Dementia with Lewy bodies: findings from an international multicentre study
Identifieur interne : 000B65 ( Main/Corpus ); précédent : 000B64; suivant : 000B66Dementia with Lewy bodies: findings from an international multicentre study
Auteurs : Teodoro Del Ser ; Ian Mckeith ; Ravi Anand ; Ana Cicin-Sain ; Roberto Ferrara ; René SpiegelSource :
- International Journal of Geriatric Psychiatry [ 0885-6230 ] ; 2000-11.
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- KwdEn :
Abstract
Objectives. To describe the baseline demographic, neuropsychiatric and neurological data of a large selected clinical sample of patients with dementia with Lewy Bodies (DLB) from an international multicentre trial with rivastigmine. To examine the usefulness of the Consensus Criteria for the diagnosis of DLB in different countries. Methods. Seventeen centres from Spain, the UK and Italy recruited patients diagnosed clinically as probable DLB according to recent Consensus Criteria (McKeith et al., 1996). A standard clinical protocol including inclusion/exclusion criteria, collection of demographic and medical data, cognitive (Mini Mental State Examination: MMSE), motor (Unified Parkinson's Disease Rating Scale: UPDRS) and neuropsychiatric (Neuropsychiatric Inventory: NPI) examinations, was applied after obtaining informed consent. Data were summarised and compared across countries with uni‐ and multivariate analyses. Results. One hundred and twenty patients were recruited: 56.7% males, mean (SD) age 73.9 (6.4) years, range 57 – 87 years. Sixty percent fulfilled all three core diagnostic features of DLB, and 40% only two (‘parkinsonism’ 92.4%, ‘cognitive fluctuations’ 89.1%, ‘visual hallucinations’ 77.3%). ‘Systematised delusions’ (46%) and ‘repeated falls’ (42%) were the most frequent supportive diagnostic features. There were no differences across countries in demographic, diagnostic or clinical features. Patients showed a wide range of psychopathology which was weakly correlated with cognitive impairment. Some mild extrapyramidal signs (EPS) were observed in most patients. Conclusions. The Consensus Criteria for DLB can be consistently applied across many different sites for multicentre studies. ‘Parkinsonism’ and ‘cognitive fluctuations’ as core features and ‘systematised delusions’ and ‘repeated falls’ as supportive features are the most frequent diagnostic clues. Neuropsychiatric disturbances, in particular apathy, delusions, hallucinations and anxiety, and mild symmetric EPS are frequent in DLB and are only related weakly to cognitive impairment. Copyright © 2000 John Wiley & Sons, Ltd.
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DOI: 10.1002/1099-1166(200011)15:11<1034::AID-GPS231>3.0.CO;2-5
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dementia with Lewy bodies: findings from an international multicentre study</title><author><name sortKey="Del Ser, Teodoro" sort="Del Ser, Teodoro" uniqKey="Del Ser T" first="Teodoro" last="Del Ser">Teodoro Del Ser</name><affiliation><mods:affiliation>Hospital Severo Ochoa, Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Mckeith, Ian" sort="Mckeith, Ian" uniqKey="Mckeith I" first="Ian" last="Mckeith">Ian Mckeith</name><affiliation><mods:affiliation>Newcastle General Hospital, Newcastle upon Tyne, UK</mods:affiliation></affiliation></author><author><name sortKey="Anand, Ravi" sort="Anand, Ravi" uniqKey="Anand R" first="Ravi" last="Anand">Ravi Anand</name><affiliation><mods:affiliation>Novartis Pharmaceuticals Corporation, New Jersey, USA</mods:affiliation></affiliation></author><author><name sortKey="Cicin Ain, Ana" sort="Cicin Ain, Ana" uniqKey="Cicin Ain A" first="Ana" last="Cicin-Sain">Ana Cicin-Sain</name><affiliation><mods:affiliation>Novartis Pharma AG, Basel, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Ferrara, Roberto" sort="Ferrara, Roberto" uniqKey="Ferrara R" first="Roberto" last="Ferrara">Roberto Ferrara</name><affiliation><mods:affiliation>Novartis Farma Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Spiegel, Rene" sort="Spiegel, Rene" uniqKey="Spiegel R" first="René" last="Spiegel">René Spiegel</name><affiliation><mods:affiliation>Novartis Pharma AG, Basel, Switzerland</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6C656BA32E7D0BE6E54575EB4D2114F4246DD1C9</idno><date when="2000" year="2000">2000</date><idno type="doi">10.1002/1099-1166(200011)15:11<1034::AID-GPS231>3.0.CO;2-5</idno><idno