Visualizing receptors for neurotransmitters in the human brain with autoradiography
Identifieur interne : 000E16 ( Main/Corpus ); précédent : 000E15; suivant : 000E17Visualizing receptors for neurotransmitters in the human brain with autoradiography
Auteurs : M. Palacios ; Giorgia Chinaglia ; Alphonse ProbstSource :
- Neurosurgical Review [ 0344-5607 ] ; 1989-03-01.
Abstract
Abstract: Receptors for neurotransmitters and drugs are now well characterized at the molecular level. Thanks to the development of numerous radiolabeled molecules and to the use of autoradiography it is possible to study the characteristics and distribution of these receptors with the anatomical resolution of the microscope. We have used quantitative receptor autoradiography to examine receptors in the human brain and to study receptor alterations in neurodegenerative diseases of the human brain. Alterations in the density and distribution of receptors have been found in diseases such as amyothrophic lateral sclerosis, Huntington's Chorea, Parkinson's disease and Alzheimer's disease. In these diseases different types of receptor alterations have been found. The most characteristic ones are selective receptor losses associated with neuronal losses. Alterations such as receptor hypersensitivity due to degeneration of target areas have also been observed. In some cases no correlations between alterations of the neurotransmitters and receptors have been found. These results indicate that different receptors are associated with specific neuronal systems and could be used as markers for these neuronal populations in different pathological studies. The possibility of visualizing receptors in the living human with noninvasive techniques such as PET could lead to the future use of receptor alterations as a diagnostic tool.
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DOI: 10.1007/BF01787120
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Palacios</name><affiliation><mods:affiliation>Preclinical Research, Sandoz Ltd, CH-4002, Basel, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Chinaglia, Giorgia" sort="Chinaglia, Giorgia" uniqKey="Chinaglia G" first="Giorgia" last="Chinaglia">Giorgia Chinaglia</name><affiliation><mods:affiliation>Preclinical Research, Sandoz Ltd, CH-4002, Basel, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Probst, Alphonse" sort="Probst, Alphonse" uniqKey="Probst A" first="Alphonse" last="Probst">Alphonse Probst</name><affiliation><mods:affiliation>Department of Neuropathology, Institute of Pathology University of Basel, CH-4002, Basel, Switzerland</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3489641DD76D9E95C586FD058B0278EC84AEE42B</idno><date when="1989" year="1989">1989</date><idno type="doi">10.1007/BF01787120</idno><idno type="url">https://api.istex.fr/document/3489641DD76D9E95C586FD058B0278EC84AEE42B/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000E16</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Visualizing receptors for neurotransmitters in the human brain with autoradiography</title><author><name sortKey="Palacios, M" sort="Palacios, M" uniqKey="Palacios M" first="M." last="Palacios">M. Palacios</name><affiliation><mods:affiliation>Preclinical Research, Sandoz Ltd, CH-4002, Basel, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Chinaglia, Giorgia" sort="Chinaglia, Giorgia" uniqKey="Chinaglia G" first="Giorgia" last="Chinaglia">Giorgia Chinaglia</name><affiliation><mods:affiliation>Preclinical Research, Sandoz Ltd, CH-4002, Basel, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Probst, Alphonse" sort="Probst, Alphonse" uniqKey="Probst A" first="Alphonse" last="Probst">Alphonse Probst</name><affiliation><mods:affiliation>Department of Neuropathology, Institute of Pathology University of Basel, CH-4002, Basel, Switzerland</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Neurosurgical Review</title><title level="j" type="abbrev">Neurosurg. 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Thanks to the development of numerous radiolabeled molecules and to the use of autoradiography it is possible to study the characteristics and distribution of these receptors with the anatomical resolution of the microscope. We have used quantitative receptor autoradiography to examine receptors in the human brain and to study receptor alterations in neurodegenerative diseases of the human brain. Alterations in the density and distribution of receptors have been found in diseases such as amyothrophic lateral sclerosis, Huntington's Chorea, Parkinson's disease and Alzheimer's disease. In these diseases different types of receptor alterations have been found. The most characteristic ones are selective receptor losses associated with neuronal losses. Alterations such as receptor hypersensitivity due to degeneration of target areas have also been observed. In some cases no correlations between alterations of the neurotransmitters and receptors have been found. These results indicate that different receptors are associated with specific neuronal systems and could be used as markers for these neuronal populations in different pathological studies. The possibility of visualizing receptors in the living human with noninvasive techniques such as PET could lead to the future use of receptor alterations as a diagnostic tool.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>José M. Palacios</name><affiliations><json:string>Preclinical Research, Sandoz Ltd, CH-4002, Basel, Switzerland</json:string></affiliations></json:item><json:item><name>Giorgia Chinaglia</name><affiliations><json:string>Preclinical Research, Sandoz Ltd, CH-4002, Basel, Switzerland</json:string></affiliations></json:item><json:item><name>Alphonse Probst</name><affiliations><json:string>Department of Neuropathology, Institute of Pathology University of Basel, CH-4002, Basel, Switzerland</json:string></affiliations></json:item></author><articleId><json:string>Art4</json:string><json:string>BF01787120</json:string></articleId><language><json:string>eng</json:string></language><abstract>Abstract: Receptors for neurotransmitters and drugs are now well characterized at the molecular level. Thanks to the development of numerous radiolabeled molecules and to the use of autoradiography it is possible to study the characteristics and distribution of these receptors with the anatomical resolution of the microscope. We have used quantitative receptor autoradiography to examine receptors in the human brain and to study receptor alterations in neurodegenerative diseases of the human brain. Alterations in the density and distribution of receptors have been found in diseases such as amyothrophic lateral sclerosis, Huntington's Chorea, Parkinson's disease and Alzheimer's disease. In these diseases different types of receptor alterations have been found. The most characteristic ones are selective receptor losses associated with neuronal losses. Alterations such as receptor hypersensitivity due to degeneration of target areas have also been observed. In some cases no correlations between alterations of the neurotransmitters and receptors have been found. 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Rev.</title><idno type="JournalID">10143</idno><idno type="pISSN">0344-5607</idno><idno type="eISSN">1437-2320</idno><idno type="IssueArticleCount">20</idno><idno type="VolumeIssueCount">4</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1989-03-01"></date><biblScope unit="volume">12</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="11">11</biblScope><biblScope unit="page" to="20">20</biblScope></imprint></monogr><idno type="istex">3489641DD76D9E95C586FD058B0278EC84AEE42B</idno><idno type="DOI">10.1007/BF01787120</idno><idno type="ArticleID">Art4</idno><idno type="ArticleID">BF01787120</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1989</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Receptors for neurotransmitters and drugs are now well characterized at the molecular level. Thanks to the development of numerous radiolabeled molecules and to the use of autoradiography it is possible to study the characteristics and distribution of these receptors with the anatomical resolution of the microscope. We have used quantitative receptor autoradiography to examine receptors in the human brain and to study receptor alterations in neurodegenerative diseases of the human brain. Alterations in the density and distribution of receptors have been found in diseases such as amyothrophic lateral sclerosis, Huntington's Chorea, Parkinson's disease and Alzheimer's disease. In these diseases different types of receptor alterations have been found. The most characteristic ones are selective receptor losses associated with neuronal losses. Alterations such as receptor hypersensitivity due to degeneration of target areas have also been observed. In some cases no correlations between alterations of the neurotransmitters and receptors have been found. These results indicate that different receptors are associated with specific neuronal systems and could be used as markers for these neuronal populations in different pathological studies. The possibility of visualizing receptors in the living human with noninvasive techniques such as PET could lead to the future use of receptor alterations as a diagnostic tool.