Brain perfusion differences in Parkinsonian disorders
Identifieur interne : 000D99 ( Main/Corpus ); précédent : 000D98; suivant : 000E00Brain perfusion differences in Parkinsonian disorders
Auteurs : Noriyuki Kimura ; Syojirou Hanaki ; Teruaki Masuda ; Takuya Hanaoka ; Yusuke Hazama ; Toshio Okazaki ; Ryuki Arakawa ; Toshihide KumamotoSource :
- Movement Disorders [ 0885-3185 ] ; 2011-12.
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- KwdEn :
Abstract
We aimed to objectively examine the brain perfusion differences between PD, Parkinson variant of multiple system atrophy, and progressive supranuclear palsy. 99mTc ethylcysteinate dimer single‐photon emission CT (SPECT) was performed in 28 patients with PD, 12 with Parkinson variant of multiple system atrophy, 19 with progressive supranuclear palsy, and 17 age‐ and sex‐matched control subjects. A voxel‐by‐voxel group analysis, using statistical parametric mapping 8, was performed to detect the differences of regional cerebral blood flow among three diseases and control groups. Regional cerebral blood flow was measured using the noninvasive Patlak plot method and calculated using a fully automated region of interest technique. Progressive supranuclear palsy showed decreased regional cerebral blood flow in the cingulate gyrus and thalamus, whereas Parkinson variant of multiple system atrophy showed decreased regional cerebral blood flow in the cerebellum, compared with other patients and controls. Regional cerebral blood flow in the thalamus could be used to discriminate progressive supranuclear palsy from other diseases and control subjects with high sensitivity. These findings suggest that parkinsonian disorders, such as PD, Parkinson variant of multiple system atrophy, and progressive supranuclear palsy show a distinct SPECT pattern in the frontal cortex, thalamus, and cerebellum. Moreover, the measurements of regional cerebral blood flow in the thalamus and cerebellum may be helpful in screening for the differential diagnosis of parkinsonian syndrome. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23915
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Takuya" uniqKey="Hanaoka T" first="Takuya" last="Hanaoka">Takuya Hanaoka</name><affiliation><mods:affiliation>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</mods:affiliation></affiliation></author><author><name sortKey="Hazama, Yusuke" sort="Hazama, Yusuke" uniqKey="Hazama Y" first="Yusuke" last="Hazama">Yusuke Hazama</name><affiliation><mods:affiliation>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</mods:affiliation></affiliation></author><author><name sortKey="Okazaki, Toshio" sort="Okazaki, Toshio" uniqKey="Okazaki T" first="Toshio" last="Okazaki">Toshio Okazaki</name><affiliation><mods:affiliation>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</mods:affiliation></affiliation></author><author><name sortKey="Arakawa, Ryuki" sort="Arakawa, Ryuki" uniqKey="Arakawa R" first="Ryuki" last="Arakawa">Ryuki Arakawa</name><affiliation><mods:affiliation>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kumamoto, Toshihide" sort="Kumamoto, Toshihide" uniqKey="Kumamoto T" first="Toshihide" last="Kumamoto">Toshihide Kumamoto</name><affiliation><mods:affiliation>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-12">2011-12</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="2530">2530</biblScope><biblScope unit="page" to="2537">2537</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">8E23D893BE5A9AB37A2192BB335DBCDECFD63617</idno><idno type="DOI">10.1002/mds.23915</idno><idno type="ArticleID">MDS23915</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>FineSRT</term><term>Parkinson variant of multiple system atrophy</term><term>Parkinson's disease</term><term>brain perfusion SPECT</term><term>progressive supranuclear palsy</term><term>statistical parametric mapping 8</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We aimed to objectively examine the brain perfusion differences between PD, Parkinson variant of multiple system atrophy, and progressive supranuclear palsy. 99mTc ethylcysteinate dimer single‐photon emission CT (SPECT) was performed in 28 patients with PD, 12 with Parkinson variant of multiple system atrophy, 19 with progressive supranuclear palsy, and 17 age‐ and sex‐matched control subjects. A voxel‐by‐voxel group analysis, using statistical parametric mapping 8, was performed to detect the differences of regional cerebral blood flow among three diseases and control groups. Regional cerebral blood flow was measured using the noninvasive Patlak plot method and calculated using a fully automated region of interest technique. Progressive supranuclear palsy showed decreased regional cerebral blood flow in the cingulate gyrus and thalamus, whereas Parkinson variant of multiple system atrophy showed decreased regional cerebral blood flow in the cerebellum, compared with other patients and controls. Regional cerebral blood flow in the thalamus could be used to discriminate progressive supranuclear palsy from other diseases and control subjects with high sensitivity. These findings suggest that parkinsonian disorders, such as PD, Parkinson variant of multiple system atrophy, and progressive supranuclear palsy show a distinct SPECT pattern in the frontal cortex, thalamus, and cerebellum. Moreover, the measurements of regional cerebral blood flow in the thalamus and cerebellum may be