Parkinson‐related genetics in patients treated with deep brain stimulation
Identifieur interne : 001149 ( Main/Corpus ); précédent : 001148; suivant : 001150Parkinson‐related genetics in patients treated with deep brain stimulation
Auteurs : K. K. Johansen ; J. V. J Rgensen ; L. R. White ; M. J. Farrer ; J. O. AaslySource :
- Acta Neurologica Scandinavica [ 0001-6314 ] ; 2011-03.
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Abstract
Johansen KK, Jørgensen JV, White LR, Farrer MJ, Aasly JO. Parkinson‐related genetics in patients treated with deep brain stimulation.
Acta Neurol Scand: 2011: 123: 201–206.
© 2010 John Wiley & Sons A/S. Objectives – To analyze the frequency of mutations associated with Parkinson’s disease (PD) in a general PD population compared to patients with PD selected for deep brain stimulation (DBS) and evaluate the outcome of surgery. Material and methods – A total of 630 consecutive patients with PD were genetically screened, and 60 had DBS surgery, 37 subthalamic nucleus (STN), 21 ventrointermediate nucleus of thalamus (VIM), and two globus pallidus internus (GPi). Results – Mutations in LRRK2, PRKN, and PINK1 were found: the first two of these being overrepresented in STN‐operated patients, but none being found in VIM‐operated patients. Clinical outcome of the surgery was similar in patients with mutations compared to those without. Conclusions – In a consecutive PD population, patients treated with STN‐DBS are overrepresented for PD‐related mutations and they seem to benefit from DBS as well as patients without mutations.
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DOI: 10.1111/j.1600-0404.2010.01387.x
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Parkinson‐related genetics in patients treated with deep brain stimulation</title><author><name sortKey="Johansen, K K" sort="Johansen, K K" uniqKey="Johansen K" first="K. K." last="Johansen">K. K. Johansen</name><affiliation><mods:affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, St Olav’s University Hospital, Trondheim, Norway</mods:affiliation></affiliation></author><author><name sortKey="J Rgensen, J V" sort="J Rgensen, J V" uniqKey="J Rgensen J" first="J. V." last="J Rgensen">J. V. J Rgensen</name><affiliation><mods:affiliation>Department of Neurosurgery, St Olav’s University Hospital, Trondheim, Norway</mods:affiliation></affiliation></author><author><name sortKey="White, L R" sort="White, L R" uniqKey="White L" first="L. R." last="White">L. R. White</name><affiliation><mods:affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, St Olav’s University Hospital, Trondheim, Norway</mods:affiliation></affiliation></author><author><name sortKey="Farrer, M J" sort="Farrer, M J" uniqKey="Farrer M" first="M. J." last="Farrer">M. J. Farrer</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA</mods:affiliation></affiliation></author><author><name sortKey="Aasly, J O" sort="Aasly, J O" uniqKey="Aasly J" first="J. O." last="Aasly">J. O. Aasly</name><affiliation><mods:affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, St Olav’s University Hospital, Trondheim, Norway</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5E26C7DB06F8E087DFB47F09C05BC1B4BCDEA71E</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1111/j.1600-0404.2010.01387.x</idno><idno type="url">https://api.istex.fr/document/5E26C7DB06F8E087DFB47F09C05BC1B4BCDEA71E/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001149</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Parkinson‐related genetics in patients treated with deep brain stimulation</title><author><name sortKey="Johansen, K K" sort="Johansen, K K" uniqKey="Johansen K" first="K. K." last="Johansen">K. K. Johansen</name><affiliation><mods:affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, St Olav’s University Hospital, Trondheim, Norway</mods:affiliation></affiliation></author><author><name sortKey="J Rgensen, J V" sort="J Rgensen, J V" uniqKey="J Rgensen J" first="J. V." last="J Rgensen">J. V. J Rgensen</name><affiliation><mods:affiliation>Department of Neurosurgery, St Olav’s University Hospital, Trondheim, Norway</mods:affiliation></affiliation></author><author><name sortKey="White, L R" sort="White, L R" uniqKey="White L" first="L. R." last="White">L. R. White</name><affiliation><mods:affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, St Olav’s