Zur Biosynthese von Aminosäuren aus Glukose im Zentralnervensystem beim Parkinsonsyndrom
Identifieur interne : 001302 ( Main/Corpus ); précédent : 001301; suivant : 001303Zur Biosynthese von Aminosäuren aus Glukose im Zentralnervensystem beim Parkinsonsyndrom
Auteurs : E. Gründig ; W. Mayer ; F. GerstenbrandSource :
- Archiv für Psychiatrie und Nervenkrankheiten [ 0003-9373 ] ; 1983-11-01.
Abstract
Summary: The incorporation of labelled carbon from glucose U-14C into CSF amino acids was investigated in three patients with Parkinson's disease and in three control persons with comparable age and physical stature. 1. Comparing the specific radioactivities of serum and CSF one can postulate that the labelled amino acids found in the CSF are synthesized mainly by brain tissue. 2. The resorption of glucose into the CNS and therefore the synthesis of amino acids from glucose was more rapid in controls; labelled alanine and glutamine appeared later in the CSF of the patients. 3. As expected, in the controls the specific radioactivity of glutamic acid was found to be higher than that of glutamine, in patients the labelling of glutamine was higher as was that of serine, glycine, aspartic acid and asparagine. From our knowledge concerning the compartmentation of the metabolism of glutamate, we assume that in Parkinsonism the metabolic activity of neurons is reduced but that of astroglia is enhanced.
Url:
DOI: 10.1007/BF00346090
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Gerstenbrand</name><affiliations><json:string>Medizinisch Chemisches Institut der Universität Wien, Währingerstrasse 10, A-1090, Wien</json:string></affiliations></json:item></author><articleId><json:string>Art6</json:string><json:string>BF00346090</json:string></articleId><language><json:string>deu</json:string></language><qualityIndicators><score>6.404</score><pdfVersion>1.3</pdfVersion><pdfPageSize>468 x 684 pts</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1009</abstractCharCount><pdfWordCount>4472</pdfWordCount><pdfCharCount>30700</pdfCharCount><pdfPageCount>12</pdfPageCount><abstractWordCount>161</abstractWordCount></qualityIndicators><title>Zur Biosynthese von Aminosäuren aus Glukose im Zentralnervensystem beim Parkinsonsyndrom</title><genre><json:string>research-article</json:string></genre><host><volume>233</volume><pages><last>408</last><first>397</first></pages><issn><json:string>0003-9373</json:string></issn><issue>5</issue><subject><json:item><value>Neurosciences</value></json:item><json:item><value>Neurology</value></json:item><json:item><value>Psychiatry</value></json:item></subject><journalId><json:string>406</json:string></journalId><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1433-8491</json:string></eissn><title>Archiv für Psychiatrie und Nervenkrankheiten</title><publicationDate>1983</publicationDate><copyrightDate>1983</copyrightDate></host><publicationDate>1983</publicationDate><copyrightDate>1983</copyrightDate><doi><json:string>10.1007/BF00346090</json:string></doi><id>AD74DB42724F64D2E32B385D16CBE25183AAA592</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/AD74DB42724F64D2E32B385D16CBE25183AAA592/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/AD74DB42724F64D2E32B385D16CBE25183AAA592/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/AD74DB42724F64D2E32B385D16CBE25183AAA592/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="de">Zur Biosynthese von Aminosäuren aus Glukose im Zentralnervensystem beim Parkinsonsyndrom</title><title level="a" type="alt" xml:lang="en">Biosynthesis of amino acids in human central nervous system and Parkinsonism</title><respStmt xml:id="ISTEX-API" resp="Références bibliographiques récupérées via GROBID" name="ISTEX-API (INIST-CNRS)"></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><availability><p>SPRINGER</p></availability><date>1983-07-12</date></publicationStmt><notesStmt><note>Sonderdruckanfragen an : E. Gründig</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="de">Zur Biosynthese von Aminosäuren aus Glukose im Zentralnervensystem beim Parkinsonsyndrom</title><title level="a" type="alt" xml:lang="en">Biosynthesis of amino acids in human central nervous system and Parkinsonism</title><author><persName><forename type="first">E.</forename><surname>Gründig</surname></persName><affiliation>Medizinisch Chemisches Institut der Universität Wien, Währingerstrasse 10, A-1090, Wien</affiliation></author><author><persName><forename type="first">W.