Apathy may herald cognitive decline and dementia in Parkinson's disease
Identifieur interne : 000F20 ( Main/Corpus ); précédent : 000F19; suivant : 000F21Apathy may herald cognitive decline and dementia in Parkinson's disease
Auteurs : Kathy Dujardin ; Pascal Sockeel ; Marie Delliaux ; Alain Destée ; Luc DefebvreSource :
- Movement Disorders [ 0885-3185 ] ; 2009-12-15.
English descriptors
- KwdEn :
Abstract
Apathy is usually defined as a lack of motivation. It may occur as part of another disorder (notably depression and dementia) or as an isolated syndrome. In Parkinson's disease (PD), apathy is common and several studies have reported an association between this condition and more severe cognitive symptoms, such as executive dysfunction. However, this association has not been thoroughly investigated. The aim of this study (in nondepressed, nondemented PD patients) was to examine whether or not cognitive decline and/or dementia occurred more frequently in apathetic subjects than in nonapathetic subjects. Forty consecutive PD patients participated in the study (20 with apathy and 20 without). None of the subjects were either demented or depressed at the time of study entry. The patients' cognitive functions were extensively assessed twice: at study entry and after an 18‐month follow‐up period. At study entry, the apathetic PD patients had significantly lower global cognitive status and executive function scores than the nonapathetic subjects. After a median period of 18 months, the rate of conversion to dementia was found to be significantly higher in the apathetic group than in the nonapathetic group (8 of 20 and 1 of 20, respectively). Even in nondemented patients, the decrease over time in cognitive performance (mainly executive function but also memory impairment) was significantly greater in apathetic subjects than in nonapathetic subjects. These findings suggest that in nondemented, nondepressed PD patients, apathy may be a predictive factor for dementia and cognitive decline over time. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22843
Links to Exploration step
ISTEX:72DC3784C7CF440CB2CF969B872F9568FB6CF91ALe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Apathy may herald cognitive decline and dementia in Parkinson's disease</title><author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name><affiliation><mods:affiliation>Université Lille Nord de France, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Sockeel, Pascal" sort="Sockeel, Pascal" uniqKey="Sockeel P" first="Pascal" last="Sockeel">Pascal Sockeel</name><affiliation><mods:affiliation>Université Lille Nord de France, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Psychology Department, Villeneuve d'Ascq, France</mods:affiliation></affiliation></author><author><name sortKey="Delliaux, Marie" sort="Delliaux, Marie" uniqKey="Delliaux M" first="Marie" last="Delliaux">Marie Delliaux</name><affiliation><mods:affiliation>Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation><mods:affiliation>Université Lille Nord de France, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><affiliation><mods:affiliation>Université Lille Nord de France, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center, Lille, France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:72DC3784C7CF440CB2CF969B872F9568FB6CF91A</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22843</idno><idno type="url">https://api.istex.fr/document/72DC3784C7CF440CB2CF969B872F9568FB6CF91A/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000F20</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Apathy may herald cognitive decline and dementia in Parkinson's disease</title><author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name><affiliation><mods:affiliation>Université Lille Nord de France, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Sockeel, Pascal" sort="Sockeel, Pascal" uniqKey="Sockeel P" first="Pascal" last="Sockeel">Pascal Sockeel</name><affiliation><mods:affiliation>Université Lille Nord de France, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Psychology Department, Villeneuve d'Ascq, France</mods:affiliation></affiliation></author><author><name sortKey="Delliaux, Marie" sort="Delliaux, Marie" uniqKey="Delliaux M" first="Marie" last="Delliaux">Marie Delliaux</name><affiliation><mods:affiliation>Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation><mods:affiliation>Université Lille Nord de France, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><affiliation><mods:affiliation>Université Lille Nord de France, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center, Lille, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-12-15">2009-12-15</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="page" from="2391">2391</biblScope><biblScope unit="page" to="2397">2397</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">72DC3784C7CF440CB2CF969B872F9568FB6CF91A</idno><idno type="DOI">10.1002/mds.22843</idno><idno type="ArticleID">MDS22843</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>apathy</term><term>basal ganglia</term><term>cognition</term><term>dementia</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Apathy is usually defined as a lack of motivation. It may occur as part of another disorder (notably depression and dementia) or as an isolated syndrome. In Parkinson's disease (PD), apathy is common and several studies have reported an association between this condition and more severe cognitive symptoms, such as executive dysfunction. However, this association has not been thoroughly investigated. The aim of this study (in nondepressed, nondemented PD patients) was to examine whether or not cognitive decline and/or dementia occurred more frequently in apathetic subjects than in nonapathetic subjects. Forty consecutive PD patients participated in the study (20 with apathy and 20 without). None of the subjects were either demented or depressed at the time of study entry. The patients' cognitive functions were extensively assessed twice: at study entry and after an 18‐month follow‐up period. At study entry, the apathetic PD patients had significantly lower global cognitive status and executive function scores than the nonapathetic subjects. After a median period of 18 months, the rate of conversion to dementia was found to be significantly higher in the apathetic group than in the nonapathetic group (8 of 20 and 1 of 20, respectively). Even in nondemented patients, the decrease over time in cognitive performance (mainly executive function but also memory impairment) was significantly greater in apathetic subjects than in nonapathetic subjects. These findings suggest that in nondemented, nondepressed PD patients, apathy may be a predictive factor for dementia and cognitive decline over time. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Kathy Dujardin PhD</name><affiliations><json:string>Université Lille Nord de France, France</json:string><json:string>Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center, Lille, France</json:string></affiliations></json:item><json:item><name>Pascal Sockeel PhD</name><affiliations><json:string>Université Lille Nord de France, France</json:string><json:string>Psychology Department, Villeneuve d'Ascq, France</json:string></affiliations></json:item><json:item><name>Marie Delliaux MPsych</name><affiliations><json:string>Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center, Lille, France</json:string></affiliations></json:item><json:item><name>Alain Destée MD, PhD</name><affiliations><json:string>Université Lille Nord de France, France</json:string><json:string>Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center, Lille, France</json:string></affiliations></json:item><json:item><name>Luc Defebvre MD, PhD</name><affiliations><json:string>Université Lille Nord de France, France</json:string><json:string>Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center, Lille, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>dementia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cognition</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>apathy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>basal ganglia</value></json:item></subject><articleId><json:string>MDS22843</json:string></articleId><language><json:string>eng</json:string></language><abstract>Apathy is usually defined as a lack of motivation. It may occur as part of another disorder (notably depression and dementia) or as an isolated syndrome. In Parkinson's disease (PD), apathy is common and several studies have reported an association between this condition and more severe cognitive symptoms, such as executive dysfunction. However, this association has not been thoroughly investigated. The aim of this study (in nondepressed, nondemented PD patients) was to examine whether or not cognitive decline and/or dementia occurred more frequently in apathetic subjects than in nonapathetic subjects. Forty consecutive PD patients participated in the study (20 with apathy and 20 without). None of the subjects were either demented or depressed at the time of study entry. The patients' cognitive functions were extensively assessed twice: at study entry and after an 18‐month follow‐up period. At study entry, the apathetic PD patients had significantly lower global cognitive status and executive function scores than the nonapathetic subjects. After a median period of 18 months, the rate of conversion to dementia was found to be significantly higher in the apathetic group than in the nonapathetic group (8 of 20 and 1 of 20, respectively). Even in nondemented patients, the decrease over time in cognitive performance (mainly executive function but also memory impairment) was significantly greater in apathetic subjects than in nonapathetic subjects. These findings suggest that in nondemented, nondepressed PD patients, apathy may be a predictive factor for dementia and cognitive decline over time. © 2009 Movement Disorder Society</abstract><qualityIndicators><score>7.18</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1649</abstractCharCount><pdfWordCount>4204</pdfWordCount><pdfCharCount>27100</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>248</abstractWordCount></qualityIndicators><title>Apathy may herald cognitive decline and dementia in Parkinson's disease</title><genre><json:string>article</json:string></genre><host><volume>24</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>7</total><last>2397</last><first>2391</first></pages><issn><json:string>0885-3185</json:string></issn><issue>16</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1002/mds.22843</json:string></doi><id>72DC3784C7CF440CB2CF969B872F9568FB6CF91A</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/72DC3784C7CF440CB2CF969B872F9568FB6CF91A/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/72DC3784C7CF440CB2CF969B872F9568FB6CF91A/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/72DC3784C7CF440CB2CF969B872F9568FB6CF91A/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Apathy may herald cognitive decline and dementia in Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2009</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: Nothing to report.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Apathy may herald cognitive decline and dementia in Parkinson's disease</title><author><persName><forename type="first">Kathy</forename><surname>Dujardin</surname></persName><roleName type="degree">PhD</roleName><note type="correspondence"><p>Correspondence: Neurologie et Pathologie du Mouvement, Neurologie A, Hôpital Salengro, Centre Hospitalier Universitaire, F‐59037 Lille Cedex, France</p></note><affiliation>Université Lille Nord de France, France</affiliation><affiliation>Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center, Lille, France</affiliation></author><author><persName><forename type="first">Pascal</forename><surname>Sockeel</surname></persName><roleName type="degree">PhD</roleName><affiliation>Université Lille Nord de France, France</affiliation><affiliation>Psychology Department, Villeneuve d'Ascq, France</affiliation></author><author><persName><forename type="first">Marie</forename><surname>Delliaux</surname></persName><roleName