University Hospital, Trondheim, Norway</mods:affiliation></affiliation></author><author><name sortKey="Farrer, M J" sort="Farrer, M J" uniqKey="Farrer M" first="M. J." last="Farrer">M. J. Farrer</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA</mods:affiliation></affiliation></author><author><name sortKey="Aasly, J O" sort="Aasly, J O" uniqKey="Aasly J" first="J. O." last="Aasly">J. O. Aasly</name><affiliation><mods:affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, St Olav’s University Hospital, Trondheim, Norway</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neurologica Scandinavica</title><idno type="ISSN">0001-6314</idno><idno type="eISSN">1600-0404</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-03">2011-03</date><biblScope unit="volume">123</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="201">201</biblScope><biblScope unit="page" to="206">206</biblScope></imprint><idno type="ISSN">0001-6314</idno></series><idno type="istex">5E26C7DB06F8E087DFB47F09C05BC1B4BCDEA71E</idno><idno type="DOI">10.1111/j.1600-0404.2010.01387.x</idno><idno type="ArticleID">ANE1387</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-6314</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>GPi</term><term>LRRK2</term><term>PINK1</term><term>PRKN</term><term>STN</term><term>VIM</term><term>p.G2019S</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Johansen KK, Jørgensen JV, White LR, Farrer MJ, Aasly JO. Parkinson‐related genetics in patients treated with deep brain stimulation.
Acta Neurol Scand: 2011: 123: 201–206.
© 2010 John Wiley & Sons A/S. Objectives – To analyze the frequency of mutations associated with Parkinson’s disease (PD) in a general PD population compared to patients with PD selected for deep brain stimulation (DBS) and evaluate the outcome of surgery. Material and methods – A total of 630 consecutive patients with PD were genetically screened, and 60 had DBS surgery, 37 subthalamic nucleus (STN), 21 ventrointermediate nucleus of thalamus (VIM), and two globus pallidus internus (GPi). Results – Mutations in LRRK2, PRKN, and PINK1 were found: the first two of these being overrepresented in STN‐operated patients, but none being found in VIM‐operated patients. Clinical outcome of the surgery was similar in patients with mutations compared to those without. Conclusions – In a consecutive PD population, patients treated with STN‐DBS are overrepresented for PD‐related mutations and they seem to benefit from DBS as well as patients without mutations.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>K. K. Johansen</name><affiliations><json:string>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</json:string><json:string>Department of Neurology, St Olav’s University Hospital, Trondheim, Norway</json:string></affiliations></json:item><json:item><name>J. V. Jørgensen</name><affiliations><json:string>Department of Neurosurgery, St Olav’s University Hospital, Trondheim, Norway</json:string></affiliations></json:item><json:item><name>L. R. White</name><affiliations><json:string>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</json:string><json:string>Department of Neurology, St Olav’s University Hospital, Trondheim, Norway</json:string></affiliations></json:item><json:item><name>M. J. Farrer</name><affiliations><json:string>Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA</json:string></affiliations></json:item><json:item><name>J. O. Aasly</name><affiliations><json:string>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</json:string><json:string>Department of Neurology, St Olav’s University Hospital, Trondheim, Norway</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>GPi</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>LRRK2</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>p.G2019S</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PRKN</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PINK1</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>STN</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>VIM</value></json:item></subject><articleId><json:string>ANE1387</json:string></articleId><language><json:string>eng</json:string></language><abstract>Johansen KK, Jørgensen JV, White LR, Farrer MJ, Aasly JO. Parkinson‐related genetics in patients treated with deep brain stimulation.
Acta Neurol Scand: 2011: 123: 201–206.
