Apolipoprotein E ε4 allele is associated with Parkinson disease risk in a Mexican Mestizo population
Identifieur interne : 000F67 ( Main/Corpus ); précédent : 000F66; suivant : 000F68Apolipoprotein E ε4 allele is associated with Parkinson disease risk in a Mexican Mestizo population
Auteurs : Marisol L Pez ; Jorge Guerrero ; Petra Yescas ; Marie-Catherine Boll ; Itziar Familiar ; Adriana Ochoa ; Astrid Rasmussen ; María Elisa AlonsoSource :
- Movement Disorders [ 0885-3185 ] ; 2007-02-15.
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Abstract
We investigated the association between apolipoprotein E (APOE) alleles and genotypes and Parkinson disease (PD) in 229 unrelated Mexican Mestizo PD patients and 229 controls. Results showed that both APOE‐ε4 allele and APOE ε4/ε3 genotype are associated with PD (OR = 1.736, P = 0.011; OR = 1.688, P = 0.019, respectively). Mean age at onset of PD was not associated to any APOE allele or genotype, but was significantly earlier in familial PD when compared to sporadic cases (P = 0.025). © 2006 Movement Disorder Society
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DOI: 10.1002/mds.21340
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Itziar" sort="Familiar, Itziar" uniqKey="Familiar I" first="Itziar" last="Familiar">Itziar Familiar</name><affiliation><mods:affiliation>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</mods:affiliation></affiliation></author><author><name sortKey="Ochoa, Adriana" sort="Ochoa, Adriana" uniqKey="Ochoa A" first="Adriana" last="Ochoa">Adriana Ochoa</name><affiliation><mods:affiliation>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</mods:affiliation></affiliation></author><author><name sortKey="Rasmussen, Astrid" sort="Rasmussen, Astrid" uniqKey="Rasmussen A" first="Astrid" last="Rasmussen">Astrid Rasmussen</name><affiliation><mods:affiliation>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</mods:affiliation></affiliation></author><author><name sortKey="Alonso, Maria Elisa" sort="Alonso, Maria Elisa" uniqKey="Alonso M" first="María Elisa" last="Alonso">María Elisa Alonso</name><affiliation><mods:affiliation>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-02-15">2007-02-15</date><biblScope unit="volume">22</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="417">417</biblScope><biblScope unit="page" to="420">420</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">1F26F976DA25D22D7F6FA08029AC30197ED4BF7B</idno><idno type="DOI">10.1002/mds.21340</idno><idno type="ArticleID">MDS21340</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson disease</term><term>age at onset</term><term>apolipoprotein E</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated the association between apolipoprotein E (APOE) alleles and genotypes and Parkinson disease (PD) in 229 unrelated Mexican Mestizo PD patients and 229 controls. Results showed that both APOE‐ε4 allele and APOE ε4/ε3 genotype are associated with PD (OR = 1.736, P = 0.011; OR = 1.688, P = 0.019, respectively). Mean age at onset of PD was not associated to any APOE allele or genotype, but was significantly earlier in familial PD when compared to sporadic cases (P = 0.025). © 2006 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Marisol López PhD</name><affiliations><json:string>Department of Biological Systems, Universidad Autónoma Metropolitana Xochimilco, Mexico City, Mexico</json:string></affiliations></json:item><json:item><name>Jorge Guerrero BSc</name><affiliations><json:string>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</json:string></affiliations></json:item><json:item><name>Petra Yescas MSc</name><affiliations><json:string>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</json:string></affiliations></json:item><json:item><name>Marie‐Catherine Boll MD, PhD</name><affiliations><json:string>Division of Neurology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</json:string></affiliations></json:item><json:item><name>Itziar Familiar MD</name><affiliations><json:string>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</json:string></affiliations></json:item><json:item><name>Adriana Ochoa MSc</name><affiliations><json:string>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</json:string></affiliations></json:item><json:item><name>Astrid Rasmussen MD, PhD</name><affiliations><json:string>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</json:string></affiliations></json:item><json:item><name>María Elisa Alonso MD</name><affiliations><json:string>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>apolipoprotein E</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>age