Electrophysiological abnormalities of the atrial muscle in patients with sinus node dysfunction without tachyarrhythmias
Identifieur interne : 001607 ( Main/Corpus ); précédent : 001606; suivant : 001608Electrophysiological abnormalities of the atrial muscle in patients with sinus node dysfunction without tachyarrhythmias
Auteurs : Osmar Antonio Centurion ; Masahiko Fukatani ; Atsushi Konoe ; Muneo Tanigawa ; Akihiko Shimizu ; Shojiro Isomoto ; Mitsuo Kadena ; Kunitake HashibaSource :
- International Journal of Cardiology [ 0167-5273 ] ; 1992.
Abstract
The duration and the number of fragmented deflections of the right atrial electrograms were assessed and quantitatively measured in 74 patients who underwent endocardial catheter mapping during sinus rhythm. The bipolar electrograms were recorded at 12 sites in the right atrium. An abnormal atrial electrogram was defined as a duration of 100 ms or longer, and/or 8 or more fragmented deflections, according to our previous criteria. The patients were divided into two groups. The control group consisted of 41 age-matched patients with normal sinus node function and without paroxysmal atrial fibrillation. The study group comprised 33 patients with sinus node dysfunction but without tachyarrhythmias.Abnormal atrial electrograms were observed in 8 (19.5%) control patients, and in 16 (48.5%) sinus node dysfunction patients; p < 0.02. The total number of abnormal electrograms was 14 (2.89%) of 483 atrial electrograms in controls, and 36 (9.38%) of 384 in the study group; p < 0.0002. The mean duration (75.6 ± 17) and the mean number of fragmented deflections (4.1 ± 2) of the total atrial electrograms in the sinus node dysfunction group was significantly greater than that in controls (70.9 ± 11 and 3.6 ± 1, respectively); p < 0.01. The mean number of abnormal electrograms per patient in the study group (1.06 ± 1.8) was significantly higher than that in the control group (0.3 ± 0.8); p < 0.05.These data suggest that: (1) there is a significantly greater electrophysiological abnormality of the atrial muscle in patients with sinus node dysfunction but without paroxysmal atrial fibrillation than in age-matched controls, and (2) not only the sinus node but also the atrial muscle is electrophysiologically altered in patients with sinus node dysfunction but without tachyarrhythmias.
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DOI: 10.1016/0167-5273(92)90130-U
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Konoe</name><affiliation><mods:affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</mods:affiliation></affiliation></author><author><name sortKey="Tanigawa, Muneo" sort="Tanigawa, Muneo" uniqKey="Tanigawa M" first="Muneo" last="Tanigawa">Muneo Tanigawa</name><affiliation><mods:affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</mods:affiliation></affiliation></author><author><name sortKey="Shimizu, Akihiko" sort="Shimizu, Akihiko" uniqKey="Shimizu A" first="Akihiko" last="Shimizu">Akihiko Shimizu</name><affiliation><mods:affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</mods:affiliation></affiliation></author><author><name sortKey="Isomoto, Shojiro" sort="Isomoto, Shojiro" uniqKey="Isomoto S" first="Shojiro" last="Isomoto">Shojiro Isomoto</name><affiliation><mods:affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kadena, Mitsuo" sort="Kadena, Mitsuo" uniqKey="Kadena M" first="Mitsuo" last="Kadena">Mitsuo Kadena</name><affiliation><mods:affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</mods:affiliation></affiliation></author><author><name sortKey="Hashiba, Kunitake" sort="Hashiba, Kunitake" uniqKey="Hashiba K" first="Kunitake" last="Hashiba">Kunitake Hashiba</name><affiliation><mods:affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8F99EB482A7472D5CD4F620D8C66962E8DC10587</idno><date when="1992" year="1992">1992</date><idno type="doi">10.1016/0167-5273(92)90130-U</idno><idno 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Japan</mods:affiliation></affiliation></author><author><name sortKey="Konoe, Atsushi" sort="Konoe, Atsushi" uniqKey="Konoe A" first="Atsushi" last="Konoe">Atsushi Konoe</name><affiliation><mods:affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</mods:affiliation></affiliation></author><author><name sortKey="Tanigawa, Muneo" sort="Tanigawa, Muneo" uniqKey="Tanigawa M" first="Muneo" last="Tanigawa">Muneo Tanigawa</name><affiliation><mods:affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</mods:affiliation></affiliation></author><author><name sortKey="Shimizu, Akihiko" sort="Shimizu, Akihiko" uniqKey="Shimizu