The use of smell identification tests in the diagnosis of Parkinson's disease in Brazil
Identifieur interne : 001630 ( Main/Corpus ); précédent : 001629; suivant : 001631The use of smell identification tests in the diagnosis of Parkinson's disease in Brazil
Auteurs : Laura Silveira-Moriyama ; Margarete De Jesus Carvalho ; Regina Katzenschlager ; Aviva Petrie ; Ronald Ranvaud ; Egberto Reis Barbosa ; Andrew J. LeesSource :
- Movement Disorders [ 0885-3185 ] ; 2008-12-15.
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Abstract
Smell identification tests may be of routine clinical value in the differential diagnosis of PD but are subject to cultural variation and have not been systematically evaluated in the Brazilian population. We have applied culturally adapted translations of the University of Pennsylvania 40‐item smell identification test (UPSIT‐40) and the 16‐item identification test from Sniffin' Sticks (SS‐16) to nondemented Brazilian PD patients and controls. Pearson's correlation coefficient between the test scores was 0.76 (95% CI 0.70–0.81, n = 204, P < 0.001). To calculate reliability measures for each test we used the diagnosis (either PD or control) as outcome variable for separate logistic regression analyses using the score in the UPSIT‐40 or the SS‐16 as a covariate. The SS‐16 specificity was 89.0% with a sensitivity of 81.1% (106 PD and 118 controls). The UPSIT‐40 specificity was 83.5% and its sensitivity 82.1% (95 PD and 109 controls). Regression curves were used to associate an individual's smell test score with the probability of belonging to the PD, as opposed to the control group. Our data provide support for the use of the UPSIT‐40 and SS‐16 to help distinguish early PD from controls. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22241
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The use of smell identification tests in the diagnosis of Parkinson's disease in Brazil</title><author><name sortKey="Silveira Oriyama, Laura" sort="Silveira Oriyama, Laura" uniqKey="Silveira Oriyama L" first="Laura" last="Silveira-Moriyama">Laura Silveira-Moriyama</name><affiliation><mods:affiliation>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Carvalho, Margarete De Jesus" sort="Carvalho, Margarete De Jesus" uniqKey="Carvalho M" first="Margarete De Jesus" last="Carvalho">Margarete De Jesus Carvalho</name><affiliation><mods:affiliation>Neurology Department, São Paulo School of Medicine, University of São Paulo, São Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Katzenschlager, Regina" sort="Katzenschlager, Regina" uniqKey="Katzenschlager R" first="Regina" last="Katzenschlager">Regina Katzenschlager</name><affiliation><mods:affiliation>Department of Neurology, Donauspital/Sozialmedizinisches Zentrum Ost, Vienna, Austria</mods:affiliation></affiliation></author><author><name sortKey="Petrie, Aviva" sort="Petrie, Aviva" uniqKey="Petrie A" first="Aviva" last="Petrie">Aviva Petrie</name><affiliation><mods:affiliation>Biostatistics Unit, UCL Eastman Dental Institute, London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Ranvaud, Ronald" sort="Ranvaud, Ronald" uniqKey="Ranvaud R" first="Ronald" last="Ranvaud">Ronald Ranvaud</name><affiliation><mods:affiliation>Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Barbosa, Egberto Reis" sort="Barbosa, Egberto Reis" uniqKey="Barbosa E" first="Egberto Reis" last="Barbosa">Egberto Reis Barbosa</name><affiliation><mods:affiliation>Neurology Department, São Paulo School of Medicine, University of São Paulo, São Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew J. 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Lees</name><affiliation><mods:affiliation>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. 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We have applied culturally adapted translations of the University of Pennsylvania 40‐item smell identification test (UPSIT‐40) and the 16‐item identification test from Sniffin' Sticks (SS‐16) to nondemented Brazilian PD patients and controls. Pearson's correlation coefficient between the test scores was 0.76 (95% CI 0.70–0.81, n = 204, P < 0.001). To calculate reliability measures for each test we used the diagnosis (either PD or control) as outcome variable for separate logistic regression analyses using the score in the UPSIT‐40 or the SS‐16 as a covariate. The SS‐16 specificity was 89.0% with a sensitivity of 81.1% (106 PD and 118 controls). The UPSIT‐40 specificity was 83.5% and its sensitivity 82.1% (95 PD and 109 controls). Regression curves were used to associate an individual's smell test score with the probability of belonging to the PD, as opposed to the control group. Our data provide