MF.01 Prevalence of depression in Parkinson's disease: relationship with gender and motor subtype
Identifieur interne : 001170 ( Main/Corpus ); précédent : 001169; suivant : 001171MF.01 Prevalence of depression in Parkinson's disease: relationship with gender and motor subtype
Auteurs : I. Tendolkar ; T. Van Der Hoek ; M. Van Der Marck ; R. EsselinkSource :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2011-08.
Abstract
Aims Depression is the most common neuropsychiatric disturbance in Parkinson's disease. Evidence is accumulating that motor subtype may be a critical risk factor for the development of depression throughout the disease and that the gender prevalence seen for common depression may not hold for patients with Parkinson's disease. Here we set out to analyse a database containing information about motor subtype, gender and depression in a large pool of well-characterised patients with idiopathic Parkinson's disease. Methods Standardised neurological and psychiatric tests were administered to 224 patients (154 male) suffering from idiopathic Parkinson at the Parkinson Centre Nijmegen (ParC) of the Radboud University Nijmegen Medical Centre (UMCN) in the Netherlands. ParC is an outpatient centre recognised as Centre of Excellence by the National Parkinson Foundation. The data were collected during a 3-day programme for diagnosis and the development of an individual multidisciplinary treatment programme. Data were statistically analysed using SPSS. Results Of the 224 patients, 74 (33%) suffered from the tremor-dominant subtype, 129 (56%) had a bradykinetic/rigidity subtype and 24 (11%) patients were diagnosed as having a postural instability and gait disorder subtype. Overall and for each of the subtypes, there was a significant higher prevalence of males in the group (minimum t(255)=12.9; p=0.000). We therefore corrected subsequent analyses for this difference in prevalence. Duration of illness did not differ between groups. Our statistical analysis further indicated that the prevalence of depression did not differ between male and female in any of the groups both for minor and major depression. Conclusions Our data contained a homogenous set of patients suffering from idiopathic Parkinsons disease in a mild to moderate stage. We could not replicate recent evidence of a predominance of depression in the postural instability and gait disorder subtype in this sample possibly due the stage of the disease. Our data, however, do suggest that contrary to the general population there is an equal prevalence of male and female patients suffering from minor or major depression. These results may suggest that there is a different pathophysiology underlying depression in Parkinson's diseases independent of subtype.
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DOI: 10.1136/jnnp-2011-300504.12
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>MF.01 Prevalence of depression in Parkinson's disease: relationship with gender and motor subtype</title><author><name sortKey="Tendolkar, I" sort="Tendolkar, I" uniqKey="Tendolkar I" first="I" last="Tendolkar">I. Tendolkar</name><affiliation><mods:affiliation>Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</mods:affiliation></affiliation><affiliation><mods:affiliation>Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Van Der Hoek, T" sort="Van Der Hoek, T" uniqKey="Van Der Hoek T" first="T" last="Van Der Hoek">T. Van Der Hoek</name><affiliation><mods:affiliation>Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Van Der Marck, M" sort="Van Der Marck, M" uniqKey="Van Der Marck M" first="M" last="Van Der Marck">M. Van Der Marck</name><affiliation><mods:affiliation>Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Esselink, R" sort="Esselink, R" uniqKey="Esselink R" first="R" last="Esselink">R. Esselink</name><affiliation><mods:affiliation>Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:98A0415A9CCAE6D4D2DA83031059FF9291BA60B5</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1136/jnnp-2011-300504.12</idno><idno type="url">https://api.istex.fr/document/98A0415A9CCAE6D4D2DA83031059FF9291BA60B5/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001170</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">MF.01 Prevalence of depression in Parkinson's disease: relationship with gender and motor subtype</title><author><name sortKey="Tendolkar, I" sort="Tendolkar, I" uniqKey="Tendolkar I" first="I" last="Tendolkar">I. Tendolkar</name><affiliation><mods:affiliation>Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</mods:affiliation></affiliation><affiliation><mods:affiliation>Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Van Der Hoek, T" sort="Van Der Hoek, T" uniqKey="Van Der Hoek T" first="T" last="Van Der Hoek">T. Van Der Hoek</name><affiliation><mods:affiliation>Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Van Der Marck, M" sort="Van Der Marck, M" uniqKey="Van Der Marck M" first="M" last="Van Der Marck">M. Van Der Marck</name><affiliation><mods:affiliation>Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Esselink, R" sort="Esselink, R" uniqKey="Esselink R" first="R" last="Esselink">R. Esselink</name><affiliation><mods:affiliation>Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2011-08">2011-08</date><biblScope unit="volume">82</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="e2">e2</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">98A0415A9CCAE6D4D2DA83031059FF9291BA60B5</idno><idno type="DOI">10.1136/jnnp-2011-300504.12</idno><idno type="href">jnnp-82-e2-4.pdf</idno><idno type="ArticleID">jnnp-2011-300504.12</idno><idno type="local">jnnp;82/8/e2-l</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Aims Depression is the most common neuropsychiatric disturbance in Parkinson's disease. Evidence is accumulating that motor subtype may be a critical risk factor for the development of depression throughout the disease and that the gender prevalence seen for common depression may not hold for patients with Parkinson's disease. Here we set out to analyse a database containing information about motor subtype, gender and depression in a large pool of well-characterised patients with idiopathic Parkinson's disease. Methods Standardised neurological and psychiatric tests were administered to 224 patients (154 male) suffering from idiopathic Parkinson at the Parkinson Centre Nijmegen (ParC) of the Radboud University Nijmegen Medical Centre (UMCN) in the Netherlands. ParC is an outpatient centre recognised as Centre of Excellence by the National Parkinson Foundation. The data were collected during a 3-day programme for diagnosis and the development of an individual multidisciplinary treatment programme. Data were statistically analysed using SPSS. Results Of the 224 patients, 74 (33%) suffered from the tremor-dominant subtype, 129 (56%) had a bradykinetic/rigidity subtype and 24 (11%) patients were diagnosed as having a postural instability and gait disorder subtype. Overall and for each of the subtypes, there was a significant higher prevalence of males in the group (minimum t(255)=12.9; p=0.000). We therefore corrected subsequent analyses for this difference in prevalence. Duration of illness did not differ between groups. Our statistical analysis further indicated that the prevalence of depression did not differ between male and female in any of the groups both for minor and major depression. Conclusions Our data contained a homogenous set of patients suffering from idiopathic Parkinsons disease in a mild to moderate stage. We could not replicate recent evidence of a predominance of depression in the postural instability and gait disorder subtype in this sample possibly due the stage of the disease. Our data, however, do suggest that contrary to the general population there is an equal prevalence of male and female patients suffering from minor or major depression. These results may suggest that there is a different pathophysiology underlying depression in Parkinson's diseases independent of subtype.</div></front></TEI><istex><corpusName>bmj</corpusName><author><json:item><name>I Tendolkar</name><affiliations><json:string>Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</json:string><json:string>Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, The Netherlands</json:string></affiliations></json:item><json:item><name>T van der Hoek</name><affiliations><json:string>Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</json:string></affiliations></json:item><json:item><name>M van der Marck</name><affiliations><json:string>Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</json:string></affiliations></json:item><json:item><name>R Esselink</name><affiliations><json:string>Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>British Neuropsychiatry Association 24th AGM, 10/11 February 2011, Institute of Child Health, Central London</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Aims Depression is the most common neuropsychiatric disturbance in Parkinson's disease. Evidence is accumulating that motor subtype may be a critical risk factor for the development of depression throughout the disease and that the gender prevalence seen for common depression may not hold for patients with Parkinson's disease. Here we set out to analyse a database containing information about motor subtype, gender and depression in a large pool of well-characterised patients with idiopathic Parkinson's disease. Methods Standardised neurological and psychiatric tests were administered to 224 patients (154 male) suffering from idiopathic Parkinson at the Parkinson Centre Nijmegen (ParC) of the Radboud University Nijmegen Medical Centre (UMCN) in the Netherlands. ParC is an outpatient centre recognised as Centre of Excellence by the National Parkinson Foundation. The data were collected during a 3-day programme for diagnosis and the development of an individual multidisciplinary treatment programme. Data were statistically analysed using SPSS. Results Of the 224 patients, 74 (33%) suffered from the tremor-dominant subtype, 129 (56%) had a bradykinetic/rigidity subtype and 24 (11%) patients were diagnosed as having a postural instability and gait disorder subtype. Overall and for each of the subtypes, there was a significant higher prevalence of males in the group (minimum t(255)=12.9; p=0.000). We therefore corrected subsequent analyses for this difference in prevalence. Duration of illness did not differ between groups. Our statistical analysis further indicated that the prevalence of depression did not differ between male and female in any of the groups both for minor and major depression. Conclusions Our data contained a homogenous set of patients suffering from idiopathic Parkinsons disease in a mild to moderate stage. We could not replicate recent evidence of a predominance of depression in the postural instability and gait disorder subtype in this sample possibly due the stage of the disease. Our data, however, do suggest that contrary to the general population there is an equal prevalence of male and female patients suffering from minor or major depression. These results may suggest that there is a different pathophysiology underlying depression in Parkinson's diseases independent of subtype.</abstract><qualityIndicators><score>5.353</score><pdfVersion>1.6</pdfVersion><pdfPageSize>595.276 x 793.701 pts</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>1</keywordCount><abstractCharCount>2337</abstractCharCount><pdfWordCount>853</pdfWordCount><pdfCharCount>5974</pdfCharCount><pdfPageCount>1</pdfPageCount><abstractWordCount>343</abstractWordCount></qualityIndicators><title>MF.01 Prevalence of depression in Parkinson's disease: relationship with gender and motor subtype</title><genre><json:string>abstract</json:string></genre><host><volume>82</volume><pages><first>e2</first></pages><issn><json:string>0022-3050</json:string></issn><issue>8</issue><genre></genre><language><json:string>unknown</json:string></language><eissn><json:string>1468-330X</json:string></eissn><title>Journal of Neurology, Neurosurgery & Psychiatry</title></host><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1136/jnnp-2011-300504.12</json:string></doi><id>98A0415A9CCAE6D4D2DA83031059FF9291BA60B5</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/98A0415A9CCAE6D4D2DA83031059FF9291BA60B5/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/98A0415A9CCAE6D4D2DA83031059FF9291BA60B5/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/98A0415A9CCAE6D4D2DA83031059FF9291BA60B5/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">MF.01 Prevalence of depression in Parkinson's disease: relationship with gender and motor subtype</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>BMJ Publishing Group Ltd</publisher><availability><p>BMJ</p></availability><date>2011</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">MF.01 Prevalence of depression in Parkinson's disease: relationship with gender and motor subtype</title><author><persName><forename type="first">I</forename><surname>Tendolkar</surname></persName><affiliation>Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</affiliation><affiliation>Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, The Netherlands</affiliation></author><author><persName><forename type="first">T</forename><surname>van der Hoek</surname></persName><affiliation>Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</affiliation></author><author><persName><forename type="first">M</forename><surname>van der Marck</surname></persName><affiliation>Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</affiliation></author><author><persName><forename type="first">R</forename><surname>Esselink</surname></persName><affiliation>Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</affiliation></author></analytic><monogr><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="pISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2011-08"></date><biblScope unit="volume">82</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="e2">e2</biblScope></imprint></monogr><idno type="istex">98A0415A9CCAE6D4D2DA83031059FF9291BA60B5</idno><idno type="DOI">10.1136/jnnp-2011-300504.12</idno><idno type="href">jnnp-82-e2-4.pdf</idno><idno type="ArticleID">jnnp-2011-300504.12</idno><idno type="local">jnnp;82/8/e2-l</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Aims Depression is the most common neuropsychiatric disturbance in Parkinson's disease. Evidence is accumulating that motor subtype may be a critical risk factor for the development of depression throughout the disease and that the gender prevalence seen for common depression may not hold for patients with Parkinson's disease. Here we set out to analyse a database containing information about motor subtype, gender and depression in a large pool of well-characterised patients with idiopathic Parkinson's disease. Methods Standardised neurological and psychiatric tests were administered to 224 patients (154 male) suffering from idiopathic Parkinson at the Parkinson Centre Nijmegen (ParC) of the Radboud University Nijmegen Medical Centre (UMCN) in the Netherlands. ParC is an outpatient centre recognised as Centre of Excellence by the National Parkinson Foundation. The data were collected during a 3-day programme for diagnosis and the development of an individual multidisciplinary treatment programme. Data were statistically analysed using SPSS. Results Of the 224 patients, 74 (33%) suffered from the tremor-dominant subtype, 129 (56%) had a bradykinetic/rigidity subtype and 24 (11%) patients were diagnosed as having a postural instability and gait disorder subtype. Overall and for each of the subtypes, there was a significant higher prevalence of males in the group (minimum t(255)=12.9; p=0.000). We therefore corrected subsequent analyses for this difference in prevalence. Duration of illness did not differ between groups. Our statistical analysis further indicated that the prevalence of depression did not differ between male and female in any of the groups both for minor and major depression. Conclusions Our data contained a homogenous set of patients suffering from idiopathic Parkinsons disease in a mild to moderate stage. We could not replicate recent evidence of a predominance of depression in the postural instability and gait disorder subtype in this sample possibly due the stage of the disease. Our data, however, do suggest that contrary to the general population there is an equal prevalence of male and female patients suffering from minor or major depression. These results may suggest that there is a different pathophysiology underlying depression in Parkinson's diseases independent of subtype.</p></abstract></profileDesc><revisionDesc><change when="2011-08">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/98A0415A9CCAE6D4D2DA83031059FF9291BA60B5/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="abstract"><front><journal-meta><journal-id journal-id-type="hwp">jnnp</journal-id><journal-id journal-id-type="nlm-ta">J Neurol Neurosurg Psychiatry</journal-id><journal-id journal-id-type="publisher-id">jnnp</journal-id><journal-title>Journal of Neurology, Neurosurgery & Psychiatry</journal-title><abbrev-journal-title abbrev-type="publisher">J Neurol Neurosurg Psychiatry</abbrev-journal-title><abbrev-journal-title>J Neurol Neurosurg Psychiatry</abbrev-journal-title><issn pub-type="ppub">0022-3050</issn><issn pub-type="epub">1468-330X</issn><publisher><publisher-name>BMJ Publishing Group Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">jnnp-2011-300504.12</article-id><article-id pub-id-type="doi">10.1136/jnnp-2011-300504.12</article-id><article-id pub-id-type="other">jnnp;82/8/e2-l</article-id><article-id pub-id-type="other">jnnp;jnnp-2011-300504.12</article-id><article-id pub-id-type="other">e2.4</article-id><article-id pub-id-type="other">jnnp-2011-300504.12</article-id><article-categories><subj-group subj-group-type="heading"><subject>British Neuropsychiatry Association 24th AGM, 10/11 February 2011, Institute of Child Health, Central London</subject></subj-group><series-title>Members' Forum</series-title></article-categories><title-group><article-title>MF.01 Prevalence of depression in Parkinson's disease: relationship with gender and motor subtype</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Tendolkar</surname><given-names>I</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>van der Hoek</surname><given-names>T</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>van der Marck</surname><given-names>M</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Esselink</surname><given-names>R</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib></contrib-group><aff id="aff1"><label>1</label>Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</aff><aff id="aff2"><label>2</label>Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, The Netherlands</aff><aff id="aff3"><label>3</label>Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</aff><pub-date pub-type="ppub"><month>8</month><year>2011</year></pub-date><volume>82</volume><volume-id pub-id-type="other">82</volume-id><volume-id pub-id-type="other">82</volume-id><issue>8</issue><issue-id pub-id-type="other">jnnp;82/8</issue-id><issue-id pub-id-type="other">8</issue-id><issue-id pub-id-type="other">82/8</issue-id><fpage seq="4">e2</fpage><permissions><copyright-statement>© 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</copyright-statement><copyright-year>2011</copyright-year></permissions><self-uri content-type="pdf" xlink:role="full-text" xlink:href="jnnp-82-e2-4.pdf"></self-uri><abstract><sec><title>Aims</title><p>Depression is the most common neuropsychiatric disturbance in Parkinson's disease. Evidence is accumulating that motor subtype may be a critical risk factor for the development of depression throughout the disease and that the gender prevalence seen for common depression may not hold for patients with Parkinson's disease. Here we set out to analyse a database containing information about motor subtype, gender and depression in a large pool of well-characterised patients with idiopathic Parkinson's disease.</p></sec><sec><title>Methods</title><p>Standardised neurological and psychiatric tests were administered to 224 patients (154 male) suffering from idiopathic Parkinson at the Parkinson Centre Nijmegen (ParC) of the Radboud University Nijmegen Medical Centre (UMCN) in the Netherlands. ParC is an outpatient centre recognised as Centre of Excellence by the National Parkinson Foundation. The data were collected during a 3-day programme for diagnosis and the development of an individual multidisciplinary treatment programme. Data were statistically analysed using SPSS.</p></sec><sec><title>Results</title><p>Of the 224 patients, 74 (33%) suffered from the tremor-dominant subtype, 129 (56%) had a bradykinetic/rigidity subtype and 24 (11%) patients were diagnosed as having a postural instability and gait disorder subtype. Overall and for each of the subtypes, there was a significant higher prevalence of males in the group (minimum t(255)=12.9; p=0.000). We therefore corrected subsequent analyses for this difference in prevalence. Duration of illness did not differ between groups. Our statistical analysis further indicated that the prevalence of depression did not differ between male and female in any of the groups both for minor and major depression.