at onset</value></json:item></subject><articleId><json:string>MDS21340</json:string></articleId><language><json:string>eng</json:string></language><abstract>We investigated the association between apolipoprotein E (APOE) alleles and genotypes and Parkinson disease (PD) in 229 unrelated Mexican Mestizo PD patients and 229 controls. Results showed that both APOE‐ε4 allele and APOE ε4/ε3 genotype are associated with PD (OR = 1.736, P = 0.011; OR = 1.688, P = 0.019, respectively). Mean age at onset of PD was not associated to any APOE allele or genotype, but was significantly earlier in familial PD when compared to sporadic cases (P = 0.025). © 2006 Movement Disorder Society</abstract><qualityIndicators><score>3.601</score><pdfVersion>1.3</pdfVersion><pdfPageSize>594 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>3</keywordCount><abstractCharCount>522</abstractCharCount><pdfWordCount>2557</pdfWordCount><pdfCharCount>16665</pdfCharCount><pdfPageCount>4</pdfPageCount><abstractWordCount>87</abstractWordCount></qualityIndicators><title>Apolipoprotein E ε4 allele is associated with Parkinson disease risk in a Mexican Mestizo population</title><genre><json:string>article</json:string></genre><host><volume>22</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>3</total><last>420</last><first>417</first></pages><issn><json:string>0885-3185</json:string></issn><issue>3</issue><subject><json:item><value>Brief Report</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2007</publicationDate><copyrightDate>2007</copyrightDate><doi><json:string>10.1002/mds.21340</json:string></doi><id>1F26F976DA25D22D7F6FA08029AC30197ED4BF7B</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/1F26F976DA25D22D7F6FA08029AC30197ED4BF7B/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/1F26F976DA25D22D7F6FA08029AC30197ED4BF7B/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/1F26F976DA25D22D7F6FA08029AC30197ED4BF7B/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Apolipoprotein E ε4 allele is associated with Parkinson disease risk in a Mexican Mestizo population</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2007</date></publicationStmt><notesStmt><note>Consejo Nacional de Ciencia y Tecnología de México - No. CONACYT 6836;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Apolipoprotein E ε4 allele is associated with Parkinson disease risk in a Mexican Mestizo population</title><author><persName><forename type="first">Marisol</forename><surname>López</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Biological Systems, Universidad Autónoma Metropolitana Xochimilco, Mexico City, Mexico</affiliation></author><author><persName><forename type="first">Jorge</forename><surname>Guerrero</surname></persName><roleName type="degree">BSc</roleName><affiliation>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</affiliation></author><author><persName><forename type="first">Petra</forename><surname>Yescas</surname></persName><roleName type="degree">MSc</roleName><affiliation>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</affiliation></author><author><persName><forename type="first">Marie‐Catherine</forename><surname>Boll</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Division of Neurology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</affiliation></author><author><persName><forename type="first">Itziar</forename><surname>Familiar</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</affiliation></author><author><persName><forename type="first">Adriana</forename><surname>Ochoa</surname></persName><roleName type="degree">MSc</roleName><affiliation>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</affiliation></author><author><persName><forename type="first">Astrid</forename><surname>Rasmussen</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</affiliation></author><author><persName><forename type="first">María Elisa</forename><surname>Alonso</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Departamento de Neurogenética, Insurgentes Sur 3877, Colonia La Fama, Tlalpan, 14269 México D.F., Mexico</p></note><affiliation>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. 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Results showed that both APOE‐ε4 allele and APOE ε4/ε3 genotype are associated with PD (OR = 1.736, P = 0.011; OR = 1.688, P = 0.019, respectively). 