type="degree">MPsych</roleName><affiliation>Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center, Lille, France</affiliation></author><author><persName><forename type="first">Alain</forename><surname>Destée</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Université Lille Nord de France, France</affiliation><affiliation>Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center, Lille, France</affiliation></author><author><persName><forename type="first">Luc</forename><surname>Defebvre</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Université Lille Nord de France, France</affiliation><affiliation>Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center, Lille, France</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-12-15"></date><biblScope unit="volume">24</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="page" from="2391">2391</biblScope><biblScope unit="page" to="2397">2397</biblScope></imprint></monogr><idno type="istex">72DC3784C7CF440CB2CF969B872F9568FB6CF91A</idno><idno type="DOI">10.1002/mds.22843</idno><idno type="ArticleID">MDS22843</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Apathy is usually defined as a lack of motivation. It may occur as part of another disorder (notably depression and dementia) or as an isolated syndrome. In Parkinson's disease (PD), apathy is common and several studies have reported an association between this condition and more severe cognitive symptoms, such as executive dysfunction. However, this association has not been thoroughly investigated. The aim of this study (in nondepressed, nondemented PD patients) was to examine whether or not cognitive decline and/or dementia occurred more frequently in apathetic subjects than in nonapathetic subjects. Forty consecutive PD patients participated in the study (20 with apathy and 20 without). None of the subjects were either demented or depressed at the time of study entry. The patients' cognitive functions were extensively assessed twice: at study entry and after an 18‐month follow‐up period. At study entry, the apathetic PD patients had significantly lower global cognitive status and executive function scores than the nonapathetic subjects. After a median period of 18 months, the rate of conversion to dementia was found to be significantly higher in the apathetic group than in the nonapathetic group (8 of 20 and 1 of 20, respectively). Even in nondemented patients, the decrease over time in cognitive performance (mainly executive function but also memory impairment) was significantly greater in apathetic subjects than in nonapathetic subjects. These findings suggest that in nondemented, nondepressed PD patients, apathy may be a predictive factor for dementia and cognitive decline over time. © 2009 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>dementia</term></item><item><term>cognition</term></item><item><term>apathy</term></item><item><term>basal ganglia</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-05-22">Received</change><change when="2009-09-19">Registration</change><change when="2009-12-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/72DC3784C7CF440CB2CF969B872F9568FB6CF91A/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="160"><doi origin="wiley" registered="yes">10.1002/mds.v24:16</doi><numberingGroup><numbering type="journalVolume" number="24">24</numbering><numbering type="journalIssue">16</numbering></numberingGroup><coverDate startDate="2009-12-15">15 December 2009</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="120" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22843</doi><idGroup><id type="unit" value="MDS22843"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2009 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2009-05-22"></event><event type="manuscriptAccepted" date="2009-09-19"></event><event type="firstOnline" date="2009-11-11"></event><event type="publishedOnlineFinalForm" date="2009-12-18"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2009-11-11"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.4.7 mode:FullText source:FullText result:FullText" date="2011-02-24"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">2391</numbering><numbering type="pageLast">2397</numbering></numberingGroup><correspondenceTo>Neurologie et Pathologie du Mouvement, Neurologie A, Hôpital Salengro, Centre Hospitalier Universitaire, F‐59037 Lille Cedex, France</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22843.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="36"></count><count type="wordTotal" number="5590"></count></countGroup><titleGroup><title type="main" xml:lang="en">Apathy may herald cognitive decline and dementia in Parkinson's disease<link href="#fn1"></link></title><title type="short" xml:lang="en">Apathy in Parkinson's Disease</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><givenNames>Kathy</givenNames><familyName>Dujardin</familyName><degrees>PhD</degrees></personName><contactDetails><email normalForm="k-dujardin@chru-lille.fr">k‐dujardin@chru‐lille.fr</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1 #af3"><personName><givenNames>Pascal</givenNames><familyName>Sockeel</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Marie</givenNames><familyName>Delliaux</familyName><degrees>MPsych</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Alain</givenNames><familyName>Destée</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Luc</givenNames><familyName>Defebvre</familyName><degrees>MD, PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="FR" type="organization"><unparsedAffiliation>Université Lille Nord de France, France</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="FR" type="organization"><unparsedAffiliation>Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center, Lille, France</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="FR" type="organization"><unparsedAffiliation>Psychology Department, Villeneuve d'Ascq, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">dementia</keyword><keyword xml:id="kwd2">cognition</keyword><keyword xml:id="kwd3">apathy</keyword><keyword xml:id="kwd4">basal ganglia</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Apathy