Depression in mild dementia: associations with diagnosis, APOE genotype and clinical features
Identifieur interne : 000E56 ( Main/Corpus ); précédent : 000E55; suivant : 000E57Depression in mild dementia: associations with diagnosis, APOE genotype and clinical features
Auteurs : Friederike Fritze ; Uwe Ehrt ; Hogne S Nnesyn ; Martin Kurz ; Tibor Hortobágyi ; Sabine Piepenstock Nore ; Clive Ballard ; Dag AarslandSource :
- International Journal of Geriatric Psychiatry [ 0885-6230 ] ; 2011-10.
English descriptors
Abstract
Background: Depression is common in dementia, with important clinical implications. Few studies of depression in dementia with Lewy bodies are available, and the results are inconsistent. Objective: To examine the frequency of depression and its characteristics and correlates, in people with mild dementia. Methods: All referrals for patients with a first time diagnosis of dementia to geriatric and older psychiatry outpatient clinics in the counties of Rogaland and Hordaland in Western Norway from March 2005 to March 2007 were screened for the study. Participants and their caregivers underwent a comprehensive and standardised diagnostic and assessment procedure. The depression subitem of the neuropsychiatric inventory (NPId) and Montgomery and Åsberg depression rating scale (MADRS) were used to estimate depression. Cut‐off scores for any depression were 0/1 (NPId) and 6/7 (MADRS), and for clinically significant depression 3/4 and 14/15, respectively. Results: Two hundered and twenty‐three subjects with dementia participated, of whom 59 and 50% showed symptoms of depression assessed by NPI or MADRS, respectively, and 25 and 16% had clinically significant depression as measured by NPI and MADRS, respectively. Depression was more frequent in dementia with Lewy bodies (DLB) than in Alzheimer's disease (AD; p < 0.05). APOE genotype was available in 153 patients, and in AD, but not in DLB, a general linear model showed that the presence of APOEε4 allele was significantly associated with depression (F = 4.14; p = 0.045). Conclusion: Depression is common even in mild dementia, and more common and severe in DLB compared to AD. Future studies should explore the longitudinal course of depression in DLB, and the neural underpinnings of depression in DLB. Copyright © 2010 John Wiley & Sons, Ltd.
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DOI: 10.1002/gps.2643
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Nnesyn, Hogne" sort="S Nnesyn, Hogne" uniqKey="S Nnesyn H" first="Hogne" last="S Nnesyn">Hogne S Nnesyn</name><affiliation><mods:affiliation>Department of Internal Medicine, Section of Geriatrics, Stavanger University Hospital, Hillevåg, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Kurz, Martin" sort="Kurz, Martin" uniqKey="Kurz M" first="Martin" last="Kurz">Martin Kurz</name><affiliation><mods:affiliation>Clinic for Neurology, Stavanger University Hospital, Hillevåg, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Hortobagyi, Tibor" sort="Hortobagyi, Tibor" uniqKey="Hortobagyi T" first="Tibor" last="Hortobágyi">Tibor Hortobágyi</name><affiliation><mods:affiliation>Department of Clinical Neuroscience, Medical Research Council (MRC) Centre for Neurodegeneration Research, King's College London, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Nore, Sabine Piepenstock" sort="Nore, Sabine Piepenstock" uniqKey="Nore S" first="Sabine Piepenstock" last="Nore">Sabine Piepenstock Nore</name><affiliation><mods:affiliation>Section for Geriatric Medicine, Haraldsplass Hospital, Bergen, Norway</mods:affiliation></affiliation></author><author><name sortKey="Ballard, Clive" sort="Ballard, Clive" uniqKey="Ballard C" first="Clive" last="Ballard">Clive Ballard</name><affiliation><mods:affiliation>Wolfson Centre for Age‐Realted Diseases, King's College London, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name><affiliation><mods:affiliation>Department for Geriatric Psychiatry, Psychiatric Clinic, Stavanger University Hospital, Hillevåg, Stavanger, Norway</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">International Journal of Geriatric Psychiatry</title><title level="j" type="abbrev">Int. 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Psychiatry</title><idno type="ISSN">0885-6230</idno><idno type="eISSN">1099-1166</idno><imprint><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2011-10">2011-10</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1054">1054</biblScope><biblScope unit="page" to="1061">1061</biblScope></imprint><idno type="ISSN">0885-6230</idno></series><idno type="istex">ACD2EF97F29D6586C78ED9317D7C8A65EBA22D6C</idno><idno type="DOI">10.1002/gps.2643</idno><idno type="ArticleID">GPS2643</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-6230</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer's disease</term><term>dementia</term><term>dementia with Lewy bodies</term><term>depression</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Depression is common in dementia, with important clinical implications. Few studies of depression in dementia with Lewy bodies are available, and the results are inconsistent. Objective: To examine the frequency of depression and its characteristics and correlates, in people with mild dementia. Methods: All referrals for patients with a first time diagnosis of dementia to geriatric and older psychiatry outpatient clinics in the counties of Rogaland and Hordaland in Western Norway from March 2005 to March 2007 were screened for the study. Participants and their caregivers underwent a comprehensive and standardised diagnostic and assessment procedure. The depression subitem of the neuropsychiatric inventory (NPId) and Montgomery and Åsberg depression rating scale (MADRS) were used to estimate depression. Cut‐off scores for any depression were 0/1 (NPId) and 6/7 (MADRS), and for clinically significant depression 3/4 and 14/15, respectively. Results: Two hundered and twenty‐three subjects with dementia participated, of whom 59 and 50% showed symptoms of depression assessed by NPI or MADRS, respectively, and 25 and 16% had clinically significant depression as measured by NPI and MADRS, respectively. Depression was more frequent in dementia with Lewy bodies (DLB) than in Alzheimer's disease (AD; p < 0.05). APOE genotype was available in 153 patients, and in AD, but not in DLB, a general linear model showed that the presence of APOEε4 allele was significantly associated with depression (F = 4.14; p = 0.045). Conclusion: Depression is common even in mild dementia, and more common and severe in DLB compared to AD. Future studies should explore the longitudinal course of depression in DLB, and the neural underpinnings of depression in DLB. Copyright © 2010 John Wiley & Sons, Ltd.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Friederike Fritze</name><affiliations><json:string>Department for Geriatric Psychiatry, Psychiatric Clinic, Stavanger University Hospital, Hillevåg, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Uwe Ehrt</name><affiliations><json:string>Department for Geriatric Psychiatry, Psychiatric Clinic, Stavanger University Hospital, Hillevåg, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Hogne Sønnesyn</name><affiliations><json:string>Department of Internal Medicine, Section of Geriatrics, Stavanger University Hospital, Hillevåg, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Martin Kurz</name><affiliations><json:string>Clinic for Neurology, Stavanger University Hospital, Hillevåg, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Tibor Hortobágyi</name><affiliations><json:string>Department of Clinical Neuroscience, Medical Research Council (MRC) Centre for Neurodegeneration Research, King's College London, London, UK</json:string></affiliations></json:item><json:item><name>Sabine Piepenstock Nore</name><affiliations><json:string>Section for Geriatric Medicine, Haraldsplass Hospital, Bergen, Norway</json:string></affiliations></json:item><json:item><name>Clive Ballard</name><affiliations><json:string>Wolfson Centre for Age‐Realted Diseases, King's College London, London, UK</json:string></affiliations></json:item><json:item><name>Dag Aarsland</name><affiliations><json:string>Department for Geriatric Psychiatry, Psychiatric Clinic, Stavanger University Hospital, Hillevåg, Stavanger, Norway</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>dementia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Alzheimer's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dementia with Lewy bodies</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>depression</value></json:item></subject><articleId><json:string>GPS2643</json:string></articleId><language><json:string>eng</json:string></language><abstract>Background: Depression is common in dementia, with important clinical implications. Few studies of depression in dementia with Lewy bodies are available, and the results are inconsistent. Objective: To examine the frequency of depression and its characteristics and correlates, in people with mild dementia. Methods: All referrals for patients with a first time diagnosis of dementia to geriatric and older psychiatry outpatient clinics in the counties of Rogaland and Hordaland in Western Norway from March 2005 to March 2007 were screened for the