Parkinson's disease in Arabs: A systematic review
Identifieur interne : 001040 ( Main/Corpus ); précédent : 001039; suivant : 001041Parkinson's disease in Arabs: A systematic review
Auteurs : Hani T. S. Benamer ; Rajith De Silva ; Khurram A. Siddiqui ; Donald G. GrossetSource :
- Movement Disorders [ 0885-3185 ] ; 2008-07-15.
English descriptors
- KwdEn :
Abstract
Studies of specific populations have provided invaluable knowledge about Parkinson's disease (PD), especially in the field of genetics. The present report systematically reviews the medical literature on PD in Arabs. Medline and Embase were searched, and 24 article were identified: genetic (n = 17), epidemiological (n = 3), and clinical series (n = 5). Both autosomal dominant and recessive forms of inherited PD are described, associated with four genes (Parkin, PINK1, LRRK2, and PARK9). The G2019S LRRK2 mutation is more common in both familial (37–42%) and apparently sporadic PD (41%) in North African Arabs than in Europeans and North Americans (2–3%). The incidence of PD is reported at 4.5 per 100,000 person‐years and reported prevalence at 27 to 43 per 100,000 persons. Hospital‐based clinical series suggest that parkinsonism is the commonest movement disorder. Clinical features of PD in Arabs are not significantly different from those reported elsewhere. PD was reported as the cause of dementia in around 7% of Arabs. The majority of studies relate to the role of genes in the etiology of PD in North African Arabs. Further genetic, epidemiological and clinical studies from the majority of Arabic countries may enhance our understanding of PD. © 2008 Movement Disorder Society.
Url:
DOI: 10.1002/mds.22041
Links to Exploration step
ISTEX:80AD9F4DC2C273C6392C9594BC347FF978675AEELe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Parkinson's disease in Arabs: A systematic review</title><author><name sortKey="Benamer, Hani T S" sort="Benamer, Hani T S" uniqKey="Benamer H" first="Hani T. S." last="Benamer">Hani T. S. Benamer</name><affiliation><mods:affiliation>Department of Neurology, Queen Elizabeth Neuroscience Centre, Queen Elizabeth University Hospital, Birmingham, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="De Silva, Rajith" sort="De Silva, Rajith" uniqKey="De Silva R" first="Rajith" last="De Silva">Rajith De Silva</name><affiliation><mods:affiliation>Department of Neurology, Essex Centre for Neurological Sciences, Queen's Hospital, Romford, Essex, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Siddiqui, Khurram A" sort="Siddiqui, Khurram A" uniqKey="Siddiqui K" first="Khurram A." last="Siddiqui">Khurram A. Siddiqui</name><affiliation><mods:affiliation>Section of Neurology, Neuroscience Center, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia</mods:affiliation></affiliation></author><author><name sortKey="Grosset, Donald G" sort="Grosset, Donald G" uniqKey="Grosset D" first="Donald G." last="Grosset">Donald G. Grosset</name><affiliation><mods:affiliation>Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:80AD9F4DC2C273C6392C9594BC347FF978675AEE</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1002/mds.22041</idno><idno type="url">https://api.istex.fr/document/80AD9F4DC2C273C6392C9594BC347FF978675AEE/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001040</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Parkinson's disease in Arabs: A systematic review</title><author><name sortKey="Benamer, Hani T S" sort="Benamer, Hani T S" uniqKey="Benamer H" first="Hani T. S." last="Benamer">Hani T. S. Benamer</name><affiliation><mods:affiliation>Department of Neurology, Queen Elizabeth Neuroscience Centre, Queen Elizabeth University Hospital, Birmingham, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="De Silva, Rajith" sort="De Silva, Rajith" uniqKey="De Silva R" first="Rajith" last="De Silva">Rajith De Silva</name><affiliation><mods:affiliation>Department of Neurology, Essex Centre for Neurological Sciences, Queen's Hospital, Romford, Essex, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Siddiqui, Khurram A" sort="Siddiqui, Khurram A" uniqKey="Siddiqui K" first="Khurram A." last="Siddiqui">Khurram A. Siddiqui</name><affiliation><mods:affiliation>Section of Neurology, Neuroscience Center, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia</mods:affiliation></affiliation></author><author><name sortKey="Grosset, Donald G" sort="Grosset, Donald G" uniqKey="Grosset D" first="Donald G." last="Grosset">Donald G. Grosset</name><affiliation><mods:affiliation>Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-07-15">2008-07-15</date><biblScope unit="volume">23</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1205">1205</biblScope><biblScope unit="page" to="1210">1210</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">80AD9F4DC2C273C6392C9594BC347FF978675AEE</idno><idno type="DOI">10.1002/mds.22041</idno><idno type="ArticleID">MDS22041</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arabs</term><term>Parkinson's disease</term><term>epidemiology</term><term>genetics</term><term>parkinsonism</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Studies of specific populations have provided invaluable knowledge about Parkinson's disease (PD), especially in the field of genetics. The present report systematically reviews the medical literature on PD in Arabs. Medline and Embase were searched, and 24 article were identified: genetic (n = 17), epidemiological (n = 3), and clinical series (n = 5). Both autosomal dominant and recessive forms of inherited PD are described, associated with four genes (Parkin, PINK1, LRRK2, and PARK9). The G2019S LRRK2 mutation is more common in both familial (37–42%) and apparently sporadic PD (41%) in North African Arabs than in Europeans and North Americans (2–3%). The incidence of PD is reported at 4.5 per 100,000 person‐years and reported prevalence at 27 to 43 per 100,000 persons. Hospital‐based clinical series suggest that parkinsonism is the commonest movement disorder. Clinical features of PD in Arabs are not significantly different from those reported elsewhere. PD was reported as the cause of dementia in around 7% of Arabs. The majority of studies relate to the role of genes in the etiology of PD in North African Arabs. Further genetic, epidemiological and clinical studies from the majority of Arabic countries may enhance our understanding of PD. © 2008 Movement Disorder Society.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Hani T.S. Benamer PhD, FRCP</name><affiliations><json:string>Department of Neurology, Queen Elizabeth Neuroscience Centre, Queen Elizabeth University Hospital, Birmingham, United Kingdom</json:string></affiliations></json:item><json:item><name>Rajith de Silva MD, FRCP</name><affiliations><json:string>Department of Neurology, Essex Centre for Neurological Sciences, Queen's Hospital, Romford, Essex, United Kingdom</json:string></affiliations></json:item><json:item><name>Khurram A. Siddiqui MB, MRCP</name><affiliations><json:string>Section of Neurology, Neuroscience Center, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia</json:string></affiliations></json:item><json:item><name>Donald G. Grosset MD, FRCP</name><affiliations><json:string>Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>parkinsonism</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Arabs</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>genetics</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>epidemiology</value></json:item></subject><articleId><json:string>MDS22041</json:string></articleId><language><json:string>eng</json:string></language><abstract>Studies of specific populations have provided invaluable knowledge about Parkinson's disease (PD), especially in the field of genetics. The present report systematically reviews the medical literature on PD in Arabs. Medline and Embase were searched, and 24 article were identified: genetic (n = 17), epidemiological (n = 3), and clinical series (n = 5). Both autosomal dominant and recessive forms of inherited PD are described, associated with four genes (Parkin, PINK1, LRRK2, and PARK9). The G2019S LRRK2 mutation is more common in both familial (37–42%) and apparently sporadic PD (41%) in North African Arabs than in Europeans and North Americans (2–3%). The incidence of PD is reported at 4.5 per 100,000 person‐years and reported prevalence at 27 to 43 per 100,000 persons. Hospital‐based clinical series suggest that parkinsonism is the commonest movement disorder. Clinical features of PD in Arabs are not significantly different from those reported elsewhere. PD was reported as the cause of dementia in around 7% of Arabs. The majority of studies relate to the role of genes in the etiology of PD in North African Arabs. Further genetic, epidemiological and clinical studies from the majority of Arabic countries may enhance our understanding of PD. © 2008 Movement Disorder Society.</abstract><qualityIndicators><score>5.888</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1295</abstractCharCount><pdfWordCount>3464</pdfWordCount><pdfCharCount>22810</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>202</abstractWordCount></qualityIndicators><title>Parkinson's disease in Arabs: A systematic review</title><genre><json:string>review-article</json:string></genre><host><volume>23</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>6</total><last>1210</last><first>1205</first></pages><issn><json:string>0885-3185</json:string></issn><issue>9</issue><subject><json:item><value>Review</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2008</publicationDate><copyrightDate>2008</copyrightDate><doi><json:string>10.1002/mds.22041</json:string></doi><id>80AD9F4DC2C273C6392C9594BC347FF978675AEE</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/80AD9F4DC2C273C6392C9594BC347FF978675AEE/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/80AD9F4DC2C273C6392C9594BC347FF978675AEE/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/80AD9F4DC2C273C6392C9594BC347FF978675AEE/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Parkinson's disease in Arabs: A systematic review</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2008</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Parkinson's disease in Arabs: A systematic review</title><author><persName><forename type="first">Hani T.S.</forename><surname>Benamer</surname></persName><roleName type="degree">PhD, FRCP</roleName><note type="correspondence"><p>Correspondence: Department of Neurology, Queen Elizabeth Neuroscience Centre, Queen Elizabeth University Hospital, Edgbaston, Birmingham, United Kingdom B15 2TH</p></note><affiliation>Department of Neurology, Queen Elizabeth Neuroscience Centre, Queen Elizabeth University Hospital, Birmingham, United Kingdom</affiliation></author><author><persName><forename type="first">Rajith</forename><surname>de Silva</surname></persName><roleName type="degree">MD, FRCP</roleName><affiliation>Department of Neurology, Essex Centre for Neurological Sciences, Queen's Hospital, Romford, Essex, United Kingdom</affiliation></author><author><persName><forename type="first">Khurram A.</forename><surname>Siddiqui</surname></persName><roleName type="degree">MB, MRCP</roleName><affiliation>Section of Neurology, Neuroscience Center, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia</affiliation></author><author><persName><forename type="first">Donald G.</forename><surname>Grosset</surname></persName><roleName type="degree">MD, FRCP</roleName><affiliation>Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-07-15"></date><biblScope unit="volume">23</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1205">1205</biblScope><biblScope unit="page" to="1210">1210</biblScope></imprint></monogr><idno type="istex">80AD9F4DC2C273C6392C9594BC347FF978675AEE</idno><idno type="DOI">10.1002/mds.22041</idno><idno type="ArticleID">MDS22041</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Studies of specific populations have provided invaluable knowledge about Parkinson's disease (PD), especially in the field of genetics. The present report systematically reviews the medical literature on PD in Arabs. Medline and Embase were searched, and 24 article were identified: genetic (n = 17), epidemiological (n = 3), and clinical series (n = 5). Both autosomal dominant and recessive forms of inherited PD are described, associated with four genes (Parkin, PINK1, LRRK2, and PARK9). The G2019S LRRK2 mutation is more common in both familial (37–42%) and apparently sporadic PD (41%) in North African Arabs than in Europeans and North Americans (2–3%). The incidence of PD is reported at 4.5 per 100,000 person‐years and reported prevalence at 27 to 43 per 100,000 persons. Hospital‐based clinical series suggest that parkinsonism is the commonest movement disorder. Clinical features of PD in Arabs are not significantly different from those reported elsewhere. PD was reported as the cause of dementia in around 7% of Arabs. The majority of studies relate to the role of genes in the etiology of PD in North African Arabs. Further genetic, epidemiological and clinical studies from the majority of Arabic countries may enhance our understanding of PD. © 2008 Movement Disorder Society.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>parkinsonism</term></item><item><term>Arabs</term></item><item><term>genetics</term></item><item><term>epidemiology</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Review</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-10-11">Received</change><change when="2008-02-23">Registration</change><change when="2008-07-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/80AD9F4DC2C273C6392C9594BC347FF978675AEE/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="90"><doi origin="wiley" registered="yes">10.1002/mds.v23:9</doi><numberingGroup><numbering type="journalVolume" number="23">23</numbering><numbering type="journalIssue">9</numbering></numberingGroup><coverDate startDate="2008-07-15">15 July 2008</coverDate></publicationMeta><publicationMeta level="unit" type="reviewArticle" position="10" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22041</doi><idGroup><id type="unit" value="MDS22041"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="articleCategory">Review</title><title type="tocHeading1">Reviews</title></titleGroup><copyright ownership="thirdParty">Copyright © 2008 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2007-10-11"></event><event type="manuscriptRevised" date="2008-02-21"></event><event type="manuscriptAccepted" date="2008-02-23"></event><event type="firstOnline" date="2008-04-28"></event><event type="publishedOnlineFinalForm" date="2008-07-29"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2008-04-28"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.4.7 mode:FullText" date="2011-03-17"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">1205</numbering><numbering type="pageLast">1210</numbering></numberingGroup><correspondenceTo>Department of Neurology, Queen Elizabeth Neuroscience Centre, Queen Elizabeth University Hospital, Edgbaston, Birmingham, United Kingdom B15 2TH</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22041.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="48"></count><count type="wordTotal" number="3952"></count></countGroup><titleGroup><title type="main" xml:lang="en">Parkinson's disease in Arabs: A systematic review</title><title type="short" xml:lang="en">Parkinson's Disease in Arabs</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Hani T.S.</givenNames><familyName>Benamer</familyName><degrees>PhD, FRCP</degrees></personName><contactDetails><email>benamer@doctors.org.uk</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Rajith</givenNames><familyName>de Silva</familyName><degrees>MD, FRCP</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Khurram A.</givenNames><familyName>Siddiqui</familyName><degrees>MB, MRCP</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Donald G.</givenNames><familyName>Grosset</familyName><degrees>MD, FRCP</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="GB" type="organization"><unparsedAffiliation>Department of Neurology, Queen Elizabeth Neuroscience Centre, Queen Elizabeth University Hospital, Birmingham, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="GB" type="organization"><unparsedAffiliation>Department of Neurology, Essex Centre for Neurological Sciences, Queen's Hospital, Romford, Essex, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="SA" type="organization"><unparsedAffiliation>Section of Neurology, Neuroscience Center, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="GB" type="organization"><unparsedAffiliation>Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">parkinsonism</keyword><keyword xml:id="kwd3">Arabs</keyword><keyword xml:id="kwd4">genetics</keyword><keyword xml:id="kwd5">epidemiology</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Studies of specific populations have provided invaluable knowledge about Parkinson's disease (PD), especially in the field of genetics. The present report systematically reviews the medical literature on PD in Arabs. Medline and Embase were searched, and 24 article were identified: genetic (n = 17), epidemiological (n = 3), and clinical series (n = 5). Both autosomal dominant and recessive forms of inherited PD are described, associated with four genes (<i>Parkin, PINK1, LRRK2,</i> and <i>PARK9</i>). The G2019S <i>LRRK2</i> mutation is more common in both familial (37–42%) and apparently sporadic PD (41%) in North African Arabs than in Europeans and North Americans (2–3%). The incidence of PD is reported at 4.5 per 100,000 person‐years and reported prevalence at 27 to 43 per 100,000 persons. Hospital‐based clinical series suggest that parkinsonism is the commonest movement disorder. Clinical features of PD in Arabs are not significantly different from those reported elsewhere. PD was reported as the cause of dementia in around 7% of Arabs. The majority of studies relate to the role of genes in the etiology of PD in North African Arabs. Further genetic, epidemiological and clinical studies from the majority of Arabic countries may enhance our understanding of PD. © 2008 Movement Disorder Society.