Characterizing mild cognitive impairment in Parkinson's disease
Identifieur interne : 000C80 ( Main/Corpus ); précédent : 000C79; suivant : 000C81Characterizing mild cognitive impairment in Parkinson's disease
Auteurs : John C. Dalrymple-Alford ; Leslie Livingston ; Michael R. Macaskill ; Charlotte Graham ; Tracy R. Melzer ; Richard J. Porter ; Richard Watts ; Tim J. AndersonSource :
- Movement Disorders [ 0885-3185 ] ; 2011-03.
English descriptors
Abstract
There is growing interest in identifying Parkinson's disease (PD) patients with mild cognitive impairment (PD‐MCI), but widely disparate criteria have been used. We assessed 143 PD patients and 50 matched controls on 20 measures across 4 cognitive domains (executive function, attention and working memory, learning and memory, visuoperception). Twenty‐four patients met criteria for dementia (PD‐D); nondementia patients were classified as either with normal cognition or MCI for 12 neuropsychological criteria. We compared the influence of these criteria on the distribution of global cognitive performance in the resulting PD‐MCI groups relative to the control and PD‐D groups. Different criteria produced substantial variation in the proportion of PD‐MCI cases identified. Fourteen percent PD‐MCI was found when using 2 scores in 1 domain at 2 standard deviations (SD) below normative scores, with no controls identified as MCI, through to 89% PD‐MCI with 1 score in 1 domain at 1 SD below normative scores, when 70% of controls were identified as MCI. The balance of cases with impaired cognition but not those with generally intact cognition was better served by using criteria that required 2 specific deficit scores or deficits across 2 domains. As comparisons with external normative data may have greater applicability across centers, we suggest that 2 scores at −1.5 SD within any single domain (30% PD‐MCI) or 1 score at −1.5 SD in each of 2 domains (37% PD‐MCI) provide suitable criteria to minimize the inclusion of cognitively well patients. Clinical dementia rating did not improve the relative identification of cognitively impaired and unimpaired nondementia PD patients. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23592
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ISTEX:AD8544816B0BAACC89B0859E85D9C46B7DFB2051Le document en format XML
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We assessed 143 PD patients and 50 matched controls on 20 measures across 4 cognitive domains (executive function, attention and working memory, learning and memory, visuoperception). Twenty‐four patients met criteria for dementia (PD‐D); nondementia patients were classified as either with normal cognition or MCI for 12 neuropsychological criteria. We compared the influence of these criteria on the distribution of global cognitive performance in the resulting PD‐MCI groups relative to the control and PD‐D groups. Different criteria produced substantial variation in the proportion of PD‐MCI cases identified. Fourteen percent PD‐MCI was found when using 2 scores in 1 domain at 2 standard deviations (SD) below normative scores, with no controls identified as MCI, through to 89% PD‐MCI with 1 score in 1 domain at 1 SD below normative scores, when 70% of controls were identified as MCI. The balance of cases with impaired cognition but not those with generally intact cognition was better served by using criteria that required 2 specific deficit scores or deficits across 2 domains. As comparisons with external normative data may have greater applicability across centers, we suggest that 2 scores at −1.5 SD within any single domain (30% PD‐MCI) or 1 score at −1.5 SD in each of 2 domains (37% PD‐MCI) provide suitable criteria to minimize the inclusion of cognitively well patients. Clinical dementia rating did not improve the relative identification of cognitively impaired and unimpaired nondementia PD patients. © 2011 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>John C. Dalrymple‐Alford PhD</name><affiliations><json:string>Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</json:string><json:string>Department of Psychology, University of Canterbury, Christchurch, New Zealand</json:string><json:string>Department of Medicine, University of Otago, Christchurch, New Zealand</json:string></affiliations></json:item><json:item><name>Leslie Livingston BA</name><affiliations><json:string>Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</json:string><json:string>Department of Medicine, University of Otago, Christchurch, New Zealand</json:string></affiliations></json:item><json:item><name>Michael R. MacAskill PhD</name><affiliations><json:string>Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</json:string><json:string>Department of Medicine, University of Otago, Christchurch, New