type="url">https://api.istex.fr/document/6C656BA32E7D0BE6E54575EB4D2114F4246DD1C9/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000B65</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Dementia with Lewy bodies: findings from an international multicentre study</title><author><name sortKey="Del Ser, Teodoro" sort="Del Ser, Teodoro" uniqKey="Del Ser T" first="Teodoro" last="Del Ser">Teodoro Del Ser</name><affiliation><mods:affiliation>Hospital Severo Ochoa, Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Mckeith, Ian" sort="Mckeith, Ian" uniqKey="Mckeith I" first="Ian" last="Mckeith">Ian Mckeith</name><affiliation><mods:affiliation>Newcastle General Hospital, Newcastle upon Tyne, UK</mods:affiliation></affiliation></author><author><name sortKey="Anand, Ravi" sort="Anand, Ravi" uniqKey="Anand R" first="Ravi" last="Anand">Ravi Anand</name><affiliation><mods:affiliation>Novartis Pharmaceuticals Corporation, New Jersey, USA</mods:affiliation></affiliation></author><author><name sortKey="Cicin Ain, Ana" sort="Cicin Ain, Ana" uniqKey="Cicin Ain A" first="Ana" last="Cicin-Sain">Ana Cicin-Sain</name><affiliation><mods:affiliation>Novartis Pharma AG, Basel, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Ferrara, Roberto" sort="Ferrara, Roberto" uniqKey="Ferrara R" first="Roberto" last="Ferrara">Roberto Ferrara</name><affiliation><mods:affiliation>Novartis Farma Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Spiegel, Rene" sort="Spiegel, Rene" uniqKey="Spiegel R" first="René" last="Spiegel">René Spiegel</name><affiliation><mods:affiliation>Novartis Pharma AG, Basel, Switzerland</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">International Journal of Geriatric Psychiatry</title><title level="j" type="abbrev">Int. J. Geriat. Psychiatry</title><idno type="ISSN">0885-6230</idno><idno type="eISSN">1099-1166</idno><imprint><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2000-11">2000-11</date><biblScope unit="volume">15</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1034">1034</biblScope><biblScope unit="page" to="1045">1045</biblScope></imprint><idno type="ISSN">0885-6230</idno></series><idno type="istex">6C656BA32E7D0BE6E54575EB4D2114F4246DD1C9</idno><idno type="DOI">10.1002/1099-1166(200011)15:11<1034::AID-GPS231>3.0.CO;2-5</idno><idno type="ArticleID">GPS231</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-6230</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>consensus criteria</term><term>dementia with Lewy bodies</term><term>multicentre study</term><term>pharmaceuticals</term><term>rivastigmine</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="fr">Objectives. To describe the baseline demographic, neuropsychiatric and neurological data of a large selected clinical sample of patients with dementia with Lewy Bodies (DLB) from an international multicentre trial with rivastigmine. To examine the usefulness of the Consensus Criteria for the diagnosis of DLB in different countries. Methods. Seventeen centres from Spain, the UK and Italy recruited patients diagnosed clinically as probable DLB according to recent Consensus Criteria (McKeith et al., 1996). A standard clinical protocol including inclusion/exclusion criteria, collection of demographic and medical data, cognitive (Mini Mental State Examination: MMSE), motor (Unified Parkinson's Disease Rating Scale: UPDRS) and neuropsychiatric (Neuropsychiatric Inventory: NPI) examinations, was applied after obtaining informed consent. Data were summarised and compared across countries with uni‐ and multivariate analyses. Results. One hundred and twenty patients were recruited: 56.7% males, mean (SD) age 73.9 (6.4) years, range 57 – 87 years. Sixty percent fulfilled all three core diagnostic features of DLB, and 40% only two (‘parkinsonism’ 92.4%, ‘cognitive fluctuations’ 89.1%, ‘visual hallucinations’ 77.3%). ‘Systematised delusions’ (46%) and ‘repeated falls’ (42%) were the most frequent supportive diagnostic features. There were no differences across countries in demographic, diagnostic or clinical features. Patients showed a wide range of psychopathology which was weakly correlated with cognitive impairment. Some mild extrapyramidal signs (EPS) were observed in most patients. Conclusions. The Consensus Criteria for DLB can be consistently applied across many different sites for multicentre studies. ‘Parkinsonism’ and ‘cognitive fluctuations’ as core features and ‘systematised delusions’ and ‘repeated falls’ as supportive features are the most frequent diagnostic clues. Neuropsychiatric disturbances, in particular apathy, delusions, hallucinations and anxiety, and mild symmetric EPS are frequent in DLB and are only related weakly to cognitive impairment. Copyright © 2000 John Wiley & Sons, Ltd.