Trends in Parkinson’s disease related mortality in England and Wales, 1993–2006
Identifieur interne : 001613 ( Main/Corpus ); précédent : 001612; suivant : 001614Trends in Parkinson’s disease related mortality in England and Wales, 1993–2006
Auteurs : A. Q. N. Mylne ; C. Griffiths ; C. Rooney ; P. DoyleSource :
- European Journal of Neurology [ 1351-5101 ] ; 2009-09.
English descriptors
- KwdEn :
Abstract
Background: This paper describes changes in Parkinson’s disease (PD) mortality in England and Wales between 1993 and 2006 using all information on death certificates. Methods: Information on deaths was obtained from the Office for National Statistics. Mortality rates for any mention of PD on death certificates were directly age‐standardized using the European standard population. Average yearly changes in mortality rates were estimated using linear regression. The underlying cause of death on death certificates where PD was mentioned was examined by sex and calendar period. Results: Male PD age‐standardized mortality rates for any mention of PD decreased from 15.0 to 11.7 per 100 000 between 1993 and 2006. Female PD mortality rates fell from 6.3 to 4.9 per 100 000. Decreases were greater for older age‐groups. The proportion of deaths with PD recorded as the underlying cause increased by 50% in 2001 following implementation of the 10th revision of the International Classification of Diseases (ICD). Conclusion: Parkinson’s disease mortality rates in England and Wales are decreasing, especially for men and for older age‐groups. Because of data limitations we are unable to ascertain whether the decrease of PD recorded on death certificates is because of a reduction in PD incidence, or to improved survival for PD patients resulting from advancements in PD treatments or to improvements in general medical care. The dramatic increase in PD as the underlying cause of death following ICD revision in 2001 demonstrates the dangers of using underlying cause of death to investigate mortality trends without being aware of the potential for artifacts.
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DOI: 10.1111/j.1468-1331.2009.02715.x
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ISTEX:4CFC749879CAE97C9E19D87708E33758DA1B5456Le document en format XML
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Rooney</name><affiliation><mods:affiliation>Office for National Statistics, Newport, UK</mods:affiliation></affiliation></author><author><name sortKey="Doyle, P" sort="Doyle, P" uniqKey="Doyle P" first="P." last="Doyle">P. Doyle</name><affiliation><mods:affiliation>Department of Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:4CFC749879CAE97C9E19D87708E33758DA1B5456</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1111/j.1468-1331.2009.02715.x</idno><idno type="url">https://api.istex.fr/document/4CFC749879CAE97C9E19D87708E33758DA1B5456/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001613</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Trends in Parkinson’s disease related mortality in England and Wales, 1993–2006</title><author><name sortKey="Mylne, A Q N" sort="Mylne, A Q N" uniqKey="Mylne A" first="A. Q. N." last="Mylne">A. Q. N. Mylne</name><affiliation><mods:affiliation>Department of Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Griffiths, C" sort="Griffiths, C" uniqKey="Griffiths C" first="C." last="Griffiths">C. Griffiths</name><affiliation><mods:affiliation>Office for National Statistics, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Rooney, C" sort="Rooney, C" uniqKey="Rooney C" first="C." last="Rooney">C. Rooney</name><affiliation><mods:affiliation>Office for National Statistics, Newport, UK</mods:affiliation></affiliation></author><author><name sortKey="Doyle, P" sort="Doyle, P" uniqKey="Doyle P" first="P." last="Doyle">P. Doyle</name><affiliation><mods:affiliation>Department of Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2009-09">2009-09</date><biblScope unit="volume">16</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1010">1010</biblScope><biblScope unit="page" to="1016">1016</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">4CFC749879CAE97C9E19D87708E33758DA1B5456</idno><idno type="DOI">10.1111/j.1468-1331.2009.02715.x</idno><idno type="ArticleID">ENE2715</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>England</term><term>Parkinson disease</term><term>Wales</term><term>mortality</term><term>trends</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: This paper describes changes in Parkinson’s disease (PD) mortality in England and Wales between 1993 and 2006 using all information on death certificates. Methods: Information on deaths was obtained from the Office for National Statistics. Mortality rates for any mention of PD on death certificates were directly age‐standardized using the European standard population. Average yearly changes in mortality rates were estimated using linear regression. The underlying cause of death on death certificates where PD was mentioned was examined by sex and calendar period. Results: Male PD age‐standardized mortality rates for any mention of PD decreased from 15.0 to 11.7 per 100 000 between 1993 and 2006. Female PD mortality rates fell from 6.3 to 4.9 per 100 000. Decreases were greater for older age‐groups. The proportion of deaths with PD recorded as the underlying cause increased by 50% in 2001 following implementation of the 10th revision of the International Classification of Diseases (ICD). Conclusion: Parkinson’s disease mortality rates in England and Wales are decreasing, especially for men and for older age‐groups. Because of data limitations we are unable to ascertain whether the decrease of PD recorded on death certificates is because of a reduction in PD incidence, or to improved survival for PD patients resulting from advancements in PD treatments or to improvements in general medical care. The dramatic increase in PD as the underlying cause of death following ICD revision in 2001 demonstrates the dangers of using underlying cause of death to investigate mortality trends without being aware of the potential for artifacts.