study. Participants and their caregivers underwent a comprehensive and standardised diagnostic and assessment procedure. The depression subitem of the neuropsychiatric inventory (NPId) and Montgomery and Åsberg depression rating scale (MADRS) were used to estimate depression. Cut‐off scores for any depression were 0/1 (NPId) and 6/7 (MADRS), and for clinically significant depression 3/4 and 14/15, respectively. Results: Two hundered and twenty‐three subjects with dementia participated, of whom 59 and 50% showed symptoms of depression assessed by NPI or MADRS, respectively, and 25 and 16% had clinically significant depression as measured by NPI and MADRS, respectively. Depression was more frequent in dementia with Lewy bodies (DLB) than in Alzheimer's disease (AD; p > 0.05). APOE genotype was available in 153 patients, and in AD, but not in DLB, a general linear model showed that the presence of APOEε4 allele was significantly associated with depression (F = 4.14; p = 0.045). Conclusion: Depression is common even in mild dementia, and more common and severe in DLB compared to AD. Future studies should explore the longitudinal course of depression in DLB, and the neural underpinnings of depression in DLB. Copyright © 2010 John Wiley & Sons, Ltd.</abstract><qualityIndicators><score>8</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595 x 791 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1812</abstractCharCount><pdfWordCount>5294</pdfWordCount><pdfCharCount>34116</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>269</abstractWordCount></qualityIndicators><title>Depression in mild dementia: associations with diagnosis, APOE genotype and clinical features</title><genre><json:string>article</json:string></genre><host><volume>26</volume><publisherId><json:string>GPS</json:string></publisherId><pages><total>8</total><last>1061</last><first>1054</first></pages><issn><json:string>0885-6230</json:string></issn><issue>10</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1099-1166</json:string></eissn><title>International Journal of Geriatric Psychiatry</title><doi><json:string>10.1002/(ISSN)1099-1166</json:string></doi></host><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/gps.2643</json:string></doi><id>ACD2EF97F29D6586C78ED9317D7C8A65EBA22D6C</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/ACD2EF97F29D6586C78ED9317D7C8A65EBA22D6C/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/ACD2EF97F29D6586C78ED9317D7C8A65EBA22D6C/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/ACD2EF97F29D6586C78ED9317D7C8A65EBA22D6C/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Depression in mild dementia: associations with diagnosis, APOE genotype and clinical features</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><availability><p>WILEY</p></availability><date>2011</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Depression in mild dementia: associations with diagnosis, APOE genotype and clinical features</title><author><persName><forename type="first">Friederike</forename><surname>Fritze</surname></persName><note type="correspondence"><p>Correspondence: Department for Geriatric Psychiatry, Psychiatric Clinic, Stavanger University Hospital, Hillevåg, Stavanger, Norway.</p></note><affiliation>Department for Geriatric Psychiatry, Psychiatric Clinic, Stavanger University Hospital, Hillevåg, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Uwe</forename><surname>Ehrt</surname></persName><affiliation>Department for Geriatric Psychiatry, Psychiatric Clinic, Stavanger University Hospital, Hillevåg, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Hogne</forename><surname>Sønnesyn</surname></persName><affiliation>Department of Internal Medicine, Section of Geriatrics, Stavanger University Hospital, Hillevåg, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Martin</forename><surname>Kurz</surname></persName><affiliation>Clinic for Neurology, Stavanger University Hospital, Hillevåg, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Tibor</forename><surname>Hortobágyi</surname></persName><affiliation>Department of Clinical Neuroscience, Medical Research Council (MRC) Centre for Neurodegeneration Research, King's College London, London, UK</affiliation></author><author><persName><forename type="first">Sabine Piepenstock</forename><surname>Nore</surname></persName><affiliation>Section for Geriatric Medicine, Haraldsplass Hospital, Bergen, Norway</affiliation></author><author><persName><forename type="first">Clive</forename><surname>Ballard</surname></persName><affiliation>Wolfson Centre for Age‐Realted Diseases, King's College London, London, UK</affiliation></author><author><persName><forename