Striatal dopamine transporter imaging correlates with depressive symptoms and tower of London task performance in Parkinson's disease
Identifieur interne : 000F42 ( Main/Corpus ); précédent : 000F41; suivant : 000F43Striatal dopamine transporter imaging correlates with depressive symptoms and tower of London task performance in Parkinson's disease
Auteurs : Irena Rektorova ; Hana Srovnalova ; Radka Kubikova ; Jiri PrasekSource :
- Movement Disorders [ 0885-3185 ] ; 2008-08-15.
English descriptors
Abstract
We studied whether the 123I‐FP‐CIT uptake in the striatum correlates with depressive symptoms and cognitive performance in patients with Parkinson's disease (PD). Twenty patients with PD without major depression and/or dementia (mean age 61.7 ± 12.7 years) underwent the 123I‐FP‐CIT SPECT. Depressive symptoms and cognitive performance were assessed in the ON state. The ratios of striatal to occipital binding for the entire striatum, putamina, and putamen to the caudate (put/caud) index were calculated in the basal ganglia. The association between neuropsychiatric measures and dopamine transporter (DAT) availability was calculated; multiple regression analysis was used to assess association with age and disease duration. We found significant correlations between Montgomery and Asberg Depression Rating Scale (MARDS) and Tower of London (TOL) task scores and 123I‐FP‐CIT uptake in various striatal ROIs. Multiple regression analysis confirmed the significant relationship between TOL performance and put/caud ratio (P = 0.001) and to age (P = 0.001), and between MADRS and left striatal (P = 0.005) and putaminal DAT availability (P = 0.003). Our pilot study results demonstrate that imaging with 123I‐FP‐CIT SPECT appears to be sensitive for detecting dopaminergic deficit associated with mild depressive symptoms and specific cognitive dysfunction in patients with PD, yet without a current depressive episode and/or dementia. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22158
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Twenty patients with PD without major depression and/or dementia (mean age 61.7 ± 12.7 years) underwent the 123I‐FP‐CIT SPECT. Depressive symptoms and cognitive performance were assessed in the ON state. The ratios of striatal to occipital binding for the entire striatum, putamina, and putamen to the caudate (put/caud) index were calculated in the basal ganglia. The association between neuropsychiatric measures and dopamine transporter (DAT) availability was calculated; multiple regression analysis was used to assess association with age and disease duration. We found significant correlations between Montgomery and Asberg Depression Rating Scale (MARDS) and Tower of London (TOL) task scores and 123I‐FP‐CIT uptake in various striatal ROIs. Multiple regression analysis confirmed the significant relationship between TOL performance and put/caud ratio (P = 0.001) and to age (P = 0.001), and between MADRS and left striatal (P = 0.005) and putaminal DAT availability (P = 0.003). Our pilot study results demonstrate that imaging with 123I‐FP‐CIT SPECT appears to be sensitive for detecting dopaminergic deficit associated with mild depressive symptoms and specific cognitive dysfunction in patients with PD, yet without a current depressive episode and/or dementia. © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Irena Rektorova MD, PhD</name><affiliations><json:string>Movement Disorders Centre, First Department of Neurology, Masaryk University, St. Anne's Teaching Hospital, Brno, Czech Republic</json:string></affiliations></json:item><json:item><name>Hana Srovnalova MD</name><affiliations><json:string>Movement Disorders Centre, First Department of Neurology, Masaryk University, St. Anne's Teaching Hospital, Brno, Czech Republic</json:string></affiliations></json:item><json:item><name>Radka Kubikova</name><affiliations><json:string>Movement Disorders Centre, First Department of Neurology, Masaryk University, St. Anne's Teaching Hospital, Brno, Czech Republic</json:string></affiliations></json:item><json:item><name>Jiri Prasek MD, PhD</name><affiliations><json:string>Department of Nuclear Medicine, Masaryk University, Teaching Hospital Bohunice, Brno, Czech Republic</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>DaT scan</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>depressive</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cognitive</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Tower of London task</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item></subject><articleId><json:string>MDS22158</json:string></articleId><language><json:string>eng</json:string></language><abstract>We studied whether the 123I‐FP‐CIT uptake in the striatum correlates with depressive symptoms and cognitive performance in patients with Parkinson's disease (PD). 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Twenty patients with PD without major depression and/or dementia (mean age 61.7 ± 12.7 years) underwent the 123I‐FP‐CIT SPECT. Depressive symptoms and cognitive performance were assessed in the ON state. The ratios of striatal to occipital binding for the entire striatum, putamina, and putamen to the caudate (put/caud) index were calculated in the basal ganglia. The association between neuropsychiatric measures and dopamine transporter (DAT) availability was calculated; multiple regression analysis was used to assess association with age and disease duration. We found significant correlations between Montgomery and Asberg Depression Rating Scale (MARDS) and Tower of London (TOL) task scores and 123I‐FP‐CIT uptake in various striatal ROIs. Multiple regression analysis confirmed the significant relationship between TOL performance and put/caud ratio (P = 0.001) and to age (P = 0.001), and between MADRS and left striatal (P = 0.005) and putaminal DAT availability (P = 0.003). Our pilot study results demonstrate that imaging with 123I‐FP‐CIT SPECT appears to be sensitive for detecting dopaminergic deficit associated with mild depressive symptoms and specific cognitive dysfunction in patients with PD, yet without a current