A" first="Akihiko" last="Shimizu">Akihiko Shimizu</name><affiliation><mods:affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</mods:affiliation></affiliation></author><author><name sortKey="Isomoto, Shojiro" sort="Isomoto, Shojiro" uniqKey="Isomoto S" first="Shojiro" last="Isomoto">Shojiro Isomoto</name><affiliation><mods:affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kadena, Mitsuo" sort="Kadena, Mitsuo" uniqKey="Kadena M" first="Mitsuo" last="Kadena">Mitsuo Kadena</name><affiliation><mods:affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</mods:affiliation></affiliation></author><author><name sortKey="Hashiba, Kunitake" sort="Hashiba, Kunitake" uniqKey="Hashiba K" first="Kunitake" last="Hashiba">Kunitake Hashiba</name><affiliation><mods:affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">International Journal of Cardiology</title><title level="j" type="abbrev">IJCA</title><idno type="ISSN">0167-5273</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992">1992</date><biblScope unit="volume">37</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="41">41</biblScope><biblScope unit="page" to="50">50</biblScope></imprint><idno type="ISSN">0167-5273</idno></series><idno type="istex">8F99EB482A7472D5CD4F620D8C66962E8DC10587</idno><idno type="DOI">10.1016/0167-5273(92)90130-U</idno><idno type="PII">0167-5273(92)90130-U</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0167-5273</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The duration and the number of fragmented deflections of the right atrial electrograms were assessed and quantitatively measured in 74 patients who underwent endocardial catheter mapping during sinus rhythm. The bipolar electrograms were recorded at 12 sites in the right atrium. An abnormal atrial electrogram was defined as a duration of 100 ms or longer, and/or 8 or more fragmented deflections, according to our previous criteria. The patients were divided into two groups. The control group consisted of 41 age-matched patients with normal sinus node function and without paroxysmal atrial fibrillation. The study group comprised 33 patients with sinus node dysfunction but without tachyarrhythmias.Abnormal atrial electrograms were observed in 8 (19.5%) control patients, and in 16 (48.5%) sinus node dysfunction patients; p < 0.02. The total number of abnormal electrograms was 14 (2.89%) of 483 atrial electrograms in controls, and 36 (9.38%) of 384 in the study group; p < 0.0002. The mean duration (75.6 ± 17) and the mean number of fragmented deflections (4.1 ± 2) of the total atrial electrograms in the sinus node dysfunction group was significantly greater than that in controls (70.9 ± 11 and 3.6 ± 1, respectively); p < 0.01. The mean number of abnormal electrograms per patient in the study group (1.06 ± 1.8) was significantly higher than that in the control group (0.3 ± 0.8); p < 0.05.These data suggest that: (1) there is a significantly greater electrophysiological abnormality of the atrial muscle in patients with sinus node dysfunction but without paroxysmal atrial fibrillation than in age-matched controls, and (2) not only the sinus node but also the atrial muscle is electrophysiologically altered in patients with sinus node dysfunction but without tachyarrhythmias.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Osmar Antonio Centurion</name><affiliations><json:string>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</json:string></affiliations></json:item><json:item><name>Masahiko Fukatani</name><affiliations><json:string>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</json:string></affiliations></json:item><json:item><name>Atsushi Konoe</name><affiliations><json:string>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</json:string></affiliations></json:item><json:item><name>Muneo Tanigawa</name><affiliations><json:string>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</json:string></affiliations></json:item><json:item><name>Akihiko Shimizu</name><affiliations><json:string>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</json:string></affiliations></json:item><json:item><name>Shojiro Isomoto</name><affiliations><json:string>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</json:string></affiliations></json:item><json:item><name>Mitsuo Kadena</name><affiliations><json:string>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</json:string></affiliations></json:item><json:item><name>Kunitake Hashiba</name><affiliations><json:string>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Electrophysiology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Intra-atrial