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Teodoro Del Ser</name><affiliations><json:string>Hospital Severo Ochoa, Madrid, Spain</json:string></affiliations></json:item><json:item><name>Ian McKeith</name><affiliations><json:string>Newcastle General Hospital, Newcastle upon Tyne, UK</json:string></affiliations></json:item><json:item><name>Ravi Anand</name><affiliations><json:string>Novartis Pharmaceuticals Corporation, New Jersey, USA</json:string></affiliations></json:item><json:item><name>Ana Cicin‐Sain</name><affiliations><json:string>Novartis Pharma AG, Basel, Switzerland</json:string></affiliations></json:item><json:item><name>Roberto Ferrara</name><affiliations><json:string>Novartis Farma Milan, Italy</json:string></affiliations></json:item><json:item><name>René Spiegel</name><affiliations><json:string>Novartis Pharma AG, Basel, Switzerland</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>dementia with Lewy bodies</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>pharmaceuticals</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>rivastigmine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>multicentre study</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>consensus criteria</value></json:item></subject><articleId><json:string>GPS231</json:string></articleId><language><json:string>eng</json:string></language><abstract>Objectives. To describe the baseline demographic, neuropsychiatric and neurological data of a large selected clinical sample of patients with dementia with Lewy Bodies (DLB) from an international multicentre trial with rivastigmine. To examine the usefulness of the Consensus Criteria for the diagnosis of DLB in different countries. Methods. Seventeen centres from Spain, the UK and Italy recruited patients diagnosed clinically as probable DLB according to recent Consensus Criteria (McKeith et al., 1996). A standard clinical protocol including inclusion/exclusion criteria, collection of demographic and medical data, cognitive (Mini Mental State Examination: MMSE), motor (Unified Parkinson's Disease Rating Scale: UPDRS) and neuropsychiatric (Neuropsychiatric Inventory: NPI) examinations, was applied after obtaining informed consent. Data were summarised and compared across countries with uni‐ and multivariate analyses. Results. One hundred and twenty patients were recruited: 56.7% males, mean (SD) age 73.9 (6.4) years, range 57 – 87 years. Sixty percent fulfilled all three core diagnostic features of DLB, and 40% only two (‘parkinsonism’ 92.4%, ‘cognitive fluctuations’ 89.1%, ‘visual hallucinations’ 77.3%). ‘Systematised delusions’ (46%) and ‘repeated falls’ (42%) were the most frequent supportive diagnostic features. There were no differences across countries in demographic, diagnostic or clinical features. Patients showed a wide range of psychopathology which was weakly correlated with cognitive impairment. Some mild extrapyramidal signs (EPS) were observed in most patients. Conclusions. The Consensus Criteria for DLB can be consistently applied across many different sites for multicentre studies. ‘Parkinsonism’ and ‘cognitive fluctuations’ as core features and ‘systematised delusions’ and ‘repeated falls’ as supportive features are the most frequent diagnostic clues. Neuropsychiatric disturbances, in particular apathy, delusions, hallucinations and anxiety, and mild symmetric EPS are frequent in DLB and are only related weakly to cognitive impairment. Copyright © 2000 John Wiley & Sons, Ltd.</abstract><qualityIndicators><score>8</score><pdfVersion>1.2</pdfVersion><pdfPageSize>567 x 737 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>2128</abstractCharCount><pdfWordCount>5795</pdfWordCount><pdfCharCount>38292</pdfCharCount><pdfPageCount>12</pdfPageCount><abstractWordCount>287</abstractWordCount></qualityIndicators><title>Dementia with Lewy bodies: findings from an international multicentre study</title><genre><json:string>article</json:string></genre><host><volume>15</volume><publisherId><json:string>GPS</json:string></publisherId><pages><total>12</total><last>1045</last><first>1034</first></pages><issn><json:string>0885-6230</json:string></issn><issue>11</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1099-1166</json:string></eissn><title>International Journal of