Incidence of Parkinson's disease and atypical parkinsonism: Russian population‐based study
Identifieur interne : 000D89 ( Main/Corpus ); précédent : 000D88; suivant : 000D90Incidence of Parkinson's disease and atypical parkinsonism: Russian population‐based study
Auteurs : Yaroslav Winter ; Yury Bezdolnyy ; Elena Katunina ; Gagik Avakjan ; Jens P. Reese ; Jens Klotsche ; Wolfgang H. Oertel ; Richard Dodel ; Eugene GusevSource :
- Movement Disorders [ 0885-3185 ] ; 2010-02-15.
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- KwdEn :
Abstract
Data on the incidence of Parkinson's disease (PD) and atypical parkinsonian syndromes (APS) in East European countries and Asia are limited. The objective of this prospective population‐based study was to determine the incidence of PD and APS in the Russian population. The study area was a large district of Moscow with a population of 1,237,900 inhabitants. Multiple sources of case ascertainment were used to identify incident cases of PD and APS between July 2006 and December 2008. All incident cases were examined by a specialist and followed up prospectively to confirm the diagnosis. The age‐standardized incidence rates per 100,000/year were 9.03 [95% confidence interval (CI) 8.01–10.15] for PD, 0.11 (95% CI 0.03–0.23) for multiple system atrophy, 0.14 (95% CI 0.08–0.21) for progressive supranuclear palsy, and 0.02 (95% CI 0.01–0.12) for corticobasal degeneration. The age‐standardized male‐to‐female ratio of PD was 0.87 for all ages and 1.46 for those aged 60 and older. A high proportion of new cases with PD (34%) and APS (50%) had comorbid depressive symptoms. Given the rapid growth of the elderly population in Eastern Europe and Asia, the epidemiology of PD and APS in these regions should be investigated in greater depth. The incidence of PD in our study was slightly lower than in studies of Western populations and the male‐to‐female ratio was closer to those reported in studies from Asia. The clinical implication of our study is that it highlights the need for better diagnosis and treatment of depression in early stages of PD. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.22966
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Oertel</name><affiliation><mods:affiliation>Department of Neurology, Philipps‐University, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Dodel, Richard" sort="Dodel, Richard" uniqKey="Dodel R" first="Richard" last="Dodel">Richard Dodel</name><affiliation><mods:affiliation>Department of Neurology, Philipps‐University, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Gusev, Eugene" sort="Gusev, Eugene" uniqKey="Gusev E" first="Eugene" last="Gusev">Eugene Gusev</name><affiliation><mods:affiliation>Department of Neurology, Russian Medical State University, Moscow, Russia</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-02-15">2010-02-15</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="349">349</biblScope><biblScope unit="page" to="356">356</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">1AD18BB3AB430D24FD87C985D32D8331DF1766AA</idno><idno type="DOI">10.1002/mds.22966</idno><idno type="ArticleID">MDS22966</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>epidemiology</term><term>incidence</term><term>multiple system atrophy</term><term>progressive supranuclear palsy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Data on the incidence of Parkinson's disease (PD) and atypical parkinsonian syndromes (APS) in East European countries and Asia are limited. The objective of this prospective population‐based study was to determine the incidence of PD and APS in the Russian population. The study area was a large district of Moscow with a population of 1,237,900 inhabitants. Multiple sources of case ascertainment were used to identify incident cases of PD and APS between July 2006 and December 2008. All incident cases were examined by a specialist and followed up prospectively to confirm the diagnosis. The age‐standardized incidence rates per 100,000/year were 9.03 [95% confidence interval (CI) 8.01–10.15] for PD, 0.11 (95% CI 0.03–0.23) for multiple system atrophy, 0.14 (95% CI 0.08–0.21) for progressive supranuclear palsy, and 0.02 (95% CI 0.01–0.12) for corticobasal degeneration. The age‐standardized male‐to‐female ratio of PD was 0.87 for all ages and 1.46 for those aged 60 and older. A high proportion of new cases with PD (34%) and APS (50%) had comorbid depressive symptoms. Given the rapid growth of the elderly population in Eastern Europe and Asia, the epidemiology of PD and APS in these regions should be investigated in greater depth. The incidence of PD in our study was slightly lower than in studies of Western populations and the male‐to‐female ratio was closer to those reported in studies from Asia. The clinical implication of our study is that it highlights the need for better diagnosis and treatment of depression in early stages of PD. © 2010 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Yaroslav Winter MD</name><affiliations><json:string>Department of Neurology, Philipps‐University, Marburg, Germany</json:string></affiliations></json:item><json:item><name>Yury Bezdolnyy MD</name><affiliations><json:string>Department of Neurology, Russian