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corresponding="yes"><personName><givenNames>María Elisa</givenNames><familyName>Alonso</familyName><degrees>MD</degrees></personName><contactDetails><email>elisaav@servidor.unam.mx</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="MX" type="organization"><unparsedAffiliation>Department of Biological Systems, Universidad Autónoma Metropolitana Xochimilco, Mexico City, Mexico</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="MX" type="organization"><unparsedAffiliation>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="MX" type="organization"><unparsedAffiliation>Division of Neurology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson disease</keyword><keyword xml:id="kwd2">apolipoprotein E</keyword><keyword xml:id="kwd3">age at onset</keyword></keywordGroup><fundingInfo><fundingAgency>Consejo Nacional de Ciencia y Tecnología de México</fundingAgency><fundingNumber>CONACYT 6836</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>We investigated the association between apolipoprotein E (<i>APOE</i>) alleles and genotypes and Parkinson disease (PD) in 229 unrelated Mexican Mestizo PD patients and 229 controls. Results showed that both <i>APOE</i>‐ε4 allele and <i>APOE</i> ε4/ε3 genotype are associated with PD (OR = 1.736, <i>P</i> = 0.011; OR = 1.688, <i>P</i> = 0.019, respectively). Mean age at onset of PD was not associated to any <i>APOE</i> allele or genotype, but was significantly earlier in familial PD when compared to sporadic cases (<i>P</i> = 0.025). © 2006 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Apolipoprotein E ε4 allele is associated with Parkinson disease risk in a Mexican Mestizo population</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>APOE and Parkinson Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Apolipoprotein E ε4 allele is associated with Parkinson disease risk in a Mexican Mestizo population</title></titleInfo><name type="personal"><namePart type="given">Marisol</namePart><namePart type="family">López</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Biological Systems, Universidad Autónoma Metropolitana Xochimilco, Mexico City, Mexico</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jorge</namePart><namePart type="family">Guerrero</namePart><namePart type="termsOfAddress">BSc</namePart><affiliation>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Petra</namePart><namePart type="family">Yescas</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marie‐Catherine</namePart><namePart type="family">Boll</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Division of Neurology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Itziar</namePart><namePart type="family">Familiar</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Adriana</namePart><namePart type="family">Ochoa</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Astrid</namePart><namePart type="family">Rasmussen</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">María Elisa</namePart><namePart type="family">Alonso</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico</affiliation><description>Correspondence: Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Departamento de Neurogenética, Insurgentes Sur 3877, Colonia La Fama, Tlalpan, 14269 México D.F., Mexico</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007-02-15</dateIssued><dateCaptured encoding="w3cdtf">2006-10-05</dateCaptured><dateValid encoding="w3cdtf">2006-10-25</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">1</extent><extent unit="references">15</extent><extent unit="words">2109</extent></physicalDescription><abstract lang="en">We investigated the association between apolipoprotein E (APOE) alleles and genotypes and Parkinson disease (PD) in 229 unrelated Mexican Mestizo PD patients and 229 controls. Results showed that both APOE‐ε4 allele and APOE ε4/ε3 genotype are associated with PD (OR = 1.736, P = 0.011; OR = 1.688, P = 0.019, respectively). Mean age at onset of PD was not associated to any APOE allele or genotype, but was significantly earlier in familial PD when compared to sporadic cases (P = 0.025). © 2006 Movement Disorder Society</abstract><note type="funding">Consejo Nacional de Ciencia y Tecnología de México - No. CONACYT 6836; </note><subject lang="en"><genre>Keywords</genre><topic>Parkinson disease</topic><topic>apolipoprotein E</topic><topic>age at onset</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>417</start><end>420</end><total>3</total></extent></part></relatedItem><identifier type="istex">1F26F976DA25D22D7F6FA08029AC30197ED4BF7B</identifier><identifier type="DOI">10.1002/mds.21340</identifier><identifier type="ArticleID">MDS21340</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2006 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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