Geriatric Psychiatry</title><doi><json:string>10.1002/(ISSN)1099-1166</json:string></doi></host><publicationDate>2000</publicationDate><copyrightDate>2000</copyrightDate><doi><json:string>10.1002/1099-1166(200011)15:11>1034::AID-GPS231>3.0.CO;2-5</json:string></doi><id>6C656BA32E7D0BE6E54575EB4D2114F4246DD1C9</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/6C656BA32E7D0BE6E54575EB4D2114F4246DD1C9/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/6C656BA32E7D0BE6E54575EB4D2114F4246DD1C9/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/6C656BA32E7D0BE6E54575EB4D2114F4246DD1C9/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Dementia with Lewy bodies: findings from an international multicentre study</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><availability><p>WILEY</p></availability><date>2000</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Dementia with Lewy bodies: findings from an international multicentre study</title><author><persName><forename type="first">Teodoro</forename><surname>Del Ser</surname></persName><note type="correspondence"><p>Correspondence: Section of Neurology, Hospital Severo Ochoa, 28911 Leganes, Madrid, Spain.</p></note><affiliation>Hospital Severo Ochoa, Madrid, Spain</affiliation></author><author><persName><forename type="first">Ian</forename><surname>McKeith</surname></persName><affiliation>Newcastle General Hospital, Newcastle upon Tyne, UK</affiliation></author><author><persName><forename type="first">Ravi</forename><surname>Anand</surname></persName><affiliation>Novartis Pharmaceuticals Corporation, New Jersey, USA</affiliation></author><author><persName><forename type="first">Ana</forename><surname>Cicin‐Sain</surname></persName><affiliation>Novartis Pharma AG, Basel, Switzerland</affiliation></author><author><persName><forename type="first">Roberto</forename><surname>Ferrara</surname></persName><affiliation>Novartis Farma Milan, Italy</affiliation></author><author><persName><forename type="first">René</forename><surname>Spiegel</surname></persName><affiliation>Novartis Pharma AG, Basel, Switzerland</affiliation></author></analytic><monogr><title level="j">International Journal of Geriatric Psychiatry</title><title level="j" type="abbrev">Int. J. Geriat. Psychiatry</title><idno type="pISSN">0885-6230</idno><idno type="eISSN">1099-1166</idno><idno type="DOI">10.1002/(ISSN)1099-1166</idno><imprint><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2000-11"></date><biblScope unit="volume">15</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1034">1034</biblScope><biblScope unit="page" to="1045">1045</biblScope></imprint></monogr><idno type="istex">6C656BA32E7D0BE6E54575EB4D2114F4246DD1C9</idno><idno type="DOI">10.1002/1099-1166(200011)15:11<1034::AID-GPS231>3.0.CO;2-5</idno><idno type="ArticleID">GPS231</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2000</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="fr"><p>Objectives. To describe the baseline demographic, neuropsychiatric and neurological data of a large selected clinical sample of patients with dementia with Lewy Bodies (DLB) from an international multicentre trial with rivastigmine. To examine the usefulness of the Consensus Criteria for the diagnosis of DLB in different countries. Methods. Seventeen centres from Spain, the UK and Italy recruited patients diagnosed clinically as probable DLB according to recent Consensus Criteria (McKeith et al., 1996). A standard clinical protocol including inclusion/exclusion criteria, collection of demographic and medical data, cognitive (Mini Mental State Examination: MMSE), motor (Unified Parkinson's Disease Rating Scale: UPDRS) and neuropsychiatric (Neuropsychiatric Inventory: NPI) examinations, was applied after obtaining informed consent. Data were summarised and compared across countries with uni‐ and multivariate analyses. Results. One hundred and twenty patients were recruited: 56.7% males, mean (SD) age 73.9 (6.4) years, range 57 – 87 years. Sixty percent fulfilled all three core diagnostic features of DLB, and 40% only two (‘parkinsonism’ 92.4%, ‘cognitive fluctuations’ 89.1%, ‘visual hallucinations’ 77.3%). ‘Systematised delusions’ (46%) and ‘repeated falls’ (42%) were the most frequent supportive diagnostic features. There were no differences across countries in demographic, diagnostic or clinical features. Patients showed a wide range of psychopathology which was weakly correlated with cognitive impairment. Some mild extrapyramidal signs (EPS) were observed in most patients. Conclusions. The Consensus Criteria for DLB can be consistently applied across many different sites for multicentre studies. ‘Parkinsonism’ and ‘cognitive fluctuations’ as core features and ‘systematised delusions’ and ‘repeated falls’ as supportive features are the most frequent diagnostic clues. Neuropsychiatric disturbances, in particular apathy, delusions, hallucinations and anxiety, and mild symmetric EPS are frequent in DLB and are only related weakly to cognitive impairment. Copyright © 2000 John Wiley & Sons, Ltd.