Is impact of fatigue an independent factor associated with physical activity in patients with idiopathic Parkinson's disease?
Identifieur interne : 000C86 ( Main/Corpus ); précédent : 000C85; suivant : 000C87Is impact of fatigue an independent factor associated with physical activity in patients with idiopathic Parkinson's disease?
Auteurs : Roy Elbers ; Erwin E. H. Van Wegen ; Lynn Rochester ; Victoria Hetherington ; Alice Nieuwboer ; Anne-Marie Willems ; Diana Jones ; Gert KwakkelSource :
- Movement Disorders [ 0885-3185 ] ; 2009-07-30.
English descriptors
Abstract
To investigate the longitudinal association between fatigue and physical activity in Parkinson's disease (PD) and determine whether this association is distorted by potential confounders. Data from baseline, 3, 6, and 12 week assessments in a single blind randomized clinical trial with cross‐over design were used (N = 153). The Multidimensional Fatigue Inventory (MFI) was used to assess fatigue and an activity monitor to measure amount of physical activity (defined as % dynamic activity during each monitoring session). Time‐independent and time‐dependent factors were investigated for their possible univariate association with dynamic activity. Random coefficient analysis was applied. Candidate confounders were successively added to the longitudinal association model to determine if the association between dynamic activity and fatigue was distorted. A proportional change beyond 15% was considered to be significant. Fatigue was significantly associated with physical activity (β = −0.099, SE = 0.032, P = 0.002). This association was not significantly distorted by type of intervention, age, gender, social support, disease duration, disease severity, motor impairment, cognition, anxiety, or medication intake. Depression caused proportional change of 22.2% in the regression coefficient of MFI. After controlling for depression, a significant association between MFI and dynamic activity remained (β = −0.121, SE = 0.036, P = 0.000). The association found between fatigue and dynamic activity suggests that patients who experience higher levels of fatigue are less physically active. However, the total explained variance of dynamic activity by fatigue alone was small, suggesting that fatigue is only a minor factor in the complex of behavioral aspects that affect the amount of physical activity in patients with PD. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22664
Links to Exploration step
ISTEX:F8F19BB7BE1F264E8967E854AC1DBC357B98DB98Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Is impact of fatigue an independent factor associated with physical activity in patients with idiopathic Parkinson's disease?</title><author><name sortKey="Elbers, Roy" sort="Elbers, Roy" uniqKey="Elbers R" first="Roy" last="Elbers">Roy Elbers</name><affiliation><mods:affiliation>University of Applied Sciences Leiden, Department of Physiotherapy, Leiden, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Van Wegen, Erwin E H" sort="Van Wegen, Erwin E H" uniqKey="Van Wegen E" first="Erwin E. H." last="Van Wegen">Erwin E. H. Van Wegen</name><affiliation><mods:affiliation>VU University Medical Center, Research Institute MOVE, Department of Rehabilitation Medicine, Amsterdam, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Rochester, Lynn" sort="Rochester, Lynn" uniqKey="Rochester L" first="Lynn" last="Rochester">Lynn Rochester</name><affiliation><mods:affiliation>Newcastle University, Clinical Ageing Research Unit, Newcastle upon Tyne, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Hetherington, Victoria" sort="Hetherington, Victoria" uniqKey="Hetherington V" first="Victoria" last="Hetherington">Victoria Hetherington</name><affiliation><mods:affiliation>St. Nicholas Hospital, Dementias and Neurodegenerative Diseases Research Network, Newcastle upon Tyne, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Nieuwboer, Alice" sort="Nieuwboer, Alice" uniqKey="Nieuwboer A" first="Alice" last="Nieuwboer">Alice Nieuwboer</name><affiliation><mods:affiliation>Katholieke Universiteit, Department of Rehabilitation Sciences, Leuven, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Willems, Anne Arie" sort="Willems, Anne Arie" uniqKey="Willems A" first="Anne-Marie" last="Willems">Anne-Marie Willems</name><affiliation><mods:affiliation>Katholieke Universiteit, Department of Rehabilitation Sciences, Leuven, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Jones, Diana" sort="Jones, Diana" uniqKey="Jones D" first="Diana" last="Jones">Diana Jones</name><affiliation><mods:affiliation>Northumbria University, School of Health, Community & Education Studies, Newcastle, Newcastle