and mild cognitive impairment in early Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Ventricular Size and Cognition in PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Ventricular enlargement and mild cognitive impairment in early Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Turi O.</namePart><namePart type="family">Dalaker</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><description>Correspondence: Department of Radiology, Stavanger University Hospital, PO. Box 8100, N‐4068 Stavanger, Norway</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robert</namePart><namePart type="family">Zivadinov</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><affiliation>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Deepa Preeti</namePart><namePart type="family">Ramasamy</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mona K.</namePart><namePart type="family">Beyer</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Guido</namePart><namePart type="family">Alves</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kolbjorn S.</namePart><namePart type="family">Bronnick</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ole‐Bjorn</namePart><namePart type="family">Tysnes</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</affiliation><affiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dag</namePart><namePart type="family">Aarsland</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Division of Psychiatry, Stavanger University Hospital, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan P.</namePart><namePart type="family">Larsen</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-02-01</dateIssued><dateCaptured encoding="w3cdtf">2010-04-02</dateCaptured><dateValid encoding="w3cdtf">2010-08-30</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">2</extent><extent unit="references">31</extent><extent unit="words">4290</extent></physicalDescription><abstract lang="en">Mild cognitive impairment (MCI) may predict future development of dementia in Parkinson's disease (PD). We aimed to examine the extent of subcortical brain atrophy in patients with early PD with and without MCI compared to normal controls (NC). Participating in a population‐based study were 43 early, drug‐naïve PD patients and 41 NC. Eleven patients were classified with MCI (MCI PD) and 32 patients without (non‐MCI PD). Volumetric segmentation of 3D‐T1 weighted brain MRI was performed using FreeSurfer. Groups were compared applying MANCOVA corrected for total intracranial volume, age, and sex. Results showed that left inferior lateral ventricle and third ventricle volumes were significantly larger in MCI PD than in non‐MCI PD and NC. Fourth ventricular size in MCI PD was significantly different from NC and highly correlated with memory performance in MCI PD patients. This suggests that cognitive dysfunction in early PD may be associated with ventricular enlargement. © 2010 Movement Disorder Society</abstract><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles can be found in the online version of this article.</note><note type="funding">Dr. Larry D. Jacobs Fellowship, the Research Council of Norway - No. 186966; </note><note type="funding">Norwegian Society of Radiology</note><note type="funding">Western Norway Regional Health Authority - No. 911218; </note><note type="funding">Research Council of Norway - No. 177966; </note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>MRI</topic><topic>volumetric MRI</topic><topic>MCI (mild cognitive impairment)</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><note type="content"> Additional Supporting Information may be found in the online version of this article.Supporting Info Item: Supporting Table - </note><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>297</start><end>301</end><total>5</total></extent></part></relatedItem><identifier type="istex">BFFCD73D1AA85D14FB940CCE57AE9592AA4E7CB5</identifier><identifier type="DOI">10.1002/mds.23443</identifier><identifier type="ArticleID">MDS23443</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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