Zealand</json:string></affiliations></json:item><json:item><name>Charlotte Graham MA</name><affiliations><json:string>Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</json:string><json:string>Department of Medicine, University of Otago, Christchurch, New Zealand</json:string></affiliations></json:item><json:item><name>Tracy R. Melzer BSc(HONS)</name><affiliations><json:string>Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</json:string><json:string>Department of Medicine, University of Otago, Christchurch, New Zealand</json:string></affiliations></json:item><json:item><name>Richard J. Porter MBBS(HONS), MD</name><affiliations><json:string>Department of Psychological Medicine, University of Otago, Christchurch, New Zealand</json:string></affiliations></json:item><json:item><name>Richard Watts PhD</name><affiliations><json:string>Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</json:string><json:string>Department of Physics and Astronomy, University of Canterbury, Christchurch, New Zealand</json:string></affiliations></json:item><json:item><name>Tim J. Anderson FRACP, MD</name><affiliations><json:string>Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</json:string><json:string>Department of Medicine, University of Otago, Christchurch, New Zealand</json:string><json:string>Department of Neurology, Christchurch Hospital, Christchurch, New Zealand</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mild cognitive impairment</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dementia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cognition</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>criteria</value></json:item></subject><articleId><json:string>MDS23592</json:string></articleId><language><json:string>eng</json:string></language><abstract>There is growing interest in identifying Parkinson's disease (PD) patients with mild cognitive impairment (PD‐MCI), but widely disparate criteria have been used. We assessed 143 PD patients and 50 matched controls on 20 measures across 4 cognitive domains (executive function, attention and working memory, learning and memory, visuoperception). Twenty‐four patients met criteria for dementia (PD‐D); nondementia patients were classified as either with normal cognition or MCI for 12 neuropsychological criteria. We compared the influence of these criteria on the distribution of global cognitive performance in the resulting PD‐MCI groups relative to the control and PD‐D groups. Different criteria produced substantial variation in the proportion of PD‐MCI cases identified. Fourteen percent PD‐MCI was found when using 2 scores in 1 domain at 2 standard deviations (SD) below normative scores, with no controls identified as MCI, through to 89% PD‐MCI with 1 score in 1 domain at 1 SD below normative scores, when 70% of controls were identified as MCI. The balance of cases with impaired cognition but not those with generally intact cognition was better served by using criteria that required 2 specific deficit scores or deficits across 2 domains. As comparisons with external normative data may have greater applicability across centers, we suggest that 2 scores at −1.5 SD within any single domain (30% PD‐MCI) or 1 score at −1.5 SD in each of 2 domains (37% PD‐MCI) provide suitable criteria to minimize the inclusion of cognitively well patients. 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C.</forename><surname>Dalrymple‐Alford</surname></persName><roleName type="degree">PhD</roleName><note type="correspondence"><p>Correspondence: Van der Veer Institute for Parkinson's and Brain Research, 66 Stewart St., Christchurch 8011, New Zealand</p></note><affiliation>Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</affiliation><affiliation>Department of Psychology, University of Canterbury, Christchurch, New Zealand</affiliation><affiliation>Department of Medicine, University of Otago, Christchurch, New Zealand</affiliation></author><author><persName><forename type="first">Leslie</forename><surname>Livingston</surname></persName><roleName type="degree">BA</roleName><affiliation>Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</affiliation><affiliation>Department of Medicine, University of Otago, Christchurch, New Zealand</affiliation></author><author><persName><forename type="first">Michael R.</forename><surname>MacAskill</surname></persName><roleName type="degree">PhD</roleName><affiliation>Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</affiliation><affiliation>Department of Medicine, University of Otago, Christchurch, New Zealand</affiliation></author><author><persName><forename type="first">Charlotte</forename><surname>Graham</surname></persName><roleName type="degree">MA</roleName><affiliation>Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</affiliation><affiliation>Department of Medicine, University of Otago, Christchurch, New Zealand</affiliation></author><author><persName><forename type="first">Tracy R.