upon Tyne, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Kwakkel, Gert" sort="Kwakkel, Gert" uniqKey="Kwakkel G" first="Gert" last="Kwakkel">Gert Kwakkel</name><affiliation><mods:affiliation>VU University Medical Center, Research Institute MOVE, Department of Rehabilitation Medicine, Amsterdam, The Netherlands</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F8F19BB7BE1F264E8967E854AC1DBC357B98DB98</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22664</idno><idno type="url">https://api.istex.fr/document/F8F19BB7BE1F264E8967E854AC1DBC357B98DB98/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000C86</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Is impact of fatigue an independent factor associated with physical activity in patients with idiopathic Parkinson's disease?</title><author><name sortKey="Elbers, Roy" sort="Elbers, Roy" uniqKey="Elbers R" first="Roy" last="Elbers">Roy Elbers</name><affiliation><mods:affiliation>University of Applied Sciences Leiden, Department of Physiotherapy, Leiden, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Van Wegen, Erwin E H" sort="Van Wegen, Erwin E H" uniqKey="Van Wegen E" first="Erwin E. H." last="Van Wegen">Erwin E. H. Van Wegen</name><affiliation><mods:affiliation>VU University Medical Center, Research Institute MOVE, Department of Rehabilitation Medicine, Amsterdam, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Rochester, Lynn" sort="Rochester, Lynn" uniqKey="Rochester L" first="Lynn" last="Rochester">Lynn Rochester</name><affiliation><mods:affiliation>Newcastle University, Clinical Ageing Research Unit, Newcastle upon Tyne, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Hetherington, Victoria" sort="Hetherington, Victoria" uniqKey="Hetherington V" first="Victoria" last="Hetherington">Victoria Hetherington</name><affiliation><mods:affiliation>St. Nicholas Hospital, Dementias and Neurodegenerative Diseases Research Network, Newcastle upon Tyne, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Nieuwboer, Alice" sort="Nieuwboer, Alice" uniqKey="Nieuwboer A" first="Alice" last="Nieuwboer">Alice Nieuwboer</name><affiliation><mods:affiliation>Katholieke Universiteit, Department of Rehabilitation Sciences, Leuven, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Willems, Anne Arie" sort="Willems, Anne Arie" uniqKey="Willems A" first="Anne-Marie" last="Willems">Anne-Marie Willems</name><affiliation><mods:affiliation>Katholieke Universiteit, Department of Rehabilitation Sciences, Leuven, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Jones, Diana" sort="Jones, Diana" uniqKey="Jones D" first="Diana" last="Jones">Diana Jones</name><affiliation><mods:affiliation>Northumbria University, School of Health, Community & Education Studies, Newcastle, Newcastle upon Tyne, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Kwakkel, Gert" sort="Kwakkel, Gert" uniqKey="Kwakkel G" first="Gert" last="Kwakkel">Gert Kwakkel</name><affiliation><mods:affiliation>VU University Medical Center, Research Institute MOVE, Department of Rehabilitation Medicine, Amsterdam, The Netherlands</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-07-30">2009-07-30</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1512">1512</biblScope><biblScope unit="page" to="1518">1518</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">F8F19BB7BE1F264E8967E854AC1DBC357B98DB98</idno><idno type="DOI">10.1002/mds.22664</idno><idno type="ArticleID">MDS22664</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>activity monitoring</term><term>fatigue</term><term>physical activity</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate the longitudinal association between fatigue and physical activity in Parkinson's disease (PD) and determine whether this association is distorted by potential confounders. Data from baseline, 3, 6, and 12 week assessments in a single blind randomized clinical trial with cross‐over design were used (N = 153). The Multidimensional Fatigue Inventory (MFI) was used to assess fatigue and an activity monitor to measure amount of physical activity (defined as % dynamic activity during each monitoring session). Time‐independent and time‐dependent factors were investigated for their possible univariate association with dynamic activity. Random coefficient analysis was applied. Candidate confounders were successively added to the longitudinal association model to determine if the association between dynamic activity and fatigue was distorted. A proportional change beyond 15% was considered to be significant. Fatigue was significantly associated with physical activity (β = −0.099, SE = 0.032, P = 0.002). This association was not significantly