type="first">Dag</forename><surname>Aarsland</surname></persName><affiliation>Department for Geriatric Psychiatry, Psychiatric Clinic, Stavanger University Hospital, Hillevåg, Stavanger, Norway</affiliation></author></analytic><monogr><title level="j">International Journal of Geriatric Psychiatry</title><title level="j" type="abbrev">Int. J. Geriat. Psychiatry</title><idno type="pISSN">0885-6230</idno><idno type="eISSN">1099-1166</idno><idno type="DOI">10.1002/(ISSN)1099-1166</idno><imprint><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2011-10"></date><biblScope unit="volume">26</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1054">1054</biblScope><biblScope unit="page" to="1061">1061</biblScope></imprint></monogr><idno type="istex">ACD2EF97F29D6586C78ED9317D7C8A65EBA22D6C</idno><idno type="DOI">10.1002/gps.2643</idno><idno type="ArticleID">GPS2643</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background: Depression is common in dementia, with important clinical implications. Few studies of depression in dementia with Lewy bodies are available, and the results are inconsistent. Objective: To examine the frequency of depression and its characteristics and correlates, in people with mild dementia. Methods: All referrals for patients with a first time diagnosis of dementia to geriatric and older psychiatry outpatient clinics in the counties of Rogaland and Hordaland in Western Norway from March 2005 to March 2007 were screened for the study. Participants and their caregivers underwent a comprehensive and standardised diagnostic and assessment procedure. The depression subitem of the neuropsychiatric inventory (NPId) and Montgomery and Åsberg depression rating scale (MADRS) were used to estimate depression. Cut‐off scores for any depression were 0/1 (NPId) and 6/7 (MADRS), and for clinically significant depression 3/4 and 14/15, respectively. Results: Two hundered and twenty‐three subjects with dementia participated, of whom 59 and 50% showed symptoms of depression assessed by NPI or MADRS, respectively, and 25 and 16% had clinically significant depression as measured by NPI and MADRS, respectively. Depression was more frequent in dementia with Lewy bodies (DLB) than in Alzheimer's disease (AD; p < 0.05). APOE genotype was available in 153 patients, and in AD, but not in DLB, a general linear model showed that the presence of APOEε4 allele was significantly associated with depression (F = 4.14; p = 0.045). Conclusion: Depression is common even in mild dementia, and more common and severe in DLB compared to AD. Future studies should explore the longitudinal course of depression in DLB, and the neural underpinnings of depression in DLB. Copyright © 2010 John Wiley & Sons, Ltd.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>dementia</term></item><item><term>Alzheimer's disease</term></item><item><term>dementia with Lewy bodies</term></item><item><term>depression</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-02-20">Received</change><change when="2010-09-03">Registration</change><change when="2011-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/ACD2EF97F29D6586C78ED9317D7C8A65EBA22D6C/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Ltd.</publisherName><publisherLoc>Chichester, UK</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1099-1166</doi><issn type="print">0885-6230</issn><issn type="electronic">1099-1166</issn><idGroup><id type="product" value="GPS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY">International Journal of Geriatric Psychiatry</title><title type="short">Int. 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type="tableTotal" number="2"></count><count type="referenceTotal" number="63"></count></countGroup><titleGroup><title type="main" xml:lang="en">Depression in mild dementia: associations with diagnosis, APOE genotype and clinical features</title><title type="short" xml:lang="en">Depression in mild dementia</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Friederike</givenNames><familyName>Fritze</familyName></personName><contactDetails><email>ffri@sus.no</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Uwe</givenNames><familyName>Ehrt</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Hogne</givenNames><familyName>Sønnesyn</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Martin</givenNames><familyName>Kurz</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Tibor</givenNames><familyName>Hortobágyi</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Sabine