Salivary production in Parkinson's disease
Identifieur interne : 001332 ( Main/Corpus ); précédent : 001331; suivant : 001333Salivary production in Parkinson's disease
Auteurs : Melisa Proulx ; François P. De Courval ; Michael A. Wiseman ; Michel PanissetSource :
- Movement Disorders [ 0885-3185 ] ; 2005-02.
English descriptors
- KwdEn :
Abstract
Hypersialorrhea is a common phenomenon in Parkinson disease (PD). The objective of this study was to determine whether patients with PD had an abnormally increased production of saliva and whether the production of saliva could be associated to factors related to either the disease characteristics or to its treatment. A total of 83 patients with PD and 55 control subjects participated in this study. Because of the age difference between the two groups, comparisons were made on a ±2‐year age‐matched sample of 44 PD patients and 44 control subjects. PD patients produced significantly less saliva than control subjects. Correlations were obtained with the 83 PD patients between unstimulated salivary flow and patients characteristics. When controlling for age, sex, and Hoehn and Yahr scale, decreased production of saliva correlated significantly with the dose of levodopa and the symptoms of xerostomia. When controlling for medications, there was no relationship between the production of saliva and the evolution of the disease. This study shows that patients with PD produce less saliva than normal. Factors influencing the production of saliva include the use of levodopa and female gender. Our results may have implications for the treatment of drooling in PD. © 2004 Movement Disorder Society
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DOI: 10.1002/mds.20189
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ISTEX:FC1B060221401BE4E4ADF66F0E8F26AACDCC36D7Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-02">2005-02</date><biblScope unit="volume">20</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="204">204</biblScope><biblScope unit="page" to="207">207</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">FC1B060221401BE4E4ADF66F0E8F26AACDCC36D7</idno><idno type="DOI">10.1002/mds.20189</idno><idno type="ArticleID">MDS20189</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>drooling</term><term>dysphagia</term><term>hypersialorrhea</term><term>levodopa</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hypersialorrhea is a common phenomenon in Parkinson disease (PD). The objective of this study was to determine whether patients with PD had an abnormally increased production of saliva and whether the production of saliva could be associated to factors related to either the disease characteristics or to its treatment. A total of 83 patients with PD and 55 control subjects participated in this study. Because of the age difference between the two groups, comparisons were made on a ±2‐year age‐matched sample of 44 PD patients and 44 control subjects. PD patients produced significantly less saliva than control subjects. Correlations were obtained with the 83 PD patients between unstimulated salivary flow and patients characteristics. When controlling for age, sex, and Hoehn and Yahr scale, decreased production of saliva correlated significantly with the dose of levodopa and the symptoms of xerostomia. When controlling for medications, there was no relationship between the production of saliva and the evolution of the disease. This study shows that patients with PD produce less saliva than normal. Factors influencing the production of saliva include the use of levodopa and female gender. Our results may have implications for the treatment of drooling in PD. © 2004 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Melisa Proulx BA</name><affiliations><json:string>Movement Disorders Clinic, McGill Centre for Studies in Aging, McGill University, Québec, Canada</json:string><json:string>Faculté de médecine dentaire, Université de Montréal, Québec, Canada</json:string></affiliations></json:item><json:item><name>François P. De Courval MSc</name><affiliations><json:string>Movement Disorders Clinic, McGill Centre for Studies in Aging, McGill University, Québec, Canada</json:string></affiliations></json:item><json:item><name>Michael A. Wiseman DDS, FASGD</name><affiliations><json:string>Faculty of Dentistry, McGill University, Québec, Canada</json:string></affiliations></json:item><json:item><name>Michel Panisset MD</name><affiliations><json:string>Movement Disorders Clinic, McGill Centre for Studies in Aging, McGill University, Québec, Canada</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>drooling</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dysphagia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hypersialorrhea</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>levodopa</value></json:item></subject><articleId><json:string>MDS20189</json:string></articleId><language><json:string>eng</json:string></language><abstract>Hypersialorrhea is a common phenomenon in Parkinson disease (PD). 