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>Medicine & Public Health</head><item><term>Neurosurgery</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1989-03-01">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-3-2">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/3489641DD76D9E95C586FD058B0278EC84AEE42B/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Springer, Publisher found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer-Verlag</PublisherName><PublisherLocation>Berlin/Heidelberg</PublisherLocation></PublisherInfo><Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>10143</JournalID><JournalPrintISSN>0344-5607</JournalPrintISSN><JournalElectronicISSN>1437-2320</JournalElectronicISSN><JournalTitle>Neurosurgical Review</JournalTitle><JournalAbbreviatedTitle>Neurosurg. 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Thanks to the development of numerous radiolabeled molecules and to the use of autoradiography it is possible to study the characteristics and distribution of these receptors with the anatomical resolution of the microscope. We have used quantitative receptor autoradiography to examine receptors in the human brain and to study receptor alterations in neurodegenerative diseases of the human brain.</Para><Para>Alterations in the density and distribution of receptors have been found in diseases such as amyothrophic lateral sclerosis, Huntington's Chorea, Parkinson's disease and Alzheimer's disease. In these diseases different types of receptor alterations have been found. The most characteristic ones are selective receptor losses associated with neuronal losses. Alterations such as receptor hypersensitivity due to degeneration of target areas have also been observed. In some cases no correlations between alterations of the neurotransmitters and receptors have been found. These results indicate that different receptors are associated with specific neuronal systems and could be used as markers for these neuronal populations in different pathological studies. The possibility of visualizing receptors in the living human with noninvasive techniques such as PET could lead to the future use of receptor alterations as a diagnostic tool.</Para></Abstract><KeywordGroup Language="En"><Heading>Keywords</Heading><Keyword>Autoradiography</Keyword><Keyword>human brain</Keyword><Keyword>neurotransmitters</Keyword><Keyword>receptors</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Visualizing receptors for neurotransmitters in the human brain with autoradiography</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Visualizing receptors for neurotransmitters in the human brain with autoradiography</title></titleInfo><name type="personal"><namePart type="given">José</namePart><namePart type="given">M.</namePart><namePart type="family">Palacios</namePart><affiliation>Preclinical Research, Sandoz Ltd, CH-4002, Basel, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giorgia</namePart><namePart type="family">Chinaglia</namePart><affiliation>Preclinical Research, Sandoz Ltd, CH-4002, Basel, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alphonse</namePart><namePart type="family">Probst</namePart><affiliation>Department of Neuropathology, Institute of Pathology University of Basel, CH-4002, Basel, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="ReviewPaper"></genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateIssued encoding="w3cdtf">1989-03-01</dateIssued><copyrightDate encoding="w3cdtf">1989</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Abstract: Receptors for neurotransmitters and drugs are now well characterized at the molecular level. Thanks to the development of numerous radiolabeled molecules and to the use of autoradiography it is possible to study the characteristics and distribution of these receptors with the anatomical resolution of the microscope. We have used quantitative receptor autoradiography to examine receptors in the human brain and to study receptor alterations in neurodegenerative diseases of the human brain. Alterations in the density and distribution of receptors have been found in diseases such as amyothrophic lateral sclerosis, Huntington's Chorea, Parkinson's disease and Alzheimer's disease. In these diseases different types of receptor alterations have been found. The most characteristic ones are selective receptor losses associated with neuronal losses. Alterations such as receptor hypersensitivity due to degeneration of target areas have also been observed. In some cases no correlations between alterations of the neurotransmitters and receptors have been found. These results indicate that different receptors are associated with specific neuronal systems and could be used as markers for these neuronal populations in different pathological studies. The possibility of visualizing receptors in the living human with noninvasive techniques such as PET could lead to the future use of receptor alterations as a diagnostic tool.</abstract><note>Invited articles</note><relatedItem type="host"><titleInfo><title>Neurosurgical Review</title></titleInfo><titleInfo type="abbreviated"><title>Neurosurg. 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