</forename><surname>Melzer</surname></persName><roleName type="degree">BSc(HONS)</roleName><affiliation>Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</affiliation><affiliation>Department of Medicine, University of Otago, Christchurch, New Zealand</affiliation></author><author><persName><forename type="first">Richard J.</forename><surname>Porter</surname></persName><roleName type="degree">MBBS(HONS), MD</roleName><affiliation>Department of Psychological Medicine, University of Otago, Christchurch, New Zealand</affiliation></author><author><persName><forename type="first">Richard</forename><surname>Watts</surname></persName><roleName type="degree">PhD</roleName><affiliation>Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</affiliation><affiliation>Department of Physics and Astronomy, University of Canterbury, Christchurch, New Zealand</affiliation></author><author><persName><forename type="first">Tim J.</forename><surname>Anderson</surname></persName><roleName type="degree">FRACP, MD</roleName><affiliation>Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</affiliation><affiliation>Department of Medicine, University of Otago, Christchurch, New 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We assessed 143 PD patients and 50 matched controls on 20 measures across 4 cognitive domains (executive function, attention and working memory, learning and memory, visuoperception). Twenty‐four patients met criteria for dementia (PD‐D); nondementia patients were classified as either with normal cognition or MCI for 12 neuropsychological criteria. We compared the influence of these criteria on the distribution of global cognitive performance in the resulting PD‐MCI groups relative to the control and PD‐D groups. Different criteria produced substantial variation in the proportion of PD‐MCI cases identified. Fourteen percent PD‐MCI was found when using 2 scores in 1 domain at 2 standard deviations (SD) below normative scores, with no controls identified as MCI, through to 89% PD‐MCI with 1 score in 1 domain at 1 SD below normative scores, when 70% of controls were identified as MCI. The balance of cases with impaired cognition but not those with generally intact cognition was better served by using criteria that required 2 specific deficit scores or deficits across 2 domains. As comparisons with external normative data may have greater applicability across centers, we suggest that 2 scores at −1.5 SD within any single domain (30% PD‐MCI) or 1 score at −1.5 SD in each of 2 domains (37% PD‐MCI) provide suitable criteria to minimize the inclusion of cognitively well patients. Clinical dementia rating did not improve the relative identification of cognitively impaired and unimpaired nondementia PD patients. © 2011 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>mild cognitive impairment</term></item><item><term>dementia</term></item><item><term>cognition</term></item><item><term>criteria</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-07-20">Received</change><change when="2010-11-22">Registration</change><change when="2011-03">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/AD8544816B0BAACC89B0859E85D9C46B7DFB2051/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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number="2"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="40"></count><count type="wordTotal" number="7393"></count></countGroup><titleGroup><title type="main" xml:lang="en">Characterizing mild cognitive impairment in Parkinson's disease<link href="#fn1"></link></title><title type="short" xml:lang="en">MCI Criteria for Parkinson's Disease</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2 #af3" corresponding="yes"><personName><givenNames>John C.</givenNames><familyName>Dalrymple‐Alford</familyName><degrees>PhD</degrees></personName><contactDetails><email normalForm="john.dalrymple-alford@canterbury.ac.nz">john.dalrymple‐alford@canterbury.ac.nz</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1 #af3"><personName><givenNames>Leslie</givenNames><familyName>Livingston</familyName><degrees>BA</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1 #af3"><personName><givenNames>Michael R.</givenNames><familyName>MacAskill</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1 #af3"><personName><givenNames>Charlotte</givenNames><familyName>Graham</familyName><degrees>MA</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1 #af3"><personName><givenNames>Tracy R.</givenNames><familyName>Melzer</familyName><degrees>BSc(HONS)</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Richard J.