</forename><surname>Mayer</surname></persName><affiliation>Neurologie in der Universitätsklinik, Innsbruck, Austria</affiliation></author><author><persName><forename type="first">F.</forename><surname>Gerstenbrand</surname></persName><affiliation>Medizinisch Chemisches Institut der Universität Wien, Währingerstrasse 10, A-1090, Wien</affiliation></author></analytic><monogr><title level="j">Archiv für Psychiatrie und Nervenkrankheiten</title><title level="j" type="abbrev">Arch Psychiatr Nervenkr</title><idno type="JournalID">406</idno><idno type="pISSN">0003-9373</idno><idno type="eISSN">1433-8491</idno><idno type="IssueArticleCount">7</idno><idno type="VolumeIssueCount">6</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1983-11-01"></date><biblScope unit="volume">233</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="397">397</biblScope><biblScope unit="page" to="408">408</biblScope></imprint></monogr><idno type="istex">AD74DB42724F64D2E32B385D16CBE25183AAA592</idno><idno type="DOI">10.1007/BF00346090</idno><idno type="ArticleID">Art6</idno><idno type="ArticleID">BF00346090</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1983-07-12</date></creation><langUsage><language ident="de">de</language></langUsage><abstract xml:lang="en"><p>Summary: The incorporation of labelled carbon from glucose U-14C into CSF amino acids was investigated in three patients with Parkinson's disease and in three control persons with comparable age and physical stature. 1. Comparing the specific radioactivities of serum and CSF one can postulate that the labelled amino acids found in the CSF are synthesized mainly by brain tissue. 2. The resorption of glucose into the CNS and therefore the synthesis of amino acids from glucose was more rapid in controls; labelled alanine and glutamine appeared later in the CSF of the patients. 3. As expected, in the controls the specific radioactivity of glutamic acid was found to be higher than that of glutamine, in patients the labelling of glutamine was higher as was that of serine, glycine, aspartic acid and asparagine. From our knowledge concerning the compartmentation of the metabolism of glutamate, we assume that in Parkinsonism the metabolic activity of neurons is reduced but that of astroglia is enhanced.</p></abstract><abstract xml:lang="de"><p>Zusammenfassung: Bei drei Parkinsonpatienten wurde im Vergleich zu drei dem Alter und Status entsprechenden Personen der Einbau von markiertem Kohlenstoff aus U-14C-Glukose in Linquoraminosäuren untersucht. Die Ergebnisse lassen sich folgendermaßen zusammenfassen: 1. Der Vergleich der spezifischen Aktivitäten der Aminosäuren in Blut und Liquor zeigte, daß vorwiegend das Hirngewebe als Ursprung der markierten Arminosäuren im Liquor anzusehen ist. 2. Die Resorption der Glukose in das Zentralnervensystem und damit der Umsatz der Glukose zu Aminosäuren war bei den Kontrollpersonen rascher als bei den Patienten, was u.a. aus dem Zeitpunkt des Auftauchens von markiertem Alanin und Glutamin im Lumballiquor geschlossen werden kann. 3. Während bei den Kontrollpersonen die spezifische Aktivität der Glutaminsäure im Liquor höher war als die Markierung des Glutamins, war bei den Parkinsonpatienten die Markierung des Glutamins höher, desgleichen die Markierung von Serin und Glycin, aber auch von Asparaginsäure und Asparagin. Auf Grund der bekannten Kompartimentierung des Glutamatstoffwechsels im ZNS zeigt dieses Ergebnis, daß bei der Paralysis agitans nicht nur —wie man bisher annahm —ein neuraler Effekt vorliegt, sondern auch gliäre Elemente an der Störung beteiligt sind. Einer verminderten metabolischen Aktivität neuronalen Gewebes steht eine gesteigerte der Astroglia gegenüber.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>Medicine & Public Health</head><item><term>Neurosciences</term></item><item><term>Neurology</term></item><item><term>Psychiatry</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1983-07-12">Created</change><change when="1983-11-01">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-3-2">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/AD74DB42724F64D2E32B385D16CBE25183AAA592/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Springer, Publisher found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType 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and Parkinsonism</ArticleTitle><ArticleFirstPage>397</ArticleFirstPage><ArticleLastPage>408</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2004</Year><Month>9</Month><Day>2</Day></RegistrationDate><Received><Year>1983</Year><Month>7</Month><Day>12</Day></Received></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1983</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>406</JournalID><VolumeIDStart>233</VolumeIDStart><VolumeIDEnd>233</VolumeIDEnd><IssueIDStart>5</IssueIDStart><IssueIDEnd>5</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>E.