distorted by type of intervention, age, gender, social support, disease duration, disease severity, motor impairment, cognition, anxiety, or medication intake. Depression caused proportional change of 22.2% in the regression coefficient of MFI. After controlling for depression, a significant association between MFI and dynamic activity remained (β = −0.121, SE = 0.036, P = 0.000). The association found between fatigue and dynamic activity suggests that patients who experience higher levels of fatigue are less physically active. However, the total explained variance of dynamic activity by fatigue alone was small, suggesting that fatigue is only a minor factor in the complex of behavioral aspects that affect the amount of physical activity in patients with PD. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Roy Elbers MSc</name><affiliations><json:string>University of Applied Sciences Leiden, Department of Physiotherapy, Leiden, The Netherlands</json:string></affiliations></json:item><json:item><name>Erwin E.H. van Wegen PhD</name><affiliations><json:string>VU University Medical Center, Research Institute MOVE, Department of Rehabilitation Medicine, Amsterdam, The Netherlands</json:string></affiliations></json:item><json:item><name>Lynn Rochester PhD</name><affiliations><json:string>Newcastle University, Clinical Ageing Research Unit, Newcastle upon Tyne, United Kingdom</json:string></affiliations></json:item><json:item><name>Victoria Hetherington MPhil</name><affiliations><json:string>St. Nicholas Hospital, Dementias and Neurodegenerative Diseases Research Network, Newcastle upon Tyne, United Kingdom</json:string></affiliations></json:item><json:item><name>Alice Nieuwboer PhD</name><affiliations><json:string>Katholieke Universiteit, Department of Rehabilitation Sciences, Leuven, Belgium</json:string></affiliations></json:item><json:item><name>Anne‐Marie Willems PhD</name><affiliations><json:string>Katholieke Universiteit, Department of Rehabilitation Sciences, Leuven, Belgium</json:string></affiliations></json:item><json:item><name>Diana Jones PhD</name><affiliations><json:string>Northumbria University, School of Health, Community & Education Studies, Newcastle, Newcastle upon Tyne, United Kingdom</json:string></affiliations></json:item><json:item><name>Gert Kwakkel PhD</name><affiliations><json:string>VU University Medical Center, Research Institute MOVE, Department of Rehabilitation Medicine, Amsterdam, The Netherlands</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>fatigue</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>physical activity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>activity monitoring</value></json:item></subject><articleId><json:string>MDS22664</json:string></articleId><language><json:string>eng</json:string></language><abstract>To investigate the longitudinal association between fatigue and physical activity in Parkinson's disease (PD) and determine whether this association is distorted by potential confounders. Data from baseline, 3, 6, and 12 week assessments in a single blind randomized clinical trial with cross‐over design were used (N = 153). The Multidimensional Fatigue Inventory (MFI) was used to assess fatigue and an activity monitor to measure amount of physical activity (defined as % dynamic activity during each monitoring session). Time‐independent and time‐dependent factors were investigated for their possible univariate association with dynamic activity. Random coefficient analysis was applied. Candidate confounders were successively added to the longitudinal association model to determine if the association between dynamic activity and fatigue was distorted. A proportional change beyond 15% was considered to be significant. Fatigue was significantly associated with physical activity (β = −0.099, SE = 0.032, P = 0.002). This association was not significantly distorted by type of intervention, age, gender, social support, disease duration, disease severity, motor impairment, cognition, anxiety, or medication intake. Depression caused proportional change of 22.2% in the regression coefficient of MFI. After controlling for depression, a significant association between MFI and dynamic activity remained (β = −0.121, SE = 0.036, P = 0.000). The association found between fatigue and dynamic activity suggests that patients who experience higher levels of fatigue are less physically active. However, the total explained variance of dynamic activity by fatigue alone was small, suggesting that fatigue is only a minor factor in the complex of behavioral aspects that affect the amount of physical activity in patients with PD. © 2009 Movement Disorder Society</abstract><qualityIndicators><score>7.288</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1865</abstractCharCount><pdfWordCount>4288</pdfWordCount><pdfCharCount>29366</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>267</abstractWordCount></qualityIndicators><title>Is impact of fatigue an independent factor associated with physical activity in patients with idiopathic Parkinson's disease?