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>A. Q. N. Mylne</name><affiliations><json:string>Department of Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</json:string></affiliations></json:item><json:item><name>C. Griffiths</name><affiliations><json:string>Office for National Statistics, London, UK</json:string></affiliations></json:item><json:item><name>C. Rooney</name><affiliations><json:string>Office for National Statistics, Newport, UK</json:string></affiliations></json:item><json:item><name>P. Doyle</name><affiliations><json:string>Department of Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>England</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mortality</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>trends</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Wales</value></json:item></subject><articleId><json:string>ENE2715</json:string></articleId><language><json:string>eng</json:string></language><abstract>Background: This paper describes changes in Parkinson’s disease (PD) mortality in England and Wales between 1993 and 2006 using all information on death certificates. Methods: Information on deaths was obtained from the Office for National Statistics. Mortality rates for any mention of PD on death certificates were directly age‐standardized using the European standard population. Average yearly changes in mortality rates were estimated using linear regression. The underlying cause of death on death certificates where PD was mentioned was examined by sex and calendar period. Results: Male PD age‐standardized mortality rates for any mention of PD decreased from 15.0 to 11.7 per 100 000 between 1993 and 2006. Female PD mortality rates fell from 6.3 to 4.9 per 100 000. Decreases were greater for older age‐groups. The proportion of deaths with PD recorded as the underlying cause increased by 50% in 2001 following implementation of the 10th revision of the International Classification of Diseases (ICD). Conclusion: Parkinson’s disease mortality rates in England and Wales are decreasing, especially for men and for older age‐groups. Because of data limitations we are unable to ascertain whether the decrease of PD recorded on death certificates is because of a reduction in PD incidence, or to improved survival for PD patients resulting from advancements in PD treatments or to improvements in general medical care. The dramatic increase in PD as the underlying cause of death following ICD revision in 2001 demonstrates the dangers of using underlying cause of death to investigate mortality trends without being aware of the potential for artifacts.</abstract><qualityIndicators><score>6.169</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1667</abstractCharCount><pdfWordCount>3169</pdfWordCount><pdfCharCount>20653</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>253</abstractWordCount></qualityIndicators><title>Trends in Parkinson’s disease related mortality in England and Wales, 1993–2006</title><genre><json:string>article</json:string></genre><host><volume>16</volume><publisherId><json:string>ENE</json:string></publisherId><pages><total>9</total><last>1016</last><first>1010</first></pages><issn><json:string>1351-5101</json:string></issn><issue>9</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1468-1331</json:string></eissn><title>European Journal of Neurology</title><doi><json:string>10.1111/(ISSN)1468-1331</json:string></doi></host><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1111/j.1468-1331.2009.02715.x</json:string></doi><id>4CFC749879CAE97C9E19D87708E33758DA1B5456</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/4CFC749879CAE97C9E19D87708E33758DA1B5456/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/4CFC749879CAE97C9E19D87708E33758DA1B5456/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/4CFC749879CAE97C9E19D87708E33758DA1B5456/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Trends in Parkinson’s disease related mortality in England and Wales, 1993–2006</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>2009</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Trends in Parkinson’s disease related mortality in England and Wales, 1993–2006</title><author><persName><forename type="first">A. Q. N.</forename><surname>Mylne</surname></persName><affiliation>Department of Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</affiliation></author><author><persName><forename type="first">C.</forename><surname>Griffiths</surname></persName><affiliation>Office for National Statistics, London, UK</affiliation></author><author><persName><forename type="first">C.</forename><surname>Rooney</surname></persName><affiliation>Office for National Statistics, Newport, UK</affiliation></author><author><persName><forename type="first">P.