Piepenstock</givenNames><familyName>Nore</familyName></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Clive</givenNames><familyName>Ballard</familyName></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Dag</givenNames><familyName>Aarsland</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="NO" type="organization"><unparsedAffiliation>Department for Geriatric Psychiatry, Psychiatric Clinic, Stavanger University Hospital, Hillevåg, Stavanger, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="NO" type="organization"><unparsedAffiliation>Department of Internal Medicine, Section of Geriatrics, Stavanger University Hospital, Hillevåg, Stavanger, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="NO" type="organization"><unparsedAffiliation>Clinic for Neurology, Stavanger University Hospital, Hillevåg, Stavanger, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="GB" type="organization"><unparsedAffiliation>Department of Clinical Neuroscience, Medical Research Council (MRC) Centre for Neurodegeneration Research, King's College London, London, UK</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="NO" type="organization"><unparsedAffiliation>Section for Geriatric Medicine, Haraldsplass Hospital, Bergen, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="GB" type="organization"><unparsedAffiliation>Wolfson Centre for Age‐Realted Diseases, King's College London, London, UK</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">dementia</keyword><keyword xml:id="kwd2">Alzheimer's disease</keyword><keyword xml:id="kwd3">dementia with Lewy bodies</keyword><keyword xml:id="kwd4">depression</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main">Background</title><p>Depression is common in dementia, with important clinical implications. Few studies of depression in dementia with Lewy bodies are available, and the results are inconsistent.</p></section><section xml:id="abs1-2"><title type="main">Objective</title><p>To examine the frequency of depression and its characteristics and correlates, in people with mild dementia.</p></section><section xml:id="abs1-3"><title type="main">Methods</title><p>All referrals for patients with a first time diagnosis of dementia to geriatric and older psychiatry outpatient clinics in the counties of Rogaland and Hordaland in Western Norway from March 2005 to March 2007 were screened for the study. Participants and their caregivers underwent a comprehensive and standardised diagnostic and assessment procedure. The depression subitem of the neuropsychiatric inventory (NPId) and Montgomery and Åsberg depression rating scale (MADRS) were used to estimate depression. Cut‐off scores for any depression were 0/1 (NPId) and 6/7 (MADRS), and for clinically significant depression 3/4 and 14/15, respectively.</p></section><section xml:id="abs1-4"><title type="main">Results</title><p>Two hundered and twenty‐three subjects with dementia participated, of whom 59 and 50% showed symptoms of depression assessed by NPI or MADRS, respectively, and 25 and 16% had clinically significant depression as measured by NPI and MADRS, respectively. Depression was more frequent in dementia with Lewy bodies (DLB) than in Alzheimer's disease (AD; <i>p</i> < 0.05). APOE genotype was available in 153 patients, and in AD, but not in DLB, a general linear model showed that the presence of APOEε4 allele was significantly associated with depression (<i>F</i> = 4.14; <i>p</i> = 0.045).</p></section><section xml:id="abs1-5"><title type="main">Conclusion</title><p>Depression is common even in mild dementia, and more common and severe in DLB compared to AD. Future studies should explore the longitudinal course of depression in DLB, and the neural underpinnings of depression in DLB. Copyright © 2010 John Wiley & Sons, Ltd.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Depression in mild dementia: associations with diagnosis, APOE genotype and clinical features</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Depression in mild dementia</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Depression in mild dementia: associations with diagnosis, APOE genotype and clinical features</title></titleInfo><name type="personal"><namePart type="given">Friederike</namePart><namePart type="family">Fritze</namePart><affiliation>Department for Geriatric Psychiatry, Psychiatric Clinic, Stavanger University Hospital, Hillevåg, Stavanger, Norway</affiliation><description>Correspondence: Department for Geriatric Psychiatry, Psychiatric Clinic, Stavanger University Hospital, Hillevåg, Stavanger, Norway.