</GivenName><FamilyName>Gründig</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>W.</GivenName><FamilyName>Mayer</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>F.</GivenName><FamilyName>Gerstenbrand</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgName>Medizinisch Chemisches Institut der Universität Wien</OrgName><OrgAddress><Street>Währingerstrasse 10</Street><Postcode>A-1090</Postcode><City>Wien</City></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgName>Neurologie in der Universitätsklinik</OrgName><OrgAddress><City>Innsbruck</City><Country>Austria</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>The incorporation of labelled carbon from glucose U-<Superscript>14</Superscript>C into CSF amino acids was investigated in three patients with Parkinson's disease and in three control persons with comparable age and physical stature.<OrderedList><ListItem><ItemNumber>1.</ItemNumber><ItemContent><Para>Comparing the specific radioactivities of serum and CSF one can postulate that the labelled amino acids found in the CSF are synthesized mainly by brain tissue.</Para></ItemContent></ListItem><ListItem><ItemNumber>2.</ItemNumber><ItemContent><Para>The resorption of glucose into the CNS and therefore the synthesis of amino acids from glucose was more rapid in controls; labelled alanine and glutamine appeared later in the CSF of the patients.</Para></ItemContent></ListItem><ListItem><ItemNumber>3.</ItemNumber><ItemContent><Para>As expected, in the controls the specific radioactivity of glutamic acid was found to be higher than that of glutamine, in patients the labelling of glutamine was higher as was that of serine, glycine, aspartic acid and asparagine.</Para></ItemContent></ListItem></OrderedList></Para><Para>From our knowledge concerning the compartmentation of the metabolism of glutamate, we assume that in Parkinsonism the metabolic activity of neurons is reduced but that of astroglia is enhanced.</Para></Abstract><Abstract ID="Abs2" Language="De"><Heading>Zusammenfassung</Heading><Para>Bei drei Parkinsonpatienten wurde im Vergleich zu drei dem Alter und Status entsprechenden Personen der Einbau von markiertem Kohlenstoff aus U-<Superscript>14</Superscript>C-Glukose in Linquoraminosäuren untersucht. Die Ergebnisse lassen sich folgendermaßen zusammenfassen:<OrderedList><ListItem><ItemNumber>1.</ItemNumber><ItemContent><Para>Der Vergleich der spezifischen Aktivitäten der Aminosäuren in Blut und Liquor zeigte, daß vorwiegend das Hirngewebe als Ursprung der markierten Arminosäuren im Liquor anzusehen ist.</Para></ItemContent></ListItem><ListItem><ItemNumber>2.</ItemNumber><ItemContent><Para>Die Resorption der Glukose in das Zentralnervensystem und damit der Umsatz der Glukose zu Aminosäuren war bei den Kontrollpersonen rascher als bei den Patienten, was u.a. aus dem Zeitpunkt des Auftauchens von markiertem Alanin und Glutamin im Lumballiquor geschlossen werden kann.</Para></ItemContent></ListItem><ListItem><ItemNumber>3.</ItemNumber><ItemContent><Para>Während bei den Kontrollpersonen die spezifische Aktivität der Glutaminsäure im Liquor höher war als die Markierung des Glutamins, war bei den Parkinsonpatienten die Markierung des Glutamins höher, desgleichen die Markierung von Serin und Glycin, aber auch von Asparaginsäure und Asparagin.</Para></ItemContent></ListItem></OrderedList></Para><Para>Auf Grund der bekannten Kompartimentierung des Glutamatstoffwechsels im ZNS zeigt dieses Ergebnis, daß bei der Paralysis agitans nicht nur —wie man bisher annahm —ein neuraler Effekt vorliegt, sondern auch gliäre Elemente an der Störung beteiligt sind. Einer verminderten metabolischen Aktivität neuronalen Gewebes steht eine gesteigerte der Astroglia gegenüber.