The assessment of depression in Parkinson’s disease
Identifieur interne : 001595 ( Main/Corpus ); précédent : 001594; suivant : 001596The assessment of depression in Parkinson’s disease
Auteurs : J. Koerts ; K. L. Leenders ; M. Koning ; A. Bouma ; M. Van BeilenSource :
- European Journal of Neurology [ 1351-5101 ] ; 2008-05.
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- KwdEn :
Abstract
Background: Motor symptoms form the hallmark of Parkinson’s Disease (PD), although features like depression are often present. Depression rating scales [e.g. Montgomery‐Åsberg Depression Rating Scale (MADRS)] used in PD measure affective, cognitive and somatic symptoms. An important clinical question is which items of the MADRS are likely to be influenced by PD symptoms. Methods: Depression was assessed in 43 PD patients who scored below the cut‐off of the MADRS and who differed widely in motor severity. Results: Parkinson’s Disease patients scored relatively highest on Concentration difficulties, Reduced sleep and Inner tension. Reduced sleep, Lassitude and Suicidal thoughts were associated with motor severity and specifically with Bradykinesia, Rigidity and Axial impairment, however not with Tremor. To avoid a possible influence on our results of coincidentally included PD patients with a depression, all associations between somatic MADRS items and motor severity were corrected for the influence of affective symptoms of depression. All associations remained significant. Discussion: In conclusion, the items Reduced sleep and Lassitude of the MADRS are likely to be influenced by motor symptoms. The high score on Concentration difficulties is suggested to be a reflection of cognitive dysfunction in PD. Thus, when assessing depression in PD, using a depression rating scale like the MADRS, adjusted cut‐off scores are required.
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DOI: 10.1111/j.1468-1331.2008.02101.x
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Leenders</name><affiliation><mods:affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</mods:affiliation></affiliation><affiliation><mods:affiliation>School for Behavioral and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Koning, M" sort="Koning, M" uniqKey="Koning M" first="M." last="Koning">M. Koning</name><affiliation><mods:affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Bouma, A" sort="Bouma, A" uniqKey="Bouma A" first="A." last="Bouma">A. Bouma</name><affiliation><mods:affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</mods:affiliation></affiliation><affiliation><mods:affiliation>School for Behavioral and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Beilen, M Van" sort="Beilen, M Van" uniqKey="Beilen M" first="M. Van" last="Beilen">M. Van Beilen</name><affiliation><mods:affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</mods:affiliation></affiliation><affiliation><mods:affiliation>School for Behavioral and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F76C68D81157B9123C85FECCC60892FA56D6EDE9</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1111/j.1468-1331.2008.02101.x</idno><idno type="url">https://api.istex.fr/document/F76C68D81157B9123C85FECCC60892FA56D6EDE9/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001595</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The assessment of depression in Parkinson’s disease</title><author><name sortKey="Koerts, J" sort="Koerts, J" uniqKey="Koerts J" first="J." last="Koerts">J. Koerts</name><affiliation><mods:affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</mods:affiliation></affiliation><affiliation><mods:affiliation>School for Behavioral and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Leenders, K L" sort="Leenders, K L" uniqKey="Leenders K" first="K. L." last="Leenders">K. L. Leenders</name><affiliation><mods:affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</mods:affiliation></affiliation><affiliation><mods:affiliation>School for Behavioral and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Koning, M" sort="Koning, M" uniqKey="Koning M" first="M." last="Koning">M. Koning</name><affiliation><mods:affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Bouma, A" sort="Bouma, A" uniqKey="Bouma A" first="A." last="Bouma">A. Bouma</name><affiliation><mods:affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</mods:affiliation></affiliation><affiliation><mods:affiliation>School for Behavioral and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Beilen, M Van" sort="Beilen, M Van" uniqKey="Beilen M" first="M. Van" last="Beilen">M. Van Beilen</name><affiliation><mods:affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</mods:affiliation></affiliation><affiliation><mods:affiliation>School for Behavioral and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-05">2008-05</date><biblScope unit="volume">15</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="487">487</biblScope><biblScope unit="page" to="492">492</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">F76C68D81157B9123C85FECCC60892FA56D6EDE9</idno><idno type="DOI">10.1111/j.1468-1331.2008.02101.x</idno><idno type="ArticleID">ENE2101</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>MADRS</term><term>Parkinson</term><term>assessment</term><term>depression</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Motor symptoms form the hallmark of Parkinson’s Disease (PD), although features like depression are often present. Depression rating scales [e.g. Montgomery‐Åsberg Depression Rating Scale (MADRS)] used in PD measure affective, cognitive and somatic symptoms. An important clinical question is which items of the MADRS are likely to be influenced by PD symptoms. Methods: Depression was assessed in 43 PD