</givenNames><familyName>Porter</familyName><degrees>MBBS(HONS), MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1 #af5"><personName><givenNames>Richard</givenNames><familyName>Watts</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1 #af3 #af6"><personName><givenNames>Tim J.</givenNames><familyName>Anderson</familyName><degrees>FRACP, MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="NZ" type="organization"><unparsedAffiliation>Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="NZ" type="organization"><unparsedAffiliation>Department of Psychology, University of Canterbury, Christchurch, New Zealand</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="NZ" type="organization"><unparsedAffiliation>Department of Medicine, University of Otago, Christchurch, New Zealand</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="NZ" type="organization"><unparsedAffiliation>Department of Psychological Medicine, University of Otago, Christchurch, New Zealand</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="NZ" type="organization"><unparsedAffiliation>Department of Physics and Astronomy, University of Canterbury, Christchurch, New Zealand</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="NZ" type="organization"><unparsedAffiliation>Department of Neurology, Christchurch Hospital, Christchurch, New Zealand</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">mild cognitive impairment</keyword><keyword xml:id="kwd3">dementia</keyword><keyword xml:id="kwd4">cognition</keyword><keyword xml:id="kwd5">criteria</keyword></keywordGroup><fundingInfo><fundingAgency>Neurological Foundation of New Zealand</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Canterbury Medical Research Foundation</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Neurology Trust</fundingAgency></fundingInfo><supportingInformation><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds23592:MDS_23592_sm_authorroles"></mediaResource><caption>Author Roles and Disclosures</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>There is growing interest in identifying Parkinson's disease (PD) patients with mild cognitive impairment (PD‐MCI), but widely disparate criteria have been used. We assessed 143 PD patients and 50 matched controls on 20 measures across 4 cognitive domains (executive function, attention and working memory, learning and memory, visuoperception). Twenty‐four patients met criteria for dementia (PD‐D); nondementia patients were classified as either with normal cognition or MCI for 12 neuropsychological criteria. We compared the influence of these criteria on the distribution of global cognitive performance in the resulting PD‐MCI groups relative to the control and PD‐D groups. Different criteria produced substantial variation in the proportion of PD‐MCI cases identified. Fourteen percent PD‐MCI was found when using 2 scores in 1 domain at 2 standard deviations (SD) below normative scores, with no controls identified as MCI, through to 89% PD‐MCI with 1 score in 1 domain at 1 SD below normative scores, when 70% of controls were identified as MCI. The balance of cases with impaired cognition but not those with generally intact cognition was better served by using criteria that required 2 specific deficit scores or deficits across 2 domains. As comparisons with external normative data may have greater applicability across centers, we suggest that 2 scores at −1.5 SD within any single domain (30% PD‐MCI) or 1 score at −1.5 SD in each of 2 domains (37% PD‐MCI) provide suitable criteria to minimize the inclusion of cognitively well patients. Clinical dementia rating did not improve the relative identification of cognitively impaired and unimpaired nondementia PD patients. © 2011 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p><b>Relevant conflict of interest:</b> Nothing to report.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Characterizing mild cognitive impairment in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>MCI Criteria for Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Characterizing mild cognitive impairment in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">John C.</namePart><namePart type="family">Dalrymple‐Alford</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</affiliation><affiliation>Department of Psychology, University of Canterbury, Christchurch, New Zealand</affiliation><affiliation>Department of Medicine, University of Otago, Christchurch, New Zealand</affiliation><description>Correspondence: Van der Veer Institute for Parkinson's and Brain Research, 66 Stewart St., Christchurch 8011, New Zealand</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Leslie</namePart><namePart type="family">Livingston</namePart><namePart type="termsOfAddress">BA</namePart><affiliation>Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</affiliation><affiliation>Department of Medicine, University of Otago, Christchurch, New Zealand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael R.