helpful in screening for the differential diagnosis of parkinsonian syndrome. © 2011 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Noriyuki Kimura</name><affiliations><json:string>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</json:string></affiliations></json:item><json:item><name>Syojirou Hanaki</name><affiliations><json:string>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</json:string></affiliations></json:item><json:item><name>Teruaki Masuda</name><affiliations><json:string>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</json:string></affiliations></json:item><json:item><name>Takuya Hanaoka</name><affiliations><json:string>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</json:string></affiliations></json:item><json:item><name>Yusuke Hazama</name><affiliations><json:string>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</json:string></affiliations></json:item><json:item><name>Toshio Okazaki</name><affiliations><json:string>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</json:string></affiliations></json:item><json:item><name>Ryuki Arakawa</name><affiliations><json:string>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</json:string></affiliations></json:item><json:item><name>Toshihide Kumamoto</name><affiliations><json:string>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson variant of multiple system atrophy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>progressive supranuclear palsy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>brain perfusion SPECT</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>FineSRT</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>statistical parametric mapping 8</value></json:item></subject><articleId><json:string>MDS23915</json:string></articleId><language><json:string>eng</json:string></language><abstract>We aimed to objectively examine the brain perfusion differences between PD, Parkinson variant of multiple system atrophy, and progressive supranuclear palsy. 99mTc ethylcysteinate dimer single‐photon emission CT (SPECT) was performed in 28 patients with PD, 12 with Parkinson variant of multiple system atrophy, 19 with progressive supranuclear palsy, and 17 age‐ and sex‐matched control subjects. A voxel‐by‐voxel group analysis, using statistical parametric mapping 8, was performed to detect the differences of regional cerebral blood flow among three diseases and control groups. Regional cerebral blood flow was measured using the noninvasive Patlak plot method and calculated using a fully automated region of interest technique. Progressive supranuclear palsy showed decreased regional cerebral blood flow in the cingulate gyrus and thalamus, whereas Parkinson variant of multiple system atrophy showed decreased regional cerebral blood flow in the cerebellum, compared with other patients and controls. Regional cerebral blood flow in the thalamus could be used to discriminate progressive supranuclear palsy from other diseases and control subjects with high sensitivity. These findings suggest that parkinsonian disorders, such as PD, Parkinson variant of multiple system atrophy, and progressive supranuclear palsy show a distinct SPECT pattern in the frontal cortex, thalamus, and cerebellum. Moreover, the measurements of regional cerebral blood flow in the thalamus and cerebellum may be helpful in screening for the differential diagnosis of parkinsonian syndrome. © 2011 Movement Disorder Society</abstract><qualityIndicators><score>6.913</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>1612</abstractCharCount><pdfWordCount>4213</pdfWordCount><pdfCharCount>26585</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>225</abstractWordCount></qualityIndicators><title>Brain perfusion differences in Parkinsonian disorders</title><genre><json:string>article</json:string></genre><host><volume>26</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>8</total><last>2537</last><first>2530</first></pages><issn><json:string>0885-3185</json:string></issn><issue>14</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/mds.23915</json:string></doi><id>8E23D893BE5A9AB37A2192BB335DBCDECFD63617</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/8E23D893BE5A9AB37A2192BB335DBCDECFD63617/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/8E23D893BE5A9AB37A2192BB335DBCDECFD63617/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/8E23D893BE5A9AB37A2192BB335DBCDECFD63617/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Brain perfusion differences in Parkinsonian disorders</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2011</date></publicationStmt><notesStmt><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Brain perfusion differences in Parkinsonian disorders</title><author><persName><forename type="first">Noriyuki</forename><surname>Kimura</surname></persName><note type="correspondence"><p>Correspondence: Department of Internal Medicine III, Oita University, Faculty of Medicine, Idaigaoka 1‐1, Hasama, Yufu, Oita 879‐5593, Japan</p></note><affiliation>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</affiliation></author><author><persName><forename type="first">Syojirou</forename><surname>Hanaki</surname></persName><affiliation>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</affiliation></author><author><persName><forename