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This study shows that patients with PD produce less saliva than normal. Factors influencing the production of saliva include the use of levodopa and female gender. Our results may have implications for the treatment of drooling in PD. © 2004 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>drooling</term></item><item><term>dysphagia</term></item><item><term>hypersialorrhea</term></item><item><term>levodopa</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2003-11-11">Received</change><change when="2004-03-22">Registration</change><change when="2005-02">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/FC1B060221401BE4E4ADF66F0E8F26AACDCC36D7/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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The objective of this study was to determine whether patients with PD had an abnormally increased production of saliva and whether the production of saliva could be associated to factors related to either the disease characteristics or to its treatment. A total of 83 patients with PD and 55 control subjects participated in this study. Because of the age difference between the two groups, comparisons were made on a ±2‐year age‐matched sample of 44 PD patients and 44 control subjects. PD patients produced significantly less saliva than control subjects. Correlations were obtained with the 83 PD patients between unstimulated salivary flow and patients characteristics. When controlling for age, sex, and Hoehn and Yahr scale, decreased production of saliva correlated significantly with the dose of levodopa and the symptoms of xerostomia. When controlling for medications, there was no relationship between the production of saliva and the evolution of the disease. This study shows that patients with PD produce less saliva than normal. Factors influencing the production of saliva include the use of levodopa and female gender. Our results may have implications for the treatment of drooling in PD. © 2004 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Salivary production in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Salivary Production in Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Salivary production in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Melisa</namePart><namePart type="family">Proulx</namePart><namePart type="termsOfAddress">BA</namePart><affiliation>Movement Disorders Clinic, McGill Centre for Studies in Aging, McGill University, Québec, Canada</affiliation><affiliation>Faculté de médecine dentaire, Université de Montréal, Québec, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">François P.</namePart><namePart type="family">De Courval</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Movement Disorders Clinic, McGill Centre for Studies in Aging, McGill University, Québec, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael A.</namePart><namePart type="family">Wiseman</namePart><namePart type="termsOfAddress">DDS, FASGD</namePart><affiliation>Faculty of Dentistry, McGill University, Québec, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michel</namePart><namePart type="family">Panisset</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorders Clinic, McGill Centre for Studies in Aging, McGill University, Québec, Canada</affiliation><description>Correspondence: Movement Disorders Clinic, McGill Centre for Studies in Aging, 6825, boul, LaSalle, Verdun, Quebec, Canada, H4H 1R3</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2005-02</dateIssued><dateCaptured encoding="w3cdtf">2003-11-11</dateCaptured><dateValid encoding="w3cdtf">2004-03-22</dateValid><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">2</extent><extent unit="references">26</extent><extent unit="words">2708</extent></physicalDescription><abstract lang="en">Hypersialorrhea is a common phenomenon in Parkinson disease (PD). The objective of this study was to determine whether patients with PD had an abnormally increased production of saliva and whether the production of saliva could be associated to factors related to either the disease characteristics or to its treatment. A total of 83 patients with PD and 55 control subjects participated in this study. Because of the age difference between the two groups, comparisons were made on a ±2‐year age‐matched sample of 44 PD patients and 44 control subjects. PD patients produced significantly less saliva than control subjects. Correlations were obtained with the 83 PD patients between unstimulated salivary flow and patients characteristics. When controlling for age, sex, and Hoehn and Yahr scale, decreased production of saliva correlated significantly with the dose of levodopa and the symptoms of xerostomia. When controlling for medications, there was no relationship between the production of saliva and the evolution of the disease. This study shows that patients with PD produce less saliva than normal. Factors influencing the production of saliva include the use of levodopa and female gender. Our results may have implications for the treatment of drooling in PD. © 2004 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>drooling</topic><topic>dysphagia</topic><topic>hypersialorrhea</topic><topic>levodopa</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. 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