© 2010 John Wiley & Sons A/S. Objectives – To analyze the frequency of mutations associated with Parkinson’s disease (PD) in a general PD population compared to patients with PD selected for deep brain stimulation (DBS) and evaluate the outcome of surgery. Material and methods – A total of 630 consecutive patients with PD were genetically screened, and 60 had DBS surgery, 37 subthalamic nucleus (STN), 21 ventrointermediate nucleus of thalamus (VIM), and two globus pallidus internus (GPi). Results – Mutations in LRRK2, PRKN, and PINK1 were found: the first two of these being overrepresented in STN‐operated patients, but none being found in VIM‐operated patients. Clinical outcome of the surgery was similar in patients with mutations compared to those without. Conclusions – In a consecutive PD population, patients treated with STN‐DBS are overrepresented for PD‐related mutations and they seem to benefit from DBS as well as patients without mutations.</abstract><qualityIndicators><score>5.067</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>7</keywordCount><abstractCharCount>1138</abstractCharCount><pdfWordCount>3051</pdfWordCount><pdfCharCount>19605</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>168</abstractWordCount></qualityIndicators><title>Parkinson‐related genetics in patients treated with deep brain stimulation</title><genre><json:string>article</json:string></genre><host><volume>123</volume><publisherId><json:string>ANE</json:string></publisherId><pages><total>6</total><last>206</last><first>201</first></pages><issn><json:string>0001-6314</json:string></issn><issue>3</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1600-0404</json:string></eissn><title>Acta Neurologica Scandinavica</title><doi><json:string>10.1111/(ISSN)1600-0404</json:string></doi></host><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1111/j.1600-0404.2010.01387.x</json:string></doi><id>5E26C7DB06F8E087DFB47F09C05BC1B4BCDEA71E</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/5E26C7DB06F8E087DFB47F09C05BC1B4BCDEA71E/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/5E26C7DB06F8E087DFB47F09C05BC1B4BCDEA71E/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/5E26C7DB06F8E087DFB47F09C05BC1B4BCDEA71E/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Parkinson‐related genetics in patients treated with deep brain stimulation</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>2011</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Parkinson‐related genetics in patients treated with deep brain stimulation</title><author><persName><forename type="first">K. K.</forename><surname>Johansen</surname></persName><affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</affiliation><affiliation>Department of Neurology, St Olav’s University Hospital, Trondheim, Norway</affiliation></author><author><persName><forename type="first">J. V.</forename><surname>Jørgensen</surname></persName><affiliation>Department of Neurosurgery, St Olav’s University Hospital, Trondheim, Norway</affiliation></author><author><persName><forename type="first">L. R.</forename><surname>White</surname></persName><affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</affiliation><affiliation>Department of Neurology, St Olav’s University Hospital, Trondheim, Norway</affiliation></author><author><persName><forename type="first">M. J.</forename><surname>Farrer</surname></persName><affiliation>Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA</affiliation></author><author><persName><forename type="first">J. O.</forename><surname>Aasly</surname></persName><affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</affiliation><affiliation>Department of Neurology, St Olav’s University Hospital, Trondheim, Norway</affiliation></author></analytic><monogr><title level="j">Acta Neurologica Scandinavica</title><idno type="pISSN">0001-6314</idno><idno type="eISSN">1600-0404</idno><idno type="DOI">10.1111/(ISSN)1600-0404</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-03"></date><biblScope unit="volume">123</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="201">201</biblScope><biblScope unit="page" to="206">206</biblScope></imprint></monogr><idno type="istex">5E26C7DB06F8E087DFB47F09C05BC1B4BCDEA71E</idno><idno type="DOI">10.1111/j.1600-0404.2010.01387.x</idno><idno type="ArticleID">ANE1387</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Johansen KK, Jørgensen JV, White LR, Farrer MJ, Aasly JO. Parkinson‐related genetics in patients treated with deep brain stimulation.
Acta Neurol Scand: 2011: 123: 201–206.