type="first">Teruaki</forename><surname>Masuda</surname></persName><affiliation>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</affiliation></author><author><persName><forename type="first">Takuya</forename><surname>Hanaoka</surname></persName><affiliation>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</affiliation></author><author><persName><forename type="first">Yusuke</forename><surname>Hazama</surname></persName><affiliation>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</affiliation></author><author><persName><forename type="first">Toshio</forename><surname>Okazaki</surname></persName><affiliation>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</affiliation></author><author><persName><forename type="first">Ryuki</forename><surname>Arakawa</surname></persName><affiliation>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</affiliation></author><author><persName><forename type="first">Toshihide</forename><surname>Kumamoto</surname></persName><affiliation>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-12"></date><biblScope unit="volume">26</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="2530">2530</biblScope><biblScope unit="page" to="2537">2537</biblScope></imprint></monogr><idno type="istex">8E23D893BE5A9AB37A2192BB335DBCDECFD63617</idno><idno type="DOI">10.1002/mds.23915</idno><idno type="ArticleID">MDS23915</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We aimed to objectively examine the brain perfusion differences between PD, Parkinson variant of multiple system atrophy, and progressive supranuclear palsy. 99mTc ethylcysteinate dimer single‐photon emission CT (SPECT) was performed in 28 patients with PD, 12 with Parkinson variant of multiple system atrophy, 19 with progressive supranuclear palsy, and 17 age‐ and sex‐matched control subjects. A voxel‐by‐voxel group analysis, using statistical parametric mapping 8, was performed to detect the differences of regional cerebral blood flow among three diseases and control groups. Regional cerebral blood flow was measured using the noninvasive Patlak plot method and calculated using a fully automated region of interest technique. Progressive supranuclear palsy showed decreased regional cerebral blood flow in the cingulate gyrus and thalamus, whereas Parkinson variant of multiple system atrophy showed decreased regional cerebral blood flow in the cerebellum, compared with other patients and controls. Regional cerebral blood flow in the thalamus could be used to discriminate progressive supranuclear palsy from other diseases and control subjects with high sensitivity. These findings suggest that parkinsonian disorders, such as PD, Parkinson variant of multiple system atrophy, and progressive supranuclear palsy show a distinct SPECT pattern in the frontal cortex, thalamus, and cerebellum. Moreover, the measurements of regional cerebral blood flow in the thalamus and cerebellum may be helpful in screening for the differential diagnosis of parkinsonian syndrome. © 2011 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>Parkinson variant of multiple system atrophy</term></item><item><term>progressive supranuclear palsy</term></item><item><term>brain perfusion SPECT</term></item><item><term>FineSRT</term></item><item><term>statistical parametric mapping 8</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2011-02-10">Received</change><change when="2011-07-15">Registration</change><change when="2011-12">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/8E23D893BE5A9AB37A2192BB335DBCDECFD63617/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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affiliationRef="#af1"><personName><givenNames>Syojirou</givenNames><familyName>Hanaki</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Teruaki</givenNames><familyName>Masuda</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Takuya</givenNames><familyName>Hanaoka</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Yusuke</givenNames><familyName>Hazama</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Toshio</givenNames><familyName>Okazaki</familyName></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Ryuki</givenNames><familyName>Arakawa</familyName></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Toshihide</givenNames><familyName>Kumamoto</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="JP" type="organization"><unparsedAffiliation>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">Parkinson variant of multiple system atrophy</keyword><keyword xml:id="kwd3">progressive supranuclear palsy</keyword><keyword xml:id="kwd4">brain perfusion SPECT</keyword><keyword xml:id="kwd5">FineSRT</keyword><keyword xml:id="kwd6">statistical parametric mapping 8</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>We aimed to objectively examine the brain perfusion differences between PD, Parkinson variant of multiple system atrophy, and progressive supranuclear palsy. <sup>99m</sup>Tc ethylcysteinate dimer single‐photon emission CT (SPECT) was performed in 28 patients with PD, 12 with Parkinson variant of multiple system atrophy, 19 with progressive supranuclear palsy, and 17 age‐ and sex‐matched control subjects. A voxel‐by‐voxel group analysis, using statistical parametric mapping 8, was performed to detect the differences of regional cerebral blood flow among three diseases and control groups. Regional cerebral blood flow was measured using the noninvasive Patlak plot method and calculated using a fully automated