support for the use of the UPSIT‐40 and SS‐16 to help distinguish early PD from controls. © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Laura Silveira‐Moriyama MD</name><affiliations><json:string>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom</json:string></affiliations></json:item><json:item><name>Margarete de Jesus Carvalho MD</name><affiliations><json:string>Neurology Department, São Paulo School of Medicine, University of São Paulo, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>Regina Katzenschlager MD</name><affiliations><json:string>Department of Neurology, Donauspital/Sozialmedizinisches Zentrum Ost, Vienna, Austria</json:string></affiliations></json:item><json:item><name>Aviva Petrie MSc, CStat</name><affiliations><json:string>Biostatistics Unit, UCL Eastman Dental Institute, London, United Kingdom</json:string></affiliations></json:item><json:item><name>Ronald Ranvaud PhD</name><affiliations><json:string>Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>Egberto Reis Barbosa MD</name><affiliations><json:string>Neurology Department, São Paulo School of Medicine, University of São Paulo, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>Andrew J. 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We have applied culturally adapted translations of the University of Pennsylvania 40‐item smell identification test (UPSIT‐40) and the 16‐item identification test from Sniffin' Sticks (SS‐16) to nondemented Brazilian PD patients and controls. Pearson's correlation coefficient between the test scores was 0.76 (95% CI 0.70–0.81, n = 204, P > 0.001). To calculate reliability measures for each test we used the diagnosis (either PD or control) as outcome variable for separate logistic regression analyses using the score in the UPSIT‐40 or the SS‐16 as a covariate. The SS‐16 specificity was 89.0% with a sensitivity of 81.1% (106 PD and 118 controls). The UPSIT‐40 specificity was 83.5% and its sensitivity 82.1% (95 PD and 109 controls). Regression curves were used to associate an individual's smell test score with the probability of belonging to the PD, as opposed to the control group. 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Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-12-15"></date><biblScope unit="volume">23</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="page" from="2328">2328</biblScope><biblScope unit="page" to="2334">2334</biblScope></imprint></monogr><idno type="istex">A920E27D967749D5AC0629AB0D713B3DF3781659</idno><idno type="DOI">10.1002/mds.22241</idno><idno type="ArticleID">MDS22241</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Smell identification tests may be of routine clinical value in the differential diagnosis of PD but are subject to cultural variation and have not been systematically evaluated in the Brazilian population. We have applied culturally adapted translations of the University of Pennsylvania 40‐item smell identification test (UPSIT‐40) and the 16‐item identification test from Sniffin' Sticks (SS‐16) to nondemented Brazilian PD patients and controls. Pearson's correlation coefficient between the test scores was 0.76 (95% CI 0.70–0.81, n = 204, P < 0.001). To calculate reliability measures for each test we used the diagnosis (either PD or control) as outcome variable for separate logistic regression analyses using the score in the UPSIT‐40 or the SS‐16 as a covariate. The SS‐16 specificity was 89.0% with a sensitivity of 81.1% (106 PD and 118 controls). The UPSIT‐40 specificity was 83.5% and its sensitivity 82.1% (95 PD and 109 controls). Regression curves were used to associate an individual's smell test score with the probability of belonging to the PD, as opposed to the control group. Our data provide support for the use of the UPSIT‐40 and SS‐16 to help distinguish early PD from controls. © 2008 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>UPSIT</term></item><item><term>smell</term></item><item><term>Sniffin sticks</term></item><item><term>olfaction</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-05-02">Received</change><change when="2008-06-30">Registration</change><change when="2008-12-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/A920E27D967749D5AC0629AB0D713B3DF3781659/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="160"><doi origin="wiley" registered="yes">10.1002/mds.v23:16</doi><numberingGroup><numbering type="journalVolume" number="23">23</numbering><numbering type="journalIssue">16</numbering></numberingGroup><coverDate startDate="2008-12-15">15 December 2008</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="60" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22241</doi><idGroup><id type="unit" value="MDS22241"></id></idGroup><countGroup><count type="pageTotal" number="13"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2008 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2008-05-02"></event><event type="manuscriptRevised" date="2008-06-09"></event><event type="manuscriptAccepted" date="2008-06-30"></event><event type="publishedOnlineEarlyUnpaginated" date="2008-09-10"></event><event type="firstOnline" date="2008-09-10"></event><event type="publishedOnlineFinalForm" date="2008-12-21"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.6 mode:FullText source:FullText result:FullText" date="2010-04-21"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">2328</numbering><numbering type="pageLast">2334</numbering></numberingGroup><correspondenceTo>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, 1 Wakefield St., London WC1N 1PJ, United Kingdom</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22241.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="40"></count><count type="wordTotal" number="5014"></count></countGroup><titleGroup><title type="main" xml:lang="en">The use of smell identification tests in the diagnosis of Parkinson's disease in Brazil<link href="#fn1"></link></title><title type="short" xml:lang="en">Smell Tests in the Diagnosis of PD in Brazil</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Laura</givenNames><familyName>Silveira‐Moriyama</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Margarete de Jesus</givenNames><familyName>Carvalho</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Regina</givenNames><familyName>Katzenschlager</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Aviva</givenNames><familyName>Petrie</familyName><degrees>MSc, CStat</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Ronald</givenNames><familyName>Ranvaud</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Egberto Reis</givenNames><familyName>Barbosa</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Andrew J.</givenNames><familyName>Lees</familyName><degrees>MD</degrees></personName><contactDetails><email>alees@ion.ucl.ac.uk</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="GB" type="organization"><unparsedAffiliation>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="BR" type="organization"><unparsedAffiliation>Neurology Department, São Paulo School of Medicine, University of São Paulo, São Paulo, Brazil</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="AT" type="organization"><unparsedAffiliation>Department of Neurology, Donauspital/Sozialmedizinisches Zentrum Ost, Vienna, Austria</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="GB" type="organization"><unparsedAffiliation>Biostatistics Unit, UCL Eastman Dental Institute, London, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="BR" type="organization"><unparsedAffiliation>Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">UPSIT</keyword><keyword xml:id="kwd3">smell</keyword><keyword xml:id="kwd4">Sniffin sticks</keyword><keyword xml:id="kwd5">olfaction</keyword></keywordGroup><fundingInfo><fundingAgency>Reta Lila Weston Trust</fundingAgency></fundingInfo><supportingInformation><p> Additional Supporting Information may be found in the online version of this article. </p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds22241:MDS22241Appendix1"></mediaResource><caption>APPENDIX 1. Brazilian version of the UPSIT‐40 used for this study</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds22241:MDS22241Appendix2"></mediaResource><caption>APPENDIX 2. Brazilian version of the SS‐16 used for this study</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Smell identification tests may be of routine clinical value in the differential diagnosis of PD but are subject to cultural variation and have not been systematically evaluated in the Brazilian population. We have applied culturally adapted translations of the University of Pennsylvania 40‐item smell identification test (UPSIT‐40) and the 16‐item identification test from Sniffin' Sticks (SS‐16) to nondemented Brazilian PD patients and controls. Pearson's correlation coefficient between the test scores was 0.76 (95% CI 0.70–0.81, n = 204, <i>P</i> < 0.001). To calculate reliability measures for each test we used the diagnosis (either PD or control) as outcome variable for separate logistic regression analyses using the score in the UPSIT‐40 or the SS‐16 as a covariate. The SS‐16 specificity was 89.0% with a sensitivity of 81.1% (106 PD and 118 controls). The UPSIT‐40 specificity was 83.5% and its sensitivity 82.1% (95 PD and 109 controls). Regression curves were used to associate an individual's smell test score with the probability of belonging to the PD, as opposed to the control group. Our data provide support for the use of the UPSIT‐40 and SS‐16 to help distinguish early PD from controls. © 2008 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: None reported.