</namePart><namePart type="family">MacAskill</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</affiliation><affiliation>Department of Medicine, University of Otago, Christchurch, New Zealand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Charlotte</namePart><namePart type="family">Graham</namePart><namePart type="termsOfAddress">MA</namePart><affiliation>Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</affiliation><affiliation>Department of Medicine, University of Otago, Christchurch, New Zealand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tracy R.</namePart><namePart type="family">Melzer</namePart><namePart type="termsOfAddress">BSc(HONS)</namePart><affiliation>Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</affiliation><affiliation>Department of Medicine, University of Otago, Christchurch, New Zealand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Richard J.</namePart><namePart type="family">Porter</namePart><namePart type="termsOfAddress">MBBS(HONS), MD</namePart><affiliation>Department of Psychological Medicine, University of Otago, Christchurch, New Zealand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Richard</namePart><namePart type="family">Watts</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</affiliation><affiliation>Department of Physics and Astronomy, University of Canterbury, Christchurch, New Zealand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tim J.</namePart><namePart type="family">Anderson</namePart><namePart type="termsOfAddress">FRACP, MD</namePart><affiliation>Van der Veer Institute for Parkinson's and Brain Research, Christchurch, New Zealand</affiliation><affiliation>Department of Medicine, University of Otago, Christchurch, New Zealand</affiliation><affiliation>Department of Neurology, Christchurch Hospital, Christchurch, New Zealand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-03</dateIssued><dateCaptured encoding="w3cdtf">2010-07-20</dateCaptured><dateValid encoding="w3cdtf">2010-11-22</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">3</extent><extent unit="references">40</extent><extent unit="words">7393</extent></physicalDescription><abstract lang="en">There is growing interest in identifying Parkinson's disease (PD) patients with mild cognitive impairment (PD‐MCI), but widely disparate criteria have been used. We assessed 143 PD patients and 50 matched controls on 20 measures across 4 cognitive domains (executive function, attention and working memory, learning and memory, visuoperception). Twenty‐four patients met criteria for dementia (PD‐D); nondementia patients were classified as either with normal cognition or MCI for 12 neuropsychological criteria. We compared the influence of these criteria on the distribution of global cognitive performance in the resulting PD‐MCI groups relative to the control and PD‐D groups. Different criteria produced substantial variation in the proportion of PD‐MCI cases identified. Fourteen percent PD‐MCI was found when using 2 scores in 1 domain at 2 standard deviations (SD) below normative scores, with no controls identified as MCI, through to 89% PD‐MCI with 1 score in 1 domain at 1 SD below normative scores, when 70% of controls were identified as MCI. The balance of cases with impaired cognition but not those with generally intact cognition was better served by using criteria that required 2 specific deficit scores or deficits across 2 domains. As comparisons with external normative data may have greater applicability across centers, we suggest that 2 scores at −1.5 SD within any single domain (30% PD‐MCI) or 1 score at −1.5 SD in each of 2 domains (37% PD‐MCI) provide suitable criteria to minimize the inclusion of cognitively well patients. Clinical dementia rating did not improve the relative identification of cognitively impaired and unimpaired nondementia PD patients. © 2011 Movement Disorder Society</abstract><note type="additional physical form">Author Roles and Disclosures</note><note type="content">*Relevant conflict of interest: Nothing to report.</note><note type="funding">Neurological Foundation of New Zealand</note><note type="funding">Canterbury Medical Research Foundation</note><note type="funding">Neurology Trust</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>mild cognitive impairment</topic><topic>dementia</topic><topic>cognition</topic><topic>criteria</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>629</start><end>636</end><total>8</total></extent></part></relatedItem><identifier type="istex">AD8544816B0BAACC89B0859E85D9C46B7DFB2051</identifier><identifier type="DOI">10.1002/mds.23592</identifier><identifier type="ArticleID">MDS23592</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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