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Uwe</namePart><namePart type="family">Ehrt</namePart><affiliation>Department for Geriatric Psychiatry, Psychiatric Clinic, Stavanger University Hospital, Hillevåg, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hogne</namePart><namePart type="family">Sønnesyn</namePart><affiliation>Department of Internal Medicine, Section of Geriatrics, Stavanger University Hospital, Hillevåg, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Martin</namePart><namePart type="family">Kurz</namePart><affiliation>Clinic for Neurology, Stavanger University Hospital, Hillevåg, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tibor</namePart><namePart type="family">Hortobágyi</namePart><affiliation>Department of Clinical Neuroscience, Medical Research Council (MRC) Centre for Neurodegeneration Research, King's College London, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sabine Piepenstock</namePart><namePart type="family">Nore</namePart><affiliation>Section for Geriatric Medicine, Haraldsplass Hospital, Bergen, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Clive</namePart><namePart type="family">Ballard</namePart><affiliation>Wolfson Centre for Age‐Realted Diseases, King's College London, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dag</namePart><namePart type="family">Aarsland</namePart><affiliation>Department for Geriatric Psychiatry, Psychiatric Clinic, Stavanger University Hospital, Hillevåg, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>John Wiley & Sons, Ltd.</publisher><place><placeTerm type="text">Chichester, UK</placeTerm></place><dateIssued encoding="w3cdtf">2011-10</dateIssued><dateCaptured encoding="w3cdtf">2010-02-20</dateCaptured><dateValid encoding="w3cdtf">2010-09-03</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">2</extent><extent unit="references">63</extent></physicalDescription><abstract lang="en">Background: Depression is common in dementia, with important clinical implications. Few studies of depression in dementia with Lewy bodies are available, and the results are inconsistent. Objective: To examine the frequency of depression and its characteristics and correlates, in people with mild dementia. Methods: All referrals for patients with a first time diagnosis of dementia to geriatric and older psychiatry outpatient clinics in the counties of Rogaland and Hordaland in Western Norway from March 2005 to March 2007 were screened for the study. Participants and their caregivers underwent a comprehensive and standardised diagnostic and assessment procedure. The depression subitem of the neuropsychiatric inventory (NPId) and Montgomery and Åsberg depression rating scale (MADRS) were used to estimate depression. Cut‐off scores for any depression were 0/1 (NPId) and 6/7 (MADRS), and for clinically significant depression 3/4 and 14/15, respectively. Results: Two hundered and twenty‐three subjects with dementia participated, of whom 59 and 50% showed symptoms of depression assessed by NPI or MADRS, respectively, and 25 and 16% had clinically significant depression as measured by NPI and MADRS, respectively. Depression was more frequent in dementia with Lewy bodies (DLB) than in Alzheimer's disease (AD; p < 0.05). APOE genotype was available in 153 patients, and in AD, but not in DLB, a general linear model showed that the presence of APOEε4 allele was significantly associated with depression (F = 4.14; p = 0.045). Conclusion: Depression is common even in mild dementia, and more common and severe in DLB compared to AD. Future studies should explore the longitudinal course of depression in DLB, and the neural underpinnings of depression in DLB. Copyright © 2010 John Wiley & Sons, Ltd.</abstract><subject lang="en"><genre>Keywords</genre><topic>dementia</topic><topic>Alzheimer's disease</topic><topic>dementia with Lewy bodies</topic><topic>depression</topic></subject><relatedItem type="host"><titleInfo><title>International Journal of Geriatric Psychiatry</title></titleInfo><titleInfo type="abbreviated"><title>Int. J. Geriat. Psychiatry</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-6230</identifier><identifier type="eISSN">1099-1166</identifier><identifier type="DOI">10.1002/(ISSN)1099-1166</identifier><identifier type="PublisherID">GPS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>1054</start><end>1061</end><total>8</total></extent></part></relatedItem><identifier type="istex">ACD2EF97F29D6586C78ED9317D7C8A65EBA22D6C</identifier><identifier type="DOI">10.1002/gps.2643</identifier><identifier type="ArticleID">GPS2643</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 John Wiley & Sons, Ltd.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>John Wiley & Sons, Ltd.</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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