patients who scored below the cut‐off of the MADRS and who differed widely in motor severity. Results: Parkinson’s Disease patients scored relatively highest on Concentration difficulties, Reduced sleep and Inner tension. Reduced sleep, Lassitude and Suicidal thoughts were associated with motor severity and specifically with Bradykinesia, Rigidity and Axial impairment, however not with Tremor. To avoid a possible influence on our results of coincidentally included PD patients with a depression, all associations between somatic MADRS items and motor severity were corrected for the influence of affective symptoms of depression. All associations remained significant. Discussion: In conclusion, the items Reduced sleep and Lassitude of the MADRS are likely to be influenced by motor symptoms. The high score on Concentration difficulties is suggested to be a reflection of cognitive dysfunction in PD. Thus, when assessing depression in PD, using a depression rating scale like the MADRS, adjusted cut‐off scores are required.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>J. Koerts</name><affiliations><json:string>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</json:string><json:string>School for Behavioral and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</json:string></affiliations></json:item><json:item><name>K. L. Leenders</name><affiliations><json:string>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</json:string><json:string>School for Behavioral and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</json:string></affiliations></json:item><json:item><name>M. Koning</name><affiliations><json:string>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</json:string></affiliations></json:item><json:item><name>A. Bouma</name><affiliations><json:string>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</json:string><json:string>School for Behavioral and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</json:string></affiliations></json:item><json:item><name>M. van Beilen</name><affiliations><json:string>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</json:string><json:string>School for Behavioral and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>assessment</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>depression</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MADRS</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson</value></json:item></subject><articleId><json:string>ENE2101</json:string></articleId><language><json:string>eng</json:string></language><abstract>Background: Motor symptoms form the hallmark of Parkinson’s Disease (PD), although features like depression are often present. Depression rating scales [e.g. Montgomery‐Åsberg Depression Rating Scale (MADRS)] used in PD measure affective, cognitive and somatic symptoms. An important clinical question is which items of the MADRS are likely to be influenced by PD symptoms. Methods: Depression was assessed in 43 PD patients who scored below the cut‐off of the MADRS and who differed widely in motor severity. Results: Parkinson’s Disease patients scored relatively highest on Concentration difficulties, Reduced sleep and Inner tension. Reduced sleep, Lassitude and Suicidal thoughts were associated with motor severity and specifically with Bradykinesia, Rigidity and Axial impairment, however not with Tremor. To avoid a possible influence on our results of coincidentally included PD patients with a depression, all associations between somatic MADRS items and motor severity were corrected for the influence of affective symptoms of depression. All associations remained significant. Discussion: In conclusion, the items Reduced sleep and Lassitude of the MADRS are likely to be influenced by motor symptoms. The high score on Concentration difficulties is suggested to be a reflection of cognitive dysfunction in PD. Thus, when assessing depression in PD, using a depression rating scale like the MADRS, adjusted cut‐off scores are required.</abstract><qualityIndicators><score>6.292</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1451</abstractCharCount><pdfWordCount>3784</pdfWordCount><pdfCharCount>24673</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>209</abstractWordCount></qualityIndicators><title>The assessment of depression in Parkinson’s disease</title><genre><json:string>article</json:string></genre><host><volume>15</volume><publisherId><json:string>ENE</json:string></publisherId><pages><total>6</total><last>492</last><first>487</first></pages><issn><json:string>1351-5101</json:string></issn><issue>5</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1468-1331</json:string></eissn><title>European Journal of Neurology</title><doi><json:string>10.1111/(ISSN)1468-1331</json:string></doi></host><publicationDate>2008</publicationDate><copyrightDate>2008</copyrightDate><doi><json:string>10.1111/j.1468-1331.2008.02101.x</json:string></doi><id>F76C68D81157B9123C85FECCC60892FA56D6EDE9</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/F76C68D81157B9123C85FECCC60892FA56D6EDE9/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/F76C68D81157B9123C85FECCC60892FA56D6EDE9/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/F76C68D81157B9123C85FECCC60892FA56D6EDE9/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">The assessment of depression in Parkinson’s disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>2008</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">The assessment of depression in Parkinson’s disease</title><author><persName><forename type="first">J.</forename><surname>Koerts</surname></persName><affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation><affiliation>School for Behavioral and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation></author><author><persName><forename type="first">K. L.