</forename><surname>Doyle</surname></persName><affiliation>Department of Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</affiliation></author></analytic><monogr><title level="j">European Journal of Neurology</title><idno type="pISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><idno type="DOI">10.1111/(ISSN)1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2009-09"></date><biblScope unit="volume">16</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1010">1010</biblScope><biblScope unit="page" to="1016">1016</biblScope></imprint></monogr><idno type="istex">4CFC749879CAE97C9E19D87708E33758DA1B5456</idno><idno type="DOI">10.1111/j.1468-1331.2009.02715.x</idno><idno type="ArticleID">ENE2715</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background: This paper describes changes in Parkinson’s disease (PD) mortality in England and Wales between 1993 and 2006 using all information on death certificates. Methods: Information on deaths was obtained from the Office for National Statistics. Mortality rates for any mention of PD on death certificates were directly age‐standardized using the European standard population. Average yearly changes in mortality rates were estimated using linear regression. The underlying cause of death on death certificates where PD was mentioned was examined by sex and calendar period. Results: Male PD age‐standardized mortality rates for any mention of PD decreased from 15.0 to 11.7 per 100 000 between 1993 and 2006. Female PD mortality rates fell from 6.3 to 4.9 per 100 000. Decreases were greater for older age‐groups. The proportion of deaths with PD recorded as the underlying cause increased by 50% in 2001 following implementation of the 10th revision of the International Classification of Diseases (ICD). Conclusion: Parkinson’s disease mortality rates in England and Wales are decreasing, especially for men and for older age‐groups. Because of data limitations we are unable to ascertain whether the decrease of PD recorded on death certificates is because of a reduction in PD incidence, or to improved survival for PD patients resulting from advancements in PD treatments or to improvements in general medical care. The dramatic increase in PD as the underlying cause of death following ICD revision in 2001 demonstrates the dangers of using underlying cause of death to investigate mortality trends without being aware of the potential for artifacts.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>England</term></item><item><term>mortality</term></item><item><term>Parkinson disease</term></item><item><term>trends</term></item><item><term>Wales</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-09">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/4CFC749879CAE97C9E19D87708E33758DA1B5456/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1468-1331</doi><issn type="print">1351-5101</issn><issn type="electronic">1468-1331</issn><idGroup><id type="product" value="ENE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF NEUROLOGY">European Journal of Neurology</title></titleGroup></publicationMeta><publicationMeta level="part" position="09009"><doi origin="wiley">10.1111/ene.2009.16.issue-9</doi><numberingGroup><numbering type="journalVolume" number="16">16</numbering><numbering type="journalIssue" number="9">9</numbering></numberingGroup><coverDate startDate="2009-09">September 2009</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="10" status="forIssue"><doi origin="wiley">10.1111/j.1468-1331.2009.02715.x</doi><idGroup><id type="unit" value="ENE2715"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><copyright>© 2009 The Author(s). Journal compilation © 2009 EFNS</copyright><eventGroup><event type="firstOnline" date="2009-06-15"></event><event type="publishedOnlineFinalForm" date="2009-08-07"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-06"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-24"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="1010">1010</numbering><numbering type="pageLast" number="1016">1016</numbering></numberingGroup><correspondenceTo>Pat Doyle, Department of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, UK (tel.: +44 (0)20 7927 2084; fax: +44 207 580 6897; e‐mail: <email>pat.doyle@lshtm.ac.uk</email>).</correspondenceTo><objectNameGroup><objectName elementName="appendix">Appendix</objectName></objectNameGroup><linkGroup><link type="toTypesetVersion" href="file:ENE.ENE2715.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 17 October 2008 Accepted 10 March 2009</unparsedEditorialHistory><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="4"></count></countGroup><titleGroup><title type="main">Trends in Parkinson’s disease related mortality in England and Wales, 1993–2006</title><title type="shortAuthors">A. Q. N. Mylne <i>et al.</i></title><title type="short">Trends in Parkinson’s disease related mortality in England and Wales, 1993–2006</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>A. Q. N.</givenNames><familyName>Mylne</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>C.</givenNames><familyName>Griffiths</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3"><personName><givenNames>C.</givenNames><familyName>Rooney</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>P.</givenNames><familyName>Doyle</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="GB"><unparsedAffiliation>Department of Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="GB"><unparsedAffiliation>Office for National Statistics, London, UK</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="GB"><unparsedAffiliation>Office for National Statistics, Newport, UK</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">England</keyword><keyword xml:id="k2">mortality</keyword><keyword xml:id="k3">Parkinson disease</keyword><keyword xml:id="k4">trends</keyword><keyword xml:id="k5">Wales</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Background: </b> This paper describes changes in Parkinson’s disease (PD) mortality in England and Wales between 1993 and 2006 using all information on death certificates.