© 2010 John Wiley & Sons A/S. Objectives – To analyze the frequency of mutations associated with Parkinson’s disease (PD) in a general PD population compared to patients with PD selected for deep brain stimulation (DBS) and evaluate the outcome of surgery. Material and methods – A total of 630 consecutive patients with PD were genetically screened, and 60 had DBS surgery, 37 subthalamic nucleus (STN), 21 ventrointermediate nucleus of thalamus (VIM), and two globus pallidus internus (GPi). Results – Mutations in LRRK2, PRKN, and PINK1 were found: the first two of these being overrepresented in STN‐operated patients, but none being found in VIM‐operated patients. Clinical outcome of the surgery was similar in patients with mutations compared to those without. Conclusions – In a consecutive PD population, patients treated with STN‐DBS are overrepresented for PD‐related mutations and they seem to benefit from DBS as well as patients without mutations.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>GPi</term></item><item><term>LRRK2</term></item><item><term>p.G2019S</term></item><item><term>PRKN</term></item><item><term>PINK1</term></item><item><term>STN</term></item><item><term>VIM</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2011-03">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/5E26C7DB06F8E087DFB47F09C05BC1B4BCDEA71E/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0404</doi><issn type="print">0001-6314</issn><issn type="electronic">1600-0404</issn><idGroup><id type="product" value="ANE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ACTA NEUROLOGICA SCANDINAVICA">Acta Neurologica Scandinavica</title></titleGroup></publicationMeta><publicationMeta level="part" position="03103"><doi origin="wiley">10.1111/ane.2011.123.issue-3</doi><numberingGroup><numbering type="journalVolume" number="123">123</numbering><numbering type="journalIssue" number="3">3</numbering></numberingGroup><coverDate startDate="2011-03">March 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="8" status="forIssue"><doi origin="wiley">10.1111/j.1600-0404.2010.01387.x</doi><idGroup><id type="unit" value="ANE1387"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="tocHeading1"><i>Original articles</i></title></titleGroup><copyright>© 2010 John Wiley & Sons A/S</copyright><eventGroup><event type="firstOnline" date="2011-01-27"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2010-06-09"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.4.4 mode:FullText" date="2011-01-27"></event><event type="publishedOnlineFinalForm" date="2011-01-27"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-15"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="201">201</numbering><numbering type="pageLast" number="206">206</numbering></numberingGroup><correspondenceTo>Krisztina K. Johansen, Department of Neuroscience, Norwegian University of Science and Technology,
Edvard Griegs gt. 8, N‐7006 Trondheim, Norway
Tel.: +47 72575793
Fax: +47 72575657
e‐mail: <email>krisztina.k.johansen@ntnu.no</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ANE.ANE1387.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication April 21, 2010</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="5"></count></countGroup><titleGroup><title type="main">Parkinson‐related genetics in patients treated with deep brain stimulation</title><title type="shortAuthors"><b>Johansen et al.</b></title><title type="short"><b>Genetics in DBS patients</b></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a2"><personName><givenNames>K. K.</givenNames><familyName>Johansen</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a3"><personName><givenNames>J. V.</givenNames><familyName>Jørgensen</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1 #a2"><personName><givenNames>L. R.</givenNames><familyName>White</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a4"><personName><givenNames>M. J.</givenNames><familyName>Farrer</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1 #a2"><personName><givenNames>J. O.</givenNames><familyName>Aasly</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="NO"><unparsedAffiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="NO"><unparsedAffiliation>Department of Neurology, St Olav’s University Hospital, Trondheim, Norway</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="NO"><unparsedAffiliation>Department of Neurosurgery, St Olav’s University Hospital, Trondheim, Norway</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="US"><unparsedAffiliation>Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">GPi</keyword><keyword xml:id="k2"><i>LRRK2</i></keyword><keyword xml:id="k3">p.G2019S</keyword><keyword xml:id="k4"><i>PRKN</i></keyword><keyword xml:id="k5"><i>PINK1</i></keyword><keyword xml:id="k6">STN</keyword><keyword xml:id="k7">VIM</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>Johansen KK, Jørgensen JV, White LR, Farrer MJ, Aasly JO. Parkinson‐related genetics in patients treated with deep brain stimulation.
Acta Neurol Scand: 2011: 123: 201–206.