depressive episode and/or dementia. © 2008 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>DaT scan</term></item><item><term>depressive</term></item><item><term>cognitive</term></item><item><term>Tower of London task</term></item><item><term>Parkinson's disease</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-07-12">Received</change><change when="2008-05-04">Registration</change><change when="2008-08-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/03BB200A22E8AA8FD7F447A017A40A488B458E67/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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Twenty patients with PD without major depression and/or dementia (mean age 61.7 ± 12.7 years) underwent the <sup>123</sup>I‐FP‐CIT SPECT. Depressive symptoms and cognitive performance were assessed in the ON state. The ratios of striatal to occipital binding for the entire striatum, putamina, and putamen to the caudate (put/caud) index were calculated in the basal ganglia. The association between neuropsychiatric measures and dopamine transporter (DAT) availability was calculated; multiple regression analysis was used to assess association with age and disease duration. We found significant correlations between Montgomery and Asberg Depression Rating Scale (MARDS) and Tower of London (TOL) task scores and <sup>123</sup>I‐FP‐CIT uptake in various striatal ROIs. Multiple regression analysis confirmed the significant relationship between TOL performance and put/caud ratio (<i>P</i> = 0.001) and to age (<i>P</i> = 0.001), and between MADRS and left striatal (<i>P</i> = 0.005) and putaminal DAT availability (<i>P</i> = 0.003). Our pilot study results demonstrate that imaging with <sup>123</sup>I‐FP‐CIT SPECT appears to be sensitive for detecting dopaminergic deficit associated with mild depressive symptoms and specific cognitive dysfunction in patients with PD, yet without a current depressive episode and/or dementia. © 2008 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Striatal dopamine transporter imaging correlates with depressive symptoms and tower of London task performance in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Striatal DAT Imaging</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Striatal dopamine transporter imaging correlates with depressive symptoms and tower of London task performance in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Irena</namePart><namePart type="family">Rektorova</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Movement Disorders Centre, First Department of Neurology, Masaryk University, St. Anne's Teaching Hospital, Brno, Czech Republic</affiliation><description>Correspondence: First Department of Neurology, Masaryk University and St Anne's Hospital, Pekarska 53, 656 91, Brno, Czech republic</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hana</namePart><namePart type="family">Srovnalova</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorders Centre, First Department of Neurology, Masaryk University, St. Anne's Teaching Hospital, Brno, Czech Republic</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Radka</namePart><namePart type="family">Kubikova</namePart><affiliation>Movement Disorders Centre, First Department of Neurology, Masaryk University, St. Anne's Teaching Hospital, Brno, Czech Republic</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jiri</namePart><namePart type="family">Prasek</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Nuclear Medicine, Masaryk University, Teaching Hospital Bohunice, Brno, Czech Republic</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-08-15</dateIssued><dateCaptured encoding="w3cdtf">2007-07-12</dateCaptured><dateValid encoding="w3cdtf">2008-05-04</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">4</extent><extent unit="references">68</extent><extent unit="words">5679</extent></physicalDescription><abstract lang="en">We studied whether the 123I‐FP‐CIT uptake in the striatum correlates with depressive symptoms and cognitive performance in patients with Parkinson's disease (PD). Twenty patients with PD without major depression and/or dementia (mean age 61.7 ± 12.7 years) underwent the 123I‐FP‐CIT SPECT. Depressive symptoms and cognitive performance were assessed in the ON state. The ratios of striatal to occipital binding for the entire striatum, putamina, and putamen to the caudate (put/caud) index were calculated in the basal ganglia. The association between neuropsychiatric measures and dopamine transporter (DAT) availability was calculated; multiple regression analysis was used to assess association with age and disease duration. We found significant correlations between Montgomery and Asberg Depression Rating Scale (MARDS) and Tower of London (TOL) task scores and 123I‐FP‐CIT uptake in various striatal ROIs. Multiple regression analysis confirmed the significant relationship between TOL performance and put/caud ratio (P = 0.001) and to age (P = 0.001), and between MADRS and left striatal (P = 0.005) and putaminal DAT availability (P = 0.003). Our pilot study results demonstrate that imaging with 123I‐FP‐CIT SPECT appears to be sensitive for detecting dopaminergic deficit associated with mild depressive symptoms and specific cognitive dysfunction in patients with PD, yet without a current depressive episode and/or dementia. © 2008 Movement Disorder Society</abstract><note type="funding">Czech Ministry of Education - No. #MSD 0021‐622‐404; </note><subject lang="en"><genre>Keywords</genre><topic>DaT scan</topic><topic>depressive</topic><topic>cognitive</topic><topic>Tower of London task</topic><topic>Parkinson's disease</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><detail type="issue"><caption>no.</caption><number>11</number></detail><extent unit="pages"><start>1580</start><end>1587</end><total>8</total></extent></part></relatedItem><identifier type="istex">03BB200A22E8AA8FD7F447A017A40A488B458E67</identifier><identifier type="DOI">10.1002/mds.22158</identifier><identifier type="ArticleID">MDS22158</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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