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The use of smell identification tests in the diagnosis of Parkinson's disease in Brazil</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Smell Tests in the Diagnosis of PD in Brazil</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The use of smell identification tests in the diagnosis of Parkinson's disease in Brazil</title></titleInfo><name type="personal"><namePart type="given">Laura</namePart><namePart type="family">Silveira‐Moriyama</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Margarete de Jesus</namePart><namePart type="family">Carvalho</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurology Department, São Paulo School of Medicine, University of São Paulo, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Regina</namePart><namePart type="family">Katzenschlager</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Donauspital/Sozialmedizinisches Zentrum Ost, Vienna, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Aviva</namePart><namePart type="family">Petrie</namePart><namePart type="termsOfAddress">MSc, CStat</namePart><affiliation>Biostatistics Unit, UCL Eastman Dental Institute, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ronald</namePart><namePart type="family">Ranvaud</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Egberto Reis</namePart><namePart type="family">Barbosa</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurology Department, São Paulo School of Medicine, University of São Paulo, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andrew J.</namePart><namePart type="family">Lees</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, United Kingdom</affiliation><description>Correspondence: Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, 1 Wakefield St., London WC1N 1PJ, United Kingdom</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-12-15</dateIssued><dateCaptured encoding="w3cdtf">2008-05-02</dateCaptured><dateValid encoding="w3cdtf">2008-06-30</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent><extent unit="references">40</extent><extent unit="words">5014</extent></physicalDescription><abstract lang="en">Smell identification tests may be of routine clinical value in the differential diagnosis of PD but are subject to cultural variation and have not been systematically evaluated in the Brazilian population. We have applied culturally adapted translations of the University of Pennsylvania 40‐item smell identification test (UPSIT‐40) and the 16‐item identification test from Sniffin' Sticks (SS‐16) to nondemented Brazilian PD patients and controls. Pearson's correlation coefficient between the test scores was 0.76 (95% CI 0.70–0.81, n = 204, P < 0.001). To calculate reliability measures for each test we used the diagnosis (either PD or control) as outcome variable for separate logistic regression analyses using the score in the UPSIT‐40 or the SS‐16 as a covariate. The SS‐16 specificity was 89.0% with a sensitivity of 81.1% (106 PD and 118 controls). The UPSIT‐40 specificity was 83.5% and its sensitivity 82.1% (95 PD and 109 controls). Regression curves were used to associate an individual's smell test score with the probability of belonging to the PD, as opposed to the control group. Our data provide support for the use of the UPSIT‐40 and SS‐16 to help distinguish early PD from controls. © 2008 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None reported.</note><note type="funding">Reta Lila Weston Trust</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>UPSIT</topic><topic>smell</topic><topic>Sniffin sticks</topic><topic>olfaction</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><note type="content"> Additional Supporting Information may be found in the online version of this article.Supporting Info Item: APPENDIX 1. Brazilian version of the UPSIT‐40 used for this study - APPENDIX 2. Brazilian version of the SS‐16 used for this study - </note><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><detail type="issue"><caption>no.</caption><number>16</number></detail><extent unit="pages"><start>2328</start><end>2334</end><total>13</total></extent></part></relatedItem><identifier type="istex">A920E27D967749D5AC0629AB0D713B3DF3781659</identifier><identifier type="DOI">10.1002/mds.22241</identifier><identifier type="ArticleID">MDS22241</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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