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>dementia with Lewy bodies</term></item><item><term>pharmaceuticals</term></item><item><term>rivastigmine</term></item><item><term>multicentre study</term></item><item><term>consensus criteria</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1999-10-07">Received</change><change when="2000-01-27">Registration</change><change when="2000-11">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/6C656BA32E7D0BE6E54575EB4D2114F4246DD1C9/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Ltd.</publisherName><publisherLoc>Chichester, UK</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1099-1166</doi><issn type="print">0885-6230</issn><issn type="electronic">1099-1166</issn><idGroup><id type="product" value="GPS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY">International Journal of Geriatric Psychiatry</title><title type="short">Int. 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To describe the baseline demographic, neuropsychiatric and neurological data of a large selected clinical sample of patients with dementia with Lewy Bodies (DLB) from an international multicentre trial with rivastigmine. To examine the usefulness of the Consensus Criteria for the diagnosis of DLB in different countries.</p><p><i>Methods</i>. Seventeen centres from Spain, the UK and Italy recruited patients diagnosed clinically as probable DLB according to recent Consensus Criteria (McKeith <i>et al</i>., 1996). A standard clinical protocol including inclusion/exclusion criteria, collection of demographic and medical data, cognitive (Mini Mental State Examination: MMSE), motor (Unified Parkinson's Disease Rating Scale: UPDRS) and neuropsychiatric (Neuropsychiatric Inventory: NPI) examinations, was applied after obtaining informed consent. Data were summarised and compared across countries with uni‐ and multivariate analyses.</p><p><i>Results</i>. One hundred and twenty patients were recruited: 56.7% males, mean (SD) age 73.9 (6.4) years, range 57 – 87 years. Sixty percent fulfilled all three core diagnostic features of DLB, and 40% only two (‘parkinsonism’ 92.4%, ‘cognitive fluctuations’ 89.1%, ‘visual hallucinations’ 77.3%). ‘Systematised delusions’ (46%) and ‘repeated falls’ (42%) were the most frequent supportive diagnostic features. There were no differences across countries in demographic, diagnostic or clinical features. Patients showed a wide range of psychopathology which was weakly correlated with cognitive impairment. Some mild extrapyramidal signs (EPS) were observed in most patients.</p><p><i>Conclusions</i>. The Consensus Criteria for DLB can be consistently applied across many different sites for multicentre studies. ‘Parkinsonism’ and ‘cognitive fluctuations’ as core features and ‘systematised delusions’ and ‘repeated falls’ as supportive features are the most frequent diagnostic clues. Neuropsychiatric disturbances, in particular apathy, delusions, hallucinations and anxiety, and mild symmetric EPS are frequent in DLB and are only related weakly to cognitive impairment. Copyright © 2000 John Wiley & Sons, Ltd.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Dementia with Lewy bodies: findings from an international multicentre study</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>DEMENTIA WITH LEWY BODIES</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Dementia with Lewy bodies: findings from an international multicentre study</title></titleInfo><name type="personal"><namePart type="given">Teodoro</namePart><namePart type="family">Del Ser</namePart><affiliation>Hospital Severo Ochoa, Madrid, Spain</affiliation><description>Correspondence: Section of Neurology, Hospital Severo Ochoa, 28911 Leganes, Madrid, Spain.