© 2010 John Wiley & Sons A/S.</p><p><b>Objectives – </b> To analyze the frequency of mutations associated with Parkinson’s disease (PD) in a general PD population compared to patients with PD selected for deep brain stimulation (DBS) and evaluate the outcome of surgery.</p><p><b>Material and methods – </b> A total of 630 consecutive patients with PD were genetically screened, and 60 had DBS surgery, 37 subthalamic nucleus (STN), 21 ventrointermediate nucleus of thalamus (VIM), and two globus pallidus internus (GPi).</p><p><b>Results – </b> Mutations in <i>LRRK2</i>, <i>PRKN</i>, and <i>PINK1</i> were found: the first two of these being overrepresented in STN‐operated patients, but none being found in VIM‐operated patients. Clinical outcome of the surgery was similar in patients with mutations compared to those without.</p><p><b>Conclusions – </b> In a consecutive PD population, patients treated with STN‐DBS are overrepresented for PD‐related mutations and they seem to benefit from DBS as well as patients without mutations.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Parkinson‐related genetics in patients treated with deep brain stimulation</title></titleInfo><titleInfo type="abbreviated"><title>Genetics in DBS patients</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Parkinson‐related genetics in patients treated with deep brain stimulation</title></titleInfo><name type="personal"><namePart type="given">K. K.</namePart><namePart type="family">Johansen</namePart><affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</affiliation><affiliation>Department of Neurology, St Olav’s University Hospital, Trondheim, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. V.</namePart><namePart type="family">Jørgensen</namePart><affiliation>Department of Neurosurgery, St Olav’s University Hospital, Trondheim, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. R.</namePart><namePart type="family">White</namePart><affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</affiliation><affiliation>Department of Neurology, St Olav’s University Hospital, Trondheim, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. J.</namePart><namePart type="family">Farrer</namePart><affiliation>Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. O.</namePart><namePart type="family">Aasly</namePart><affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</affiliation><affiliation>Department of Neurology, St Olav’s University Hospital, Trondheim, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2011-03</dateIssued><edition>Accepted for publication April 21, 2010</edition><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">5</extent></physicalDescription><abstract lang="en">Johansen KK, Jørgensen JV, White LR, Farrer MJ, Aasly JO. Parkinson‐related genetics in patients treated with deep brain stimulation.
Acta Neurol Scand: 2011: 123: 201–206.
© 2010 John Wiley & Sons A/S. Objectives – To analyze the frequency of mutations associated with Parkinson’s disease (PD) in a general PD population compared to patients with PD selected for deep brain stimulation (DBS) and evaluate the outcome of surgery. Material and methods – A total of 630 consecutive patients with PD were genetically screened, and 60 had DBS surgery, 37 subthalamic nucleus (STN), 21 ventrointermediate nucleus of thalamus (VIM), and two globus pallidus internus (GPi). Results – Mutations in LRRK2, PRKN, and PINK1 were found: the first two of these being overrepresented in STN‐operated patients, but none being found in VIM‐operated patients. Clinical outcome of the surgery was similar in patients with mutations compared to those without. Conclusions – In a consecutive PD population, patients treated with STN‐DBS are overrepresented for PD‐related mutations and they seem to benefit from DBS as well as patients without mutations.</abstract><subject lang="en"><genre>Keywords</genre><topic>GPi</topic><topic>LRRK2</topic><topic>p.G2019S</topic><topic>PRKN</topic><topic>PINK1</topic><topic>STN</topic><topic>VIM</topic></subject><relatedItem type="host"><titleInfo><title>Acta Neurologica Scandinavica</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0001-6314</identifier><identifier type="eISSN">1600-0404</identifier><identifier type="DOI">10.1111/(ISSN)1600-0404</identifier><identifier type="PublisherID">ANE</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>123</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>201</start><end>206</end><total>6</total></extent></part></relatedItem><identifier type="istex">5E26C7DB06F8E087DFB47F09C05BC1B4BCDEA71E</identifier><identifier type="DOI">10.1111/j.1600-0404.2010.01387.x</identifier><identifier type="ArticleID">ANE1387</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2010 John Wiley & Sons A/S</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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