catheter mapping</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Prolonged and fractionated atrial electrogram</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Sinus node dysfunction</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Atrial muscle abnormality</value></json:item></subject><language><json:string>eng</json:string></language><abstract>The duration and the number of fragmented deflections of the right atrial electrograms were assessed and quantitatively measured in 74 patients who underwent endocardial catheter mapping during sinus rhythm. The bipolar electrograms were recorded at 12 sites in the right atrium. An abnormal atrial electrogram was defined as a duration of 100 ms or longer, and/or 8 or more fragmented deflections, according to our previous criteria. The patients were divided into two groups. The control group consisted of 41 age-matched patients with normal sinus node function and without paroxysmal atrial fibrillation. The study group comprised 33 patients with sinus node dysfunction but without tachyarrhythmias.Abnormal atrial electrograms were observed in 8 (19.5%) control patients, and in 16 (48.5%) sinus node dysfunction patients; p > 0.02. The total number of abnormal electrograms was 14 (2.89%) of 483 atrial electrograms in controls, and 36 (9.38%) of 384 in the study group; p > 0.0002. The mean duration (75.6 ± 17) and the mean number of fragmented deflections (4.1 ± 2) of the total atrial electrograms in the sinus node dysfunction group was significantly greater than that in controls (70.9 ± 11 and 3.6 ± 1, respectively); p > 0.01. The mean number of abnormal electrograms per patient in the study group (1.06 ± 1.8) was significantly higher than that in the control group (0.3 ± 0.8); p > 0.05.These data suggest that: (1) there is a significantly greater electrophysiological abnormality of the atrial muscle in patients with sinus node dysfunction but without paroxysmal atrial fibrillation than in age-matched controls, and (2) not only the sinus node but also the atrial muscle is electrophysiologically altered in patients with sinus node dysfunction but without tachyarrhythmias.</abstract><qualityIndicators><score>7.395</score><pdfVersion>1.2</pdfVersion><pdfPageSize>545 x 749 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1796</abstractCharCount><pdfWordCount>4395</pdfWordCount><pdfCharCount>31693</pdfCharCount><pdfPageCount>10</pdfPageCount><abstractWordCount>280</abstractWordCount></qualityIndicators><title>Electrophysiological abnormalities of the atrial muscle in patients with sinus node dysfunction without tachyarrhythmias</title><pii><json:string>0167-5273(92)90130-U</json:string></pii><genre><json:string>research-article</json:string></genre><host><volume>37</volume><pii><json:string>S0167-5273(00)X0182-9</json:string></pii><pages><last>50</last><first>41</first></pages><issn><json:string>0167-5273</json:string></issn><issue>1</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>International Journal of Cardiology</title><publicationDate>1992</publicationDate></host><categories><wos><json:string>CARDIAC & CARDIOVASCULAR SYSTEMS</json:string></wos></categories><publicationDate>1992</publicationDate><copyrightDate>1992</copyrightDate><doi><json:string>10.1016/0167-5273(92)90130-U</json:string></doi><id>8F99EB482A7472D5CD4F620D8C66962E8DC10587</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/8F99EB482A7472D5CD4F620D8C66962E8DC10587/fulltext/pdf</uri></json:item><json:item><original>true</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/8F99EB482A7472D5CD4F620D8C66962E8DC10587/fulltext/txt</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/8F99EB482A7472D5CD4F620D8C66962E8DC10587/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/8F99EB482A7472D5CD4F620D8C66962E8DC10587/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Electrophysiological abnormalities of the atrial muscle in patients with sinus node dysfunction without tachyarrhythmias</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1992</date></publicationStmt><notesStmt><note>This study was presented in part at the 55th Annual Scientific Meeting of the Japanese Circulation Society, Kyoto, Japan, March 1991.</note><note type="content">Section title: Original study</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Electrophysiological abnormalities of the atrial muscle in patients with sinus node dysfunction without tachyarrhythmias</title><author><persName><forename type="first">Osmar Antonio</forename><surname>Centurion</surname></persName><note type="correspondence"><p>Correspondence to: Dr. O.A. Centurion, Third Department of Internal Medicine, Nagasaki University School of Medicine, 7-1 Sakamoto-machi, Nagasaki, 852 Japan. Tel. 0958-47-2111 (ext. 2844). Fax 0958-46-2500.