</forename><surname>Leenders</surname></persName><affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation><affiliation>School for Behavioral and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation></author><author><persName><forename type="first">M.</forename><surname>Koning</surname></persName><affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation></author><author><persName><forename type="first">A.</forename><surname>Bouma</surname></persName><affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation><affiliation>School for Behavioral and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation></author><author><persName><forename type="first">M. van</forename><surname>Beilen</surname></persName><affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation><affiliation>School for Behavioral and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation></author></analytic><monogr><title level="j">European Journal of Neurology</title><idno type="pISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><idno type="DOI">10.1111/(ISSN)1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-05"></date><biblScope unit="volume">15</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="487">487</biblScope><biblScope unit="page" to="492">492</biblScope></imprint></monogr><idno type="istex">F76C68D81157B9123C85FECCC60892FA56D6EDE9</idno><idno type="DOI">10.1111/j.1468-1331.2008.02101.x</idno><idno type="ArticleID">ENE2101</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background: Motor symptoms form the hallmark of Parkinson’s Disease (PD), although features like depression are often present. Depression rating scales [e.g. Montgomery‐Åsberg Depression Rating Scale (MADRS)] used in PD measure affective, cognitive and somatic symptoms. An important clinical question is which items of the MADRS are likely to be influenced by PD symptoms. Methods: Depression was assessed in 43 PD patients who scored below the cut‐off of the MADRS and who differed widely in motor severity. Results: Parkinson’s Disease patients scored relatively highest on Concentration difficulties, Reduced sleep and Inner tension. Reduced sleep, Lassitude and Suicidal thoughts were associated with motor severity and specifically with Bradykinesia, Rigidity and Axial impairment, however not with Tremor. To avoid a possible influence on our results of coincidentally included PD patients with a depression, all associations between somatic MADRS items and motor severity were corrected for the influence of affective symptoms of depression. All associations remained significant. Discussion: In conclusion, the items Reduced sleep and Lassitude of the MADRS are likely to be influenced by motor symptoms. The high score on Concentration difficulties is suggested to be a reflection of cognitive dysfunction in PD. Thus, when assessing depression in PD, using a depression rating scale like the MADRS, adjusted cut‐off scores are required.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>assessment</term></item><item><term>depression</term></item><item><term>MADRS</term></item><item><term>Parkinson</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-05">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/F76C68D81157B9123C85FECCC60892FA56D6EDE9/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1468-1331</doi><issn type="print">1351-5101</issn><issn type="electronic">1468-1331</issn><idGroup><id type="product" value="ENE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF NEUROLOGY">European Journal of Neurology</title></titleGroup></publicationMeta><publicationMeta level="part" position="05005"><doi origin="wiley">10.1111/ene.2008.15.issue-5</doi><numberingGroup><numbering type="journalVolume" number="15">15</numbering><numbering type="journalIssue" number="5">5</numbering></numberingGroup><coverDate startDate="2008-05">May 2008</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="9" status="forIssue"><doi origin="wiley">10.1111/j.1468-1331.2008.02101.x</doi><idGroup><id type="unit" value="ENE2101"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><copyright>© 2008 The Author(s)</copyright><eventGroup><event type="firstOnline" date="2008-03-18"></event><event type="publishedOnlineFinalForm" date="2008-03-18"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-06"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-24"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="487">487</numbering><numbering type="pageLast" number="492">492</numbering></numberingGroup><correspondenceTo>J. Koerts, Department of Neurology, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, the Netherlands (tel.: + 31503612433; fax: +31503611707; e‐mail: <email>j.koerts@neuro.umcg.nl</email>).</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ENE.ENE2101.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 14 August 2007 Accepted 24 January 2008</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="4"></count></countGroup><titleGroup><title type="main">The assessment of depression in Parkinson’s disease</title><title type="shortAuthors">J. Koerts <i>et al.</i></title><title type="short">Parkinson’s disease and depression</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a2"><personName><givenNames>J.</givenNames><familyName>Koerts</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1 #a2"><personName><givenNames>K. L.</givenNames><familyName>Leenders</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>M.</givenNames><familyName>Koning</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1 #a2"><personName><givenNames>A.