</title><genre><json:string>article</json:string></genre><host><volume>24</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>7</total><last>1518</last><first>1512</first></pages><issn><json:string>0885-3185</json:string></issn><issue>10</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1002/mds.22664</json:string></doi><id>F8F19BB7BE1F264E8967E854AC1DBC357B98DB98</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/F8F19BB7BE1F264E8967E854AC1DBC357B98DB98/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/F8F19BB7BE1F264E8967E854AC1DBC357B98DB98/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/F8F19BB7BE1F264E8967E854AC1DBC357B98DB98/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Is impact of fatigue an independent factor associated with physical activity in patients with idiopathic Parkinson's disease?</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2009</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: Nothing to report.</note><note>European Commission - No. QLK6‐CT‐2001‐00120;</note><note>Rehabilitation in Parkinson's Disease: Strategies for Cueing</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Is impact of fatigue an independent factor associated with physical activity in patients with idiopathic Parkinson's disease?</title><author><persName><forename type="first">Roy</forename><surname>Elbers</surname></persName><roleName type="degree">MSc</roleName><affiliation>University of Applied Sciences Leiden, Department of Physiotherapy, Leiden, The Netherlands</affiliation></author><author><persName><forename type="first">Erwin E.H.</forename><surname>van Wegen</surname></persName><roleName type="degree">PhD</roleName><note type="correspondence"><p>Correspondence: Department of Rehabilitation Medicine, VU University Medical Center, de Boelelaan 1117, 1081 HV Amsterdam, PO BOX 7057, 1007 MB Amsterdam, The Netherlands</p></note><affiliation>VU University Medical Center, Research Institute MOVE, Department of Rehabilitation Medicine, Amsterdam, The Netherlands</affiliation></author><author><persName><forename type="first">Lynn</forename><surname>Rochester</surname></persName><roleName type="degree">PhD</roleName><affiliation>Newcastle University, Clinical Ageing Research Unit, Newcastle upon Tyne, United Kingdom</affiliation></author><author><persName><forename type="first">Victoria</forename><surname>Hetherington</surname></persName><roleName type="degree">MPhil</roleName><affiliation>St. Nicholas Hospital, Dementias and Neurodegenerative Diseases Research Network, Newcastle upon Tyne, United Kingdom</affiliation></author><author><persName><forename type="first">Alice</forename><surname>Nieuwboer</surname></persName><roleName type="degree">PhD</roleName><affiliation>Katholieke Universiteit, Department of Rehabilitation Sciences, Leuven, Belgium</affiliation></author><author><persName><forename type="first">Anne‐Marie</forename><surname>Willems</surname></persName><roleName type="degree">PhD</roleName><affiliation>Katholieke Universiteit, Department of Rehabilitation Sciences, Leuven, Belgium</affiliation></author><author><persName><forename type="first">Diana</forename><surname>Jones</surname></persName><roleName type="degree">PhD</roleName><affiliation>Northumbria University, School of Health, Community & Education Studies, Newcastle, Newcastle upon Tyne, United Kingdom</affiliation></author><author><persName><forename type="first">Gert</forename><surname>Kwakkel</surname></persName><roleName type="degree">PhD</roleName><affiliation>VU University Medical Center, Research Institute MOVE, Department of Rehabilitation Medicine, Amsterdam, The Netherlands</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-07-30"></date><biblScope unit="volume">24</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1512">1512</biblScope><biblScope unit="page" to="1518">1518</biblScope></imprint></monogr><idno type="istex">F8F19BB7BE1F264E8967E854AC1DBC357B98DB98</idno><idno type="DOI">10.1002/mds.22664</idno><idno type="ArticleID">MDS22664</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>To investigate the longitudinal association between fatigue and physical activity in Parkinson's disease (PD) and determine whether this association is distorted by potential confounders. Data from baseline, 