</p></note><affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</affiliation></author><author><persName><forename type="first">Masahiko</forename><surname>Fukatani</surname></persName><affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</affiliation></author><author><persName><forename type="first">Atsushi</forename><surname>Konoe</surname></persName><affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</affiliation></author><author><persName><forename type="first">Muneo</forename><surname>Tanigawa</surname></persName><affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</affiliation></author><author><persName><forename type="first">Akihiko</forename><surname>Shimizu</surname></persName><affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</affiliation></author><author><persName><forename type="first">Shojiro</forename><surname>Isomoto</surname></persName><affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</affiliation></author><author><persName><forename type="first">Mitsuo</forename><surname>Kadena</surname></persName><affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</affiliation></author><author><persName><forename type="first">Kunitake</forename><surname>Hashiba</surname></persName><affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</affiliation></author></analytic><monogr><title level="j">International Journal of Cardiology</title><title level="j" type="abbrev">IJCA</title><idno type="pISSN">0167-5273</idno><idno type="PII">S0167-5273(00)X0182-9</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992"></date><biblScope unit="volume">37</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="41">41</biblScope><biblScope unit="page" to="50">50</biblScope></imprint></monogr><idno type="istex">8F99EB482A7472D5CD4F620D8C66962E8DC10587</idno><idno type="DOI">10.1016/0167-5273(92)90130-U</idno><idno type="PII">0167-5273(92)90130-U</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1992</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The duration and the number of fragmented deflections of the right atrial electrograms were assessed and quantitatively measured in 74 patients who underwent endocardial catheter mapping during sinus rhythm. The bipolar electrograms were recorded at 12 sites in the right atrium. An abnormal atrial electrogram was defined as a duration of 100 ms or longer, and/or 8 or more fragmented deflections, according to our previous criteria. The patients were divided into two groups. The control group consisted of 41 age-matched patients with normal sinus node function and without paroxysmal atrial fibrillation. The study group comprised 33 patients with sinus node dysfunction but without tachyarrhythmias.Abnormal atrial electrograms were observed in 8 (19.5%) control patients, and in 16 (48.5%) sinus node dysfunction patients; p < 0.02. The total number of abnormal electrograms was 14 (2.89%) of 483 atrial electrograms in controls, and 36 (9.38%) of 384 in the study group; p < 0.0002. The mean duration (75.6 ± 17) and the mean number of fragmented deflections (4.1 ± 2) of the total atrial electrograms in the sinus node dysfunction group was significantly greater than that in controls (70.9 ± 11 and 3.6 ± 1, respectively); p < 0.01. The mean number of abnormal electrograms per patient in the study group (1.06 ± 1.8) was significantly higher than that in the control group (0.3 ± 0.8); p < 0.05.These data suggest that: (1) there is a significantly greater electrophysiological abnormality of the atrial muscle in patients with sinus node dysfunction but without paroxysmal atrial fibrillation than in age-matched controls, and (2) not only the sinus node but also the atrial muscle is electrophysiologically altered in patients with sinus node dysfunction but without tachyarrhythmias.</p></abstract><textClass><keywords scheme="keyword"><list><head>Article category</head><item><term>Electrophysiology</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Intra-atrial catheter mapping</term></item><item><term>Prolonged and fractionated atrial electrogram</term></item><item><term>Sinus node dysfunction</term></item><item><term>Atrial muscle abnormality</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1992-04-27">Registration</change><change when="1992">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>IJCA</jid><aid>9290130U</aid><ce:pii>0167-5273(92)90130-U</ce:pii><ce:doi>10.1016/0167-5273(92)90130-U</ce:doi><ce:copyright type="unknown" year="1992"></ce:copyright><ce:doctopics><ce:doctopic><ce:text>Electrophysiology</ce:text></ce:doctopic></ce:doctopics></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>This study was presented in part at the 55th Annual Scientific Meeting of the Japanese Circulation Society, Kyoto, Japan, March 1991.