Visual misperceptions and hallucinations in Parkinson's disease: Dysfunction of attentional control networks?
Identifieur interne : 001235 ( Main/Corpus ); précédent : 001234; suivant : 001236Visual misperceptions and hallucinations in Parkinson's disease: Dysfunction of attentional control networks?
Auteurs : James M. Shine ; Glenda M. Halliday ; Sharon L. Naismith ; Simon J. G. LewisSource :
- Movement Disorders [ 0885-3185 ] ; 2011-10.
English descriptors
- KwdEn :
Abstract
Visual misperceptions and hallucinations are a major cause of distress in patients with Parkinson's disease (PD), particularly in the advanced stages of the condition. Recent work has provided a framework for understanding the pathogenesis of these symptoms, implicating impairments from the retina to the integration of external information with preformed internal images. In this article, we propose a novel hypothesis that attempts to explain the presence of visual misperceptions and hallucinations in PD through the aberrant coordination of complimentary yet competing neural networks. We propose that hallucinations in PD reflect the relative inability to recruit activation in the dorsal attention network in the presence of an ambiguous percept, leading to overreliance on default mode network processing and salience arising from the ventral attention network. This inability is proposed to stem from improper function across cortical and subcortical structures secondary to the presence of Lewy body pathology. This hypothesis may be empirically tested by the use of targeted cognitive paradigms. In turn, this may assist our understanding of the pathophysiological mechanisms and cognitive processes contributing to visual misperceptions and hallucinations and ultimately may inform more effective treatment strategies for this troubling symptom. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23896
Links to Exploration step
ISTEX:715A33998264B427429EDE06C135538871443644Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Visual misperceptions and hallucinations in Parkinson's disease: Dysfunction of attentional control networks?</title><author><name sortKey="Shine, James M" sort="Shine, James M" uniqKey="Shine J" first="James M." last="Shine">James M. Shine</name><affiliation><mods:affiliation>Ageing Brain Centre, Brain and Mind Research Institute, the University of Sydney, Sydney, NSW, Australia</mods:affiliation></affiliation></author><author><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M." last="Halliday">Glenda M. Halliday</name><affiliation><mods:affiliation>Neuroscience Research Australia and the University of New South Wales, Sydney, NSW, Australia</mods:affiliation></affiliation></author><author><name sortKey="Naismith, Sharon L" sort="Naismith, Sharon L" uniqKey="Naismith S" first="Sharon L." last="Naismith">Sharon L. Naismith</name><affiliation><mods:affiliation>Ageing Brain Centre, Brain and Mind Research Institute, the University of Sydney, Sydney, NSW, Australia</mods:affiliation></affiliation></author><author><name sortKey="Lewis, Simon J G" sort="Lewis, Simon J G" uniqKey="Lewis S" first="Simon J. G." last="Lewis">Simon J. G. Lewis</name><affiliation><mods:affiliation>Ageing Brain Centre, Brain and Mind Research Institute, the University of Sydney, Sydney, NSW, Australia</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:715A33998264B427429EDE06C135538871443644</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23896</idno><idno type="url">https://api.istex.fr/document/715A33998264B427429EDE06C135538871443644/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001235</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Visual misperceptions and hallucinations in Parkinson's disease: Dysfunction of attentional control networks?</title><author><name sortKey="Shine, James M" sort="Shine, James M" uniqKey="Shine J" first="James M." last="Shine">James M. Shine</name><affiliation><mods:affiliation>Ageing Brain Centre, Brain and Mind Research Institute, the University of Sydney, Sydney, NSW, Australia</mods:affiliation></affiliation></author><author><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M." last="Halliday">Glenda M. Halliday</name><affiliation><mods:affiliation>Neuroscience Research Australia and the University of New South Wales, Sydney, NSW, Australia</mods:affiliation></affiliation></author><author><name sortKey="Naismith, Sharon L" sort="Naismith, Sharon L" uniqKey="Naismith S" first="Sharon L." last="Naismith">Sharon L. Naismith</name><affiliation><mods:affiliation>Ageing Brain Centre, Brain and Mind Research Institute, the University of Sydney, Sydney, NSW, Australia</mods:affiliation></affiliation></author><author><name sortKey="Lewis, Simon J G" sort="Lewis, Simon J G" uniqKey="Lewis S" first="Simon J. G." last="Lewis">Simon J. G. Lewis</name><affiliation><mods:affiliation>Ageing Brain Centre, Brain and Mind Research Institute, the University of Sydney, Sydney, NSW, Australia</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-10">2011-10</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="2154">2154</biblScope><biblScope unit="page" to="2159">2159</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">715A33998264B427429EDE06C135538871443644</idno><idno type="DOI">10.1002/mds.23896</idno><idno type="ArticleID">MDS23896</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Lewy body pathology</term><term>Parkinson's disease</term><term>neural networks; hallucinations</term><term>neurotransmitters</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Visual misperceptions and hallucinations are a major cause of distress in patients with Parkinson's disease (PD), particularly in the advanced stages of the condition. Recent work has provided a framework for understanding the pathogenesis of these symptoms, implicating impairments from the retina to the integration of external information with preformed internal images. In this article, we propose a novel hypothesis that attempts to explain the presence of visual misperceptions and hallucinations in PD through the aberrant coordination of complimentary yet competing neural networks. We propose that hallucinations in PD reflect the relative inability to recruit activation in the dorsal attention network in the presence of an ambiguous percept, leading to overreliance on default mode network processing and salience arising from the ventral attention network. This inability is proposed to stem from improper function across cortical and subcortical structures secondary to the presence of Lewy body pathology. This hypothesis may be empirically tested by the use of targeted cognitive paradigms. In turn, this may assist our understanding of the pathophysiological mechanisms and cognitive processes contributing to visual misperceptions and hallucinations and ultimately may inform more effective treatment strategies for this troubling symptom. © 2011 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>James M. Shine BSc, MBBS</name><affiliations><json:string>Ageing Brain Centre, Brain and Mind Research Institute, the University of Sydney, Sydney, NSW, Australia</json:string></affiliations></json:item><json:item><name>Glenda M. Halliday BSc, PhD</name><affiliations><json:string>Neuroscience Research Australia and the University of New South Wales, Sydney, NSW, Australia</json:string></affiliations></json:item><json:item><name>Sharon L. Naismith MAPS, CCN</name><affiliations><json:string>Ageing Brain Centre, Brain and Mind Research Institute, the University of Sydney, Sydney, NSW, Australia</json:string></affiliations></json:item><json:item><name>Simon J.G. Lewis MBBCh, BSc, MRCP, FRACP, MD</name><affiliations><json:string>Ageing Brain Centre, Brain and Mind Research Institute, the University of Sydney, Sydney, NSW, Australia</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>neurotransmitters</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Lewy body pathology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>neural networks; hallucinations</value></json:item></subject><articleId><json:string>MDS23896</json:string></articleId><language><json:string>eng</json:string></language><abstract>Visual misperceptions and hallucinations are a major cause of distress in patients with Parkinson's disease (PD), particularly in the advanced stages of the condition. Recent work has provided a framework for understanding the pathogenesis of these symptoms, implicating impairments from the retina to the integration of external information with preformed internal images. In this article, we propose a novel hypothesis that attempts to explain the presence of visual misperceptions and hallucinations in PD through the aberrant coordination of complimentary yet competing neural networks. We propose that hallucinations in PD reflect the relative inability to recruit activation in the dorsal attention network in the presence of an ambiguous percept, leading to overreliance on default mode network processing and salience arising from the ventral attention network. This inability is proposed to stem from improper function across cortical and subcortical structures secondary to the presence of Lewy body pathology. This hypothesis may be empirically tested by the use of targeted cognitive paradigms. In turn, this may assist our understanding of the pathophysiological mechanisms and cognitive processes contributing to visual misperceptions and hallucinations and ultimately may inform more effective treatment strategies for this troubling symptom. © 2011 Movement Disorder Society</abstract><qualityIndicators><score>6.866</score><pdfVersion>1.4</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1390</abstractCharCount><pdfWordCount>4014</pdfWordCount><pdfCharCount>27717</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>196</abstractWordCount></qualityIndicators><title>Visual misperceptions and hallucinations in Parkinson's disease: Dysfunction of attentional control networks?</title><genre><json:string>editorial</json:string></genre><host><volume>26</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>6</total><last>2159</last><first>2154</first></pages><issn><json:string>0885-3185</json:string></issn><issue>12</issue><subject><json:item><value>Viewpoint</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/mds.23896</json:string></doi><id>715A33998264B427429EDE06C135538871443644</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/715A33998264B427429EDE06C135538871443644/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/715A33998264B427429EDE06C135538871443644/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/715A33998264B427429EDE06C135538871443644/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Visual misperceptions and hallucinations in Parkinson's disease: Dysfunction of attentional control networks?</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2011</date></publicationStmt><notesStmt><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Visual misperceptions and hallucinations in Parkinson's disease: Dysfunction of attentional control networks?</title><author><persName><forename type="first">James M.</forename><surname>Shine</surname></persName><roleName type="degree">BSc, MBBS</roleName><affiliation>Ageing Brain Centre, Brain and Mind Research Institute, the University of Sydney, Sydney, NSW, Australia</affiliation></author><author><persName><forename type="first">Glenda M.</forename><surname>Halliday</surname></persName><roleName type="degree">BSc, PhD</roleName><affiliation>Neuroscience Research Australia and the University of New South Wales, Sydney, NSW, Australia</affiliation></author><author><persName><forename type="first">Sharon L.</forename><surname>Naismith</surname></persName><roleName type="degree">MAPS, CCN</roleName><affiliation>Ageing Brain Centre, Brain and Mind Research Institute, the University of Sydney, Sydney, NSW, Australia</affiliation></author><author><persName><forename type="first">Simon J.G.