Medical State University, Moscow, Russia</json:string></affiliations></json:item><json:item><name>Elena Katunina MD</name><affiliations><json:string>Department of Neurology, Russian Medical State University, Moscow, Russia</json:string></affiliations></json:item><json:item><name>Gagik Avakjan MD</name><affiliations><json:string>Department of Neurology, Russian Medical State University, Moscow, Russia</json:string></affiliations></json:item><json:item><name>Jens P. Reese MPH, PhD</name><affiliations><json:string>Department of Neurology, Philipps‐University, Marburg, Germany</json:string></affiliations></json:item><json:item><name>Jens Klotsche MSc</name><affiliations><json:string>Institute of Clinical Psychology and Psychotherapy, Technical University Dresden, Dresden, Germany</json:string></affiliations></json:item><json:item><name>Wolfgang H. Oertel MD</name><affiliations><json:string>Department of Neurology, Philipps‐University, Marburg, Germany</json:string></affiliations></json:item><json:item><name>Richard Dodel MD, MPH</name><affiliations><json:string>Department of Neurology, Philipps‐University, Marburg, Germany</json:string></affiliations></json:item><json:item><name>Eugene Gusev MD</name><affiliations><json:string>Department of Neurology, Russian Medical State University, Moscow, Russia</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>progressive supranuclear palsy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>multiple system atrophy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>incidence</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>epidemiology</value></json:item></subject><articleId><json:string>MDS22966</json:string></articleId><language><json:string>eng</json:string></language><abstract>Data on the incidence of Parkinson's disease (PD) and atypical parkinsonian syndromes (APS) in East European countries and Asia are limited. The objective of this prospective population‐based study was to determine the incidence of PD and APS in the Russian population. The study area was a large district of Moscow with a population of 1,237,900 inhabitants. Multiple sources of case ascertainment were used to identify incident cases of PD and APS between July 2006 and December 2008. All incident cases were examined by a specialist and followed up prospectively to confirm the diagnosis. The age‐standardized incidence rates per 100,000/year were 9.03 [95% confidence interval (CI) 8.01–10.15] for PD, 0.11 (95% CI 0.03–0.23) for multiple system atrophy, 0.14 (95% CI 0.08–0.21) for progressive supranuclear palsy, and 0.02 (95% CI 0.01–0.12) for corticobasal degeneration. The age‐standardized male‐to‐female ratio of PD was 0.87 for all ages and 1.46 for those aged 60 and older. A high proportion of new cases with PD (34%) and APS (50%) had comorbid depressive symptoms. Given the rapid growth of the elderly population in Eastern Europe and Asia, the epidemiology of PD and APS in these regions should be investigated in greater depth. The incidence of PD in our study was slightly lower than in studies of Western populations and the male‐to‐female ratio was closer to those reported in studies from Asia. The clinical implication of our study is that it highlights the need for better diagnosis and treatment of depression in early stages of PD. © 2010 Movement Disorder Society</abstract><qualityIndicators><score>7.472</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1589</abstractCharCount><pdfWordCount>4472</pdfWordCount><pdfCharCount>31197</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>253</abstractWordCount></qualityIndicators><title>Incidence of Parkinson's disease and atypical parkinsonism: Russian population‐based study</title><genre><json:string>article</json:string></genre><host><volume>25</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>8</total><last>356</last><first>349</first></pages><issn><json:string>0885-3185</json:string></issn><issue>3</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1002/mds.22966</json:string></doi><id>1AD18BB3AB430D24FD87C985D32D8331DF1766AA</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/1AD18BB3AB430D24FD87C985D32D8331DF1766AA/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/1AD18BB3AB430D24FD87C985D32D8331DF1766AA/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/1AD18BB3AB430D24FD87C985D32D8331DF1766AA/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Incidence of Parkinson's disease and atypical parkinsonism: Russian population‐based study</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2010</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: Nothing to report.