3, 6, and 12 week assessments in a single blind randomized clinical trial with cross‐over design were used (N = 153). The Multidimensional Fatigue Inventory (MFI) was used to assess fatigue and an activity monitor to measure amount of physical activity (defined as % dynamic activity during each monitoring session). Time‐independent and time‐dependent factors were investigated for their possible univariate association with dynamic activity. Random coefficient analysis was applied. Candidate confounders were successively added to the longitudinal association model to determine if the association between dynamic activity and fatigue was distorted. A proportional change beyond 15% was considered to be significant. Fatigue was significantly associated with physical activity (β = −0.099, SE = 0.032, P = 0.002). This association was not significantly distorted by type of intervention, age, gender, social support, disease duration, disease severity, motor impairment, cognition, anxiety, or medication intake. Depression caused proportional change of 22.2% in the regression coefficient of MFI. After controlling for depression, a significant association between MFI and dynamic activity remained (β = −0.121, SE = 0.036, P = 0.000). The association found between fatigue and dynamic activity suggests that patients who experience higher levels of fatigue are less physically active. However, the total explained variance of dynamic activity by fatigue alone was small, suggesting that fatigue is only a minor factor in the complex of behavioral aspects that affect the amount of physical activity in patients with PD. © 2009 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>fatigue</term></item><item><term>physical activity</term></item><item><term>activity monitoring</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-01-21">Received</change><change when="2009-04-26">Registration</change><change when="2009-07-30">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/F8F19BB7BE1F264E8967E854AC1DBC357B98DB98/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="100"><doi origin="wiley" registered="yes">10.1002/mds.v24:10</doi><numberingGroup><numbering type="journalVolume" number="24">24</numbering><numbering type="journalIssue">10</numbering></numberingGroup><coverDate startDate="2009-07-30">30 July 2009</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="130" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22664</doi><idGroup><id type="unit" value="MDS22664"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2009 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2009-01-21"></event><event type="manuscriptRevised" date="2009-03-05"></event><event type="manuscriptAccepted" date="2009-04-26"></event><event type="publishedOnlineEarlyUnpaginated" date="2009-06-09"></event><event type="firstOnline" date="2009-06-09"></event><event type="publishedOnlineFinalForm" date="2009-07-24"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">1512</numbering><numbering type="pageLast">1518</numbering></numberingGroup><correspondenceTo>Department of Rehabilitation Medicine, VU University Medical Center, de Boelelaan 1117, 1081 HV Amsterdam, PO BOX 7057, 1007 MB Amsterdam, The Netherlands</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22664.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="36"></count><count type="wordTotal" number="5825"></count></countGroup><titleGroup><title type="main" xml:lang="en">Is impact of fatigue an independent factor associated with physical activity in patients with idiopathic Parkinson's disease?<link href="#fn5"></link></title><title type="short" xml:lang="en">Fatigue and Physical Activity in PD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Roy</givenNames><familyName>Elbers</familyName><degrees>MSc</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2" corresponding="yes"><personName><givenNames>Erwin E.H.</givenNames><familyName>van Wegen</familyName><degrees>PhD</degrees></personName><contactDetails><email>e.vanwegen@vumc.nl</email></contactDetails></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Lynn</givenNames><familyName>Rochester</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Victoria</givenNames><familyName>Hetherington</familyName><degrees>MPhil</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Alice</givenNames><familyName>Nieuwboer</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Anne‐Marie</givenNames><familyName>Willems</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Diana</givenNames><familyName>Jones</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Gert</givenNames><familyName>Kwakkel</familyName><degrees>PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="NL" type="organization"><unparsedAffiliation>University