region of interest technique. Progressive supranuclear palsy showed decreased regional cerebral blood flow in the cingulate gyrus and thalamus, whereas Parkinson variant of multiple system atrophy showed decreased regional cerebral blood flow in the cerebellum, compared with other patients and controls. Regional cerebral blood flow in the thalamus could be used to discriminate progressive supranuclear palsy from other diseases and control subjects with high sensitivity. These findings suggest that parkinsonian disorders, such as PD, Parkinson variant of multiple system atrophy, and progressive supranuclear palsy show a distinct SPECT pattern in the frontal cortex, thalamus, and cerebellum. Moreover, the measurements of regional cerebral blood flow in the thalamus and cerebellum may be helpful in screening for the differential diagnosis of parkinsonian syndrome. © 2011 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p><b>Relevant conflicts of interest/financial disclosures:</b> Nothing to report.</p></note><note xml:id="fn2"><p>Full financial disclosures and author roles may be found in the online version of this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Brain perfusion differences in Parkinsonian disorders</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Brain Perfusion Differences in Parkinsonism</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Brain perfusion differences in Parkinsonian disorders</title></titleInfo><name type="personal"><namePart type="given">Noriyuki</namePart><namePart type="family">Kimura</namePart><affiliation>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</affiliation><description>Correspondence: Department of Internal Medicine III, Oita University, Faculty of Medicine, Idaigaoka 1‐1, Hasama, Yufu, Oita 879‐5593, Japan</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Syojirou</namePart><namePart type="family">Hanaki</namePart><affiliation>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Teruaki</namePart><namePart type="family">Masuda</namePart><affiliation>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Takuya</namePart><namePart type="family">Hanaoka</namePart><affiliation>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yusuke</namePart><namePart type="family">Hazama</namePart><affiliation>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Toshio</namePart><namePart type="family">Okazaki</namePart><affiliation>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ryuki</namePart><namePart type="family">Arakawa</namePart><affiliation>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Toshihide</namePart><namePart type="family">Kumamoto</namePart><affiliation>Department of Internal Medicine III, Oita University, Faculty of Medicine, Oita, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-12</dateIssued><dateCaptured encoding="w3cdtf">2011-02-10</dateCaptured><dateValid encoding="w3cdtf">2011-07-15</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">3</extent><extent unit="references">24</extent><extent unit="words">5967</extent></physicalDescription><abstract lang="en">We aimed to objectively examine the brain perfusion differences between PD, Parkinson variant of multiple system atrophy, and progressive supranuclear palsy. 99mTc ethylcysteinate dimer single‐photon emission CT (SPECT) was performed in 28 patients with PD, 12 with Parkinson variant of multiple system atrophy, 19 with progressive supranuclear palsy, and 17 age‐ and sex‐matched control subjects. A voxel‐by‐voxel group analysis, using statistical parametric mapping 8, was performed to detect the differences of regional cerebral blood flow among three diseases and control groups. Regional cerebral blood flow was measured using the noninvasive Patlak plot method and calculated using a fully automated region of interest technique. Progressive supranuclear palsy showed decreased regional cerebral blood flow in the cingulate gyrus and thalamus, whereas Parkinson variant of multiple system atrophy showed decreased regional cerebral blood flow in the cerebellum, compared with other patients and controls. Regional cerebral blood flow in the thalamus could be used to discriminate progressive supranuclear palsy from other diseases and control subjects with high sensitivity. These findings suggest that parkinsonian disorders, such as PD, Parkinson variant of multiple system atrophy, and progressive supranuclear palsy show a distinct SPECT pattern in the frontal cortex, thalamus, and cerebellum. Moreover, the measurements of regional cerebral blood flow in the thalamus and cerebellum may be helpful in screening for the differential diagnosis of parkinsonian syndrome. © 2011 Movement Disorder Society</abstract><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>Parkinson variant of multiple system atrophy</topic><topic>progressive supranuclear palsy</topic><topic>brain perfusion SPECT</topic><topic>FineSRT</topic><topic>statistical parametric mapping 8</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>14</number></detail><extent unit="pages"><start>2530</start><end>2537</end><total>8</total></extent></part></relatedItem><identifier type="istex">8E23D893BE5A9AB37A2192BB335DBCDECFD63617</identifier><identifier type="DOI">10.1002/mds.23915</identifier><identifier type="ArticleID">MDS23915</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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