</note><note>German Ministry of Education and Health - 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The objective of this prospective population‐based study was to determine the incidence of PD and APS in the Russian population. The study area was a large district of Moscow with a population of 1,237,900 inhabitants. Multiple sources of case ascertainment were used to identify incident cases of PD and APS between July 2006 and December 2008. All incident cases were examined by a specialist and followed up prospectively to confirm the diagnosis. The age‐standardized incidence rates per 100,000/year were 9.03 [95% confidence interval (CI) 8.01–10.15] for PD, 0.11 (95% CI 0.03–0.23) for multiple system atrophy, 0.14 (95% CI 0.08–0.21) for progressive supranuclear palsy, and 0.02 (95% CI 0.01–0.12) for corticobasal degeneration. The age‐standardized male‐to‐female ratio of PD was 0.87 for all ages and 1.46 for those aged 60 and older. A high proportion of new cases with PD (34%) and APS (50%) had comorbid depressive symptoms. Given the rapid growth of the elderly population in Eastern Europe and Asia, the epidemiology of PD and APS in these regions should be investigated in greater depth. The incidence of PD in our study was slightly lower than in studies of Western populations and the male‐to‐female ratio was closer to those reported in studies from Asia. The clinical implication of our study is that it highlights the need for better diagnosis and treatment of depression in early stages of PD. © 2010 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>progressive supranuclear palsy</term></item><item><term>multiple system atrophy</term></item><item><term>incidence</term></item><item><term>epidemiology</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-10-05">Received</change><change when="2009-11-17">Registration</change><change when="2010-02-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/1AD18BB3AB430D24FD87C985D32D8331DF1766AA/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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number="1"></count><count type="tableTotal" number="4"></count><count type="referenceTotal" number="45"></count><count type="wordTotal" number="6990"></count></countGroup><titleGroup><title type="main" xml:lang="en">Incidence of Parkinson's disease and atypical parkinsonism: Russian population‐based study<link href="#fn1"></link></title><title type="short" xml:lang="en">Incidence of Parkinson's Disease in Russia</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Yaroslav</givenNames><familyName>Winter</familyName><degrees>MD</degrees></personName><contactDetails><email normalForm="yaroslav.winter@med.uni-marburg.de">yaroslav.winter@med.uni‐marburg.de</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Yury</givenNames><familyName>Bezdolnyy</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Elena</givenNames><familyName>Katunina</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Gagik</givenNames><familyName>Avakjan</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Jens P.</givenNames><familyName>Reese</familyName><degrees>MPH, PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Jens</givenNames><familyName>Klotsche</familyName><degrees>MSc</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Wolfgang H.</givenNames><familyName>Oertel</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Richard</givenNames><familyName>Dodel</familyName><degrees>MD, MPH</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Eugene</givenNames><familyName>Gusev</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, Philipps‐University, Marburg, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="RU" type="organization"><unparsedAffiliation>Department of Neurology, Russian Medical State University, Moscow, Russia</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="DE" type="organization"><unparsedAffiliation>Institute of Clinical Psychology and Psychotherapy, Technical University Dresden, Dresden, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">progressive supranuclear palsy</keyword><keyword xml:id="kwd3">multiple system atrophy</keyword><keyword xml:id="kwd4">incidence</keyword><keyword xml:id="kwd5">epidemiology</keyword></keywordGroup><fundingInfo><fundingAgency>German Ministry of Education and Health</fundingAgency><fundingNumber>BMBF, 01GI/0401</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Data on the incidence of Parkinson's disease (PD) and atypical parkinsonian syndromes (APS) in East European countries and Asia are limited. The objective of this prospective population‐based study was to determine the incidence of PD and APS in the Russian population. The study area was a large district of Moscow with a population of 1,237,900 inhabitants. Multiple sources of case ascertainment were used to identify incident cases of PD and APS between July 2006 and December 2008. All incident cases were examined by a specialist and followed up prospectively to confirm the diagnosis. The age‐standardized incidence rates per 100,000/year were 9.03 [95% confidence interval (CI) 8.01–10.15] for PD, 0.11 (95% CI 0.03–0.23) for multiple system atrophy, 0.14 (95% CI 0.08–0.21) for progressive supranuclear palsy, and 0.02 (95% CI 0.01–0.12) for corticobasal degeneration. The age‐standardized male‐to‐female ratio of PD was 0.87 for all ages and 1.46 for those aged 60 and older. A high proportion of new cases with PD (34%) and APS (50%) had comorbid depressive symptoms. Given the rapid growth of the elderly population in Eastern Europe and Asia, the epidemiology of PD and APS in these regions should be investigated in greater depth. The incidence of PD in our study was slightly lower than in studies of Western populations and the male‐to‐female ratio was closer to those reported in studies from Asia. The clinical implication of our study is that it highlights the need for better diagnosis and treatment of depression in early stages of PD. © 2010 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: Nothing to report.