</p></sec><sec><title>Conclusions</title><p>Our data contained a homogenous set of patients suffering from idiopathic Parkinsons disease in a mild to moderate stage. We could not replicate recent evidence of a predominance of depression in the postural instability and gait disorder subtype in this sample possibly due the stage of the disease. Our data, however, do suggest that contrary to the general population there is an equal prevalence of male and female patients suffering from minor or major depression. These results may suggest that there is a different pathophysiology underlying depression in Parkinson's diseases independent of subtype.</p></sec></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><partName>Members' Forum</partName><title>MF.01 Prevalence of depression in Parkinson's disease: relationship with gender and motor subtype</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><partName>Members' Forum</partName><title>MF.01 Prevalence of depression in Parkinson's disease: relationship with gender and motor subtype</title></titleInfo><name type="personal"><namePart type="given">I</namePart><namePart type="family">Tendolkar</namePart><affiliation>Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</affiliation><affiliation>Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">van der Hoek</namePart><affiliation>Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">van der Marck</namePart><affiliation>Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Esselink</namePart><affiliation>Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="abstract" displayLabel="abstract"></genre><originInfo><publisher>BMJ Publishing Group Ltd</publisher><dateIssued encoding="w3cdtf">2011-08</dateIssued><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Aims Depression is the most common neuropsychiatric disturbance in Parkinson's disease. Evidence is accumulating that motor subtype may be a critical risk factor for the development of depression throughout the disease and that the gender prevalence seen for common depression may not hold for patients with Parkinson's disease. Here we set out to analyse a database containing information about motor subtype, gender and depression in a large pool of well-characterised patients with idiopathic Parkinson's disease. Methods Standardised neurological and psychiatric tests were administered to 224 patients (154 male) suffering from idiopathic Parkinson at the Parkinson Centre Nijmegen (ParC) of the Radboud University Nijmegen Medical Centre (UMCN) in the Netherlands. ParC is an outpatient centre recognised as Centre of Excellence by the National Parkinson Foundation. The data were collected during a 3-day programme for diagnosis and the development of an individual multidisciplinary treatment programme. Data were statistically analysed using SPSS. Results Of the 224 patients, 74 (33%) suffered from the tremor-dominant subtype, 129 (56%) had a bradykinetic/rigidity subtype and 24 (11%) patients were diagnosed as having a postural instability and gait disorder subtype. Overall and for each of the subtypes, there was a significant higher prevalence of males in the group (minimum t(255)=12.9; p=0.000). We therefore corrected subsequent analyses for this difference in prevalence. Duration of illness did not differ between groups. Our statistical analysis further indicated that the prevalence of depression did not differ between male and female in any of the groups both for minor and major depression. Conclusions Our data contained a homogenous set of patients suffering from idiopathic Parkinsons disease in a mild to moderate stage. We could not replicate recent evidence of a predominance of depression in the postural instability and gait disorder subtype in this sample possibly due the stage of the disease. Our data, however, do suggest that contrary to the general population there is an equal prevalence of male and female patients suffering from minor or major depression. These results may suggest that there is a different pathophysiology underlying depression in Parkinson's diseases independent of subtype.</abstract><relatedItem type="host"><titleInfo><title>Journal of Neurology, Neurosurgery & Psychiatry</title></titleInfo><titleInfo type="abbreviated"><title>J Neurol Neurosurg Psychiatry</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0022-3050</identifier><identifier type="eISSN">1468-330X</identifier><identifier type="PublisherID">jnnp</identifier><identifier type="PublisherID-hwp">jnnp</identifier><identifier type="PublisherID-nlm-ta">J Neurol Neurosurg Psychiatry</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>82</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>e2</start></extent></part></relatedItem><identifier type="istex">98A0415A9CCAE6D4D2DA83031059FF9291BA60B5</identifier><identifier type="DOI">10.1136/jnnp-2011-300504.12</identifier><identifier type="href">jnnp-82-e2-4.pdf</identifier><identifier type="ArticleID">jnnp-2011-300504.12</identifier><identifier type="local">jnnp;82/8/e2-l</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</accessCondition><recordInfo><recordContentSource>BMJ</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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