is usually defined as a lack of motivation. It may occur as part of another disorder (notably depression and dementia) or as an isolated syndrome. In Parkinson's disease (PD), apathy is common and several studies have reported an association between this condition and more severe cognitive symptoms, such as executive dysfunction. However, this association has not been thoroughly investigated. The aim of this study (in nondepressed, nondemented PD patients) was to examine whether or not cognitive decline and/or dementia occurred more frequently in apathetic subjects than in nonapathetic subjects. Forty consecutive PD patients participated in the study (20 with apathy and 20 without). None of the subjects were either demented or depressed at the time of study entry. The patients' cognitive functions were extensively assessed twice: at study entry and after an 18‐month follow‐up period. At study entry, the apathetic PD patients had significantly lower global cognitive status and executive function scores than the nonapathetic subjects. After a median period of 18 months, the rate of conversion to dementia was found to be significantly higher in the apathetic group than in the nonapathetic group (8 of 20 and 1 of 20, respectively). Even in nondemented patients, the decrease over time in cognitive performance (mainly executive function but also memory impairment) was significantly greater in apathetic subjects than in nonapathetic subjects. These findings suggest that in nondemented, nondepressed PD patients, apathy may be a predictive factor for dementia and cognitive decline over time. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: Nothing to report.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Apathy may herald cognitive decline and dementia in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Apathy in Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Apathy may herald cognitive decline and dementia in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Kathy</namePart><namePart type="family">Dujardin</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Université Lille Nord de France, France</affiliation><affiliation>Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center, Lille, France</affiliation><description>Correspondence: Neurologie et Pathologie du Mouvement, Neurologie A, Hôpital Salengro, Centre Hospitalier Universitaire, F‐59037 Lille Cedex, France</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pascal</namePart><namePart type="family">Sockeel</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Université Lille Nord de France, France</affiliation><affiliation>Psychology Department, Villeneuve d'Ascq, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marie</namePart><namePart type="family">Delliaux</namePart><namePart type="termsOfAddress">MPsych</namePart><affiliation>Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alain</namePart><namePart type="family">Destée</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Université Lille Nord de France, France</affiliation><affiliation>Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Luc</namePart><namePart type="family">Defebvre</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Université Lille Nord de France, France</affiliation><affiliation>Neurology and Movement Disorders Unit, Faculty of Medicine and University Medical Center, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-12-15</dateIssued><dateCaptured encoding="w3cdtf">2009-05-22</dateCaptured><dateValid encoding="w3cdtf">2009-09-19</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">36</extent><extent unit="words">5590</extent></physicalDescription><abstract lang="en">Apathy is usually defined as a lack of motivation. It may occur as part of another disorder (notably depression and dementia) or as an isolated syndrome. In Parkinson's disease (PD), apathy is common and several studies have reported an association between this condition and more severe cognitive symptoms, such as executive dysfunction. However, this association has not been thoroughly investigated. The aim of this study (in nondepressed, nondemented PD patients) was to examine whether or not cognitive decline and/or dementia occurred more frequently in apathetic subjects than in nonapathetic subjects. Forty consecutive PD patients participated in the study (20 with apathy and 20 without). None of the subjects were either demented or depressed at the time of study entry. The patients' cognitive functions were extensively assessed twice: at study entry and after an 18‐month follow‐up period. At study entry, the apathetic PD patients had significantly lower global cognitive status and executive function scores than the nonapathetic subjects. After a median period of 18 months, the rate of conversion to dementia was found to be significantly higher in the apathetic group than in the nonapathetic group (8 of 20 and 1 of 20, respectively). Even in nondemented patients, the decrease over time in cognitive performance (mainly executive function but also memory impairment) was significantly greater in apathetic subjects than in nonapathetic subjects. These findings suggest that in nondemented, nondepressed PD patients, apathy may be a predictive factor for dementia and cognitive decline over time. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><subject lang="en"><genre>Keywords</genre><topic>dementia</topic><topic>cognition</topic><topic>apathy</topic><topic>basal ganglia</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>16</number></detail><extent unit="pages"><start>2391</start><end>2397</end><total>7</total></extent></part></relatedItem><identifier type="istex">72DC3784C7CF440CB2CF969B872F9568FB6CF91A</identifier><identifier type="DOI">10.1002/mds.22843</identifier><identifier type="ArticleID">MDS22843</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F20 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000F20 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:72DC3784C7CF440CB2CF969B872F9568FB6CF91A
|texte= Apathy may herald cognitive decline and dementia in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |