Montreal Cognitive Assessment Performance in Patients with Parkinson's Disease with “Normal” Global Cognition According to Mini‐Mental State Examination Score
Identifieur interne : 000C16 ( Main/Corpus ); précédent : 000C15; suivant : 000C17Montreal Cognitive Assessment Performance in Patients with Parkinson's Disease with “Normal” Global Cognition According to Mini‐Mental State Examination Score
Auteurs : Sarra Nazem ; Andrew D. Siderowf ; John E. Duda ; Tom Ten Have ; Amy Colcher ; Stacy S. Horn ; Paul J. Moberg ; Jayne R. Wilkinson ; Howard I. Hurtig ; Matthew B. Stern ; Daniel WeintraubSource :
- Journal of the American Geriatrics Society [ 0002-8614 ] ; 2009-02.
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- KwdEn :
Abstract
OBJECTIVES: To examine Montreal Cognitive Assessment (MoCA) performance in patients with Parkinson's disease (PD) with “normal” global cognition according to Mini‐Mental State Examination (MMSE) score. DESIGN: A cross‐sectional comparison of the MoCA and the MMSE. SETTING: Two movement disorders centers at the University of Pennsylvania and the Philadelphia Veterans Affairs Medical Center. PARTICIPANTS: A convenience sample of 131 patients with idiopathic PD who were screened for cognitive and psychiatric complications. MEASUREMENTS: Subjects were administered the MoCA and MMSE, and only subjects defined as having a normal age‐ and education‐adjusted MMSE score were included in the analyses (N=100). As previously recommended in patients without PD, a MoCA score less than 26 was used to indicate the presence of at least mild cognitive impairment (MCI). RESULTS: Mean MMSE and MoCA scores±standard deviation were 28.8±1.1 and 24.9±3.1, respectively. More than half (52.0%) of subjects with normal MMSE scores had cognitive impairment according to their MoCA score. Impairments were seen in numerous cognitive domains, including memory, visuospatial and executive abilities, attention, and language. Predictors of cognitive impairment on the MoCA using univariate analyses were male sex, older age, lower educational level, and greater disease severity; older age was the only predictor in a multivariate model. CONCLUSION: Approximately half of patients with PD with a normal MMSE score have cognitive impairment based on the recommended MoCA cutoff score. These results suggest that MCI is common in PD and that the MoCA is a more sensitive instrument than the MMSE for its detection.
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DOI: 10.1111/j.1532-5415.2008.02096.x
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Siderowf</name><affiliation><mods:affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</mods:affiliation></affiliation></author><author><name sortKey="Duda, John E" sort="Duda, John E" uniqKey="Duda J" first="John E." last="Duda">John E. Duda</name><affiliation><mods:affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</mods:affiliation></affiliation></author><author><name sortKey="Ten Have, Tom" sort="Ten Have, Tom" uniqKey="Ten Have T" first="Tom" last="Ten Have">Tom Ten Have</name><affiliation><mods:affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</mods:affiliation></affiliation></author><author><name sortKey="Colcher, Amy" sort="Colcher, Amy" uniqKey="Colcher A" first="Amy" last="Colcher">Amy Colcher</name><affiliation><mods:affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</mods:affiliation></affiliation></author><author><name sortKey="Horn, Stacy S" sort="Horn, Stacy S" uniqKey="Horn S" first="Stacy S." last="Horn">Stacy S. Horn</name><affiliation><mods:affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</mods:affiliation></affiliation></author><author><name sortKey="Moberg, Paul J" sort="Moberg, Paul J" uniqKey="Moberg P" first="Paul J." last="Moberg">Paul J. Moberg</name><affiliation><mods:affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</mods:affiliation></affiliation></author><author><name sortKey="Wilkinson, Jayne R" sort="Wilkinson, Jayne R" uniqKey="Wilkinson J" first="Jayne R." last="Wilkinson">Jayne R. Wilkinson</name><affiliation><mods:affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</mods:affiliation></affiliation></author><author><name sortKey="Hurtig, Howard I" sort="Hurtig, Howard I" uniqKey="Hurtig H" first="Howard I." last="Hurtig">Howard I. Hurtig</name><affiliation><mods:affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</mods:affiliation></affiliation></author><author><name sortKey="Stern, Matthew B" sort="Stern, Matthew B" uniqKey="Stern M" first="Matthew B." last="Stern">Matthew B. Stern</name><affiliation><mods:affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</mods:affiliation></affiliation></author><author><name sortKey="Weintraub, Daniel" sort="Weintraub, Daniel" uniqKey="Weintraub D" first="Daniel" last="Weintraub">Daniel Weintraub</name><affiliation><mods:affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:28DEF22DE0F666948C44769386483E6752508936</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1111/j.1532-5415.2008.02096.x</idno><idno type="url">https://api.istex.fr/document/28DEF22DE0F666948C44769386483E6752508936/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000C16</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Montreal Cognitive Assessment Performance in Patients with Parkinson's Disease with “Normal” Global Cognition According to Mini‐Mental State Examination Score</title><author><name sortKey="Nazem, Sarra" sort="Nazem, Sarra" uniqKey="Nazem S" first="Sarra" last="Nazem">Sarra Nazem</name><affiliation><mods:affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</mods:affiliation></affiliation></author><author><name sortKey="Siderowf, Andrew D" sort="Siderowf, Andrew D" uniqKey="Siderowf A" first="Andrew D." last="Siderowf">Andrew D. Siderowf</name><affiliation><mods:affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</mods:affiliation></affiliation></author><author><name sortKey="Duda, John E" sort="Duda, John E" uniqKey="Duda J" first="John E." last="Duda">John E. Duda</name><affiliation><mods:affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</mods:affiliation></affiliation></author><author><name sortKey="Ten Have, Tom" sort="Ten Have, Tom" uniqKey="Ten Have T" first="Tom" last="Ten Have">Tom Ten Have</name><affiliation><mods:affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</mods:affiliation></affiliation></author><author><name sortKey="Colcher, Amy" sort="Colcher, Amy" uniqKey="Colcher A" first="Amy" last="Colcher">Amy Colcher</name><affiliation><mods:affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</mods:affiliation></affiliation></author><author><name sortKey="Horn, Stacy S" sort="Horn, Stacy S" uniqKey="Horn S" first="Stacy S." last="Horn">Stacy S. Horn</name><affiliation><mods:affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</mods:affiliation></affiliation></author><author><name sortKey="Moberg, Paul J" sort="Moberg, Paul J" uniqKey="Moberg P" first="Paul J." last="Moberg">Paul J. Moberg</name><affiliation><mods:affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</mods:affiliation></affiliation></author><author><name sortKey="Wilkinson, Jayne R" sort="Wilkinson, Jayne R" uniqKey="Wilkinson J" first="Jayne R." last="Wilkinson">Jayne R. Wilkinson</name><affiliation><mods:affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</mods:affiliation></affiliation></author><author><name sortKey="Hurtig, Howard I" sort="Hurtig, Howard I" uniqKey="Hurtig H" first="Howard I." last="Hurtig">Howard I. Hurtig</name><affiliation><mods:affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</mods:affiliation></affiliation></author><author><name sortKey="Stern, Matthew B" sort="Stern, Matthew B" uniqKey="Stern M" first="Matthew B." last="Stern">Matthew B. Stern</name><affiliation><mods:affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</mods:affiliation></affiliation></author><author><name sortKey="Weintraub, Daniel" sort="Weintraub, Daniel" uniqKey="Weintraub D" first="Daniel" last="Weintraub">Daniel Weintraub</name><affiliation><mods:affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the American Geriatrics Society</title><idno type="ISSN">0002-8614</idno><idno type="eISSN">1532-5415</idno><imprint><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2009-02">2009-02</date><biblScope unit="volume">57</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="304">304</biblScope><biblScope unit="page" to="308">308</biblScope></imprint><idno type="ISSN">0002-8614</idno></series><idno type="istex">28DEF22DE0F666948C44769386483E6752508936</idno><idno type="DOI">10.1111/j.1532-5415.2008.02096.x</idno><idno type="ArticleID">JGS2096</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0002-8614</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Mini‐Mental State Examination</term><term>Montreal Cognitive Assessment</term><term>Parkinson's disease</term><term>cognitive impairment</term><term>neuropsychology</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">OBJECTIVES: To examine Montreal Cognitive Assessment (MoCA) performance in patients with Parkinson's disease (PD) with “normal” global cognition according to Mini‐Mental State Examination (MMSE) score. DESIGN: A cross‐sectional comparison of the MoCA and the MMSE. SETTING: Two movement disorders centers at the University of Pennsylvania and the Philadelphia Veterans Affairs Medical Center. PARTICIPANTS: A convenience sample of 131 patients with idiopathic PD who were screened for cognitive and psychiatric complications. MEASUREMENTS: Subjects were administered the MoCA and MMSE, and only subjects defined as having a normal age‐ and education‐adjusted MMSE score were included in the analyses (N=100). As previously recommended in patients without PD, a MoCA score less than 26 was used to indicate the presence of at least mild cognitive impairment (MCI). RESULTS: Mean MMSE and MoCA scores±standard deviation were 28.8±1.1 and 24.9±3.1, respectively. More than half (52.0%) of subjects with normal MMSE scores had cognitive impairment according to their MoCA score. Impairments were seen in numerous cognitive domains, including memory, visuospatial and executive abilities, attention, and language. Predictors of cognitive impairment on the MoCA using univariate analyses were male sex, older age, lower educational level, and greater disease severity; older age was the only predictor in a multivariate model. CONCLUSION: Approximately half of patients with PD with a normal MMSE score have cognitive impairment based on the recommended MoCA cutoff score. These results suggest that MCI is common in PD and that the MoCA is a more sensitive instrument than the MMSE for its detection.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Sarra Nazem BA</name><affiliations><json:string>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</json:string></affiliations></json:item><json:item><name>Andrew D. Siderowf MD, MSCE</name><affiliations><json:string>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</json:string></affiliations></json:item><json:item><name>John E. Duda MD</name><affiliations><json:string>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</json:string></affiliations></json:item><json:item><name>Tom Ten Have PhD</name><affiliations><json:string>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</json:string></affiliations></json:item><json:item><name>Amy Colcher MD</name><affiliations><json:string>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</json:string></affiliations></json:item><json:item><name>Stacy S. Horn DO</name><affiliations><json:string>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</json:string></affiliations></json:item><json:item><name>Paul J. Moberg PhD</name><affiliations><json:string>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</json:string></affiliations></json:item><json:item><name>Jayne R. Wilkinson MD</name><affiliations><json:string>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</json:string></affiliations></json:item><json:item><name>Howard I. Hurtig MD</name><affiliations><json:string>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</json:string></affiliations></json:item><json:item><name>Matthew B. Stern MD</name><affiliations><json:string>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</json:string></affiliations></json:item><json:item><name>Daniel Weintraub MD</name><affiliations><json:string>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>cognitive impairment</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Mini‐Mental State Examination</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Montreal Cognitive Assessment</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>neuropsychology</value></json:item></subject><articleId><json:string>JGS2096</json:string></articleId><language><json:string>eng</json:string></language><abstract>OBJECTIVES: To examine Montreal Cognitive Assessment (MoCA) performance in patients with Parkinson's disease (PD) with “normal” global cognition according to Mini‐Mental State Examination (MMSE) score. DESIGN: A cross‐sectional comparison of the MoCA and the MMSE. SETTING: Two movement disorders centers at the University of Pennsylvania and the Philadelphia Veterans Affairs Medical Center. PARTICIPANTS: A convenience sample of 131 patients with idiopathic PD who were screened for cognitive and psychiatric complications. MEASUREMENTS: Subjects were administered the MoCA and MMSE, and only subjects defined as having a normal age‐ and education‐adjusted MMSE score were included in the analyses (N=100). As previously recommended in patients without PD, a MoCA score less than 26 was used to indicate the presence of at least mild cognitive impairment (MCI). RESULTS: Mean MMSE and MoCA scores±standard deviation were 28.8±1.1 and 24.9±3.1, respectively. More than half (52.0%) of subjects with normal MMSE scores had cognitive impairment according to their MoCA score. Impairments were seen in numerous cognitive domains, including memory, visuospatial and executive abilities, attention, and language. Predictors of cognitive impairment on the MoCA using univariate analyses were male sex, older age, lower educational level, and greater disease severity; older age was the only predictor in a multivariate model. CONCLUSION: Approximately half of patients with PD with a normal MMSE score have cognitive impairment based on the recommended MoCA cutoff score. These results suggest that MCI is common in PD and that the MoCA is a more sensitive instrument than the MMSE for its detection.</abstract><qualityIndicators><score>6.715</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1695</abstractCharCount><pdfWordCount>3751</pdfWordCount><pdfCharCount>24153</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>247</abstractWordCount></qualityIndicators><title>Montreal Cognitive Assessment Performance in Patients with Parkinson's Disease with “Normal” Global Cognition According to Mini‐Mental State Examination Score</title><genre><json:string>article</json:string></genre><host><volume>57</volume><publisherId><json:string>JGS</json:string></publisherId><pages><total>5</total><last>308</last><first>304</first></pages><issn><json:string>0002-8614</json:string></issn><issue>2</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1532-5415</json:string></eissn><title>Journal of the American Geriatrics Society</title><doi><json:string>10.1111/(ISSN)1532-5415</json:string></doi></host><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1111/j.1532-5415.2008.02096.x</json:string></doi><id>28DEF22DE0F666948C44769386483E6752508936</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/28DEF22DE0F666948C44769386483E6752508936/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/28DEF22DE0F666948C44769386483E6752508936/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/28DEF22DE0F666948C44769386483E6752508936/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Montreal Cognitive Assessment Performance in Patients with Parkinson's Disease with “Normal” Global Cognition According to Mini‐Mental State Examination Score</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><availability><p>WILEY</p></availability><date>2009</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Montreal Cognitive Assessment Performance in Patients with Parkinson's Disease with “Normal” Global Cognition According to Mini‐Mental State Examination Score</title><author><persName><forename type="first">Sarra</forename><surname>Nazem</surname></persName><roleName type="degree">BA</roleName><affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</affiliation></author><author><persName><forename type="first">Andrew D.</forename><surname>Siderowf</surname></persName><roleName type="degree">MD, MSCE</roleName><affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</affiliation></author><author><persName><forename type="first">John E.</forename><surname>Duda</surname></persName><roleName type="degree">MD</roleName><affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</affiliation></author><author><persName><forename type="first">Tom</forename><surname>Ten Have</surname></persName><roleName type="degree">PhD</roleName><affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</affiliation></author><author><persName><forename type="first">Amy</forename><surname>Colcher</surname></persName><roleName type="degree">MD</roleName><affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</affiliation></author><author><persName><forename type="first">Stacy S.</forename><surname>Horn</surname></persName><roleName type="degree">DO</roleName><affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</affiliation></author><author><persName><forename type="first">Paul J.</forename><surname>Moberg</surname></persName><roleName type="degree">PhD</roleName><affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</affiliation></author><author><persName><forename type="first">Jayne R.</forename><surname>Wilkinson</surname></persName><roleName type="degree">MD</roleName><affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</affiliation></author><author><persName><forename type="first">Howard I.</forename><surname>Hurtig</surname></persName><roleName type="degree">MD</roleName><affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</affiliation></author><author><persName><forename type="first">Matthew B.</forename><surname>Stern</surname></persName><roleName type="degree">MD</roleName><affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</affiliation></author><author><persName><forename type="first">Daniel</forename><surname>Weintraub</surname></persName><roleName type="degree">MD</roleName><affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</affiliation></author></analytic><monogr><title level="j">Journal of the American Geriatrics Society</title><idno type="pISSN">0002-8614</idno><idno type="eISSN">1532-5415</idno><idno type="DOI">10.1111/(ISSN)1532-5415</idno><imprint><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2009-02"></date><biblScope unit="volume">57</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="304">304</biblScope><biblScope unit="page" to="308">308</biblScope></imprint></monogr><idno type="istex">28DEF22DE0F666948C44769386483E6752508936</idno><idno type="DOI">10.1111/j.1532-5415.2008.02096.x</idno><idno type="ArticleID">JGS2096</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>OBJECTIVES: To examine Montreal Cognitive Assessment (MoCA) performance in patients with Parkinson's disease (PD) with “normal” global cognition according to Mini‐Mental State Examination (MMSE) score. DESIGN: A cross‐sectional comparison of the MoCA and the MMSE. SETTING: Two movement disorders centers at the University of Pennsylvania and the Philadelphia Veterans Affairs Medical Center. PARTICIPANTS: A convenience sample of 131 patients with idiopathic PD who were screened for cognitive and psychiatric complications. MEASUREMENTS: Subjects were administered the MoCA and MMSE, and only subjects defined as having a normal age‐ and education‐adjusted MMSE score were included in the analyses (N=100). As previously recommended in patients without PD, a MoCA score less than 26 was used to indicate the presence of at least mild cognitive impairment (MCI). RESULTS: Mean MMSE and MoCA scores±standard deviation were 28.8±1.1 and 24.9±3.1, respectively. More than half (52.0%) of subjects with normal MMSE scores had cognitive impairment according to their MoCA score. Impairments were seen in numerous cognitive domains, including memory, visuospatial and executive abilities, attention, and language. Predictors of cognitive impairment on the MoCA using univariate analyses were male sex, older age, lower educational level, and greater disease severity; older age was the only predictor in a multivariate model. CONCLUSION: Approximately half of patients with PD with a normal MMSE score have cognitive impairment based on the recommended MoCA cutoff score. These results suggest that MCI is common in PD and that the MoCA is a more sensitive instrument than the MMSE for its detection.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>cognitive impairment</term></item><item><term>Parkinson's disease</term></item><item><term>Mini‐Mental State Examination</term></item><item><term>Montreal Cognitive Assessment</term></item><item><term>neuropsychology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-02">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/28DEF22DE0F666948C44769386483E6752508936/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Inc</publisherName><publisherLoc>Malden, USA</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1532-5415</doi><issn type="print">0002-8614</issn><issn type="electronic">1532-5415</issn><idGroup><id type="product" value="JGS"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF AMERICAN GERIATRICS SOCIETY">Journal of the American Geriatrics Society</title></titleGroup></publicationMeta><publicationMeta level="part" position="02002"><doi origin="wiley">10.1111/jgs.2009.57.issue-2</doi><numberingGroup><numbering type="journalVolume" number="57">57</numbering><numbering type="journalIssue" number="2">2</numbering></numberingGroup><coverDate startDate="2009-02">February 2009</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="17" status="forIssue"><doi origin="wiley">10.1111/j.1532-5415.2008.02096.x</doi><idGroup><id type="unit" value="JGS2096"></id><id type="supplier" value="2096"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="tocHeading1">Brief Methodological Reports</title></titleGroup><copyright>© 2009, Copyright the Authors. Journal compilation © 2009, The American Geriatrics Society</copyright><eventGroup><event type="firstOnline" date="2008-12-11"></event><event type="publishedOnlineFinalForm" date="2009-01-28"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-10"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-31"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="304">304</numbering><numbering type="pageLast" number="308">308</numbering></numberingGroup><correspondenceTo>Address correspondence to Daniel Weintraub, 3615 Chestnut St., Room 330, Philadelphia, PA 19104. E‐mail: <email normalForm="weintrau@mail.med.upenn.edu">weintrau@mail.med.upenn.edu</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JGS.JGS2096.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="3"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="32"></count><count type="wordTotal" number="4949"></count><count type="linksCrossRef" number="47"></count></countGroup><titleGroup><title type="main">Montreal Cognitive Assessment Performance in Patients with Parkinson's Disease with “Normal” Global Cognition According to Mini‐Mental State Examination Score</title><title type="shortAuthors">NAZEM ET AL.</title><title type="short">MOCA IN PARKINSON'S DISEASE</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#aff-1-1"><personName><givenNames>Sarra</givenNames><familyName>Nazem</familyName><degrees>BA</degrees></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#aff-1-1"><personName><givenNames>Andrew D.</givenNames><familyName>Siderowf</familyName><degrees>MD, MSCE</degrees></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#aff-1-1"><personName><givenNames>John E.</givenNames><familyName>Duda</familyName><degrees>MD</degrees></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#aff-1-1"><personName><givenNames>Tom</givenNames><familyName>Ten Have</familyName><degrees>PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#aff-1-1"><personName><givenNames>Amy</givenNames><familyName>Colcher</familyName><degrees>MD</degrees></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#aff-1-1"><personName><givenNames>Stacy S.</givenNames><familyName>Horn</familyName><degrees>DO</degrees></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#aff-1-1"><personName><givenNames>Paul J.</givenNames><familyName>Moberg</familyName><degrees>PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#aff-1-1"><personName><givenNames>Jayne R.</givenNames><familyName>Wilkinson</familyName><degrees>MD</degrees></personName></creator><creator creatorRole="author" xml:id="cr9" affiliationRef="#aff-1-1"><personName><givenNames>Howard I.</givenNames><familyName>Hurtig</familyName><degrees>MD</degrees></personName></creator><creator creatorRole="author" xml:id="cr10" affiliationRef="#aff-1-1"><personName><givenNames>Matthew B.</givenNames><familyName>Stern</familyName><degrees>MD</degrees></personName></creator><creator creatorRole="author" xml:id="cr11" affiliationRef="#aff-1-1"><personName><givenNames>Daniel</givenNames><familyName>Weintraub</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="aff-1-1" countryCode="US"><unparsedAffiliation>From the <sup>*</sup>Departments of Psychiatry<sup>†</sup>Neurology<sup>§</sup>Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania<sup>‡</sup>Parkinson's Disease Research, Education and Clinical Center; and <sup>∥</sup>Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">cognitive impairment</keyword><keyword xml:id="k2">Parkinson's disease</keyword><keyword xml:id="k3">Mini‐Mental State Examination</keyword><keyword xml:id="k4">Montreal Cognitive Assessment</keyword><keyword xml:id="k5">neuropsychology</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>OBJECTIVES: </b> To examine Montreal Cognitive Assessment (MoCA) performance in patients with Parkinson's disease (PD) with “normal” global cognition according to Mini‐Mental State Examination (MMSE) score.</p><p><b>DESIGN: </b> A cross‐sectional comparison of the MoCA and the MMSE.</p><p><b>SETTING: </b> Two movement disorders centers at the University of Pennsylvania and the Philadelphia Veterans Affairs Medical Center.</p><p><b>PARTICIPANTS: </b> A convenience sample of 131 patients with idiopathic PD who were screened for cognitive and psychiatric complications.</p><p><b>MEASUREMENTS: </b> Subjects were administered the MoCA and MMSE, and only subjects defined as having a normal age‐ and education‐adjusted MMSE score were included in the analyses (N=100). As previously recommended in patients without PD, a MoCA score less than 26 was used to indicate the presence of at least mild cognitive impairment (MCI).</p><p><b>RESULTS: </b> Mean MMSE and MoCA scores±standard deviation were 28.8±1.1 and 24.9±3.1, respectively. More than half (52.0%) of subjects with normal MMSE scores had cognitive impairment according to their MoCA score. Impairments were seen in numerous cognitive domains, including memory, visuospatial and executive abilities, attention, and language. Predictors of cognitive impairment on the MoCA using univariate analyses were male sex, older age, lower educational level, and greater disease severity; older age was the only predictor in a multivariate model.</p><p><b>CONCLUSION: </b> Approximately half of patients with PD with a normal MMSE score have cognitive impairment based on the recommended MoCA cutoff score. These results suggest that MCI is common in PD and that the MoCA is a more sensitive instrument than the MMSE for its detection.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Montreal Cognitive Assessment Performance in Patients with Parkinson's Disease with “Normal” Global Cognition According to Mini‐Mental State Examination Score</title></titleInfo><titleInfo type="abbreviated"><title>MOCA IN PARKINSON'S DISEASE</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Montreal Cognitive Assessment Performance in Patients with Parkinson's Disease with “Normal” Global Cognition According to Mini‐Mental State Examination Score</title></titleInfo><name type="personal"><namePart type="given">Sarra</namePart><namePart type="family">Nazem</namePart><namePart type="termsOfAddress">BA</namePart><affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andrew D.</namePart><namePart type="family">Siderowf</namePart><namePart type="termsOfAddress">MD, MSCE</namePart><affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John E.</namePart><namePart type="family">Duda</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tom</namePart><namePart type="family">Ten Have</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Amy</namePart><namePart type="family">Colcher</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stacy S.</namePart><namePart type="family">Horn</namePart><namePart type="termsOfAddress">DO</namePart><affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paul J.</namePart><namePart type="family">Moberg</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jayne R.</namePart><namePart type="family">Wilkinson</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Howard I.</namePart><namePart type="family">Hurtig</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Matthew B.</namePart><namePart type="family">Stern</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Daniel</namePart><namePart type="family">Weintraub</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>From the*Departments of Psychiatry†Neurology§Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania‡Parkinson's Disease Research, Education and Clinical Center; and∥Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Inc</publisher><place><placeTerm type="text">Malden, USA</placeTerm></place><dateIssued encoding="w3cdtf">2009-02</dateIssued><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">32</extent><extent unit="words">4949</extent></physicalDescription><abstract lang="en">OBJECTIVES: To examine Montreal Cognitive Assessment (MoCA) performance in patients with Parkinson's disease (PD) with “normal” global cognition according to Mini‐Mental State Examination (MMSE) score. DESIGN: A cross‐sectional comparison of the MoCA and the MMSE. SETTING: Two movement disorders centers at the University of Pennsylvania and the Philadelphia Veterans Affairs Medical Center. PARTICIPANTS: A convenience sample of 131 patients with idiopathic PD who were screened for cognitive and psychiatric complications. MEASUREMENTS: Subjects were administered the MoCA and MMSE, and only subjects defined as having a normal age‐ and education‐adjusted MMSE score were included in the analyses (N=100). As previously recommended in patients without PD, a MoCA score less than 26 was used to indicate the presence of at least mild cognitive impairment (MCI). RESULTS: Mean MMSE and MoCA scores±standard deviation were 28.8±1.1 and 24.9±3.1, respectively. More than half (52.0%) of subjects with normal MMSE scores had cognitive impairment according to their MoCA score. Impairments were seen in numerous cognitive domains, including memory, visuospatial and executive abilities, attention, and language. Predictors of cognitive impairment on the MoCA using univariate analyses were male sex, older age, lower educational level, and greater disease severity; older age was the only predictor in a multivariate model. CONCLUSION: Approximately half of patients with PD with a normal MMSE score have cognitive impairment based on the recommended MoCA cutoff score. These results suggest that MCI is common in PD and that the MoCA is a more sensitive instrument than the MMSE for its detection.</abstract><subject lang="en"><genre>Keywords</genre><topic>cognitive impairment</topic><topic>Parkinson's disease</topic><topic>Mini‐Mental State Examination</topic><topic>Montreal Cognitive Assessment</topic><topic>neuropsychology</topic></subject><relatedItem type="host"><titleInfo><title>Journal of the American Geriatrics Society</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0002-8614</identifier><identifier type="eISSN">1532-5415</identifier><identifier type="DOI">10.1111/(ISSN)1532-5415</identifier><identifier type="PublisherID">JGS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>57</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>304</start><end>308</end><total>5</total></extent></part></relatedItem><identifier type="istex">28DEF22DE0F666948C44769386483E6752508936</identifier><identifier type="DOI">10.1111/j.1532-5415.2008.02096.x</identifier><identifier type="ArticleID">JGS2096</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2009, Copyright the Authors. 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