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ian</namePart><namePart type="family">McKeith</namePart><affiliation>Newcastle General Hospital, Newcastle upon Tyne, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ravi</namePart><namePart type="family">Anand</namePart><affiliation>Novartis Pharmaceuticals Corporation, New Jersey, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ana</namePart><namePart type="family">Cicin‐Sain</namePart><affiliation>Novartis Pharma AG, Basel, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roberto</namePart><namePart type="family">Ferrara</namePart><affiliation>Novartis Farma Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">René</namePart><namePart type="family">Spiegel</namePart><affiliation>Novartis Pharma AG, Basel, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>John Wiley & Sons, Ltd.</publisher><place><placeTerm type="text">Chichester, UK</placeTerm></place><dateIssued encoding="w3cdtf">2000-11</dateIssued><dateCaptured encoding="w3cdtf">1999-10-07</dateCaptured><dateValid encoding="w3cdtf">2000-01-27</dateValid><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">4</extent><extent unit="references">42</extent></physicalDescription><abstract lang="fr">Objectives. To describe the baseline demographic, neuropsychiatric and neurological data of a large selected clinical sample of patients with dementia with Lewy Bodies (DLB) from an international multicentre trial with rivastigmine. To examine the usefulness of the Consensus Criteria for the diagnosis of DLB in different countries. Methods. Seventeen centres from Spain, the UK and Italy recruited patients diagnosed clinically as probable DLB according to recent Consensus Criteria (McKeith et al., 1996). A standard clinical protocol including inclusion/exclusion criteria, collection of demographic and medical data, cognitive (Mini Mental State Examination: MMSE), motor (Unified Parkinson's Disease Rating Scale: UPDRS) and neuropsychiatric (Neuropsychiatric Inventory: NPI) examinations, was applied after obtaining informed consent. Data were summarised and compared across countries with uni‐ and multivariate analyses. Results. One hundred and twenty patients were recruited: 56.7% males, mean (SD) age 73.9 (6.4) years, range 57 – 87 years. Sixty percent fulfilled all three core diagnostic features of DLB, and 40% only two (‘parkinsonism’ 92.4%, ‘cognitive fluctuations’ 89.1%, ‘visual hallucinations’ 77.3%). ‘Systematised delusions’ (46%) and ‘repeated falls’ (42%) were the most frequent supportive diagnostic features. There were no differences across countries in demographic, diagnostic or clinical features. Patients showed a wide range of psychopathology which was weakly correlated with cognitive impairment. Some mild extrapyramidal signs (EPS) were observed in most patients. Conclusions. The Consensus Criteria for DLB can be consistently applied across many different sites for multicentre studies. ‘Parkinsonism’ and ‘cognitive fluctuations’ as core features and ‘systematised delusions’ and ‘repeated falls’ as supportive features are the most frequent diagnostic clues. Neuropsychiatric disturbances, in particular apathy, delusions, hallucinations and anxiety, and mild symmetric EPS are frequent in DLB and are only related weakly to cognitive impairment. Copyright © 2000 John Wiley & Sons, Ltd.</abstract><subject lang="en"><genre>Keywords</genre><topic>dementia with Lewy bodies</topic><topic>pharmaceuticals</topic><topic>rivastigmine</topic><topic>multicentre study</topic><topic>consensus criteria</topic></subject><relatedItem type="host"><titleInfo><title>International Journal of Geriatric Psychiatry</title></titleInfo><titleInfo type="abbreviated"><title>Int. J. Geriat. Psychiatry</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-6230</identifier><identifier type="eISSN">1099-1166</identifier><identifier type="DOI">10.1002/(ISSN)1099-1166</identifier><identifier type="PublisherID">GPS</identifier><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><detail type="issue"><caption>no.</caption><number>11</number></detail><extent unit="pages"><start>1034</start><end>1045</end><total>12</total></extent></part></relatedItem><identifier type="istex">6C656BA32E7D0BE6E54575EB4D2114F4246DD1C9</identifier><identifier type="DOI">10.1002/1099-1166(200011)15:11<1034::AID-GPS231>3.0.CO;2-5</identifier><identifier type="ArticleID">GPS231</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2000 John Wiley & Sons, Ltd.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>John Wiley & Sons, Ltd.</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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