</forename><surname>Lewis</surname></persName><roleName type="degree">MBBCh, BSc, MRCP, FRACP, MD</roleName><note type="correspondence"><p>Correspondence: Parkinson's Disease Research Clinic, 94 Mallett Street, Camperdown, Sydney, NSW, Australia, 2050</p></note><affiliation>Ageing Brain Centre, Brain and Mind Research Institute, the University of Sydney, Sydney, NSW, Australia</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-10"></date><biblScope unit="volume">26</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="2154">2154</biblScope><biblScope unit="page" to="2159">2159</biblScope></imprint></monogr><idno type="istex">715A33998264B427429EDE06C135538871443644</idno><idno type="DOI">10.1002/mds.23896</idno><idno type="ArticleID">MDS23896</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Visual misperceptions and hallucinations are a major cause of distress in patients with Parkinson's disease (PD), particularly in the advanced stages of the condition. Recent work has provided a framework for understanding the pathogenesis of these symptoms, implicating impairments from the retina to the integration of external information with preformed internal images. In this article, we propose a novel hypothesis that attempts to explain the presence of visual misperceptions and hallucinations in PD through the aberrant coordination of complimentary yet competing neural networks. We propose that hallucinations in PD reflect the relative inability to recruit activation in the dorsal attention network in the presence of an ambiguous percept, leading to overreliance on default mode network processing and salience arising from the ventral attention network. This inability is proposed to stem from improper function across cortical and subcortical structures secondary to the presence of Lewy body pathology. This hypothesis may be empirically tested by the use of targeted cognitive paradigms. In turn, this may assist our understanding of the pathophysiological mechanisms and cognitive processes contributing to visual misperceptions and hallucinations and ultimately may inform more effective treatment strategies for this troubling symptom. © 2011 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>neurotransmitters</term></item><item><term>Lewy body pathology</term></item><item><term>neural networks; hallucinations</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Viewpoint</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2011-04-21">Received</change><change when="2011-07-05">Registration</change><change when="2011-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/715A33998264B427429EDE06C135538871443644/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="120"><doi origin="wiley" registered="yes">10.1002/mds.v26.12</doi><numberingGroup><numbering type="journalVolume" number="26">26</numbering><numbering type="journalIssue">12</numbering></numberingGroup><coverDate startDate="2011-10">October 2011</coverDate></publicationMeta><publicationMeta level="unit" type="editorial" position="30" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.23896</doi><idGroup><id type="unit" value="MDS23896"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="articleCategory">Viewpoint</title><title type="tocHeading1">Viewpoint</title></titleGroup><copyright ownership="thirdParty">Copyright © 2011 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2011-04-21"></event><event type="manuscriptRevised" date="2011-06-28"></event><event type="manuscriptAccepted" date="2011-07-05"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.0.1 mode:FullText" date="2012-01-04"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-09-23"></event><event type="publishedOnlineFinalForm" date="2011-10-21"></event><event type="firstOnline" date="2011-09-23"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">2154</numbering><numbering type="pageLast">2159</numbering></numberingGroup><correspondenceTo>Parkinson's Disease Research Clinic, 94 Mallett Street, Camperdown, Sydney, NSW, Australia, 2050</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS23896.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="57"></count><count type="wordTotal" number="5174"></count></countGroup><titleGroup><title type="main" xml:lang="en">Visual misperceptions and hallucinations in Parkinson's disease: Dysfunction of attentional control networks?<link href="#fn1"></link><link href="#fn2"></link></title><title type="short" xml:lang="en">Attentional Control Networks in PD Hallucinations</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>James M.</givenNames><familyName>Shine</familyName><degrees>BSc, MBBS</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Glenda M.</givenNames><familyName>Halliday</familyName><degrees>BSc, PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Sharon L.</givenNames><familyName>Naismith</familyName><degrees>MAPS, CCN</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Simon J.G.