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Parkinsonism</Keyword><Keyword>Biosynthesis of amino acids</Keyword><Keyword>Metabolic activities</Keyword><Keyword>Neurons Astroglia</Keyword></KeywordGroup><KeywordGroup Language="De"><Heading>Schlüsselwörter</Heading><Keyword>Parkinson'sche Krankheit</Keyword><Keyword>Biosynthese von Aminosäuren im Zentralnervensystem</Keyword><Keyword>Metabolische Aktivitäten in Neuronen und Astroglia</Keyword></KeywordGroup><ArticleNote Type="Misc"><SimplePara><Emphasis Type="Italic">Sonderdruckanfragen an</Emphasis>: E. Gründig</SimplePara></ArticleNote></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="de"><title>Zur Biosynthese von Aminosäuren aus Glukose im Zentralnervensystem beim Parkinsonsyndrom</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="de"><title>Zur Biosynthese von Aminosäuren aus Glukose im Zentralnervensystem beim Parkinsonsyndrom</title></titleInfo><titleInfo lang="en"><title>Biosynthesis of amino acids in human central nervous system and Parkinsonism</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Biosynthesis of amino acids in human central nervous system and Parkinsonism</title></titleInfo><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Gründig</namePart><affiliation>Medizinisch Chemisches Institut der Universität Wien, Währingerstrasse 10, A-1090, Wien</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Mayer</namePart><affiliation>Neurologie in der Universitätsklinik, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Gerstenbrand</namePart><affiliation>Medizinisch Chemisches Institut der Universität Wien, Währingerstrasse 10, A-1090, Wien</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper"></genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1983-07-12</dateCreated><dateIssued encoding="w3cdtf">1983-11-01</dateIssued><copyrightDate encoding="w3cdtf">1983</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">de</languageTerm><languageTerm type="code" authority="iso639-2b">deu</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Summary: The incorporation of labelled carbon from glucose U-14C into CSF amino acids was investigated in three patients with Parkinson's disease and in three control persons with comparable age and physical stature. 1. Comparing the specific radioactivities of serum and CSF one can postulate that the labelled amino acids found in the CSF are synthesized mainly by brain tissue. 2. The resorption of glucose into the CNS and therefore the synthesis of amino acids from glucose was more rapid in controls; labelled alanine and glutamine appeared later in the CSF of the patients. 3. As expected, in the controls the specific radioactivity of glutamic acid was found to be higher than that of glutamine, in patients the labelling of glutamine was higher as was that of serine, glycine, aspartic acid and asparagine. From our knowledge concerning the compartmentation of the metabolism of glutamate, we assume that in Parkinsonism the metabolic activity of neurons is reduced but that of astroglia is enhanced.</abstract><abstract lang="de">Zusammenfassung: Bei drei Parkinsonpatienten wurde im Vergleich zu drei dem Alter und Status entsprechenden Personen der Einbau von markiertem Kohlenstoff aus U-14C-Glukose in Linquoraminosäuren untersucht. Die Ergebnisse lassen sich folgendermaßen zusammenfassen: 1. Der Vergleich der spezifischen Aktivitäten der Aminosäuren in Blut und Liquor zeigte, daß vorwiegend das Hirngewebe als Ursprung der markierten Arminosäuren im Liquor anzusehen ist. 2. Die Resorption der Glukose in das Zentralnervensystem und damit der Umsatz der Glukose zu Aminosäuren war bei den Kontrollpersonen rascher als bei den Patienten, was u.a. aus dem Zeitpunkt des Auftauchens von markiertem Alanin und Glutamin im Lumballiquor geschlossen werden kann. 3. Während bei den Kontrollpersonen die spezifische Aktivität der Glutaminsäure im Liquor höher war als die Markierung des Glutamins, war bei den Parkinsonpatienten die Markierung des Glutamins höher, desgleichen die Markierung von Serin und Glycin, aber auch von Asparaginsäure und Asparagin. Auf Grund der bekannten Kompartimentierung des Glutamatstoffwechsels im ZNS zeigt dieses Ergebnis, daß bei der Paralysis agitans nicht nur —wie man bisher annahm —ein neuraler Effekt vorliegt, sondern auch gliäre Elemente an der Störung beteiligt sind. Einer verminderten metabolischen Aktivität neuronalen Gewebes steht eine gesteigerte der Astroglia gegenüber.</abstract><note>Sonderdruckanfragen an : E. 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