COGNITIVE DEFICITS IN THE EARLY STAGES OF PARKINSON'S DISEASE
Identifieur interne : 001164 ( Main/Corpus ); précédent : 001163; suivant : 001165COGNITIVE DEFICITS IN THE EARLY STAGES OF PARKINSON'S DISEASE
Auteurs : A. J. Lees ; Eileen SmithSource :
- Brain [ 0006-8950 ] ; 1983-06.
Abstract
Neuropsychological tests known to reveal abnormalities in patients with frontal lobe damage were used to explore cognitive function in 30 mildly disabled, right-handed patients with idiopathic Parkinson's disease. None of the patients had received treatment and all had normal CT brain scans. Patients with depression or high ischaemia scores were excluded from the study and similar selection criteria were used for the age-matched controls. No impairment of general intellectual function was found in the patients using the WAIS and New Adult Reading IQ tests and no abnormalities were apparent on cognitive estimates and two-choice Recognition Memory Tests. Patients with Parkinson's disease, however, had significantly greater difficulty in shifting conceptual sets and produced more perseverative errors on both the modified Wisconsin Card Sorting Test and Benton's Word Fluency Test. These subtle cognitive difficulties might underlie the mental inflexibility and rigidity of Parkinson's disease and could be attributed to destruction of the ascending dopaminergic meso-corticolimbic pathway
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DOI: 10.1093/brain/106.2.257
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Lees</name><affiliation><mods:affiliation>The National Hospital for Nervous Diseases, Maida Vale, London W9 2TL</mods:affiliation></affiliation></author><author><name sortKey="Smith, Eileen" sort="Smith, Eileen" uniqKey="Smith E" first="Eileen" last="Smith">Eileen Smith</name><affiliation><mods:affiliation>The National Hospital for Nervous Diseases, Maida Vale, London W9 2TL</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:16A6AD9BD151FC4F708138864B4AC6B0A2197683</idno><date when="1983" year="1983">1983</date><idno type="doi">10.1093/brain/106.2.257</idno><idno type="url">https://api.istex.fr/document/16A6AD9BD151FC4F708138864B4AC6B0A2197683/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001164</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">COGNITIVE DEFICITS IN THE EARLY STAGES OF PARKINSON'S DISEASE</title><author><name sortKey="Lees, A J" sort="Lees, A J" uniqKey="Lees A" first="A. 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J.</forename><surname>LEES</surname></persName><affiliation>The National Hospital for Nervous Diseases, Maida Vale, London W9 2TL</affiliation></author><author><persName><forename type="first">EILEEN</forename><surname>SMITH</surname></persName><affiliation>The National Hospital for Nervous Diseases, Maida Vale, London W9 2TL</affiliation></author></analytic><monogr><title level="j">Brain</title><idno type="pISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="1983-06"></date><biblScope unit="volume">106</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="257">257</biblScope><biblScope unit="page" to="270">270</biblScope></imprint></monogr><idno type="istex">16A6AD9BD151FC4F708138864B4AC6B0A2197683</idno><idno type="DOI">10.1093/brain/106.2.257</idno><idno type="ArticleID">106.2.257</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1983</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Neuropsychological tests known to reveal abnormalities in patients with frontal lobe damage were used to explore cognitive function in 30 mildly disabled, right-handed patients with idiopathic Parkinson's disease. 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J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>SMITH</surname><given-names>EILEEN</given-names></name></contrib><aff>From the <institution>The National Hospital for Nervous Diseases</institution> <addr-line>Maida Vale, London W9 2TL</addr-line></aff></contrib-group><pub-date pub-type="ppub"><month>6</month><year>1983</year></pub-date><volume>106</volume><issue>2</issue><fpage>257</fpage><lpage>270</lpage><history><date date-type="received"><day>17</day><month>6</month><year>1982</year></date><date date-type="rev-recd"><day>19</day><month>10</month><year>1982</year></date></history><copyright-statement>© Oxford University Press</copyright-statement><copyright-year>1983</copyright-year><abstract><p>Neuropsychological tests known to reveal abnormalities in patients with frontal lobe damage were used to explore cognitive function in 30 mildly disabled, right-handed patients with idiopathic Parkinson's disease. 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