</givenNames><familyName>Bouma</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1 #a2"><personName><givenNames>M. van</givenNames><familyName>Beilen</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="NL"><unparsedAffiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="NL"><unparsedAffiliation>School for Behavioral and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">assessment</keyword><keyword xml:id="k2">depression</keyword><keyword xml:id="k3">MADRS</keyword><keyword xml:id="k4">Parkinson</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Background: </b> Motor symptoms form the hallmark of Parkinson’s Disease (PD), although features like depression are often present. Depression rating scales [e.g. Montgomery‐Åsberg Depression Rating Scale (MADRS)] used in PD measure affective, cognitive and somatic symptoms. An important clinical question is which items of the MADRS are likely to be influenced by PD symptoms.</p><p><b>Methods: </b> Depression was assessed in 43 PD patients who scored below the cut‐off of the MADRS and who differed widely in motor severity.</p><p><b>Results: </b> Parkinson’s Disease patients scored relatively highest on Concentration difficulties, Reduced sleep and Inner tension. Reduced sleep, Lassitude and Suicidal thoughts were associated with motor severity and specifically with Bradykinesia, Rigidity and Axial impairment, however not with Tremor.</p><p>To avoid a possible influence on our results of coincidentally included PD patients with a depression, all associations between somatic MADRS items and motor severity were corrected for the influence of affective symptoms of depression. All associations remained significant.</p><p><b>Discussion: </b> In conclusion, the items Reduced sleep and Lassitude of the MADRS are likely to be influenced by motor symptoms. The high score on Concentration difficulties is suggested to be a reflection of cognitive dysfunction in PD. Thus, when assessing depression in PD, using a depression rating scale like the MADRS, adjusted cut‐off scores are required.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The assessment of depression in Parkinson’s disease</title></titleInfo><titleInfo type="abbreviated"><title>Parkinson’s disease and depression</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The assessment of depression in Parkinson’s disease</title></titleInfo><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Koerts</namePart><affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation><affiliation>School for Behavioral and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. L.</namePart><namePart type="family">Leenders</namePart><affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation><affiliation>School for Behavioral and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Koning</namePart><affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Bouma</namePart><affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation><affiliation>School for Behavioral and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. van</namePart><namePart type="family">Beilen</namePart><affiliation>Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation><affiliation>School for Behavioral and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2008-05</dateIssued><edition>Received 14 August 2007 Accepted 24 January 2008</edition><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">4</extent></physicalDescription><abstract lang="en">Background: Motor symptoms form the hallmark of Parkinson’s Disease (PD), although features like depression are often present. Depression rating scales [e.g. Montgomery‐Åsberg Depression Rating Scale (MADRS)] used in PD measure affective, cognitive and somatic symptoms. An important clinical question is which items of the MADRS are likely to be influenced by PD symptoms. Methods: Depression was assessed in 43 PD patients who scored below the cut‐off of the MADRS and who differed widely in motor severity. Results: Parkinson’s Disease patients scored relatively highest on Concentration difficulties, Reduced sleep and Inner tension. Reduced sleep, Lassitude and Suicidal thoughts were associated with motor severity and specifically with Bradykinesia, Rigidity and Axial impairment, however not with Tremor. To avoid a possible influence on our results of coincidentally included PD patients with a depression, all associations between somatic MADRS items and motor severity were corrected for the influence of affective symptoms of depression. All associations remained significant. Discussion: In conclusion, the items Reduced sleep and Lassitude of the MADRS are likely to be influenced by motor symptoms. The high score on Concentration difficulties is suggested to be a reflection of cognitive dysfunction in PD. Thus, when assessing depression in PD, using a depression rating scale like the MADRS, adjusted cut‐off scores are required.</abstract><subject lang="en"><genre>Keywords</genre><topic>assessment</topic><topic>depression</topic><topic>MADRS</topic><topic>Parkinson</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neurology</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">1351-5101</identifier><identifier type="eISSN">1468-1331</identifier><identifier type="DOI">10.1111/(ISSN)1468-1331</identifier><identifier type="PublisherID">ENE</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>487</start><end>492</end><total>6</total></extent></part></relatedItem><identifier type="istex">F76C68D81157B9123C85FECCC60892FA56D6EDE9</identifier><identifier type="DOI">10.1111/j.1468-1331.2008.02101.x</identifier><identifier type="ArticleID">ENE2101</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2008 The Author(s)</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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