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Parkinson's disease in Arabs: A systematic review</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Parkinson's Disease in Arabs</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Parkinson's disease in Arabs: A systematic review</title></titleInfo><name type="personal"><namePart type="given">Hani T.S.</namePart><namePart type="family">Benamer</namePart><namePart type="termsOfAddress">PhD, FRCP</namePart><affiliation>Department of Neurology, Queen Elizabeth Neuroscience Centre, Queen Elizabeth University Hospital, Birmingham, United Kingdom</affiliation><description>Correspondence: Department of Neurology, Queen Elizabeth Neuroscience Centre, Queen Elizabeth University Hospital, Edgbaston, Birmingham, United Kingdom B15 2TH</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rajith</namePart><namePart type="family">de Silva</namePart><namePart type="termsOfAddress">MD, FRCP</namePart><affiliation>Department of Neurology, Essex Centre for Neurological Sciences, Queen's Hospital, Romford, Essex, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Khurram A.</namePart><namePart type="family">Siddiqui</namePart><namePart type="termsOfAddress">MB, MRCP</namePart><affiliation>Section of Neurology, Neuroscience Center, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Donald G.</namePart><namePart type="family">Grosset</namePart><namePart type="termsOfAddress">MD, FRCP</namePart><affiliation>Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="reviewArticle"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-07-15</dateIssued><dateCaptured encoding="w3cdtf">2007-10-11</dateCaptured><dateValid encoding="w3cdtf">2008-02-23</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">1</extent><extent unit="references">48</extent><extent unit="words">3952</extent></physicalDescription><abstract lang="en">Studies of specific populations have provided invaluable knowledge about Parkinson's disease (PD), especially in the field of genetics. The present report systematically reviews the medical literature on PD in Arabs. Medline and Embase were searched, and 24 article were identified: genetic (n = 17), epidemiological (n = 3), and clinical series (n = 5). Both autosomal dominant and recessive forms of inherited PD are described, associated with four genes (Parkin, PINK1, LRRK2, and PARK9). The G2019S LRRK2 mutation is more common in both familial (37–42%) and apparently sporadic PD (41%) in North African Arabs than in Europeans and North Americans (2–3%). The incidence of PD is reported at 4.5 per 100,000 person‐years and reported prevalence at 27 to 43 per 100,000 persons. Hospital‐based clinical series suggest that parkinsonism is the commonest movement disorder. Clinical features of PD in Arabs are not significantly different from those reported elsewhere. PD was reported as the cause of dementia in around 7% of Arabs. The majority of studies relate to the role of genes in the etiology of PD in North African Arabs. Further genetic, epidemiological and clinical studies from the majority of Arabic countries may enhance our understanding of PD. © 2008 Movement Disorder Society.</abstract><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>parkinsonism</topic><topic>Arabs</topic><topic>genetics</topic><topic>epidemiology</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Review</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><detail type="issue"><caption>no.</caption><number>9</number></detail><extent unit="pages"><start>1205</start><end>1210</end><total>6</total></extent></part></relatedItem><identifier type="istex">80AD9F4DC2C273C6392C9594BC347FF978675AEE</identifier><identifier type="DOI">10.1002/mds.22041</identifier><identifier type="ArticleID">MDS22041</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001040 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 001040 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:80AD9F4DC2C273C6392C9594BC347FF978675AEE
|texte= Parkinson's disease in Arabs: A systematic review
}}
| This area was generated with Dilib version V0.6.23. |  |