of Applied Sciences Leiden, Department of Physiotherapy, Leiden, The Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="NL" type="organization"><unparsedAffiliation>VU University Medical Center, Research Institute MOVE, Department of Rehabilitation Medicine, Amsterdam, The Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="GB" type="organization"><unparsedAffiliation>Newcastle University, Clinical Ageing Research Unit, Newcastle upon Tyne, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="GB" type="organization"><unparsedAffiliation>St. Nicholas Hospital, Dementias and Neurodegenerative Diseases Research Network, Newcastle upon Tyne, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="BE" type="organization"><unparsedAffiliation>Katholieke Universiteit, Department of Rehabilitation Sciences, Leuven, Belgium</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="GB" type="organization"><unparsedAffiliation>Northumbria University, School of Health, Community & Education Studies, Newcastle, Newcastle upon Tyne, United Kingdom</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">fatigue</keyword><keyword xml:id="kwd3">physical activity</keyword><keyword xml:id="kwd4">activity monitoring</keyword></keywordGroup><fundingInfo><fundingAgency>European Commission</fundingAgency><fundingNumber>QLK6‐CT‐2001‐00120</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Rehabilitation in Parkinson's Disease: Strategies for Cueing</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>To investigate the longitudinal association between fatigue and physical activity in Parkinson's disease (PD) and determine whether this association is distorted by potential confounders. Data from baseline, 3, 6, and 12 week assessments in a single blind randomized clinical trial with cross‐over design were used (N = 153). The Multidimensional Fatigue Inventory (MFI) was used to assess fatigue and an activity monitor to measure amount of physical activity (defined as % dynamic activity during each monitoring session). Time‐independent and time‐dependent factors were investigated for their possible univariate association with dynamic activity. Random coefficient analysis was applied. Candidate confounders were successively added to the longitudinal association model to determine if the association between dynamic activity and fatigue was distorted. A proportional change beyond 15% was considered to be significant. Fatigue was significantly associated with physical activity (β = −0.099, SE = 0.032, <i>P</i> = 0.002). This association was not significantly distorted by type of intervention, age, gender, social support, disease duration, disease severity, motor impairment, cognition, anxiety, or medication intake. Depression caused proportional change of 22.2% in the regression coefficient of MFI. After controlling for depression, a significant association between MFI and dynamic activity remained (β = −0.121, SE = 0.036, <i>P</i> = 0.000). The association found between fatigue and dynamic activity suggests that patients who experience higher levels of fatigue are less physically active. However, the total explained variance of dynamic activity by fatigue alone was small, suggesting that fatigue is only a minor factor in the complex of behavioral aspects that affect the amount of physical activity in patients with PD. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn5"><p>Potential conflict of interest: Nothing to report.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Is impact of fatigue an independent factor associated with physical activity in patients with idiopathic Parkinson's disease?</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Fatigue and Physical Activity in PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Is impact of fatigue an independent factor associated with physical activity in patients with idiopathic Parkinson's disease?</title></titleInfo><name type="personal"><namePart type="given">Roy</namePart><namePart type="family">Elbers</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>University of Applied Sciences Leiden, Department of Physiotherapy, Leiden, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Erwin E.H.