</ce:note-para></ce:article-footnote><ce:dochead><ce:textfn>Original study</ce:textfn></ce:dochead><ce:title>Electrophysiological abnormalities of the atrial muscle in patients with sinus node dysfunction without tachyarrhythmias</ce:title><ce:author-group><ce:author><ce:given-name>Osmar Antonio</ce:given-name><ce:surname>Centurion</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Masahiko</ce:given-name><ce:surname>Fukatani</ce:surname></ce:author><ce:author><ce:given-name>Atsushi</ce:given-name><ce:surname>Konoe</ce:surname></ce:author><ce:author><ce:given-name>Muneo</ce:given-name><ce:surname>Tanigawa</ce:surname></ce:author><ce:author><ce:given-name>Akihiko</ce:given-name><ce:surname>Shimizu</ce:surname></ce:author><ce:author><ce:given-name>Shojiro</ce:given-name><ce:surname>Isomoto</ce:surname></ce:author><ce:author><ce:given-name>Mitsuo</ce:given-name><ce:surname>Kadena</ce:surname></ce:author><ce:author><ce:given-name>Kunitake</ce:given-name><ce:surname>Hashiba</ce:surname></ce:author><ce:affiliation><ce:textfn>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Correspondence to: Dr. O.A. Centurion, Third Department of Internal Medicine, Nagasaki University School of Medicine, 7-1 Sakamoto-machi, Nagasaki, 852 Japan. Tel. 0958-47-2111 (ext. 2844). Fax 0958-46-2500.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="17" month="12" year="1991"></ce:date-received><ce:date-accepted day="27" month="4" year="1992"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The duration and the number of fragmented deflections of the right atrial electrograms were assessed and quantitatively measured in 74 patients who underwent endocardial catheter mapping during sinus rhythm. The bipolar electrograms were recorded at 12 sites in the right atrium. An abnormal atrial electrogram was defined as a duration of 100 ms or longer, and/or 8 or more fragmented deflections, according to our previous criteria. The patients were divided into two groups. The control group consisted of 41 age-matched patients with normal sinus node function and without paroxysmal atrial fibrillation. The study group comprised 33 patients with sinus node dysfunction but without tachyarrhythmias.</ce:simple-para><ce:simple-para>Abnormal atrial electrograms were observed in 8 (19.5%) control patients, and in 16 (48.5%) sinus node dysfunction patients; <ce:italic>p</ce:italic> < 0.02. The total number of abnormal electrograms was 14 (2.89%) of 483 atrial electrograms in controls, and 36 (9.38%) of 384 in the study group; <ce:italic>p</ce:italic> < 0.0002. The mean duration (75.6 ± 17) and the mean number of fragmented deflections (4.1 ± 2) of the total atrial electrograms in the sinus node dysfunction group was significantly greater than that in controls (70.9 ± 11 and 3.6 ± 1, respectively); <ce:italic>p</ce:italic> < 0.01. The mean number of abnormal electrograms per patient in the study group (1.06 ± 1.8) was significantly higher than that in the control group (0.3 ± 0.8); <ce:italic>p</ce:italic> < 0.05.</ce:simple-para><ce:simple-para>These data suggest that: (1) there is a significantly greater electrophysiological abnormality of the atrial muscle in patients with sinus node dysfunction but without paroxysmal atrial fibrillation than in age-matched controls, and (2) not only the sinus node but also the atrial muscle is electrophysiologically altered in patients with sinus node dysfunction but without tachyarrhythmias.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Intra-atrial catheter mapping</ce:text></ce:keyword><ce:keyword><ce:text>Prolonged and fractionated atrial electrogram</ce:text></ce:keyword><ce:keyword><ce:text>Sinus node dysfunction</ce:text></ce:keyword><ce:keyword><ce:text>Atrial muscle abnormality</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Electrophysiological abnormalities of the atrial muscle in patients with sinus node dysfunction without tachyarrhythmias</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Electrophysiological abnormalities of the atrial muscle in patients with sinus node dysfunction without tachyarrhythmias</title></titleInfo><name type="personal"><namePart type="given">Osmar Antonio</namePart><namePart type="family">Centurion</namePart><affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</affiliation><description>Correspondence to: Dr. O.A. Centurion, Third Department of Internal Medicine, Nagasaki University School of Medicine, 7-1 Sakamoto-machi, Nagasaki, 852 Japan. Tel. 0958-47-2111 (ext. 2844). Fax 0958-46-2500.