</p><p><b>Methods: </b> Information on deaths was obtained from the Office for National Statistics. Mortality rates for any mention of PD on death certificates were directly age‐standardized using the European standard population. Average yearly changes in mortality rates were estimated using linear regression. The underlying cause of death on death certificates where PD was mentioned was examined by sex and calendar period.</p><p><b>Results: </b> Male PD age‐standardized mortality rates for any mention of PD decreased from 15.0 to 11.7 per 100 000 between 1993 and 2006. Female PD mortality rates fell from 6.3 to 4.9 per 100 000. Decreases were greater for older age‐groups. The proportion of deaths with PD recorded as the underlying cause increased by 50% in 2001 following implementation of the 10th revision of the International Classification of Diseases (ICD).</p><p><b>Conclusion: </b> Parkinson’s disease mortality rates in England and Wales are decreasing, especially for men and for older age‐groups. Because of data limitations we are unable to ascertain whether the decrease of PD recorded on death certificates is because of a reduction in PD incidence, or to improved survival for PD patients resulting from advancements in PD treatments or to improvements in general medical care. The dramatic increase in PD as the underlying cause of death following ICD revision in 2001 demonstrates the dangers of using underlying cause of death to investigate mortality trends without being aware of the potential for artifacts.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Trends in Parkinson’s disease related mortality in England and Wales, 1993–2006</title></titleInfo><titleInfo type="abbreviated"><title>Trends in Parkinson’s disease related mortality in England and Wales, 1993–2006</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Trends in Parkinson’s disease related mortality in England and Wales, 1993–2006</title></titleInfo><name type="personal"><namePart type="given">A. Q. N.</namePart><namePart type="family">Mylne</namePart><affiliation>Department of Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Griffiths</namePart><affiliation>Office for National Statistics, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Rooney</namePart><affiliation>Office for National Statistics, Newport, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Doyle</namePart><affiliation>Department of Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2009-09</dateIssued><edition>Received 17 October 2008 Accepted 10 March 2009</edition><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">4</extent></physicalDescription><abstract lang="en">Background: This paper describes changes in Parkinson’s disease (PD) mortality in England and Wales between 1993 and 2006 using all information on death certificates. Methods: Information on deaths was obtained from the Office for National Statistics. Mortality rates for any mention of PD on death certificates were directly age‐standardized using the European standard population. Average yearly changes in mortality rates were estimated using linear regression. The underlying cause of death on death certificates where PD was mentioned was examined by sex and calendar period. Results: Male PD age‐standardized mortality rates for any mention of PD decreased from 15.0 to 11.7 per 100 000 between 1993 and 2006. Female PD mortality rates fell from 6.3 to 4.9 per 100 000. Decreases were greater for older age‐groups. The proportion of deaths with PD recorded as the underlying cause increased by 50% in 2001 following implementation of the 10th revision of the International Classification of Diseases (ICD). Conclusion: Parkinson’s disease mortality rates in England and Wales are decreasing, especially for men and for older age‐groups. Because of data limitations we are unable to ascertain whether the decrease of PD recorded on death certificates is because of a reduction in PD incidence, or to improved survival for PD patients resulting from advancements in PD treatments or to improvements in general medical care. The dramatic increase in PD as the underlying cause of death following ICD revision in 2001 demonstrates the dangers of using underlying cause of death to investigate mortality trends without being aware of the potential for artifacts.</abstract><subject lang="en"><genre>Keywords</genre><topic>England</topic><topic>mortality</topic><topic>Parkinson disease</topic><topic>trends</topic><topic>Wales</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neurology</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">1351-5101</identifier><identifier type="eISSN">1468-1331</identifier><identifier type="DOI">10.1111/(ISSN)1468-1331</identifier><identifier type="PublisherID">ENE</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><detail type="issue"><caption>no.</caption><number>9</number></detail><extent unit="pages"><start>1010</start><end>1016</end><total>9</total></extent></part></relatedItem><identifier type="istex">4CFC749879CAE97C9E19D87708E33758DA1B5456</identifier><identifier type="DOI">10.1111/j.1468-1331.2009.02715.x</identifier><identifier type="ArticleID">ENE2715</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2009 The Author(s). 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