</namePart><namePart type="family">van Wegen</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>VU University Medical Center, Research Institute MOVE, Department of Rehabilitation Medicine, Amsterdam, The Netherlands</affiliation><description>Correspondence: Department of Rehabilitation Medicine, VU University Medical Center, de Boelelaan 1117, 1081 HV Amsterdam, PO BOX 7057, 1007 MB Amsterdam, The Netherlands</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lynn</namePart><namePart type="family">Rochester</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Newcastle University, Clinical Ageing Research Unit, Newcastle upon Tyne, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Victoria</namePart><namePart type="family">Hetherington</namePart><namePart type="termsOfAddress">MPhil</namePart><affiliation>St. Nicholas Hospital, Dementias and Neurodegenerative Diseases Research Network, Newcastle upon Tyne, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alice</namePart><namePart type="family">Nieuwboer</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Katholieke Universiteit, Department of Rehabilitation Sciences, Leuven, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anne‐Marie</namePart><namePart type="family">Willems</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Katholieke Universiteit, Department of Rehabilitation Sciences, Leuven, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Diana</namePart><namePart type="family">Jones</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Northumbria University, School of Health, Community & Education Studies, Newcastle, Newcastle upon Tyne, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gert</namePart><namePart type="family">Kwakkel</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>VU University Medical Center, Research Institute MOVE, Department of Rehabilitation Medicine, Amsterdam, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-07-30</dateIssued><dateCaptured encoding="w3cdtf">2009-01-21</dateCaptured><dateValid encoding="w3cdtf">2009-04-26</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">36</extent><extent unit="words">5825</extent></physicalDescription><abstract lang="en">To investigate the longitudinal association between fatigue and physical activity in Parkinson's disease (PD) and determine whether this association is distorted by potential confounders. Data from baseline, 3, 6, and 12 week assessments in a single blind randomized clinical trial with cross‐over design were used (N = 153). The Multidimensional Fatigue Inventory (MFI) was used to assess fatigue and an activity monitor to measure amount of physical activity (defined as % dynamic activity during each monitoring session). Time‐independent and time‐dependent factors were investigated for their possible univariate association with dynamic activity. Random coefficient analysis was applied. Candidate confounders were successively added to the longitudinal association model to determine if the association between dynamic activity and fatigue was distorted. A proportional change beyond 15% was considered to be significant. Fatigue was significantly associated with physical activity (β = −0.099, SE = 0.032, P = 0.002). This association was not significantly distorted by type of intervention, age, gender, social support, disease duration, disease severity, motor impairment, cognition, anxiety, or medication intake. Depression caused proportional change of 22.2% in the regression coefficient of MFI. After controlling for depression, a significant association between MFI and dynamic activity remained (β = −0.121, SE = 0.036, P = 0.000). The association found between fatigue and dynamic activity suggests that patients who experience higher levels of fatigue are less physically active. However, the total explained variance of dynamic activity by fatigue alone was small, suggesting that fatigue is only a minor factor in the complex of behavioral aspects that affect the amount of physical activity in patients with PD. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><note type="funding">European Commission - No. QLK6‐CT‐2001‐00120; </note><note type="funding">Rehabilitation in Parkinson's Disease: Strategies for Cueing</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>fatigue</topic><topic>physical activity</topic><topic>activity monitoring</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>1512</start><end>1518</end><total>7</total></extent></part></relatedItem><identifier type="istex">F8F19BB7BE1F264E8967E854AC1DBC357B98DB98</identifier><identifier type="DOI">10.1002/mds.22664</identifier><identifier type="ArticleID">MDS22664</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C86 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000C86 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:F8F19BB7BE1F264E8967E854AC1DBC357B98DB98
|texte= Is impact of fatigue an independent factor associated with physical activity in patients with idiopathic Parkinson's disease?
}}
| This area was generated with Dilib version V0.6.23. |  |