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Incidence of Parkinson's disease and atypical parkinsonism: Russian population‐based study</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Incidence of Parkinson's Disease in Russia</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Incidence of Parkinson's disease and atypical parkinsonism: Russian population‐based study</title></titleInfo><name type="personal"><namePart type="given">Yaroslav</namePart><namePart type="family">Winter</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Philipps‐University, Marburg, Germany</affiliation><description>Correspondence: Department of Neurology, Philipps‐University Marburg, Rudolf‐Bultmannstr. 8, 35039 Marburg, Germany===</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yury</namePart><namePart type="family">Bezdolnyy</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Russian Medical State University, Moscow, Russia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elena</namePart><namePart type="family">Katunina</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Russian Medical State University, Moscow, Russia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gagik</namePart><namePart type="family">Avakjan</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Russian Medical State University, Moscow, Russia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jens P.</namePart><namePart type="family">Reese</namePart><namePart type="termsOfAddress">MPH, PhD</namePart><affiliation>Department of Neurology, Philipps‐University, Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jens</namePart><namePart type="family">Klotsche</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Institute of Clinical Psychology and Psychotherapy, Technical University Dresden, Dresden, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wolfgang H.</namePart><namePart type="family">Oertel</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Philipps‐University, Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Richard</namePart><namePart type="family">Dodel</namePart><namePart type="termsOfAddress">MD, MPH</namePart><affiliation>Department of Neurology, Philipps‐University, Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eugene</namePart><namePart type="family">Gusev</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Russian Medical State University, Moscow, Russia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-02-15</dateIssued><dateCaptured encoding="w3cdtf">2009-10-05</dateCaptured><dateValid encoding="w3cdtf">2009-11-17</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">4</extent><extent unit="references">45</extent><extent unit="words">6990</extent></physicalDescription><abstract lang="en">Data on the incidence of Parkinson's disease (PD) and atypical parkinsonian syndromes (APS) in East European countries and Asia are limited. The objective of this prospective population‐based study was to determine the incidence of PD and APS in the Russian population. The study area was a large district of Moscow with a population of 1,237,900 inhabitants. Multiple sources of case ascertainment were used to identify incident cases of PD and APS between July 2006 and December 2008. All incident cases were examined by a specialist and followed up prospectively to confirm the diagnosis. The age‐standardized incidence rates per 100,000/year were 9.03 [95% confidence interval (CI) 8.01–10.15] for PD, 0.11 (95% CI 0.03–0.23) for multiple system atrophy, 0.14 (95% CI 0.08–0.21) for progressive supranuclear palsy, and 0.02 (95% CI 0.01–0.12) for corticobasal degeneration. The age‐standardized male‐to‐female ratio of PD was 0.87 for all ages and 1.46 for those aged 60 and older. A high proportion of new cases with PD (34%) and APS (50%) had comorbid depressive symptoms. Given the rapid growth of the elderly population in Eastern Europe and Asia, the epidemiology of PD and APS in these regions should be investigated in greater depth. The incidence of PD in our study was slightly lower than in studies of Western populations and the male‐to‐female ratio was closer to those reported in studies from Asia. The clinical implication of our study is that it highlights the need for better diagnosis and treatment of depression in early stages of PD. © 2010 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><note type="funding">German Ministry of Education and Health - No. BMBF, 01GI/0401; </note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>progressive supranuclear palsy</topic><topic>multiple system atrophy</topic><topic>incidence</topic><topic>epidemiology</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>349</start><end>356</end><total>8</total></extent></part></relatedItem><identifier type="istex">1AD18BB3AB430D24FD87C985D32D8331DF1766AA</identifier><identifier type="DOI">10.1002/mds.22966</identifier><identifier type="ArticleID">MDS22966</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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