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Masahiko</namePart><namePart type="family">Fukatani</namePart><affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Atsushi</namePart><namePart type="family">Konoe</namePart><affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Muneo</namePart><namePart type="family">Tanigawa</namePart><affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Akihiko</namePart><namePart type="family">Shimizu</namePart><affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Shojiro</namePart><namePart type="family">Isomoto</namePart><affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mitsuo</namePart><namePart type="family">Kadena</namePart><affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kunitake</namePart><namePart type="family">Hashiba</namePart><affiliation>Third Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1992</dateIssued><dateValid encoding="w3cdtf">1992-04-27</dateValid><copyrightDate encoding="w3cdtf">1992</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The duration and the number of fragmented deflections of the right atrial electrograms were assessed and quantitatively measured in 74 patients who underwent endocardial catheter mapping during sinus rhythm. The bipolar electrograms were recorded at 12 sites in the right atrium. An abnormal atrial electrogram was defined as a duration of 100 ms or longer, and/or 8 or more fragmented deflections, according to our previous criteria. The patients were divided into two groups. The control group consisted of 41 age-matched patients with normal sinus node function and without paroxysmal atrial fibrillation. The study group comprised 33 patients with sinus node dysfunction but without tachyarrhythmias.Abnormal atrial electrograms were observed in 8 (19.5%) control patients, and in 16 (48.5%) sinus node dysfunction patients; p < 0.02. The total number of abnormal electrograms was 14 (2.89%) of 483 atrial electrograms in controls, and 36 (9.38%) of 384 in the study group; p < 0.0002. The mean duration (75.6 ± 17) and the mean number of fragmented deflections (4.1 ± 2) of the total atrial electrograms in the sinus node dysfunction group was significantly greater than that in controls (70.9 ± 11 and 3.6 ± 1, respectively); p < 0.01. The mean number of abnormal electrograms per patient in the study group (1.06 ± 1.8) was significantly higher than that in the control group (0.3 ± 0.8); p < 0.05.These data suggest that: (1) there is a significantly greater electrophysiological abnormality of the atrial muscle in patients with sinus node dysfunction but without paroxysmal atrial fibrillation than in age-matched controls, and (2) not only the sinus node but also the atrial muscle is electrophysiologically altered in patients with sinus node dysfunction but without tachyarrhythmias.</abstract><note>This study was presented in part at the 55th Annual Scientific Meeting of the Japanese Circulation Society, Kyoto, Japan, March 1991.</note><note type="content">Section title: Original study</note><subject><genre>Article category</genre><topic>Electrophysiology</topic></subject><subject><genre>Keywords</genre><topic>Intra-atrial catheter mapping</topic><topic>Prolonged and fractionated atrial electrogram</topic><topic>Sinus node dysfunction</topic><topic>Atrial muscle abnormality</topic></subject><relatedItem type="host"><titleInfo><title>International Journal of Cardiology</title></titleInfo><titleInfo type="abbreviated"><title>IJCA</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199210</dateIssued></originInfo><identifier type="ISSN">0167-5273</identifier><identifier type="PII">S0167-5273(00)X0182-9</identifier><part><date>199210</date><detail type="volume"><number>37</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>130</end></extent><extent unit="pages"><start>41</start><end>50</end></extent></part></relatedItem><identifier type="istex">8F99EB482A7472D5CD4F620D8C66962E8DC10587</identifier><identifier type="DOI">10.1016/0167-5273(92)90130-U</identifier><identifier type="PII">0167-5273(92)90130-U</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/8F99EB482A7472D5CD4F620D8C66962E8DC10587/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">CARDIAC & CARDIOVASCULAR SYSTEMS</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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