</givenNames><familyName>Lewis</familyName><degrees>MBBCh, BSc, MRCP, FRACP, MD</degrees></personName><contactDetails><email>simonl@med.usyd.edu.au</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="AU" type="organization"><unparsedAffiliation>Ageing Brain Centre, Brain and Mind Research Institute, the University of Sydney, Sydney, NSW, Australia</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="AU" type="organization"><unparsedAffiliation>Neuroscience Research Australia and the University of New South Wales, Sydney, NSW, Australia</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">neurotransmitters</keyword><keyword xml:id="kwd3">Lewy body pathology</keyword><keyword xml:id="kwd4">neural networks; hallucinations</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Visual misperceptions and hallucinations are a major cause of distress in patients with Parkinson's disease (PD), particularly in the advanced stages of the condition. Recent work has provided a framework for understanding the pathogenesis of these symptoms, implicating impairments from the retina to the integration of external information with preformed internal images. In this article, we propose a novel hypothesis that attempts to explain the presence of visual misperceptions and hallucinations in PD through the aberrant coordination of complimentary yet competing neural networks. We propose that hallucinations in PD reflect the relative inability to recruit activation in the dorsal attention network in the presence of an ambiguous percept, leading to overreliance on default mode network processing and salience arising from the ventral attention network. This inability is proposed to stem from improper function across cortical and subcortical structures secondary to the presence of Lewy body pathology. This hypothesis may be empirically tested by the use of targeted cognitive paradigms. In turn, this may assist our understanding of the pathophysiological mechanisms and cognitive processes contributing to visual misperceptions and hallucinations and ultimately may inform more effective treatment strategies for this troubling symptom. © 2011 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p><b>Relevant conflicts of interest/financial disclosures:</b> Nothing to report.</p></note><note xml:id="fn2"><p>Full financial disclosures and author roles may be found in the online version of this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Visual misperceptions and hallucinations in Parkinson's disease: Dysfunction of attentional control networks?</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Attentional Control Networks in PD Hallucinations</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Visual misperceptions and hallucinations in Parkinson's disease: Dysfunction of attentional control networks?</title></titleInfo><name type="personal"><namePart type="given">James M.</namePart><namePart type="family">Shine</namePart><namePart type="termsOfAddress">BSc, MBBS</namePart><affiliation>Ageing Brain Centre, Brain and Mind Research Institute, the University of Sydney, Sydney, NSW, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Glenda M.</namePart><namePart type="family">Halliday</namePart><namePart type="termsOfAddress">BSc, PhD</namePart><affiliation>Neuroscience Research Australia and the University of New South Wales, Sydney, NSW, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sharon L.</namePart><namePart type="family">Naismith</namePart><namePart type="termsOfAddress">MAPS, CCN</namePart><affiliation>Ageing Brain Centre, Brain and Mind Research Institute, the University of Sydney, Sydney, NSW, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Simon J.G.</namePart><namePart type="family">Lewis</namePart><namePart type="termsOfAddress">MBBCh, BSc, MRCP, FRACP, MD</namePart><affiliation>Ageing Brain Centre, Brain and Mind Research Institute, the University of Sydney, Sydney, NSW, Australia</affiliation><description>Correspondence: Parkinson's Disease Research Clinic, 94 Mallett Street, Camperdown, Sydney, NSW, Australia, 2050</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="editorial" displayLabel="editorial"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-10</dateIssued><dateCaptured encoding="w3cdtf">2011-04-21</dateCaptured><dateValid encoding="w3cdtf">2011-07-05</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">1</extent><extent unit="references">57</extent><extent unit="words">5174</extent></physicalDescription><abstract lang="en">Visual misperceptions and hallucinations are a major cause of distress in patients with Parkinson's disease (PD), particularly in the advanced stages of the condition. Recent work has provided a framework for understanding the pathogenesis of these symptoms, implicating impairments from the retina to the integration of external information with preformed internal images. In this article, we propose a novel hypothesis that attempts to explain the presence of visual misperceptions and hallucinations in PD through the aberrant coordination of complimentary yet competing neural networks. We propose that hallucinations in PD reflect the relative inability to recruit activation in the dorsal attention network in the presence of an ambiguous percept, leading to overreliance on default mode network processing and salience arising from the ventral attention network. This inability is proposed to stem from improper function across cortical and subcortical structures secondary to the presence of Lewy body pathology. This hypothesis may be empirically tested by the use of targeted cognitive paradigms. In turn, this may assist our understanding of the pathophysiological mechanisms and cognitive processes contributing to visual misperceptions and hallucinations and ultimately may inform more effective treatment strategies for this troubling symptom. © 2011 Movement Disorder Society</abstract><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>neurotransmitters</topic><topic>Lewy body pathology</topic><topic>neural networks; hallucinations</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Viewpoint</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>2154</start><end>2159</end><total>6</total></extent></part></relatedItem><identifier type="istex">715A33998264B427429EDE06C135538871443644</identifier><identifier type="DOI">10.1002/mds.23896</identifier><identifier type="ArticleID">MDS23896</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001235 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 001235 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:715A33998264B427429EDE06C135538871443644
|texte= Visual misperceptions and hallucinations in Parkinson's disease: Dysfunction of attentional control networks?
}}
| This area was generated with Dilib version V0.6.23. |  |